Mike Israetel is a sports physiologist, competitive bodybuilder, and co-founder of Renaissance Periodization, where he coaches athletes and professionals in diet and weight training. In this episode, Mike shares his journey from powerlifting to academia, breaking down the core principles of resistance training, including exercise selection, volume, intensity, and frequency. He debunks common misconceptions about strength training, explains how to structure an effective program for beginners and advanced lifters, and provides candid insights into his experience with anabolic steroids, discussing their effects on muscle growth, performance, and health risks. This conversation offers a deep dive into the science of building muscle, the realities of bodybuilding at the highest levels, and the potential of AI-driven breakthroughs to advance human performance and longevity.

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We discuss:

  • Mike’s academic journey, and early experiences in powerlifting, personal training, and sports physiology [3:30];
  • Mike’s transition from powerlifting to bodybuilding, and his scientific and artistic approach to sculpting muscle and optimizing aesthetics [9:15];
  • The value of strength training, time efficiency, and how it differs from endurance training [14:45];
  • Neurological fatigue in strength training: balancing recovery and pushing the limits [26:15];
  • The relationship between training intensity and volume, why muscle growth is not linear, and how different approaches affect results [35:00];
  • Sustainable and effective approaches to maximizing muscle growth: training close to failure while minimizing fatigue [40:00];
  • An efficient and effective resistance training program for beginners with limited time [49:00];
  • Advice for finding a good trainer [1:06:30];
  • Troubleshooting training plateaus: optimizing exercise selection, intensity, and recovery for muscle growth [1:13:30];
  • The impact of genetics, age, and lifestyle on muscle growth [1:27:45];
  • The importance of nutrition, protein intake, and consistency in both training and diet for muscle growth [1:31:00];
  • The use of anabolic steroids to boost muscle growth: doses, drug combinations, and side effects [1:35:45];
  • Long-term impact of steroid use on muscle retention, the role of genetics and individual variability, and their impact after discontinuation [1:52:15];
  • Trade-offs of long-term usage of supraphysiologic doses of testosterone: health, performance, and Mike’s future plans [2:00:45];
  • The potential for AI-driven medical breakthroughs to reverse aging and disease [2:07:30];
  • The role of AI in accelerating drug development, advancing human longevity, and overcoming biological limitations [2:19:45];
  • The philosophical implications of simulated reality, the impact of robotics on human labor and economics, and the challenge of predicting the future [2:25:15];
  • Would having kids change Mike’s philosophy around anabolic steroid use? [2:32:15];
  • The role of GLP-1 agonists in bodybuilding and general weight management, and the moral and philosophical debates surrounding their use [2:35:45]; and
  • More.

Show Notes

Mike’s academic journey, and early experiences in powerlifting, personal training, and sports physiology [3:30]

  • There’s going to be some folks listening and watching us who are probably very familiar with Mike’s work and they’ve probably come to learn about him as Peter has through endless years of being both amused and educated by his content on YouTube
  • But there’s probably a group of people here just in my audience that aren’t overlapping with yours

Give folks a chance to get to know you, and talk a little bit about your background 

  • Mike came to the US from Russia when he was 7
  • Before that, he grew up in Moscow, Russia 
  • In the US, he grew up in the metropolitan Detroit area in a place called Oak Park, Michigan 

What did you study in undergrad? 

  • Movement science, kinesiology at the University of Michigan

What sports were you playing then?

  • He wrestled in high school, but he wasn’t very good at it, wasn’t dedicated
  • He got into lifting hardcore towards the middle and end of high school
  • By the time he was in college, he was gearing up to start competing in powerlifting 
  • He actually started the Michigan Powerlifting Club
    • A team that went to meets and all that stuff
    • He was a competitive powerlifter in his undergraduate years

Peter adds, “For folks who might be confused about all the different disciplines, powerlifting is the sport where there are 3 and only 3 lifts. There’s a deadlift, a bench press, a squat, and you win by having the highest total weights across the three.”

  • So squat plus bench plus deadlift equals total, and the person with the biggest total for the weight class
    • Or absolute or by formula wins the whole thing
  • Mike was not into bodybuilding yet

Did you go off and do your PhD right away after undergrad? 

