Vicky Puig
M. Victoria Puig is a Group Leader at the Barcelona Biomedical Research Park (PRBB) and Hospital del Mar Medical Research Institute (IMIM). Her team studies the neural substrates of learning and memory enhancement, with particular focus on neural oscillations and the role of neuromodulators.
Supervisors: Yasuo Kawaguchi, Francesc Artigas, and Earl K. Miller
Address: Dr Aiguader 88, PRBB building, office 225
Supervisors: Yasuo Kawaguchi, Francesc Artigas, and Earl K. Miller
Address: Dr Aiguader 88, PRBB building, office 225
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Papers by Vicky Puig
"Es una ciudad en boca de todos por los recientes atentados. Pero también un ecosistema con enorme capacidad de crear valor, atraer talento y generar riqueza
Desde emblemas como Harvard hasta el MIT, este es un viaje por los escenarios más innovadores de un lugar que está dando forma al tiempo que vivimos
However, while dopamine D1 receptors (D1Rs) in the
prefrontal cortex (PFC) have been shown to modulate
working memory-related neural activity, their
role in the cellular basis of learning is unknown. We
recorded activity from multiple electrodes while injecting
the D1R antagonist SCH23390 in the lateral
PFC as monkeys learned visuomotor associations.
Blocking D1Rs impaired learning of novel associations
and decreased cognitive flexibility but spared
performance of already familiar associations. This
suggests a greater role for prefrontal D1Rs in learning
new, rather than performing familiar, associations.
There was a corresponding greater decrease
in neural selectivity and increase in alpha and beta
oscillations in local field potentials for novel than
for familiar associations. Our results suggest that
weak stimulation of D1Rs observed in aging and
psychiatric disorders may impair learning and PFC
function by reducing neural selectivity and exacerbating
neural oscillations associated with inattention
and cognitive deficits.
"Es una ciudad en boca de todos por los recientes atentados. Pero también un ecosistema con enorme capacidad de crear valor, atraer talento y generar riqueza
Desde emblemas como Harvard hasta el MIT, este es un viaje por los escenarios más innovadores de un lugar que está dando forma al tiempo que vivimos
However, while dopamine D1 receptors (D1Rs) in the
prefrontal cortex (PFC) have been shown to modulate
working memory-related neural activity, their
role in the cellular basis of learning is unknown. We
recorded activity from multiple electrodes while injecting
the D1R antagonist SCH23390 in the lateral
PFC as monkeys learned visuomotor associations.
Blocking D1Rs impaired learning of novel associations
and decreased cognitive flexibility but spared
performance of already familiar associations. This
suggests a greater role for prefrontal D1Rs in learning
new, rather than performing familiar, associations.
There was a corresponding greater decrease
in neural selectivity and increase in alpha and beta
oscillations in local field potentials for novel than
for familiar associations. Our results suggest that
weak stimulation of D1Rs observed in aging and
psychiatric disorders may impair learning and PFC
function by reducing neural selectivity and exacerbating
neural oscillations associated with inattention
and cognitive deficits.