{"@attributes":{"version":"2.0"},"channel":{"title":"Phys.org news tagged with:reprogramming","link":"https:\/\/phys.org\/","language":"en-us","description":"Phys.org internet news portal provides the latest news on science including: Physics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine.","item":[{"title":"Lung cells generated from mouse fibroblasts in just 7 to 10 days without stem cell tech","description":"Researchers in Japan have successfully generated lung cells similar to alveolar epithelial type 2 (AT2) cells from mouse embryonic fibroblasts without using stem cell technology. The AT2-like cells were generated in just 7 to 10 days\u2014a significant reduction compared to the approximately one month typically required by conventional stem cell-based differentiation methods.","link":"https:\/\/phys.org\/news\/2025-07-lung-cells-generated-mouse-fibroblasts.html","category":"Cell & Microbiology","pubDate":"Thu, 03 Jul 2025 12:28:03 EDT","guid":"news670764481"},{"title":"Study uses body's clock to deliver medication precisely when needed","description":"Researchers at WashU Medicine have harnessed the internal circadian clock of the body to deliver medication for an inflammatory illness precisely when it was most needed. Tissue implants incorporating genetically engineered stem cells automatically delivered anti-inflammatory medications to mouse models of rheumatoid arthritis on a daily basis right before inflammation peaked. The researchers dubbed this approach \"chronogenetics.\"","link":"https:\/\/phys.org\/news\/2025-04-body-clock-medication-precisely.html","category":"Cell & Microbiology","pubDate":"Sun, 06 Apr 2025 09:30:01 EDT","guid":"news662959779"},{"title":"Researchers challenge longstanding theories in cellular reprogramming","description":"A team led by researchers at the University of Toronto has discovered that a group of cells located in the skin and other areas of the body, called neural crest stem cells, are the source of reprogrammed neurons found by other researchers.","link":"https:\/\/phys.org\/news\/2024-11-longstanding-theories-cellular-reprogramming.html","category":"Cell & Microbiology","pubDate":"Fri, 01 Nov 2024 12:36:04 EDT","guid":"news649683362"},{"title":"Researchers uncover why cells struggle to fully change identity in reprogramming efforts","description":"A new study has shed light on the challenges of converting one type of specialized cell into another, a process critical for advances in regenerative medicine. Despite recent progress in the field, a key obstacle in maintaining the new identity of reprogrammed cells lies in their original DNA methylation patterns\u2014crucial markers that define cell identity.","link":"https:\/\/phys.org\/news\/2024-09-uncover-cells-struggle-fully-identity.html","category":"Cell & Microbiology","pubDate":"Thu, 19 Sep 2024 11:31:04 EDT","guid":"news645964262"},{"title":"Scientists reveal mechanism of maternal protein Pramel15 in promoting DNA demethylation in mouse zygotes","description":"DNA methyltransferase 1 (DNMT1) is an important DNA methyltransferase that maintains DNA methylation. The retention of DNMT1 and its cofactor UHRF1 in the cytoplasm is considered a major reason for passive DNA demethylation in the oocyte and early embryonic development.","link":"https:\/\/phys.org\/news\/2024-09-scientists-reveal-mechanism-maternal-protein.html","category":"Cell & Microbiology","pubDate":"Tue, 03 Sep 2024 10:56:02 EDT","guid":"news644579761"},{"title":"Scientists link oocyte-specific histone H1FOO to better iPS cell generation","description":"A joint research team led by Dr. Akira Kunitomi, a former postdoctoral fellow at CiRA (currently a researcher at the Gladstone Institute of Cardiovascular Disease), and ID Pharma Co., Ltd., has uncovered the crucial role of oocyte-specific linker histone, H1FOO, in enhancing reprogramming efficiency and homogeneity to primed and na\u00efve pluripotent states. The study is published in Stem Cell Reports.","link":"https:\/\/phys.org\/news\/2024-05-scientists-link-oocyte-specific-histone.html","category":"Cell & Microbiology","pubDate":"Fri, 10 May 2024 09:32:04 EDT","guid":"news634552321"},{"title":"Hooking an anchor on the DNA minor groove to facilitate gene expression during reprogramming","description":"During the reprogramming of somatic cells back into stem cells, gene regulation is controlled by pioneer transcription factors. These bind to the tightly packaged DNA in order to make it accessible.","link":"https:\/\/phys.org\/news\/2024-02-anchor-dna-minor-groove-gene.html","category":"Molecular & Computational biology","pubDate":"Mon, 26 Feb 2024 11:39:12 EST","guid":"news628169948"},{"title":"Old skin cells reprogrammed to regain