Papers by Christine E Kasper
SPECIAL SESSION: Following the Question: From Bedrest to Outer Space and Beyond
Sigma Theta Tau International's 26th International Nursing Research Congress, Jul 25, 2015
Biological Research For Nursing, Jul 1, 1999
TheinauguralissueofBiologicalResearchforNursing is the result of many years of thought and effort... more TheinauguralissueofBiologicalResearchforNursing is the result of many years of thought and effort. In the late 1980s the idea that a journal dedicated to the publication of basic research by nurse scientists was needed began to take root. As the number of nurse scientist involved in biological research grew they, like nurse scientists in the past, who engaged in basic research, published their research in science journals outside of nursing. In 1990, a symposium titled, "Physiological Foci in Nursing: Philosophy, Theory and Research" was presented at the annual meeting of Western Research Society for Nursing. Among the participants who attended the symposium many expressed the need for a nursing journal devoted to the publication of biological research. A number of factors during the late 1980s and early 1990s led to the initiation of attempts to launch a journal which would have as its central focus papers that were derived from or contributed to biological research in nursing. The National Center for Nursing Research at NIH was granted institution status and became the National Institute for Nursing Research. Biological initiatives to fund nurses doing biological research were funded and implemented by the institute. The number of nurses prepared in basic sciences increased as did the number of nurses engaged in biological research. Changes in the health care system in the United States led to changes in the scope of practice of nurses, specifically those engaged in advanced practice. The advanced practice model of nursing, exemplified by the role of the certified nurse midwife, nurse practitioner, clinical nurse specialist, and nurse anesthetist, led to the need for an extension of theoretical and research knowledge of biological phenomena which is foundational to advanced practice.
Limited information exists regarding the primary and secondary effect of affect influencing stimu... more Limited information exists regarding the primary and secondary effect of affect influencing stimuli in a natural setting. Background Observe the evolution of affect contagion among advanced practice nursing (APN) students using social network analysis and linear statistical methods. Purpose Demographics Conclusion References upon request Acknowledgments Sponsorship: This research is sponsored by the TriService Nursing Research Program, Uniformed Services University of the Health Sciences, and the Department of Veterans Affairs, funded Sandia National Laboratories under an Interagency Agreement with the Department of Energy for modeling public health events.
This 32th volume in the Annual Review of Nursing Research series. Introduction
PubMed, 2014
Following the Question: From Bedrest to Outer Space and Beyond
Monitoring of men with hot flashes following androgen ablation: A Transdisciplinary Approach
Structure Recapitulates Function
Biological Research For Nursing, Apr 1, 2000
Journal of Rehabilitation Medicine, 2003
The aim of the study was to evaluate the reliability of two clinical tests of mobility for stroke... more The aim of the study was to evaluate the reliability of two clinical tests of mobility for stroke patients. Design: The study took place in a university hospital with a case control design. Subjects: A sample of convenience including 31 subjects: a group of patients with prior stroke (n = 19); a control group (n = 12). Methods: The time(s) for sitting up from a supine position and transferring from an examination table to a chair were measured and inter-and intra-rater reliability were assessed. The source of variation in the test results as well as intra-class correlations were estimated. Results: The largest source of variation in the supine position was between subjects, and the between-tester variability was very low, with similar results for the transfer from table to chair. The intra-class correlations are all high (range 0.77-0.98). This indicates that it is of little importance which tester is performing the tests. Conclusion: Sitting up on an examination table and transferring from an examination table to a chair seem to be reliable timed clinical tests of mobility in stroke research.
Fatigue mechanisms in patients with cancer: effects of tumor necrosis factor and exercise on skeletal muscle
PubMed, Apr 1, 1992
Fatigue is a common adverse effect of cancer and its therapy. However, the specific mechanisms un... more Fatigue is a common adverse effect of cancer and its therapy. However, the specific mechanisms underlying cancer fatigue are unclear. One physiologic mechanism may involve changes in skeletal muscle protein stores or metabolite concentration. A reduction in skeletal muscle protein stores may result from endogenous tumor necrosis factor (TNF) or from TNF administered as antineoplastic therapy. This muscle wasting would require patients to exert an unusually high amount of effort to generate adequate contractile force during exercise performance or during extended periods of sitting or standing. This additional effort could result in the onset of fatigue. Additionally, cancer fatigue may develop or become exacerbated during exercise as a consequence of changes in the concentration of skeletal muscle metabolites. These biochemical alterations may interfere with force that is produced by the muscle contractile proteins. These physiologic changes may play a role in the decision to include exercise in the rehabilitation plans of patients with cancer. They also may affect ideas about fatigue.
