Related Resources

The Biological General Repository for Interaction Datasets (BioGRID) is an interaction, post-translational modification, and chemical association repository with data compiled through comprehensive curation efforts

CRISPR Screen data in BioGRID ORCS can be accessed via the BioGRID ORCS REST web service. Screens in various formats can be fetched from the BioGRID ORCS REST Service over HTTPS, programmatically or in a browser.

BioGRID themed curation projects focus on specific biological processes with disease relevance. Core genes/proteins central to the process are assembled with expert input and relevant publications curated for biological interactions. Themed curation projects are updated monthly and additional projects are generated on a regular basis.

Partners

National Institutes of Health
National Institutes of Health - Office of Research Infrastructure Programs
Canadian Institutes of Health Research
The Hospital for Sick Children (SickKids)
Princeton University

Latest News

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 86,477 publications. These additions bring our total number of non-redundant interactions to 2,201,055, raw interactions to 2,837,675, non-redundant chemical associations to 13,719, raw chemical associations to 31,144, Non-Redundant PTM Sites to 563,757 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

Posted: March 3rd, 2025 - 01:12 AM

The BioGRID ORCS curated CRISPR database has been updated to include CRISPR screens from a total of 382 different publications. These additions bring the total number of curated CRISPR screens in our database to 2,134 encompassing 93,295 genes, 809 different cell lines, 137 different cell types, and 29 different phenotypes across 5 different organisms (Budding Yeast, Human, Mouse, African Green Monkey, and Fruit Fly).

New curated data are added to our CRISPR Database in curation updates on a regular basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these CRISPR data, visit our download page or utilize our web service.

Posted: February 1st, 2025 - 10:11 PM

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 86,339 publications. These additions bring our total number of non-redundant interactions to 2,199,035, raw interactions to 2,834,410, non-redundant chemical associations to 13,719, raw chemical associations to 31,144, Non-Redundant PTM Sites to 563,757 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

Posted: February 1st, 2025 - 12:20 AM

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 86,161 publications. These additions bring our total number of non-redundant interactions to 2,194,102, raw interactions to 2,826,897, non-redundant chemical associations to 13,719, raw chemical associations to 31,144, Non-Redundant PTM Sites to 563,757 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

Posted: January 1st, 2025 - 12:22 AM

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 85,855 publications. These additions bring our total number of non-redundant interactions to 2,189,120, raw interactions to 2,818,695, non-redundant chemical associations to 13,719, raw chemical associations to 31,144, Non-Redundant PTM Sites to 563,757 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

Posted: November 1st, 2024 - 01:43 PM

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 85,657 publications. These additions bring our total number of non-redundant interactions to 2,181,625, raw interactions to 2,807,416, non-redundant chemical associations to 13,719, raw chemical associations to 31,144, Non-Redundant PTM Sites to 563,757 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

Posted: October 1st, 2024 - 03:23 PM

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 85,467 publications. These additions bring our total number of non-redundant interactions to 2,176,165, raw interactions to 2,800,228, non-redundant chemical associations to 13,719, raw chemical associations to 31,144, Non-Redundant PTM Sites to 563,757 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

Posted: September 1st, 2024 - 10:35 AM

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 85,299 publications. These additions bring our total number of non-redundant interactions to 2,171,000, raw interactions to 2,793,287, non-redundant chemical associations to 13,719, raw chemical associations to 31,144, Non-Redundant PTM Sites to 563,757 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

Posted: August 1st, 2024 - 08:14 AM

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 86,032 publications. These additions bring our total number of non-redundant interactions to 2,192,664, raw interactions to 2,824,633, non-redundant chemical associations to 13,719, raw chemical associations to 31,144, Non-Redundant PTM Sites to 563,757 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

Posted: December 1st, 2024 - 10:12 AM