Traditional gentamicin dosing every 8-24 h depending on age and weight in neonates does not provi... more Traditional gentamicin dosing every 8-24 h depending on age and weight in neonates does not provide the ideal concentration-time profile to both optimize the concentration- dependent killing by aminoglycosides and minimize toxicity. Fifty-three neonates were audited prospectively while receiving gentamicin 2.5 mg/kg every 8-24 h, aiming for peak concentra- tions (Cmax) of 6-10 mg/L and trough concentrations (Cmin) <2 mg/L.
Traditional gentamicin dosing every 8-24 h depending on age and weight in neonates does not provi... more Traditional gentamicin dosing every 8-24 h depending on age and weight in neonates does not provide the ideal concentration-time profile to both optimize the concentration- dependent killing by aminoglycosides and minimize toxicity. Fifty-three neonates were audited prospectively while receiving gentamicin 2.5 mg/kg every 8-24 h, aiming for peak concentra- tions (Cmax) of 6-10 mg/L and trough concentrations (Cmin) <2 mg/L.
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