Sarcolemmal disruption in reloaded atrophic skeletal muscle
Journal of Applied Physiology, Aug 1, 1995
The purpose of this study was to determine whether reloading of atrophied skeletal muscle after 2... more The purpose of this study was to determine whether reloading of atrophied skeletal muscle after 28 days of hind-limb unloading (HU) would produce significant sarcolemmal membrane disruption before frank necrosis. Soleus and plantaris muscles were atrophied by HU. Adult female Wistar rats (N = 13) were killed at 28 days of unloading and 4 and 7 days of reloading after HU. Rat serum albumin was used as a marker for muscle fiber disruption. Dark intracellular staining with horseradish peroxidase-conjugated anti-rat serum albumin antibody was interpreted as evidence of membrane rupture. There was a significantly different time course of disruption between plantaris and soleus muscles, with a negative correlation between cell size and occurrence of disruption. Fourteen percent of plantaris fibers were wounded after HU, peaking at day 4 of reloading (20% of cross-sectional area). Soleus demonstrated disruption only on reloading peaking in severity at day 7 (14% of fibers). It was demonstrated that sarcolemmal disruption due to atrophy and reloading does not always progress to necrosis and degeneration by the 7th day of recovery.
Prevention, Genetic Testing, and Treatment of Genetic Disease
Springer eBooks, Jun 14, 2018
Cytoplasm-To-Myonucleus Ratios in Atrophic Skeletal Muscle
Medicine and Science in Sports and Exercise, May 1, 1995
Medicine and Science in Sports and Exercise, May 1, 1993
Personal Digital Assistants and Clinical Practice
Western Journal of Nursing Research, Dec 1, 1996
Alterations in skeletal muscle related to short-term impaired physical mobility
Research in Nursing & Health, Apr 1, 1996
Expression of Titin in Skeletal Muscle Varies with Hind-Limb Unloading
Biological Research For Nursing, Oct 1, 2000
The effects of prolonged hind-limb unloading on titin antibody localization and expression of tit... more The effects of prolonged hind-limb unloading on titin antibody localization and expression of titin isozymes of single fibers from the synergistic slow-twitch soleus (SOL) and fast-twitch plantaris (PLN) of adult rats were studied after 14 and 28 days of hind-limb unloading (HU). Titin antibody localization and expression was not altered at 14 days of HU. However, there was a 4% loss in antibody to Z-band distance (Ab-Z) in the SOL and an increase of 8% in PLN Ab-Z after 28 days of HU. The titin and myosin heavy chain composition of single fibers and small bundles of fibers from control and unloaded muscles were examined using 2% to 12% sodium dodecyl sulfate-polyacrylamide gel electrophoresis. There was a marked loss of relative amounts of titin in both SOL and PLN following 28 days of HU. As the protein loads for these measures were identical, the authors conclude that these findings represent an actual loss of titin density rather than a decreased value due to a loss of total muscle mass. Laser scanning densitometry of the titin bands show a marked decrease in density and molecular weight in unloaded SOL. In the PLN, marked losses of titin density were accompanied by decreased electrophoretic motility. The results demonstrate that the titin isoform composition and titin antibody localization of skeletal muscle is altered during hind-limb unloading. Furthermore, as titin is responsible for positional stability of the sarcomere and the fiber during contraction, change in isoforms during HU may predispose atrophied muscle to injury during reuse and recovery.
Spatial Patterns of Atrophied Muscle Fibers during Exercised Recovery
Biological Research For Nursing, Jul 1, 1999
The effect of run training during the recovery period on the spatial distributions of fiber type ... more The effect of run training during the recovery period on the spatial distributions of fiber type was examined in atrophic soleus muscle of adult rats following 28 days of hindlimb suspension. During recovery, clusters of damaged and type IIC fibers were observed, which were more pronounced in the exercised animals than in both exercised and nonexercised control groups. The results indicate that exercise during recovery following suspension-induced hindlimb muscle atrophy produces changes in the soleus fiber-type cross-sectional area, both absolute and relative. These changes were not seen in the sedentary recovery group or in control rats exposed to the same exercise regimen. The author concludes that this treatment, unlike neurogenic pathologies, does not cause any remodeling during recovery, in the sense of changed adjacency relations among fiber types.
