According to Einstein, a universal time does not exist. But what if time is different than what w... more According to Einstein, a universal time does not exist. But what if time is different than what we think of it? Cosmic Microvawe Background Radiation was accepted as a reference for a universal clock and a new time concept has been constructed. According to this new concept, time was tackled as two-dimensional having both a wavelength and a frequency. What our clocks measure is actually a derivation of the frequency of time. A relativistic time dilation actually corresponds to an increase in the wavelength of time. At the point where time wavelength and time frequency is equal, where light is positioned, quantum-world and macro-world are seperated. Gravity was redefined with respect to time and the new two dimensional time fabric of the universe was speculated to be the source of dark energy causing the universe to expand. According to this new point of view quantum realm and macro-world can be better understood. This new time concept provide a basis for our understanding of quantum gravity and provide the long-sought answers to well known problems of it. A prediction of the presented theory is that the universe will expand at various rates at different regions due to the fact that particular surroundings will create different gravities and cause a different gravity-time wavelength effect yielding various time delays for calculating this rate of expansion.
Journal of Obstetrics and Gynaecology Research, Apr 27, 2021
AimThis study was designed to determine serum human leukocyte antigen‐G (HLA‐G) levels and establ... more AimThis study was designed to determine serum human leukocyte antigen‐G (HLA‐G) levels and establish whether serum HLA‐G level is related with gestational diabetes mellitus (GDM).MethodsTwenty‐five GDM patients aged between 24 and 34 years and 24 healthy pregnant women aged between 22 and 33 years were included in this study. Health status of subjects was determined by medical history, physical, and obstetric examinations. Absence of family history for Type 2 diabetes mellitus, absence of diagnosis or clinical evidence of any major disease, and absence of medication use altering glucose metabolism constituted the inclusion criteria. GDM cases who are at their 24–28 weeks of pregnancy and who have not been using any oral hypoglycemic agents were included in GDM group. Control group consisted of healthy pregnant women at their 24–28 weeks of pregnancy.ResultsWomen with GDM had significantly lower levels of serum HLA‐G than controls. HLA‐G levels were negatively correlated with all parameters of glucose metabolism including insulin (r = − 0.14; p = 0.338), fasting blood glucose (r = − 0.220; p = 0.129), 1‐h oral glucose tolerance test (OGTT) blood glucose (r = − 0.18; p = 0.271), 2‐h OGTT blood glucose (r = − 0.314; p = 0.172), homeostasis model assessment (r = − 0.226; p = 0.119), HbA1C (r = −0.342; p = 0.108), and WBC (r = −0.149; p = 0.307). There was a negative correlation between HLA‐G and BMI (r = −0.341; p = 0.016).ConclusionDecreased circulating HLA‐G level is found to be associated with insulin resistance and GDM, in this study.
BACKGROUND: Carnitine plays essential roles in energy production, oxidative stress and glucose me... more BACKGROUND: Carnitine plays essential roles in energy production, oxidative stress and glucose metabolism. This study was planned to determine serum total L-carnitine levels in non-obese women with polycystic ovary syndrome (PCOS). METHODS: There were 27 non-obese women with PCOS and 30 healthy, age-and body mass index (BMI) matched controls were evaluated in this controlled clinical study. Serum lipid sub-fractions, fasting glucose, insulin and other hormones (gonadotrophins, androgens) and total L-carnitine levels were measured. Homeostasis model assessment (HOMA-IR) was used to estimate insulin resistance. RESULTS: The women with PCOS had significantly higher serum dehydroepiandrosterone sulfate, total testosterone, free androgen index (FAI), luteinizing hormone (LH), low-density lipoprotein (LDL) cholesterol, non-high density lipoprotein (HDL) cholesterol, fasting insulin levels and HOMA-IR measurement and LH/FSH ratios than healthy women. However, total L-carnitine and sex hormone-binding globulin (SHBG) levels were significantly lower in women with PCOS. L-Carnitine level was negatively correlated with FAI, but positively correlated with SHBG. Multiple regression analysis revealed that SHBG was a strong predictor of serum total L-carnitine level. CONCLUSIONS: Decreased total L-carnitine levels may be associated with hyperandrogenism and/or insulin resistance in non-obese women with PCOS. Longterm studies are needed to evaluate carnitine metabolism in PCOS, especially with regard to the molecular basis.
