Papers by Shubham M . Shende
World Journal of Advanced Research and Reviews
Brain-targeted drug delivery is a field of research that seeks to develop new methods for deliver... more Brain-targeted drug delivery is a field of research that seeks to develop new methods for delivering drugs to the brain. This is done by overcoming the blood-brain barrier (BBB), a network of cells that tightly regulate the flow of substances between the blood and the brain. Most of the time lipophilic drugs are easily cross blood brain barrier but few of them less soluble in lipid therefore they don’t cross the blood brain barrier. After review we concluded that we can easily improve the solubility of drug using various techniques and Brain-targeted drug delivery is a promising field of research that has the potential to revolutionize the treatment of brain diseases. With further advances, it is possible that brain-targeted drug delivery will become a standard treatment for a variety of brain diseases and disorders.
EUROPEAN JOURNAL OF PHARMACEUTICAL AND MEDICAL RESEARCH, 2023
ABSTRACT
Glycerogelatin suppositories are commonly used for the treatment of various diseases su... more ABSTRACT
Glycerogelatin suppositories are commonly used for the treatment of various diseases such as rectal related disease, constipation,haemorrhoids, or prostate diseases. The development of this type of suppository requires the evaluation of their physical and chemical properties. This research paper aims to review the existing literature on the preparation and evaluation of glycerogelatin suppositories. The review focuses on glycerogelatin suppositories,
their preparation methods, and their quality control parameters. After method of preparation we conclude that Glycerogelatin suppositories are easy method of formulation. We performed drug identification test to authenticate the Diclofenac Na by UV spectrophotometer as well as calibrate the mould to avoid variations in the weights. We evaluated various parameters such as displacement value, disintegration test, dissolution test, melting point and drug content. All the results found to be satisfactory but we nee
d to check out the effectiveness of formulation to
performed clinical study.
KEYWORDS
: Glycerogelatin suppositories, Rectal, Diclofenac Na, Displacement value etc.
World Journal of Advanced Research and Reviews,, 2023
Abstract: Brain-targeted drug delivery is a field of research that seeks to develop new methods f... more Abstract: Brain-targeted drug delivery is a field of research that seeks to develop new methods for delivering drugs to the brain. This is done by overcoming the blood-brain barrier (BBB), a network of cells that tightly regulate the flow of substances
between the blood and the brain. Most of the time lipophilic drugs are easily cross blood brain barrier but few of them less soluble in lipid therefore they don’t cross the blood brain barrier. After review we concluded that we can easily
improve the solubility of drug using various techniques and Brain-targeted drug delivery is a promising field of research that has the potential to revolutionize the treatment of brain diseases. With further advances, it is possible that brain-
targeted drug delivery will become a standard treatment for a variety of brain diseases and disorders.
Keywords: Blood Brain Barrier; Brain-Targeted; CNS; Lipophilic drug; Challenges
Social Science Research Network, Apr 29, 2020
IJCRT, 2020
Topical gels or formulations have many advantages as compared to other conventional dosage form. ... more Topical gels or formulations have many advantages as compared to other conventional dosage form. Topical gels are less toxic and more effective than other dosage form. Topical gels are best choice for treat local infections and skin problems because of it directly apply on the skin or in the site. Topical gels provide action direct to the site of action. Topical gels exclude the GI irritation and metabolism of drug by which the bioavailability of drug is greater. Drug-Drug interaction and Food drug interaction is also not possible in the case of topical gels. Gels have better penetrating power because gel consists two phase. In this review a detailed study about gel, its preparation, characteristics and evaluation parameter was done.
Aim: The main objective of the present work is formulate and optimizes the combination anti-aller... more Aim: The main objective of the present work is formulate and optimizes the combination anti-allergic tablet of Cetirizine and curcumin. Rosemary extract is used to enhance the therapeutic effect in both acute and chronic cases. Material and Method: The Antiallergic tablet is formulate by the wet granulation method using various excipients like HPMC, lactose starch, Polyethylene glycol in different concentrations for optimization of excipients. Rosemary extract contains ursolic acid and rosmarinic acid. Which is shows antiinflammatory and Antiallergic activity so that it is used in the combination of Cetirizine and curcumin. Result and Discussion: FTIR spectra of API and combined with excipients showed no change in the peak indicating the absence of interaction, The prepared formulation evaluated for Precompresion studies such as bulk density, tapped density, carr’s index, Hausner’s ratio and angle of repose. The post-compression studies such as weight variation, disintegration, diss...
WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES, 2020
The human being appears to be affected with more disease than any other animal species most commo... more The human being appears to be affected with more disease than any other animal species most common disorders such as allergy, cold, fever, etc. Allergy is a state of hypersensitivity of the immunosystem against the allergen, which is entered into the body. Various clinical disorders associated with allergy-like asthma, hay fever, food allergy, Urticaria, delayed hypersensitivity. The allergic disorder can be treated by three ways of control of the environment, drug therapy, and Novel strategies. Treatment of allergic disorders from the traditional era people used herbal drug therapy and in the modern era, allopathic treatment most commonly used. Allopathic drug therapy having various side effects and researchers work on overcoming the side effect of the allopathic drug. Novel strategies are used in the treatment of allergy-like peptide vaccines and specific allergen immunotherapy .after reviewed we concluded that from the traditional era to modern era, treatment of allergy is better than better for previous treatment and further study continue for the develop a stable and effective technique for the treatment of allergy.
International Journal of Creative Research Thoughts(IJCRT), 2020
Curcumin is the major and active biological compound of C. longa. Curcumin suppress the mast cell... more Curcumin is the major and active biological compound of C. longa. Curcumin suppress the mast cell degranulation and release of histamine as well as curcumin act as immunomodulatory agent by activating T-cell and other mediators. Curcumin can suppress expression of CD80, CD86 and class-II antigens by dendritic cells and blocks the release of inflammatory cytokines like IL1β, IL6 and
TNFα from LPS-stimulated dendritic cells .After reviewed we seen that curcumin shows Antiallergic activity by different mechanisms and it also shows wide therapeutic range such as Antiallergic, antiviral (Anti-hiv) , Antidiabetic ,Antimicrobial etc. Its provides wide area for the research and development in Pharmaceutical science.
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Papers by Shubham M . Shende
Glycerogelatin suppositories are commonly used for the treatment of various diseases such as rectal related disease, constipation,haemorrhoids, or prostate diseases. The development of this type of suppository requires the evaluation of their physical and chemical properties. This research paper aims to review the existing literature on the preparation and evaluation of glycerogelatin suppositories. The review focuses on glycerogelatin suppositories,
their preparation methods, and their quality control parameters. After method of preparation we conclude that Glycerogelatin suppositories are easy method of formulation. We performed drug identification test to authenticate the Diclofenac Na by UV spectrophotometer as well as calibrate the mould to avoid variations in the weights. We evaluated various parameters such as displacement value, disintegration test, dissolution test, melting point and drug content. All the results found to be satisfactory but we nee
d to check out the effectiveness of formulation to
performed clinical study.
KEYWORDS
: Glycerogelatin suppositories, Rectal, Diclofenac Na, Displacement value etc.
between the blood and the brain. Most of the time lipophilic drugs are easily cross blood brain barrier but few of them less soluble in lipid therefore they don’t cross the blood brain barrier. After review we concluded that we can easily
improve the solubility of drug using various techniques and Brain-targeted drug delivery is a promising field of research that has the potential to revolutionize the treatment of brain diseases. With further advances, it is possible that brain-
targeted drug delivery will become a standard treatment for a variety of brain diseases and disorders.
Keywords: Blood Brain Barrier; Brain-Targeted; CNS; Lipophilic drug; Challenges
TNFα from LPS-stimulated dendritic cells .After reviewed we seen that curcumin shows Antiallergic activity by different mechanisms and it also shows wide therapeutic range such as Antiallergic, antiviral (Anti-hiv) , Antidiabetic ,Antimicrobial etc. Its provides wide area for the research and development in Pharmaceutical science.
Glycerogelatin suppositories are commonly used for the treatment of various diseases such as rectal related disease, constipation,haemorrhoids, or prostate diseases. The development of this type of suppository requires the evaluation of their physical and chemical properties. This research paper aims to review the existing literature on the preparation and evaluation of glycerogelatin suppositories. The review focuses on glycerogelatin suppositories,
their preparation methods, and their quality control parameters. After method of preparation we conclude that Glycerogelatin suppositories are easy method of formulation. We performed drug identification test to authenticate the Diclofenac Na by UV spectrophotometer as well as calibrate the mould to avoid variations in the weights. We evaluated various parameters such as displacement value, disintegration test, dissolution test, melting point and drug content. All the results found to be satisfactory but we nee
d to check out the effectiveness of formulation to
performed clinical study.
KEYWORDS
: Glycerogelatin suppositories, Rectal, Diclofenac Na, Displacement value etc.
between the blood and the brain. Most of the time lipophilic drugs are easily cross blood brain barrier but few of them less soluble in lipid therefore they don’t cross the blood brain barrier. After review we concluded that we can easily
improve the solubility of drug using various techniques and Brain-targeted drug delivery is a promising field of research that has the potential to revolutionize the treatment of brain diseases. With further advances, it is possible that brain-
targeted drug delivery will become a standard treatment for a variety of brain diseases and disorders.
Keywords: Blood Brain Barrier; Brain-Targeted; CNS; Lipophilic drug; Challenges
TNFα from LPS-stimulated dendritic cells .After reviewed we seen that curcumin shows Antiallergic activity by different mechanisms and it also shows wide therapeutic range such as Antiallergic, antiviral (Anti-hiv) , Antidiabetic ,Antimicrobial etc. Its provides wide area for the research and development in Pharmaceutical science.