youthful function","description":"Research from the Babraham Institute has developed a method to \"time jump\" human skin cells by 30 years, turning back the aging clock for cells without losing their specialized function. Work by researchers in the Institute's Epigenetics research program has been able to partly restore the function of older cells, as well as rejuvenating the molecular measures of biological age. The research is published today in the journal eLife, and while this topic is still at an early stage of exploration, it could revolutionize regenerative medicine.","link":"https:\/\/phys.org\/news\/2022-04-skin-cells-reprogrammed-regain-youthful.html","category":"Cell & Microbiology","pubDate":"Thu, 07 Apr 2022 19:00:01 EDT","guid":"news568561393"},{"title":"Stem cell secrets allow researchers to revamp reprogramming","description":"Researchers from the Babraham Institute's Epigenetics research program have been able to learn more about na\u00efve stem cell reprogramming following a genome wide functional screen. Their research, published today in Science Advances, describes the critical regulators of reprogramming and offers opportunities for a more efficient, faster way to generate human na\u00efve pluripotent stem cells.","link":"https:\/\/phys.org\/news\/2022-03-stem-cell-secrets-revamp-reprogramming.html","category":"Biotechnology","pubDate":"Fri, 25 Mar 2022 14:00:01 EDT","guid":"news567433647"},{"title":"Increasingly efficient production of human pluripotent stem cells","description":"Researchers at the University of Helsinki have developed a new, faster and more reliable technique for reverting human cells to the stem cell state. Pluripotent stem cells are a key tool in biomedicine for modeling various diseases and developing novel therapies.","link":"https:\/\/phys.org\/news\/2022-01-increasingly-efficient-production-human-pluripotent.html","category":"Cell & Microbiology","pubDate":"Fri, 21 Jan 2022 10:27:08 EST","guid":"news561983225"},{"title":"Protein domain structures affect the quality of stem cells","description":"The original iPS cells were reprogrammed by transducing four genes: OCT3\/4, SOX2, KLF4, and c-MYC. Later experiments would show that c-MYC can be replaced with MYCL. Both are MYC proteins and thus oncogenes, but animal experiments have demonstrated that iPS cells reprogrammed using MYCL are less likely to cause tumors than iPS cells reprogrammed with c-MYC. Furthermore, MYCL enhances the reprogramming efficiency, but why is unknown. A new study from CiRA reports that two domains in the MYC proteins, MYC Box domain 0 (MB0) and MB2, are responsible.","link":"https:\/\/phys.org\/news\/2021-12-protein-domain-affect-quality-stem.html","category":"Cell & Microbiology","pubDate":"Tue, 21 Dec 2021 10:54:48 EST","guid":"news559306485"},{"title":"Raman spectroscopy provides non-invasive way to track cell reprogramming","description":"In an advance that promises to facilitate research into stem cells and regenerative medicine, a RIKEN-led team has demonstrated a non-invasive method for tracking the chemical changes that accompany the reprogramming of somatic cells into stem cells.","link":"https:\/\/phys.org\/news\/2021-02-raman-spectroscopy-non-invasive-track-cell.html","category":"Analytical Chemistry","pubDate":"Fri, 12 Feb 2021 08:57:34 EST","guid":"news532342648"},{"title":"Researchers improve neuronal reprogramming by manipulating mitochondria","description":"The replacement of lost neurons is a holy grail for neuroscience. A new promising approach is the conversion of glial cells into new neurons. Improving the efficiency of this conversion or reprogramming after brain injury is an important step towards developing reliable regenerative medicine therapies. Researchers at Helmholtz Zentrum M\u00fcnchen and Ludwig Maximilians University Munich (LMU) have identified a hurdle towards an efficient conversion: the cell metabolism. By expressing neuron-enriched mitochondrial proteins at an early stage of the direct reprogramming process, the researchers achieved a four times higher conversion rate and simultaneously increased the speed of reprogramming.","link":"https:\/\/phys.org\/news\/2020-11-neuronal-reprogramming-mitochondria.html","category":"Cell & Microbiology","pubDate":"Tue, 17 Nov 2020 15:48:33 EST","guid":"news524850509"},{"title":"Sperm discovery reveals clue to genetic 'immortality'","description":"New insights into an elusive process that protects developing sperm cells from damage in growing embryos, sheds light on how genetic information passes down, uninterrupted, through generations.","link":"https:\/\/phys.org\/news\/2020-07-sperm-discovery-reveals-clue-genetic.html","category":"Molecular & Computational