Papers by Tutik Wahyuningsih
Indonesian Journal of Chemistry, Jun 13, 2010
condensation. The reaction was performed at room temperature under basic condition for 24 hours t... more condensation. The reaction was performed at room temperature under basic condition for 24 hours to give brown solid of product (m.p 64-6 5 o C) in 73.7% yield. Veratraldehyde itself was produced from alkylation of vanillin by the use of dimethylsulfate. The structure of the products was analyzed by FTIR, 1
ABSTRACT: Synthesis and characterization of 9, 10-dihydroxystearic-diethanolamide from used fryin... more ABSTRACT: Synthesis and characterization of 9, 10-dihydroxystearic-diethanolamide from used frying palm oil as nonionic surfactant has been carried out. The synthesis was performed via several steps of reaction, ie: transesterification, hydrolysis, oxidation with ...
Indonesian Journal of Chemistry, Jun 10, 2010
3-(4'-Bromophenyl)-4,6-dimethoxy-2-methylindole has been synthesized from 4,6-dimethoxyaniline vi... more 3-(4'-Bromophenyl)-4,6-dimethoxy-2-methylindole has been synthesized from 4,6-dimethoxyaniline via the modified Bischler method. Reaction of 4,6-dimethoxyaniline with 2,4-dibromopropiophenone gave an aniline ketone in 85%, and then it was protected to give the amido ketone as a white solid. Cyclization of amido ketone was performed by trifluoroacetic acid and subsequent deprotection with potassium hydroxide in methanol afforded a white solid of 3-(4'-bromophenyl)-4,6-dimethoxy-2-methylindole in 86%.
An experiment for the use of empty fruit bunch palm ash as source of base catalyst in aplication ... more An experiment for the use of empty fruit bunch palm ash as source of base catalyst in aplication for reaction of transesterification from castor oil has been done. Content of base compound in empty fruit bunch palm ash was analyzed by AAS and acidy alkalimetry. The base catalyst was extracted using methanol, and then to be used in transesterification reaction
Indonesian Journal of Chemistry, Nov 3, 2011
thin film have been prepared hydrothermally in NaOH and NH 3 solution utilizing zinc nitrate hexa... more thin film have been prepared hydrothermally in NaOH and NH 3 solution utilizing zinc nitrate hexahydrate as the precursor. ZnO thin films were grown on ITO glass substrate with the seed layer of zinc oxide. Perpendicularly aligned arrays of corrugated ZnO nanorods were grown in NaOH solution, while the chrysanthemum like structure was obtained in ammonia solution. X-Ray diffraction patterns confirmed that both morphologies presenting wurtzite crystal of ZnO. The nanorod showed strong (002) orientation of ZnO.
Indonesian Journal of Chemistry, Jul 25, 2014
-dimethoxy chalcone as reactants for synthesis of flavones was prepared through Claisen-Schmidt c... more -dimethoxy chalcone as reactants for synthesis of flavones was prepared through Claisen-Schmidt condensation reaction between 2,6-dihydroxyacetophenones,3,4-dimethoxybenzaldehyde and solid NaOH in mortar for 15 min. The yield of the product (70%) is higher than conventional method (65%). This chalcone then oxidatively cyclized with iodine to form 5-hydroxy-3',4'-dimethoxy flavone (yield 62%). Compounds synthesized were characterized by spectroscopic (IR, 1 H-NMR, and 13 C-NMR). ABSTRAK 5-hidroksi-3',4'-dimetoksi flavon dapat disintesis dengan efesien dalam dua tahap melalui pembentukan 2',6'-dihidroksi-3,4-dimetoksi kalkon dengan hasil yang baik. Senyawa 2',6'-dihidroksi-3,4-dimetoksi kalkon sebagai reaktan untuk sintesis flavon disiapkan dari reaksi kondensasi Claisen-Schmidt antara 2,6-dihidroksiasetofenon, 3,4-dimetoksibenzaldehid dan NaOH padat dalam mortar selama 15 menit. Rendemen produk baik (70%) dibandingkan dengan metode konvensional (65%). Kalkon ini kemudian disiklisasi secara oksidatif dengan adanya iodin untuk membentuk 5-hidroksi-3',4'-dimetoksi flavon (rendemen 62%). Senyawa hasil sintesis dikarakterisasi secara spektroskopi (IR, 1 H-NMR, dan 13 C-NMR).
