Papers by William Brenner
The Southern Journal of Philosophy, 1995
Philosophical Investigations, 1987
Philosophical Investigations, 2007
Philosophical Investigations, 2001
The Journal of Thoracic and Cardiovascular Surgery, 2010
Objectives: We aimed to describe management strategies for neonates with hypoplastic left heart s... more Objectives: We aimed to describe management strategies for neonates with hypoplastic left heart syndrome over the past 18 years in the United States and to identify determinants of institutional management decisions.
American Journal of Obstetrics and Gynecology, 1978
All case reports of TTP in pregnancy were reviewed. In some cases the primary diagnosis of TTP ma... more All case reports of TTP in pregnancy were reviewed. In some cases the primary diagnosis of TTP may have been inappropriate, with severe pre-eclampsia or eclampsia being the primary problem. Some cases of eclampsia and severe pre-eclampsia satisfy all the criteria for the diagnosis of TTP syndrome. However, the prognosis is much better and management of these patients is very different from the nonpregnant patient with the TTP syndrome. The use of the term TTP syndrome to describe these patients may be confusing. Two cases of eclampsia are presented where the diagnosis of TTP could have been made but would have been inappropriate.
Studies in Family Planning
American journal of obstetrics and gynecology, 1982
The reported maternal mortality of 59% that results from rupture of the liver in pregnancy is pro... more The reported maternal mortality of 59% that results from rupture of the liver in pregnancy is probably excessive if modern diagnostic and treatment techniques are fully utilized. The rarity and variable presentation should not lead to an incorrect diagnosis and possible fatal outcome. Pregnant patients or patients who recently have undergone delivery, especially those with hypertension, who complain of epigastric and/or discomfort in the right upper quadrant of the abdomen should be considered to be candidates for rupture of the liver. Ultrasound, which is generally available, is an adequate diagnostic technique in most patients. Computed tomography and technetium scanning are helpful tools. Ligation of specific bleeding points, compression, deep hepatic sutures, omental pedicles, topical agents, ligation of the hepatic artery, hepatic artery embolization, and other techniques should be used prior to performance of lobectomy. Drainage is recommended. Replacement of blood, correction...
American journal of obstetrics and gynecology, 1974
American journal of obstetrics and gynecology, 1975
Several recent reports citing increased rates of prematurity among women who have had induced fir... more Several recent reports citing increased rates of prematurity among women who have had induced first-trimester abortion suggest that forceful cervical dilatation may result in cervical incompetence in future pregnancy. There appear to be conflicting clinical impressions regarding the effectiveness on cervical softening and the reduction of cervical resistance produced by various prostaglandins. The development of the Electronic Force Monitor which is capable of precise measurement of the forces encountered in overcoming resistance during dilatation provided objective evidence with which to evaluate the effects of vaginally administered prostaglandin E2 and F2alpha suppositories. Suppositories were administered 3 hours prior to cervical dilatation, after which suction curettage was performed. Compared to the nonmedicated control group, patients receiving PGF2alpha suppositories exhibited greatly reduced cervical resistance, in some cases permitting direct introduction of the suction c...
American journal of obstetrics and gynecology, Jan 15, 1978
To determine the differences between pregnancies complicated by placenta previa and those without... more To determine the differences between pregnancies complicated by placenta previa and those without placenta previa, the characteristics of 31,070 consecutive deliveries at one institution were analyzed. The philosophy of "expectant management" of the premature fetus and frequent use of cesarean section was utilized in the 185 patients with placenta previa. A higher proportion of these patients were multiparous, were older, had had previous abortions, and were carrying a male fetus or twins. The fetal and placental weights in these patients were similar to those in other patients throughout pregnancy. Rates of prematurity, antepartum and intrapartum fetal death, neonatal death, congenital abnormality, and low Apgar scores were higher among patients with placenta previa. Data were compiled in a manner that allows the obstetrician to: (1) evaluate the fetal weight and expected fetal growth; (2) estimate the probability that his patient will deliver prematurely and will deliver...
Obstetrics & Gynecology, 1968
Progress in Lipid Research, 1981
Lipid metabolism during pregnancy is different from that of the nonpregnant state. During the fir... more Lipid metabolism during pregnancy is different from that of the nonpregnant state. During the first two trimesters of pregnancy, the mother stores fat as adipose tissue. In the third trimester, there is a reduced synthesis of new fat and increased mobilization of fatty acids from fat stores. This corresponds with relative insulin resistance thought to be due to human placental lactogen and progesterone. This results in higher levels of glucose and free fatty acids being available for placental and fetal utilization.* Recent work indicates that these differences may relate to more than the caloric concerns in pregnancy; lipid metabolism is important in a wide range of other physiological and pathological concerns during pregnancy.
Obstetrical & Gynecological Survey, 1971
Clinical Obstetrics and Gynecology, 1973
Clinical Obstetrics and Gynecology, 1978
Acta Obstetricia et Gynecologica Scandinavica, 1978
A basic understanding of the physiologic effects of the prostaglandins on the human reproductive ... more A basic understanding of the physiologic effects of the prostaglandins on the human reproductive system has been one of the diverse scientific interests of Professor Axel Ingelman-Sundberg (19). Although the obvious clinical ultility of these ubiqitous compounds directed early attention to their therapeutic aspects, more recently there has been renewed interest in the basic physiologic mechanisms of the prostaglandins in reproductive medicine. Undoubtedly, the work of Dr Ingelman-Sundberg has stimulated many of his colleagues, students, and fellow scientists to pursue such basic studies in greater details.
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Papers by William Brenner