Papers by Howard Trachtman
Progress in Transplantation, 2018
Compared to dialysis, living kidney donation has a greater chance of restoring health and is asso... more Compared to dialysis, living kidney donation has a greater chance of restoring health and is associated with better
outcomes than deceased kidney donation. Although physicians advocate for this treatment, it is uncertain how they would act as
potential living kidney donors or recipients. Methods: We surveyed 104 physicians, pediatric, and internal medicine nephrologists,
to ascertain their attitudes toward living donation. Results: Among surveyed nephrologists, there was nearly universal
support for living kidney donation as a viable medical option, and nearly all of them would support a healthy and medically cleared
patient who wishes to participate. Although support was still strong, nephrologists were significantly less likely to support their
friends and relatives participating in living kidney donation, and their support declined further for friends and relatives donating to
nonrelatives. Conclusion: Our findings suggest the need to more deeply examine physician-perceived risks involved in serving as
a living kidney donor. Based on differences in surveyed nephrologist attitudes regarding donation to and from loved ones versus
nonrelatives, we suggest that physicians should give careful consideration to how they describe the risks of living donation to
potential donors.
Nature Clinical Practice Nephrology, 2005
Integrated Blood Pressure Control, 2011
Integrated Blood Pressure Control Dovepress submit your manuscript | www.dovepress.com Dovepress ... more Integrated Blood Pressure Control Dovepress submit your manuscript | www.dovepress.com Dovepress 35 R e v I e w open access to scientific and medical research
Frontiers in Medicine, 2014
Hemolytic uremic syndrome (HUS) is characterized by thrombotic microangiopathy of the glomerular ... more Hemolytic uremic syndrome (HUS) is characterized by thrombotic microangiopathy of the glomerular microcirculation and other vascular beds. Its defining clinical phenotype is acute kidney injury (AKI), microangiopathic anemia, and thrombocytopenia. There are many etiologies of HUS including infection by Shiga toxin-producing bacterial strains, medications, viral infections, malignancy, and mutations of genes coding for proteins involved in the alternative pathway of complement. In the aggregate, although HUS is a rare disease, it is one of the most common causes of AKI in previously healthy children and accounts for a sizable number of pediatric and adult patients who progress to end stage kidney disease. There has been great progress over the past 20 years in understanding the pathophysiology of HUS and its related disorders. There has been intense focus on vascular injury in HUS as the major mechanism of disease and target for effective therapies for this acute illness. In all forms of HUS, there is evidence of both systemic and intra-glomerular inflammation and perturbations in the immune system. Renewed investigation into these aspects of HUS may prove helpful in developing new interventions that can attenuate glomerular and tubular injury and improve clinical outcomes in patients with HUS.
European Journal of Clinical Pharmacology, 2015
Nature Reviews Nephrology, 2015
The global incidence of chronic kidney disease (CKD) is increasing among individuals of all ages.... more The global incidence of chronic kidney disease (CKD) is increasing among individuals of all ages. Despite advances in proteomics, genomics and metabolomics, there remains a lack of safe and effective drugs to reverse or stabilize renal function in patients with glomerular or tubulointerstitial causes of CKD. Consequently, modifiable risk factors that are associated with a progressive decline in kidney function need to be identified. Numerous reports have documented the adverse effects that occur in response to graded exposure to a wide range of environmental chemicals. This Review summarizes the effects of such chemicals on four aspects of cardiorenal function: albuminuria, glomerular filtration rate, blood pressure and serum uric acid concentration. We focus on compounds that individuals are likely to be exposed to as a consequence of normal consumer activities or medical treatment, namely phthalates, bisphenol A, polyfluorinated alkyl acids, dioxins and furans, polycyclic aromatic hydrocarbons and polychlorinated biphenyls. Environmental exposure to these chemicals during everyday life could have adverse consequences on renal function and might contribute to progressive cumulative renal injury over a lifetime. Regulatory efforts should be made to limit individual exposure to environmental chemicals in an attempt to reduce the incidence of cardiorenal disease.
Nature Reviews Nephrology, 2014
The American journal of bioethics : AJOB, 2002
The American Journal of Bioethics, 2005
The American Journal of Bioethics, 2006
The American Journal of Bioethics, 2003
The American Journal of Bioethics, 2003
ABSTRACT
The American Journal of Bioethics, 2005
The American Journal of Bioethics, 2003
ABSTRACT
The American Journal of Bioethics, 2003
Progress in gene sequencing could make rapid whole genome sequencing of individuals affordable to... more Progress in gene sequencing could make rapid whole genome sequencing of individuals affordable to millions of persons and useful for many purposes in a future era of genomic medicine. Using the idea of $1000 genome as a focus, this article reviews the main technical, ethical, and legal issues that must be resolved to make mass genotyping of individuals cost-effective and ethically effective. It presents the case for individual ownership of a person's genome and its formation, and shows the implications of that position for rights to informed consent and privacy over sequencing, testing, and disclosing genomic information about identifiable individuals. Legal recognition of a person's right to control his or her genome and the information that it contains is essential for further progress in applying genomic discoveries to human lives.
The American Journal of Bioethics, 2007
The American Journal of Bioethics, 2009
... Autonomy and Chronic Illness: Not Two Components But Many by Camilla Scanlan, Ian Kerridge Pa... more ... Autonomy and Chronic Illness: Not Two Components But Many by Camilla Scanlan, Ian Kerridge Page 2. ... The Political Condition of Bioethics by Rob Irvine Book Reviews Review of Wesley J. Smith, Secondhand Smoke by Stephen R. Latham ...
The American Journal of Bioethics, 2004
The American Journal of Bioethics, 2002
ABSTRACT
Uploads
Papers by Howard Trachtman
outcomes than deceased kidney donation. Although physicians advocate for this treatment, it is uncertain how they would act as
potential living kidney donors or recipients. Methods: We surveyed 104 physicians, pediatric, and internal medicine nephrologists,
to ascertain their attitudes toward living donation. Results: Among surveyed nephrologists, there was nearly universal
support for living kidney donation as a viable medical option, and nearly all of them would support a healthy and medically cleared
patient who wishes to participate. Although support was still strong, nephrologists were significantly less likely to support their
friends and relatives participating in living kidney donation, and their support declined further for friends and relatives donating to
nonrelatives. Conclusion: Our findings suggest the need to more deeply examine physician-perceived risks involved in serving as
a living kidney donor. Based on differences in surveyed nephrologist attitudes regarding donation to and from loved ones versus
nonrelatives, we suggest that physicians should give careful consideration to how they describe the risks of living donation to
potential donors.
outcomes than deceased kidney donation. Although physicians advocate for this treatment, it is uncertain how they would act as
potential living kidney donors or recipients. Methods: We surveyed 104 physicians, pediatric, and internal medicine nephrologists,
to ascertain their attitudes toward living donation. Results: Among surveyed nephrologists, there was nearly universal
support for living kidney donation as a viable medical option, and nearly all of them would support a healthy and medically cleared
patient who wishes to participate. Although support was still strong, nephrologists were significantly less likely to support their
friends and relatives participating in living kidney donation, and their support declined further for friends and relatives donating to
nonrelatives. Conclusion: Our findings suggest the need to more deeply examine physician-perceived risks involved in serving as
a living kidney donor. Based on differences in surveyed nephrologist attitudes regarding donation to and from loved ones versus
nonrelatives, we suggest that physicians should give careful consideration to how they describe the risks of living donation to
potential donors.