Acta Obstetricia et Gynecologica Scandinavica, 2006
We read with interest the report by Agarwal et al. on the screening for gestational diabetes mell... more We read with interest the report by Agarwal et al. on the screening for gestational diabetes mellitus (GDM) (1). Screening tests for GDM are almost universally performed during the period from the 24th to 28th gestational weeks, as glucose intolerance increases by gestational age. So if screening is performed earlier, women with higher risks are generally detected but those with low risk are missed. In contrast, later screening detects more women, including most of those with low risk. However, late screening has the disadvantage of having less time for treatment of the detected cases (2). A reference diagnostic test is needed to compare the efficacy of a screening test. To further confuse the issue, there is no universal agreement on a reference test for GDM diagnosis. Criteria of the World Health Organization, American Diabetes Association, and National Diabetes Data Group provide different prevalences when used for GDM diagnosis (2,3). Keeping all this in mind, we assent to the difficulties of performing such a study and appreciate the authors’ effort. But while presenting their result, the authors report that ‘the mean gestational age was 26.4 weeks (median 26 weeks, SD 4.6, range 16 40 weeks)’. Table I also shows that the range of gestational age at screening for women with GDM is 18 37 weeks, while the same range for women without GDM is 16 40 weeks, as noted above. On the other hand, in the Material and methods section of the study the period for screening is defined to be between 24 and 28 weeks’ gestation. Noting that the p value for the means shows no statistical significance, we suggest that the results would be better interpreted if the women outside the defined gestational age range were excluded. We believe that using these data in statistical analysis may decrease the reliability of the study and make it difficult to compare the results with those in the literature.
A case of holoprosencephaly (HPE) with proboscis, fused eyes in one orbit, and cyclopia was diagn... more A case of holoprosencephaly (HPE) with proboscis, fused eyes in one orbit, and cyclopia was diagnosed by fetal ultrasound, computed tomography (CT), and magnetic resonance imaging (MRI). Ultrasonographic examination at 28 weeks of gestation showed fusion of the frontal part of the brain and ventricular dilation. Subsequent CT and MRI examinations confirmed this anomaly as alobar HPE. Amniocentesis followed by chromosome analysis demonstrated karyotype as de novo 45,XY, der (18;21)(q10;q10), with deletion of a short arm of chromosome 18. The pregnancy ended in a premature delivery of a male neonate weighing 1716 g at 34 weeks. Macroscopically, there were mid-frontal proboscis and single orbit with two eyes without normal nasal structures. He died 1 h after birth.
Chorioangioma is a benign tumor of the placenta showing similar histologic pattern with hemangiom... more Chorioangioma is a benign tumor of the placenta showing similar histologic pattern with hemangiomas. We aimed to present a 9×8×4 cm sized chorioangioma causing twin to twin transfusion like syndrome in a dizygotic twin pregnancy. A 30 weeks old dichorionic-diamniotic twin pregnancy with a 7×5 cm hypo-echoic mass at the placental site of one fetus who revealed a normal development, and the other having intrauterine growth retardation, was admitted to our clinic. Preeclampsia was developed in clinical follow-up at 34 th weeks of pregnancy and emergency cesarean section was performed due to fetal distress. Chorioangioma was detected on the placenta of the normal fetus. Pathologic examination of placenta revealed a 9×8×4 cm mass macroscopically with a diagnosis of chorioangioma microscopically. Chorioangiomas may cause twin to twin transfusion like syndrome in dizygotic twins and may result in various spectrum of problems in fetus depending on the size and the texture.