Indonesian Journal of Chemistry, Mar 1, 2014
An SPE followed by HPLC-DAD method with ion pair chromatography technique to analyze pharmaceutic... more An SPE followed by HPLC-DAD method with ion pair chromatography technique to analyze pharmaceuticals with acethylcholinesterase activity including pyridostigmine (PYR), galathamine (GAL), neostigmine (NEO), eserine (ESE), and donepezil (DON) in water samples was developed. Acetylcholinesterase (AChE) inhibitors have been used to treat less severe dementias such as Alzheimer's disease. Chromatographic separation was achieved using reversed-phase SymmetryShield column using gradient system with mobile phase consisting of H 2 O/ ACN (99:1, v/v) as mobile phase A with 10 mM sodium 1-hexanesulfonate and 0.1% acetic acid (HAc). The HPLC/DAD method was linear between concentrations of 5 to 100 ng/μL. The IDL and IQL ranged from 0.50 to 1.25 ng/μL and 1.5 to 3.0 ng/μL, respectively. SPE was used to extract and clean up the target substances in spiked pure water, tap water, and wastewater samples. The application of extraction method of 5 target substances in wastewater sample was divided into 2 parts: Oasis WCX (6 mL, 500 mg) for PYR and Oasis HLB (6 mL, 200 mg) for GAL, NEO, ESE and DON. The developed SPE and HPLC/DAD method is applicable for quantification of the 5 target substances in water samples in a concentration range > 50 µg/L and assumable lower for DON (> 25 µg/L).
Berkala Ilmiah Mipa, Jul 25, 2014
Indonesian Journal of Chemistry, Feb 14, 2012
A simple and effective O-allylation reaction controlled micellar catalyst system was designed and... more A simple and effective O-allylation reaction controlled micellar catalyst system was designed and synthesized. In this system, cetyltrimethylammonium bromide (CTAB) was used for micellar catalytic O-allylation of eugenol. The reaction was carried out at room temperature to avoid Claisen rearrangement product. The results showed that the optimum concentration of CTAB as a catalyst was 1.21 × 10 2 mM with a yield 81.10%. GC-MS chromatogram revealed the major product is 4-allyl-1-(allyloxy)-2-methoxybenzene with 93.30% conversion. The applications of CTAB on the micellar catalytic O-allylation of eugenol were effective to reduce the reaction temperature and diminish the Claisen rearrangement product.
Indonesian Journal of Chemistry
from eugenol have been investigated. Synthesis was conducted through three stages of reaction. Th... more from eugenol have been investigated. Synthesis was conducted through three stages of reaction. The first step was CTAB micellar catalytic O-allylation reaction at room temperature, to give 4-allyl-1-(allyloxy)-2-methoxybenzene (2). Compound (2) was subsequently heated for Claisen rearrangement and produced 2,4-diallyl-6-methoxyphenol (3). The final steps was isomerization of compound (3) in alkaline conditions in ethylene glycol, to yield 2-methoxy-4,6-di(prop-1-enyl) phenol (4). Antioxidant activity test was conducted by TBARS and DPPH methods. TBARS test showed that the compound (4) at a concentration of 50 μM could inhibit the oxidation of linoleic acid shown by the increasing of time lag phase (96 ± 2.94 min), reducing the rate of propagation (± 54.54%) and reducing of malonal dialdehyde (MDA) formation (68.04 ± 0.84%). The DPPH test revealed that compound (4) indicated DPPH free radical scavenging activity with IC 50 107.66 μM and comparable with IC 50 for BHT 107.37 μM. -4,6di(prop-1-enil) fenol (4). Uji aktivitas antioksidan dilakukan dengan metode TBARs dan DPPH. Hasil uji TBARs menunjukkan bahwa senyawa (4) pada konsentrasi 50 μM mampu menghambat oksidasi asam linoleat yang ditunjukkan dengan peningkatan waktu Lag phase (96 ± 2,94 menit), memperlambat laju propagasi (± 54,54%) serta menghambat laju pembentukan [MDA] maks (68,04 ± 0,84%). Hasil uji DPPH menunjukkan bahwa senyawa (4) mempunyai aktivitas anti radikal bebas dan mempunyai IC 50 107,66 μM yang setara dengan IC 50 BHT 107,37 μM.