  • No, he got a master’s 
  • In the exercise science field, going straight from undergraduate to a PhD is very rare
    • Usually you need a lot more preparatory work because the undergraduate curriculum typically just doesn’t teach you a whole lot of applied super specialized exercise science
  • He learned anatomy and physiology very well, but much more general curriculum
    • Especially at an RO1 school like Michigan,  they didn’t super hyper specialize
    • He learned almost nothing about sports whatsoever
    • Resistance training wasn’t a big focus there; he must have had 2 bullet points of how to resistance train in any one of his classes
    • It was chronic disease management, health, clinical application
  • Right after undergrad, he went to Appalachian State University to get a Master’s degree under Dr. Travis Triplett and Dr. Jeff McBride
  • That was a subspecialty of exercise science: strength and conditioning
    • So much closer to what he was super passionate about
  • Mike then worked for 1 year as a personal trainer
    • It’s like jail
    • He did a year in Manhattan with his colleague Mr. Nick Shaw, who’s now the co-founder and CEO of their company, RP
    • They trained folks at a private personal training studio in Manhattan (like CTOs of major companies)
  • Mike had never met a truly rich person until he met someone who was worth like $50 million
    • Turns out they’re just really nice cool people that are really chill and have the same problems everyone else does, trying to get in shape
  • In that year, Mike realized he didn’t know enough, and then he enrolled in the PhD program for sport physiology at East Tennessee State University under Dr. Mike Stone
  • That was an amazing time
  • He probably learned more in that 3 years than he ever learned at school
    • Totally immersive
    • Got to work with teams, got to work with athletes, strength and conditioning coach
    • Truly sports science work

We integrate all of the variables, sport coaching, strength and conditioning, sports medicine, nutrition, the whole gamut. Incredible experience.”‒ Mike Israetel

  • Mike got a PhD there and then taught at the University of Central Missouri for a while
  • Taught at Temple University in Philadelphia for a while
  • Then he went full depth into private industry founding RP
    • This happened during the time he was in the PhD program 
  • Sometime during the years at Temple, it became apparent that he was more productive not teaching because there was so much to do with the company
  • So he took some time away from teaching
  • Then he came back to teach under his friend Dr. Brad Schoenfeld
    • Who’s the world expert scientifically in muscle hypertrophy
    • Mike taught at his master’s program for a while
  • He left that recently to do private industry full time 

When did you start putting out these videos on YouTube? 

  • Peter only discovered them a couple years ago, but thinks he’s been doing this much longer
  • Mike started posting videos on YouTube in 2020 during peak COVID
    • He records most of his YouTube videos at his home studio
    • If he drops the “C word”, the video guy’s like, “Different take.”
    • They one-take almost everything and that they will roll back
      • The algorithm will flag it and put a COVID warning

Mike’s transition from powerlifting to bodybuilding, and his scientific and artistic approach to sculpting muscle and optimizing aesthetics [9:15]

Going back to your personal evolution as you’re going through this journey of master’s, PhD, industry, are you still focusing on powerlifting personally? 

  • Mike was focused on powerlifting up until he got into the Master’s program
  • Towards the end of undergrad he picked up a muscle magazine at the grocery store
    • Flex Magazine had an issue that summarized the prior 2002 Mr. Olympia contest with all the pictures of the bodybuilders
      • Ronnie won again; that was his 4th or 5th time winning Mr. Olympia and he didn’t look his best

Everyone suspected Jay Cutler could have beat him if he showed up that year (He almost beat him in 2001)

Figure 1. Jay Cutler and Ronnie Coleman. Image credit: M&F

  • Mike remembers reading the magazine and looking at the pictures ‒ it was enlightening because Mike realized he had an eye for aesthetics
  • Some people will see muscular physiques and they kind of all look the same, like giant veiny, overcooked hot dogs (which is not wrong)
  • Mike looked at the physiques and he was really taken aback, especially by some of them
    • [It was a feeling akin to what] normal people get when they look at very good art: that whoa, I’m looking at something very special, something that’s emotive

That’s when Mike started to pursue his own hypertrophy training (muscle growth training) 

What were you looking like at the time? 

{end of show notes preview}

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Mike Israetel, Ph.D.

Mike Israetel​ earned his PhD in Sport Physiology from East Tennessee State University. Dr. Mike is a seasoned expert in the field of fitness and performance. Formerly a professor at Lehman College, Temple University, and the University of Central Missouri, he taught a variety of exercise science courses focusing on nutrition, strength, and hypertrophy. ​

Dr. Israetel has also worked as a sports nutrition consultant for the U.S. Olympic Training Site in Johnson City, Tennessee. He has personally coached countless athletes in nutrition and weight training, and continues to push his own limits as a competitive bodybuilder and professional Brazilian Jiu Jitsu grappler.

Dr. Israetel coauthored many ebooks including The Renaissance Diet 2.0, Scientific Principles of Hypertrophy Training, Understanding Healthy Eating, Scientific Principles of Strength Training, Recovering from Training, The Minicut Manual, and How Much Should I Train. He cofounded Renaissance Periodization and is currently their head science consultant. [RP]

Instagram: drmikeisraetel

Mike’s YouTube Channel: @MikeIsraetelMakingProgress

RP YouTube Channel: @RenaissancePeriodizationWebsite: RP

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