Journal of Obstetrics and Gynaecology Research, Jul 12, 2021
AimSonoelastography is an imaging technique that measures tissue strain quantitatively. This stud... more AimSonoelastography is an imaging technique that measures tissue strain quantitatively. This study aims to investigate whether the strain rate of endometrium measured by elastography can predict pregnancy after intrauterine insemination (IUI).MethodsThis study examined 197 gonadotropin‐stimulated IUI cycles of 148 women diagnosed with unexplained infertility from February 2019 to November 2020. Endometrial thickness, pattern, and strain rate were measured by transvaginal ultrasonography immediately before the insemination. The endometrium and the parametrial tissue were selected for regions of interest, and the strain rate was calculated. The measurements were analyzed concerning the IUI outcome.ResultsOf the 197 IUI cycles, the pregnancy rate was 15.20% (n = 30), and ongoing pregnancy rate was 12.2% (n = 24). The mean strain rates were not different between pregnant and nonpregnant groups (2.68 ± 1.28 vs. 2.81 ± 1.32, p = 0.651). Strain rate was not predictive for pregnancy, shown by receiver operating characteristic curve analysis; the area under the curve was 0.526 (95% CI 0.413–0.639; p = 0.649). Pregnancy rates were significantly affected by the women's age and the inseminated sperm count. In multiple logistic regression analysis, the other parameters, including body mass index, anti‐Müllerian hormone, endometrial thickness, endometrial strain rate, and echogenic endometrial pattern, did not significantly change the odds ratio of pregnancy.ConclusionThe endometrial strain rate does not significantly affect the pregnancy rates in gonadotropin stimulated IUI cycles. It appears that strain rate does not predict IUI outcome. More research is needed to evaluate the usefulness of sonoelastography in infertility treatments.
Bu çalışmamızda polikistik över sendromunda (PKOS) serum leptin seviyelerindeki değişiklikleri ve... more Bu çalışmamızda polikistik över sendromunda (PKOS) serum leptin seviyelerindeki değişiklikleri ve bu değişikliklerin PKOS ile bağlantılı diğer hormonlarla olan ilişkilerini araştırmayı amaçladık. Bu çalışmamız 01.10.2001 -01.06.2002 tarihleri arasında izmir Atatürk Eğitim ...
Gereç ve Yöntem: İzmir Atatürk Eğitim ve Araştırma Hastanesi, 2. Kadın Hastalıkları ve Doğum Klin... more Gereç ve Yöntem: İzmir Atatürk Eğitim ve Araştırma Hastanesi, 2. Kadın Hastalıkları ve Doğum Kliniği'nde benign nedenlerle TAH+ BSO uygulanan ve östrojen replasman tedavisi almasında sakınca görülmeyen 25 olgu çalışma kapsamına alındı. Tüm hastalardan ...
Background and Aims. Cadmium (Cd) is an industrial and environmental pollutant that was shown to ... more Background and Aims. Cadmium (Cd) is an industrial and environmental pollutant that was shown to be involved in the development of some diseases. Due to high amounts of Cd in cigarettes, smokers and passive smokers are exposed to high amount of Cd. We aimed to determine whether Copper (Cu) supplementation would have a protective effect against Cd intoxication in pregnant rats and their fetuses. Methods. Experiments were performed on 27 adult female Wistar albino rats divided into three experimental groups. CdCl 2 , CdCl 2 plus CuSO 4 and only drinking water was given to different groups for 21 days. We measured cadmium (Cd), malondialdehyde (MDA), reduced glutathione (GSH), myeloperoxidase (MPO), superoxide dismutase (SOD) and catalase (CAT) levels in dams' liver, dams' kidney, fetus liver, fetus kidney, and placenta of rats. Results. In all tissues of Cd and Cd þ Cu-treated groups, Cd levels were found to be increased significantly when compared to control group. MDA levels and MPO activities were significantly increased whereas GSH levels, activities of SOD and CAT were decreased in Cd groups when compared to control group. Cu supplementation significantly prevented the increment in MDA levels and brought MPO activities back to control levels or below. Cd-induced reductions in GSH levels and SOD activities were also prevented by Cu supplementation. An increase of CAT activity after Cu supplementation was enough to revert to the control levels in some tissues. Conclusions. Our findings suggest that Cu supplementation may have a protective effect against the Cd-induced oxidative stress in liver, kidney and placental tissues of pregnant rats and fetuses.