biology","pubDate":"Fri, 17 Jul 2020 07:48:30 EDT","guid":"news514190899"},{"title":"Epigenetics Q&A: What the embryo can teach us about cell reprogramming","description":"Cell reprogramming provides an outstanding opportunity for the artificial generation of stem cells for regenerative medicine approaches in the clinic. As current cell reprogramming methods are low in efficiency, researchers around the globe aim to learn lessons from the early embryo that could lead to a more efficient and faster generation of high-quality, fully reprogrammed stem cells.","link":"https:\/\/phys.org\/news\/2020-07-epigenetics-qa-embryo-cell-reprogramming.html","category":"Cell & Microbiology","pubDate":"Mon, 06 Jul 2020 08:16:50 EDT","guid":"news513242203"},{"title":"Researchers create functional mini-liver by 3-D bioprinting","description":"Using human blood cells, Brazilian researchers have obtained hepatic organoids (\"mini-livers\") that perform all of the liver's typical functions, such as producing vital proteins, storing vitamins and secreting bile, among many others. The innovation permits the production of hepatic tissue in the laboratory in only 90 days and may in the future become an alternative to organ transplantation. The study was conducted at the Human Genome and Stem Cell Research Center (HUG-CELL).","link":"https:\/\/phys.org\/news\/2019-12-functional-mini-liver-d-bioprinting.html","category":"Cell & Microbiology","pubDate":"Wed, 18 Dec 2019 06:50:08 EST","guid":"news495874205"},{"title":"Silencing retroviruses to awaken cell potential","description":"Embryonic stem cells have the potential to differentiate into any type of cell in the human body. Once differentiated though, the newly minted somatic cells live out the rest of their days as that specific cell type and never again have the capacity to differentiate. Or so the theory goes.","link":"https:\/\/phys.org\/news\/2019-11-silencing-retroviruses-awaken-cell-potential.html","category":"Cell & Microbiology","pubDate":"Tue, 26 Nov 2019 09:38:28 EST","guid":"news493983502"},{"title":"Not all stem cells are created equal, study reveals","description":"Researchers from the University of Toronto's Institute for Biomaterials and Biomedical Engineering (IBBME) and the Donnelly Centre have discovered a population of cells \u2013 dubbed to be \"elite\" \u2013 that play a key role in the process of transforming differentiated cells into stem cells. The finding has important implications for regenerative medicine.","link":"https:\/\/phys.org\/news\/2019-03-stem-cells-equal-reveals.html","category":"Cell & Microbiology","pubDate":"Fri, 22 Mar 2019 06:57:42 EDT","guid":"news472456653"},{"title":"New type of map connects the dots in cellular reprogramming","description":"A new use of an old mathematical method analyzes a massive single-cell RNA sequencing experiment to explore how cells move from one state to another.","link":"https:\/\/phys.org\/news\/2019-02-dots-cellular-reprogramming.html","category":"Cell & Microbiology","pubDate":"Fri, 01 Feb 2019 08:50:21 EST","guid":"news468233413"},{"title":"Researchers discover for the first time how a specific cell gene affects the transformation of others","description":"An international team of seven institutions from Spain and the US including the University of Valencia has discovered for the first time that the biological activity of the c-MYC gene is necessary for cell reprogramming, the process by which a specialised cell such as a neuron is transformed into a different cell type. According to the results published in Stem Cell Reports, internal cellular activity favoured by the genes of the MYC family may be the cause of any cellular transformation.","link":"https:\/\/phys.org\/news\/2018-11-specific-cell-gene-affects.html","category":"Cell & Microbiology","pubDate":"Fri, 30 Nov 2018 10:40:02 EST","guid":"news462793563"},{"title":"Dual-function protein switch can be tweaked to improve the effectiveness of cellular reprogramming","description":"Toggling the functions of a protein that regulates gene expression during cellular reprogramming ensures cell fate conversion, an A*STAR study has found.","link":"https:\/\/phys.org\/news\/2018-11-dual-function-protein-tweaked-effectiveness-cellular.html","category":"Cell & Microbiology","pubDate":"Fri, 16 Nov 2018 08:02:00 EST","guid":"news461577702"},{"title":"Researchers identify protein essential for making stem cells","description":"Researchers at the School of Medicine have identified a new protein critical to the production of induced pluripotent stem cells, or iPS cells.","link":"https:\/\/phys.org\/news\/2018-07-protein-essential-stem-cells.html","category":"Cell & Microbiology","pubDate":"Tue, 17 Jul 2018 06:06:57 