Running during recovery from hindlimb suspension induces transient muscle injury
Journal of Applied Physiology, Feb 1, 1990
The objectives were to study morphological adaptations of soleus muscle to decreased loading indu... more The objectives were to study morphological adaptations of soleus muscle to decreased loading induced by hindlimb suspension and the effect of run training during the subsequent recovery period. Adult female Wistar rats were kept for 28 days with hindlimbs suspended. For the next 28 days, rats were assigned to a cage-sedentary or daily running group. Compared with control soleus muscles, 28 days of hindlimb suspension reduced the mass and fiber cross-sectional area to 58 and 53% of control values, respectively, and decreased type I fibers from 92 +/- 2 to 81 +/- 2%. During recovery, clusters of damaged fibers were observed in the soleus muscle, and this observation was more pronounced in trained animals. Type IIc fibers appeared transiently during recovery, and their presence was exacerbated with training, as IIc fibers increased to approximately 20% of the total by day 14 of recovery and were no longer evident at day 28. Although muscle wet mass does not differ as a result of mode of recovery at day 14, training transiently decreased the overall fiber area compared with sedentary recovery at this point. By day 28 of recovery the morphological characteristics of soleus muscle in the trained group did not differ from control muscle, whereas in the sedentary group muscle mass and overall fiber cross-sectional area were approximately 14% less than control values.
In Search of Nursing Science
SAGE Publications, Inc. eBooks, 1995
PART ONE: INTRODUCTION AND THE EMPIRICIST SCHOOL OF THOUGHT Introduction: Nursing Science for Nur... more PART ONE: INTRODUCTION AND THE EMPIRICIST SCHOOL OF THOUGHT Introduction: Nursing Science for Nursing Practice - Sue Karen Donaldson Contemporary Empiricism - Sandra J Weiss Pragmatism - Christine E Kapser The Problem with the Bottom Line PART TWO: REVOLUTIONARY/EVOLUTIONARY PHILOSOPHY OF SCIENCE Science as Tradition and Tradition Shattering - Jacquelyn Anne K Kegley Thomas Kuhn's Philosophy of Science Moving Beyond - Barbara Riegel et al A Generative Philosophy of Science Science as Problem Solving - Sara T Fry An Evolutionary Approach to the Discipline of Nursing and Nursing Administration - Cathy Rodgers Ward PART THREE: POSTMODERN PHILOSOPHY OF SCIENCE Feminism, Science and Nursing - Ruth Ginzberg The Method Question - Sandra Harding Pain: An Issue of Gender - Gayle Giboney Page Phenomenology and Science - Anna Omery and Carol Mack The Experience of Surgery - Marlene Zichi Cohen and Kenneth Norris, Jr. Phenomenological Clinical Nursing Research A Hermeneutical Human Science for Nursing - Richard H Steeves and David L Kahn Passages Through the Heart - Francelyn Reeder A Hermeneutic of Choice Critical Theory for Science of Nursing Practice - Hesook Suzie Kim and Inger Margrethe Holter Methodology for Critical Theory - Inger Margrethe Holter and Hesook Suzie Kim Critical Action Research Post-Structuralist Science - Laura Dzurec An Historical Account for Profound Visibility Severe Mental Disability? Or a Play of Wills? - Laura Dzurec PART FOUR: THE RELATIONSHIP BETWEEN SCIENCE AND PRACTICE Applied Science, Practice and Intervention Technology - Anne H Bishop and John R Scudder, Jr. Science and Practice - Hannah Dean The Nature of Knowledge Science as the Predictor of Professional Recognition and Success - Luther Chrisman Epilogue: The Journey Continues
Recovery of Plantaris Muscle from Impaired Physical Mobility
Biological Research For Nursing, Jul 1, 1999
The purpose of this investigation was to describe and compare various methods of recovering atrop... more The purpose of this investigation was to describe and compare various methods of recovering atrophied fast-twitch skeletal muscle following long-term impaired physical mobility. An animal model was used to study morphological adaptations of atrophied plantaris muscles to the effects of 28 days of hindlimb suspension (HS) followed by either sedentary recovery or run training during a 28-day recovery period. Significant atrophy, demonstrated by decreased mean fiber area (MFA,mm2), occurred during the 28-day period of HS. However, run training following long-term atrophy induced by HS did not result in the high levels of frank muscle damage and type IIC fibers previously reported in slow-twitch soleus muscle following longterm (28 days) atrophy.
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Papers by Christine E Kasper