Son yıllarda sağlık sektöründe üçüncü basamak hastanelerden tanı ve tedaviye yönelik beklenen mul... more Son yıllarda sağlık sektöründe üçüncü basamak hastanelerden tanı ve tedaviye yönelik beklenen multidisipliner yaklaşım hizmetleri giderek artmaktadır. Bu durum hastanelerde birden fazla birime müracaat gerektirmekte, bu da hastaların sonuca ulaşmada aşırı zaman kaybetmelerine ve tanı/tedavilerde gecikmelere neden olmaktadır. Bu sürecin kısaltılmasının ilk ve kolay yöntemlerinden birisi benzerlik gösteren ve iş birliği gerektiren bölümlerin birbirlerine yakın konumlandırılmasıdır. Bu çalışmada Pamukkale Üniversitesi Hastanelerinde hasta gruplarına, tanılara ve işlem türlerine göre farklılık ve benzerlik gösteren hastane bölümlerinin ortaya konulması, belirlenen ihtiyaçlarına göre de çözüm önerilerinin tanımlanması amaçlanmıştır. Gereç ve yöntem: Çalışma kümeleme analizi yöntemiyle 2019 yılında hastaneye gelmiş olan toplam 717.771 hasta üzerinden gerçekleştirilmiştir. Yirmi dokuz bölüme ait 9 farklı değişken (hasta sayısı, ortalama yaş, kanser hastaları oranı, mavi kart hasta oranı, kas iskelet sistemi ve bağ dokusu hastalıkları tanı grubuna dâhil hasta oranı, dolaşım sistemi hastalıkları tanı grubuna dâhil hasta oranı, genitoüriner sistem hastalıkları tanı grubuna dâhil hasta oranı, laboratuvar incelemesine giden hasta oranı ve radyolojik görüntülemeye giden hasta oranı) bilgisi kullanılarak toplam 9 adet küme bilgisi elde edilmiştir.
A 31-year-old woman with Youssef syndrome was reported. Vesicouterine fistula is responsible for ... more A 31-year-old woman with Youssef syndrome was reported. Vesicouterine fistula is responsible for the symptoms of Youssef syndrome. An easy and feasible diagnostic method of vesicouterine fistula is sonohysterography.
Introduction: We investigated the probable role of free-radical damage in the pathogenesis of slo... more Introduction: We investigated the probable role of free-radical damage in the pathogenesis of slow coronary flow (SCF) by using oxidative stress parameters. Methods: Sixty-four patients with angiographically proven SCF and 63 patients with normal coronary flow (NCF) pattern with similar risk profiles were enrolled in this study. We measured erythrocyte superoxide dismutase (SOD), reduced glutathione (GSH), serum malondialdehyde (MDA), catalase and myeloperoxidase (MPO) levels in all subjects.
Archives of Gynecology and Obstetrics, Sep 18, 2007
Case report Ovarian pregnancy is a rarely seen form of ectopic pregnancies. We present a 34-year-... more Case report Ovarian pregnancy is a rarely seen form of ectopic pregnancies. We present a 34-year-old women who had a diagnosis of ovarian ectopic pregnancy based on clinical and laboratory Wndings. Laparoscopic surgery was performed for conservative management of the case. Risk factors are outlined and vaginal douching as a possible cause for ectopic pregnancies have been discussed. Conclusion We suppose that frequent vaginal douching may be a risk factor for the development of ovarian ectopic pregnancies.
Background: Preeclampsia (PE) is at increased risk for maternal and/or fetal mortality or serious... more Background: Preeclampsia (PE) is at increased risk for maternal and/or fetal mortality or serious morbidity. PE is associated with ischemia and increased oxidative stress in placenta, which may lead to modification of plasma albumin to ischemia-modified-albumin (IMA). We aimed to investigate of IMA and hematological parameters in premature infants born to mothers with normal pregnancy and preeclampsia, and also in their mothers. Methods: Twentyfive pregnants with PE and their premature newborns as PE-group, and 25 normotensive pregnants and their premature newborns as control-group were included the study. Preterms are classified as small for gestational age (SGA) and non-SGA according to Fenton preterm growth chart. IMA, complete-blood-counts (CBCs), liver-function-tests (LFTs), renal-function-tests (RFTs), albumin, and C-reactive-protein levels were measured in pregnants' serum samples just before the birth and measured in their newborns' cord and serum samples at 6 th and 24 th hour of postnatal life. Clinical and demographic data of all groups were recorded. Results: While IMA, LFTs and RFTs values were significantly increased in PE-group when compared with control-group, albumin and CBC values were significantly lower in PEgroup. 40% of PE-group's newborns were SGA, and 30% of them had severe-SGA (birthweight<3 rd percentile). Cord-IMA levels were significantly increased in preterms and SGA preterms born to mothers with PE compared to control-group. No mothers and neonates died. Conclusion: This study demonstrated that serum IMA levels in addition to an increased birth rates of SGA were significantly increased in preeclampsia. We suggest that cord blood IMA levels might be a predictive biomarker for SGA preterms.