EDT","guid":"news451026407"},{"title":"Researchers develop a new method for turning skin cells into pluripotent stem cells","description":"Our bodies consist of many different kinds of cells, each with their own role. The Japanese scientist Shinya Yamanaka had made earlier the discovery, earning the Nobel Prize in 2012, that cells from adult skin can be converted to cells typical of early embryos, so-called induced pluripotent stem cells (iPSC). This process is called reprogramming.","link":"https:\/\/phys.org\/news\/2018-07-method-skin-cells-pluripotent-stem.html","category":"Cell & Microbiology","pubDate":"Fri, 06 Jul 2018 06:27:16 EDT","guid":"news450077226"},{"title":"Why male and female cells behave differently after being reprogrammed into stem cells","description":"Vincent Pasque from KU Leuven, Belgium, and Kathrin Plath from UCLA led an international study into how specialized cells are reprogrammed to induced pluripotent stem cells (iPS). The researchers discovered that female and male cells behave differently after the reprogramming process and that this is due to their different number of X chromosomes.","link":"https:\/\/phys.org\/news\/2018-04-male-female-cells-differently-reprogrammed.html","category":"Cell & Microbiology","pubDate":"Thu, 19 Apr 2018 12:00:17 EDT","guid":"news443340903"},{"title":"Scientists learn how to avoid a roadblock when reprogramming cells","description":"Over a decade ago, Shinya Yamanaka and Kazutoshi Takahashi made a discovery that would revolutionize biomedical research and trigger the field of regenerative medicine. They learned how to reprogram human adult cells into cells that behave like embryonic stem cells. Scientists were shocked that something so complex could be done so simply, and they had thousands of questions.","link":"https:\/\/phys.org\/news\/2018-04-scientists-roadblock-reprogramming-cells.html","category":"Cell & Microbiology","pubDate":"Tue, 10 Apr 2018 15:41:13 EDT","guid":"news442593659"},{"title":"In mice, a single vaccine prompts the immune system to fight breast, lung and skin cancers","description":"In the field of regenerative medicine, induced pluripotent stem cells have a lot of neat tricks up their sleeves. One of them may be teaching the immune system how to beat back cancer.","link":"https:\/\/phys.org\/news\/2018-02-mice-vaccine-prompts-immune-breast.html","category":"Cell & Microbiology","pubDate":"Fri, 16 Feb 2018 08:50:02 EST","guid":"news437992911"},{"title":"Study reveals new insight into 'immortal' plant cells","description":"A new study has revealed an undiscovered reprogramming mechanism that allows plants to maintain fitness down the generations.","link":"https:\/\/phys.org\/news\/2017-12-reveals-insight-immortal-cells.html","category":"Biotechnology","pubDate":"Mon, 18 Dec 2017 11:00:10 EST","guid":"news432816985"},{"title":"Research papers shed light on decade-long stem cell mystery","description":"A series of studies led by Monash University researcher Associate Professor Jose Polo have this week shed light on vital, yet previously unclear, aspects of cell reprogramming.","link":"https:\/\/phys.org\/news\/2017-12-papers-decade-long-stem-cell-mystery.html","category":"Cell & Microbiology","pubDate":"Thu, 07 Dec 2017 12:28:59 EST","guid":"news431872123"},{"title":"A new method for creating safer induced pluripotent stem cells","description":"Induced pluripotent stem cells (IPSCs) hold great promise in regenerative medicine, personalized medicine and drug discovery. However, while avoiding the ethical controversies associated with embryonic stem cells, they carry neoplastic risk owing to the use of the oncogenes c-Myc and Lin28. This has limited their utility in the biomedical arena.","link":"https:\/\/phys.org\/news\/2017-05-method-safer-pluripotent-stem-cells.html","category":"Cell & Microbiology","pubDate":"Wed, 24 May 2017 09:58:19 EDT","guid":"news414838688"},{"title":"Some genetic variations difficult to evaluate using current stem cell modeling techniques","description":"Some heritable but unstable genetic mutations that are passed from parent to affected offspring may not be easy to investigate using current human-induced pluripotent stem cell (hiPSC) modeling techniques, according to research conducted at The Icahn School of Medicine at Mount Sinai and published March 14, in the journal Stem Cell Reports. The study serves to caution stem cell biologists that certain rare mutations, like the ones described in the study, are difficult to recreate in laboratory-produced stem cells.","link":"https:\/\/phys.org\/news\/2017-03-genetic-variations-difficult-current-stem.html","category":"Cell & Microbiology","pubDate":"Mon, 13 Mar 2017 13:09:57 EDT","guid":"news408629391"}]}}