Akash Patil
Highly motivated and goal-oriented PhD Student dedicated to exploring novel and efficient drug delivery platforms. Being a passionate researcher, my long-term goal is to use my experiences and troubleshooting abilities to find viable solutions to current challenges in formulation development and pharmacotherapy. Over the past decade, I have actively sought opportunities and challenges to hone myself as an independent and collaborative pharmaceutical scientist.
• 8 years of experience in pharmaceutical sciences with emphasis on formulation development, biopharmaceutics, pharmacokinetic modeling, and pharmaceutical analyses.
• Successfully completed 3 independent research projects which have been published in high impact factor peer reviewed pharmaceutical journals.
• Published 6 review articles in the realm of ocular drug delivery, pharmacology, and therapeutics.
"Echinocandins in Antifungal Pharmacotherapy” in Journal of Pharmacy and Pharmacology was selected by the Infectious Diseases Today for a comprehensive review that was published on their online website – Contagion®, as "Echinocandins: A Promising New Class of Antifungal Agents".
The same article was one of Journal of Pharmacy and Pharmacology’s top 20 most downloaded and impactful papers for 2016-2017.
• Successful collaborations:
Collaborated with National Center for Natural Products Research, MS, USA on the development of novel oral antimalarial formulations for improved malarial therapy.
Collaborated with Department of Pharmaceutics and Drug Delivery, UM School of Pharmacy, in developing optimized ocular formulations for small therapeutic molecules such as amphotericin B, ciprofloxacin, triamcinolone acetonide, pilocarpine, curcumin, cannabinoids, and THC.
Supervisors: Dr. Soumyajit Majumdar and Dr. Michael Repka
• 8 years of experience in pharmaceutical sciences with emphasis on formulation development, biopharmaceutics, pharmacokinetic modeling, and pharmaceutical analyses.
• Successfully completed 3 independent research projects which have been published in high impact factor peer reviewed pharmaceutical journals.
• Published 6 review articles in the realm of ocular drug delivery, pharmacology, and therapeutics.
"Echinocandins in Antifungal Pharmacotherapy” in Journal of Pharmacy and Pharmacology was selected by the Infectious Diseases Today for a comprehensive review that was published on their online website – Contagion®, as "Echinocandins: A Promising New Class of Antifungal Agents".
The same article was one of Journal of Pharmacy and Pharmacology’s top 20 most downloaded and impactful papers for 2016-2017.
• Successful collaborations:
Collaborated with National Center for Natural Products Research, MS, USA on the development of novel oral antimalarial formulations for improved malarial therapy.
Collaborated with Department of Pharmaceutics and Drug Delivery, UM School of Pharmacy, in developing optimized ocular formulations for small therapeutic molecules such as amphotericin B, ciprofloxacin, triamcinolone acetonide, pilocarpine, curcumin, cannabinoids, and THC.
Supervisors: Dr. Soumyajit Majumdar and Dr. Michael Repka
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polymer solution. The formulation rapidly formed an in situ gel upon injecting in simulated tear fluid. Compared to aqueous GYY 4137 solution, the formulation sustained and extended the H2S release significantly (p < 0.05). Rheological study of the delivery system indicated a shear-thinning plastic flow with 43.89 ± 3.21 cP viscosity and 1.12 ± 0.15 Pa yield value which corroborates its easy syringeability and injectability. Karl Fisher titrimetry indicated presence of 0.66 ± 0.10 % weight of inherent water which does not hydrolyze GYY 4137. The NMR spectroscopic study indicated presence of 4-methoxyphenylphosphonic acid (a GYY 4137 degradation product) in STF confirming the mechanism of H2S release. Benzyl benzoate and benzyl alcohol solvent blend exhibited toxicity in Y79 retinoblastoma cells which should be substituted with less toxic solvent in a future extension of this study.
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polymer solution. The formulation rapidly formed an in situ gel upon injecting in simulated tear fluid. Compared to aqueous GYY 4137 solution, the formulation sustained and extended the H2S release significantly (p < 0.05). Rheological study of the delivery system indicated a shear-thinning plastic flow with 43.89 ± 3.21 cP viscosity and 1.12 ± 0.15 Pa yield value which corroborates its easy syringeability and injectability. Karl Fisher titrimetry indicated presence of 0.66 ± 0.10 % weight of inherent water which does not hydrolyze GYY 4137. The NMR spectroscopic study indicated presence of 4-methoxyphenylphosphonic acid (a GYY 4137 degradation product) in STF confirming the mechanism of H2S release. Benzyl benzoate and benzyl alcohol solvent blend exhibited toxicity in Y79 retinoblastoma cells which should be substituted with less toxic solvent in a future extension of this study.