According to Einstein, a universal time does not exist. But what if time is different than what w... more According to Einstein, a universal time does not exist. But what if time is different than what we think of it? Cosmic Microvawe Background Radiation was accepted as a reference for a universal clock and a new time concept has been constructed. According to this new concept, time was tackled as two-dimensional having both a wavelength and a frequency. What our clocks measure is actually a derivation of the frequency of time. A relativistic time dilation actually corresponds to an increase in the wavelength of time. At the point where time wavelength and time frequency is equal, where light is positioned, quantum-world and macro-world are seperated. Gravity was redefined with respect to time and the new two dimensional time fabric of the universe was speculated to be the source of dark energy causing the universe to expand. According to this new point of view quantum realm and macro-world can be better understood. This new time concept provide a basis for our understanding of quantum gravity and provide the long-sought answers to well known problems of it. A prediction of the presented theory is that the universe will expand at various rates at different regions due to the fact that particular surroundings will create different gravities and cause a different gravity-time wavelength effect yielding various time delays for calculating this rate of expansion.
Journal of Obstetrics and Gynaecology Research, Apr 27, 2021
AimThis study was designed to determine serum human leukocyte antigen‐G (HLA‐G) levels and establ... more AimThis study was designed to determine serum human leukocyte antigen‐G (HLA‐G) levels and establish whether serum HLA‐G level is related with gestational diabetes mellitus (GDM).MethodsTwenty‐five GDM patients aged between 24 and 34 years and 24 healthy pregnant women aged between 22 and 33 years were included in this study. Health status of subjects was determined by medical history, physical, and obstetric examinations. Absence of family history for Type 2 diabetes mellitus, absence of diagnosis or clinical evidence of any major disease, and absence of medication use altering glucose metabolism constituted the inclusion criteria. GDM cases who are at their 24–28 weeks of pregnancy and who have not been using any oral hypoglycemic agents were included in GDM group. Control group consisted of healthy pregnant women at their 24–28 weeks of pregnancy.ResultsWomen with GDM had significantly lower levels of serum HLA‐G than controls. HLA‐G levels were negatively correlated with all parameters of glucose metabolism including insulin (r = − 0.14; p = 0.338), fasting blood glucose (r = − 0.220; p = 0.129), 1‐h oral glucose tolerance test (OGTT) blood glucose (r = − 0.18; p = 0.271), 2‐h OGTT blood glucose (r = − 0.314; p = 0.172), homeostasis model assessment (r = − 0.226; p = 0.119), HbA1C (r = −0.342; p = 0.108), and WBC (r = −0.149; p = 0.307). There was a negative correlation between HLA‐G and BMI (r = −0.341; p = 0.016).ConclusionDecreased circulating HLA‐G level is found to be associated with insulin resistance and GDM, in this study.
BACKGROUND: Carnitine plays essential roles in energy production, oxidative stress and glucose me... more BACKGROUND: Carnitine plays essential roles in energy production, oxidative stress and glucose metabolism. This study was planned to determine serum total L-carnitine levels in non-obese women with polycystic ovary syndrome (PCOS). METHODS: There were 27 non-obese women with PCOS and 30 healthy, age-and body mass index (BMI) matched controls were evaluated in this controlled clinical study. Serum lipid sub-fractions, fasting glucose, insulin and other hormones (gonadotrophins, androgens) and total L-carnitine levels were measured. Homeostasis model assessment (HOMA-IR) was used to estimate insulin resistance. RESULTS: The women with PCOS had significantly higher serum dehydroepiandrosterone sulfate, total testosterone, free androgen index (FAI), luteinizing hormone (LH), low-density lipoprotein (LDL) cholesterol, non-high density lipoprotein (HDL) cholesterol, fasting insulin levels and HOMA-IR measurement and LH/FSH ratios than healthy women. However, total L-carnitine and sex hormone-binding globulin (SHBG) levels were significantly lower in women with PCOS. L-Carnitine level was negatively correlated with FAI, but positively correlated with SHBG. Multiple regression analysis revealed that SHBG was a strong predictor of serum total L-carnitine level. CONCLUSIONS: Decreased total L-carnitine levels may be associated with hyperandrogenism and/or insulin resistance in non-obese women with PCOS. Longterm studies are needed to evaluate carnitine metabolism in PCOS, especially with regard to the molecular basis.