Indonesian Journal of Chemistry
Optimization condition of the biosurfactants production by P. aeruginosa using soybean oil as sub... more Optimization condition of the biosurfactants production by P. aeruginosa using soybean oil as substrate has been examined. The media containing 10% v/v of the soybean oil and 6 days of the fermentation time was the optimum condition for the biosurfactants production. The extraction technique using different solvent polarity (nhexane, chloroform, ethyl acetate and buthanol, respectively) was applied for the isolation of the biosurfactants. The biosurfactant was found in the extract chloroform of the crude biospasoy (biosurfactants obtained from soybean oil as substrate) which then is called chlo-biospasoy. The chlo-biospasoy was identified as rhamnolipids which had oil in water (o/w) emulsion type, had the CMC of 860 mg/L and could reduced the surface tension of the water from 72 mN/m to 52 mN/m. The chlo-biospasoy could be used as an emulsifier to form emulsion between water and hydrocarbon such as palm oil, benzene, premium or toluene with various stability. The results indicated that chlobiospasoy could be used as an emulsifying and emulsion-stabilizing agent.
The aim of this experiment was to identify isolates obtained from feces of Indonesian infants and... more The aim of this experiment was to identify isolates obtained from feces of Indonesian infants and to evaluate their capability as probiotics. Identification of isolates was carried out based on morphology, physiology and biochemical identifications, and molecular identification based on 16S rRNA sequence. Morphological and physiological identification was carried out based on Gram staining, shape, motility, spore formation and catalase production. Biochemical identifications based on production of CO2 and NH3 from glucose, the ability to grow on different temperature (10 and 45°C) and pH (4.4 and 9.6), and different salt concentration (6.5 and 18%). Probiotics capability of isolates was assayed on the ability to grow on low pH (pH 2.0), on different bile salts concentration (0.3; 0.5; 1.0 and 1.5%), the capacity to grow on media with inulin as the only carbon source, and in vitro adhesion ability on porcine mucin. Morphological, physiological and biochemical identification suggest t...
ChemInform, 2006
The indole ring presents a good platform for synthesis because of its nucleophilic capacity at C3... more The indole ring presents a good platform for synthesis because of its nucleophilic capacity at C3, to a lesser extent at C2, and also through the indole anion at N1. The development of new indoles with strategically placed methoxy groups at C4 and C6, or C5 and C7, provides even better platforms not only through increased general activation, but also through specific activation at C7 and C4 respectively. As a result of this multi-faceted activity, it is possible to generate a variety of additional rings fused to the indole platform. This rather general strategy of molecular augmentation leads to new types of indole structures, some of which bear resemblance to natural indole alkaloids. A selection of examples is presented. ARKAT 2.8. Regioselective reactions of 5,7-dimethoxyindoles with aldehydes Issue ICHC-20 ARKIVOC 2006 (vii) 67-75
ChemInform, 2006
Four 7-cyano-indoles and one 2-cyano-indole have been synthesized from the related aldoximes, via... more Four 7-cyano-indoles and one 2-cyano-indole have been synthesized from the related aldoximes, via the intermediate 2,4-dinitrophenyl oxime ethers. q
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Papers by Tutik Wahyuningsih