Acta Obstetricia et Gynecologica Scandinavica, 2006
We read with interest the report by Agarwal et al. on the screening for gestational diabetes mell... more We read with interest the report by Agarwal et al. on the screening for gestational diabetes mellitus (GDM) (1). Screening tests for GDM are almost universally performed during the period from the 24th to 28th gestational weeks, as glucose intolerance increases by gestational age. So if screening is performed earlier, women with higher risks are generally detected but those with low risk are missed. In contrast, later screening detects more women, including most of those with low risk. However, late screening has the disadvantage of having less time for treatment of the detected cases (2). A reference diagnostic test is needed to compare the efficacy of a screening test. To further confuse the issue, there is no universal agreement on a reference test for GDM diagnosis. Criteria of the World Health Organization, American Diabetes Association, and National Diabetes Data Group provide different prevalences when used for GDM diagnosis (2,3). Keeping all this in mind, we assent to the difficulties of performing such a study and appreciate the authors’ effort. But while presenting their result, the authors report that ‘the mean gestational age was 26.4 weeks (median 26 weeks, SD 4.6, range 16 40 weeks)’. Table I also shows that the range of gestational age at screening for women with GDM is 18 37 weeks, while the same range for women without GDM is 16 40 weeks, as noted above. On the other hand, in the Material and methods section of the study the period for screening is defined to be between 24 and 28 weeks’ gestation. Noting that the p value for the means shows no statistical significance, we suggest that the results would be better interpreted if the women outside the defined gestational age range were excluded. We believe that using these data in statistical analysis may decrease the reliability of the study and make it difficult to compare the results with those in the literature.
A case of holoprosencephaly (HPE) with proboscis, fused eyes in one orbit, and cyclopia was diagn... more A case of holoprosencephaly (HPE) with proboscis, fused eyes in one orbit, and cyclopia was diagnosed by fetal ultrasound, computed tomography (CT), and magnetic resonance imaging (MRI). Ultrasonographic examination at 28 weeks of gestation showed fusion of the frontal part of the brain and ventricular dilation. Subsequent CT and MRI examinations confirmed this anomaly as alobar HPE. Amniocentesis followed by chromosome analysis demonstrated karyotype as de novo 45,XY, der (18;21)(q10;q10), with deletion of a short arm of chromosome 18. The pregnancy ended in a premature delivery of a male neonate weighing 1716 g at 34 weeks. Macroscopically, there were mid-frontal proboscis and single orbit with two eyes without normal nasal structures. He died 1 h after birth.
Chorioangioma is a benign tumor of the placenta showing similar histologic pattern with hemangiom... more Chorioangioma is a benign tumor of the placenta showing similar histologic pattern with hemangiomas. We aimed to present a 9×8×4 cm sized chorioangioma causing twin to twin transfusion like syndrome in a dizygotic twin pregnancy. A 30 weeks old dichorionic-diamniotic twin pregnancy with a 7×5 cm hypo-echoic mass at the placental site of one fetus who revealed a normal development, and the other having intrauterine growth retardation, was admitted to our clinic. Preeclampsia was developed in clinical follow-up at 34 th weeks of pregnancy and emergency cesarean section was performed due to fetal distress. Chorioangioma was detected on the placenta of the normal fetus. Pathologic examination of placenta revealed a 9×8×4 cm mass macroscopically with a diagnosis of chorioangioma microscopically. Chorioangiomas may cause twin to twin transfusion like syndrome in dizygotic twins and may result in various spectrum of problems in fetus depending on the size and the texture.
Journal of Obstetrics and Gynaecology Research, Jul 12, 2021
AimSonoelastography is an imaging technique that measures tissue strain quantitatively. This stud... more AimSonoelastography is an imaging technique that measures tissue strain quantitatively. This study aims to investigate whether the strain rate of endometrium measured by elastography can predict pregnancy after intrauterine insemination (IUI).MethodsThis study examined 197 gonadotropin‐stimulated IUI cycles of 148 women diagnosed with unexplained infertility from February 2019 to November 2020. Endometrial thickness, pattern, and strain rate were measured by transvaginal ultrasonography immediately before the insemination. The endometrium and the parametrial tissue were selected for regions of interest, and the strain rate was calculated. The measurements were analyzed concerning the IUI outcome.ResultsOf the 197 IUI cycles, the pregnancy rate was 15.20% (n = 30), and ongoing pregnancy rate was 12.2% (n = 24). The mean strain rates were not different between pregnant and nonpregnant groups (2.68 ± 1.28 vs. 2.81 ± 1.32, p = 0.651). Strain rate was not predictive for pregnancy, shown by receiver operating characteristic curve analysis; the area under the curve was 0.526 (95% CI 0.413–0.639; p = 0.649). Pregnancy rates were significantly affected by the women's age and the inseminated sperm count. In multiple logistic regression analysis, the other parameters, including body mass index, anti‐Müllerian hormone, endometrial thickness, endometrial strain rate, and echogenic endometrial pattern, did not significantly change the odds ratio of pregnancy.ConclusionThe endometrial strain rate does not significantly affect the pregnancy rates in gonadotropin stimulated IUI cycles. It appears that strain rate does not predict IUI outcome. More research is needed to evaluate the usefulness of sonoelastography in infertility treatments.
Bu çalışmamızda polikistik över sendromunda (PKOS) serum leptin seviyelerindeki değişiklikleri ve... more Bu çalışmamızda polikistik över sendromunda (PKOS) serum leptin seviyelerindeki değişiklikleri ve bu değişikliklerin PKOS ile bağlantılı diğer hormonlarla olan ilişkilerini araştırmayı amaçladık. Bu çalışmamız 01.10.2001 -01.06.2002 tarihleri arasında izmir Atatürk Eğitim ...
Gereç ve Yöntem: İzmir Atatürk Eğitim ve Araştırma Hastanesi, 2. Kadın Hastalıkları ve Doğum Klin... more Gereç ve Yöntem: İzmir Atatürk Eğitim ve Araştırma Hastanesi, 2. Kadın Hastalıkları ve Doğum Kliniği'nde benign nedenlerle TAH+ BSO uygulanan ve östrojen replasman tedavisi almasında sakınca görülmeyen 25 olgu çalışma kapsamına alındı. Tüm hastalardan ...
Background and Aims. Cadmium (Cd) is an industrial and environmental pollutant that was shown to ... more Background and Aims. Cadmium (Cd) is an industrial and environmental pollutant that was shown to be involved in the development of some diseases. Due to high amounts of Cd in cigarettes, smokers and passive smokers are exposed to high amount of Cd. We aimed to determine whether Copper (Cu) supplementation would have a protective effect against Cd intoxication in pregnant rats and their fetuses. Methods. Experiments were performed on 27 adult female Wistar albino rats divided into three experimental groups. CdCl 2 , CdCl 2 plus CuSO 4 and only drinking water was given to different groups for 21 days. We measured cadmium (Cd), malondialdehyde (MDA), reduced glutathione (GSH), myeloperoxidase (MPO), superoxide dismutase (SOD) and catalase (CAT) levels in dams' liver, dams' kidney, fetus liver, fetus kidney, and placenta of rats. Results. In all tissues of Cd and Cd þ Cu-treated groups, Cd levels were found to be increased significantly when compared to control group. MDA levels and MPO activities were significantly increased whereas GSH levels, activities of SOD and CAT were decreased in Cd groups when compared to control group. Cu supplementation significantly prevented the increment in MDA levels and brought MPO activities back to control levels or below. Cd-induced reductions in GSH levels and SOD activities were also prevented by Cu supplementation. An increase of CAT activity after Cu supplementation was enough to revert to the control levels in some tissues. Conclusions. Our findings suggest that Cu supplementation may have a protective effect against the Cd-induced oxidative stress in liver, kidney and placental tissues of pregnant rats and fetuses.
Son yıllarda sağlık sektöründe üçüncü basamak hastanelerden tanı ve tedaviye yönelik beklenen mul... more Son yıllarda sağlık sektöründe üçüncü basamak hastanelerden tanı ve tedaviye yönelik beklenen multidisipliner yaklaşım hizmetleri giderek artmaktadır. Bu durum hastanelerde birden fazla birime müracaat gerektirmekte, bu da hastaların sonuca ulaşmada aşırı zaman kaybetmelerine ve tanı/tedavilerde gecikmelere neden olmaktadır. Bu sürecin kısaltılmasının ilk ve kolay yöntemlerinden birisi benzerlik gösteren ve iş birliği gerektiren bölümlerin birbirlerine yakın konumlandırılmasıdır. Bu çalışmada Pamukkale Üniversitesi Hastanelerinde hasta gruplarına, tanılara ve işlem türlerine göre farklılık ve benzerlik gösteren hastane bölümlerinin ortaya konulması, belirlenen ihtiyaçlarına göre de çözüm önerilerinin tanımlanması amaçlanmıştır. Gereç ve yöntem: Çalışma kümeleme analizi yöntemiyle 2019 yılında hastaneye gelmiş olan toplam 717.771 hasta üzerinden gerçekleştirilmiştir. Yirmi dokuz bölüme ait 9 farklı değişken (hasta sayısı, ortalama yaş, kanser hastaları oranı, mavi kart hasta oranı, kas iskelet sistemi ve bağ dokusu hastalıkları tanı grubuna dâhil hasta oranı, dolaşım sistemi hastalıkları tanı grubuna dâhil hasta oranı, genitoüriner sistem hastalıkları tanı grubuna dâhil hasta oranı, laboratuvar incelemesine giden hasta oranı ve radyolojik görüntülemeye giden hasta oranı) bilgisi kullanılarak toplam 9 adet küme bilgisi elde edilmiştir.
A 31-year-old woman with Youssef syndrome was reported. Vesicouterine fistula is responsible for ... more A 31-year-old woman with Youssef syndrome was reported. Vesicouterine fistula is responsible for the symptoms of Youssef syndrome. An easy and feasible diagnostic method of vesicouterine fistula is sonohysterography.
Introduction: We investigated the probable role of free-radical damage in the pathogenesis of slo... more Introduction: We investigated the probable role of free-radical damage in the pathogenesis of slow coronary flow (SCF) by using oxidative stress parameters. Methods: Sixty-four patients with angiographically proven SCF and 63 patients with normal coronary flow (NCF) pattern with similar risk profiles were enrolled in this study. We measured erythrocyte superoxide dismutase (SOD), reduced glutathione (GSH), serum malondialdehyde (MDA), catalase and myeloperoxidase (MPO) levels in all subjects.
Archives of Gynecology and Obstetrics, Sep 18, 2007
Case report Ovarian pregnancy is a rarely seen form of ectopic pregnancies. We present a 34-year-... more Case report Ovarian pregnancy is a rarely seen form of ectopic pregnancies. We present a 34-year-old women who had a diagnosis of ovarian ectopic pregnancy based on clinical and laboratory Wndings. Laparoscopic surgery was performed for conservative management of the case. Risk factors are outlined and vaginal douching as a possible cause for ectopic pregnancies have been discussed. Conclusion We suppose that frequent vaginal douching may be a risk factor for the development of ovarian ectopic pregnancies.
Background: Preeclampsia (PE) is at increased risk for maternal and/or fetal mortality or serious... more Background: Preeclampsia (PE) is at increased risk for maternal and/or fetal mortality or serious morbidity. PE is associated with ischemia and increased oxidative stress in placenta, which may lead to modification of plasma albumin to ischemia-modified-albumin (IMA). We aimed to investigate of IMA and hematological parameters in premature infants born to mothers with normal pregnancy and preeclampsia, and also in their mothers. Methods: Twentyfive pregnants with PE and their premature newborns as PE-group, and 25 normotensive pregnants and their premature newborns as control-group were included the study. Preterms are classified as small for gestational age (SGA) and non-SGA according to Fenton preterm growth chart. IMA, complete-blood-counts (CBCs), liver-function-tests (LFTs), renal-function-tests (RFTs), albumin, and C-reactive-protein levels were measured in pregnants' serum samples just before the birth and measured in their newborns' cord and serum samples at 6 th and 24 th hour of postnatal life. Clinical and demographic data of all groups were recorded. Results: While IMA, LFTs and RFTs values were significantly increased in PE-group when compared with control-group, albumin and CBC values were significantly lower in PEgroup. 40% of PE-group's newborns were SGA, and 30% of them had severe-SGA (birthweight<3 rd percentile). Cord-IMA levels were significantly increased in preterms and SGA preterms born to mothers with PE compared to control-group. No mothers and neonates died. Conclusion: This study demonstrated that serum IMA levels in addition to an increased birth rates of SGA were significantly increased in preeclampsia. We suggest that cord blood IMA levels might be a predictive biomarker for SGA preterms.
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