Papers by Dr Bibhu Prasad Behera
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH
Introduction: It is a known clinical problem to differentiate between malignant and non malignant... more Introduction: It is a known clinical problem to differentiate between malignant and non malignant ascites because there is no single routine biochemical laboratory test that can completely distinguish between them. The diagnostic sensitivity of cytological examination is 40%-60%. Aim: To establish the correlation and evaluate the levels of ascitic fluid cholesterol and fibronectin in the differentiation of malignant and non malignant ascites, compared to conventional total protein concentration in ascitic fluid. Materials and Methods: A cross-sectional study included 93 patients with clinically detectable ascites, admitted to the Department of Medicine at SCB Medical College, Cuttack, Odisha, India. Patients over 18 years of age presenting with ascites confirmed clinically or by Ultrasonography (USG) were included. Pregnant patients, those with blunt abdominal injury, those previously diagnosed with cancer and having received anticancer treatment, those who failed to give consent, a...
International Journal of Pharmacy and Pharmaceutical Sciences
Objective: Diabetes is the most common endocrine disorder and is the leading cause of death world... more Objective: Diabetes is the most common endocrine disorder and is the leading cause of death worldwide. Thyroid dysfunction is another common endocrine disorder frequently encountered in clinical practice worldwide, second only to diabetes. The present study was undertaken with the following aims and objectives: To know the prevalence of thyroid dysfunction in type 2 diabetes mellitus and the spectrum of thyroid dysfunction in type 2 diabetes mellitus. Methods: Type 2 diabetes mellitus patients, as per World Health Organisation criteria, without pre-existing thyroid disease attending the Medicine Outpatient Department or admitted to the Department of Medicine from June 2019 to May 2020 were taken as cases. Patients with type 2 DM aged>15 y were included in our study. Patients below 15 y of age, pregnant or lactating women, patients suffering from malignancy and tuberculosis, hepatic dysfunction, renal dysfunction, and those on drugs known to affect thyroid function (steroid, oral ...
International Journal of Pharmacy and Pharmaceutical Sciences, Apr 1, 2021
Objective: India accounts for about one-fourth of the global TB burden. WHO TB statistics for Ind... more Objective: India accounts for about one-fourth of the global TB burden. WHO TB statistics for India for 2018 gives an estimated incidence fig. of 2.69 million cases (199 per one lakh population). Drug-induced Hepatotoxicity is responsible for significant morbidity and mortality of the TB patient if these drugs continued after symptoms of hepatotoxicity develop. Whether the hepatotoxicity is due to individual drugs or due to additive effects is still unclear. The management therapy for TB patients with anti-TB DIH is imperative to ensure successful TB treatment and not recurrence DIH. Aim of the current study is to find out the pattern of Liver enzyme raised after antitubercular therapy in the tribal population of Koraput district where different phylogenetic populations reside where clinically it was observed by the physician little early onset of hepatotoxicity than national and international data. Methods: A prospective study was done after clearance from the Institutional Ethical Committee, Saheed Laxman Nayak Medical College, Koraput, from January 2019 to December 2019. Patients with>15 y of age with pulmonary and extrapulmonary tuberculosis with normal liver enzymes were included. Patients having abnormal liver enzymes before treatment, seropositive TB patients with human immunodeficiency virus infection, pregnant ladies and children<15 y of age were excluded. Results: Out of 922 patients in total; 4.78% (44) tuberculosis patients developed anti TB DIH. 68.18% (30) patients are below 50 y of age and 31.82% (14) are above 50 y of age group among TB patients with DIH. Age has no statistically significant influence on the occurrence of anti-TB DIH, but there is a statistically significant influence of sex on the occurrence of anti TB DIH. The mean occurrence of anti TB DIH is 18±18.16 d. One case of anti TB DIH patients shows signs and symptoms as early as on day 6th. The commonest symptoms are nausea and vomiting in 64% of patients who developed DIH. Interruption of ATT after DIH occurred in 79.54% of patients with recurrence in only 9.9% of patients after the reintroduction of ATT. Conclusion: Anti TB DIH mostly occurred between 7-28 d of starting the ATT in this geographical region. The duration of the anti TB ATT regimen is prolonged due to DIH. We recommend that all patients should have LTs 2 w after starting ATT, even if asymptomatic.
PANACEA JOURNAL OF MEDICAL SCIENCES, Apr 15, 2022
Background: According to World Health Organization (WHO) global HIV report 2019, people living wi... more Background: According to World Health Organization (WHO) global HIV report 2019, people living with HIV is about 38 million. Especially after the advent of antiretroviral therapy (ART), in PLHIV, cardiovascular complications signify an increasingly important health concern. This vastly active HAART regimen has provided more efficient prophylactic treatment. With the increased duration of survival, this has progressed to an increased episodes of cardiovascular complications associated with PLHA. Aim of the study: The following review overviews the left ventricular dysfunction in patients with HIV infection on HAART focusing on early diagnosis, therapy and prognosis. Materials and Methods: It is a Cross sectional study conducted on HIV infected patients attending ART clinic and admitted in medicine wards of MKCG medical college & Hospital from MARCH 2017 to OCTOBER 2018 were included in the study. Results: Maximum patients were in the age group 25-49 years (68.44%) in our study. Mean age of the study group 41.32 + 11.24 years. Gender distribution shows that 82.46% of the patients were males and 14.04% were females. 4 (7%) patients have cardiac disorder. All the patients having cardiac disorders are male. Only 2 patients (3.5%) had left ventricular dysfunction with reduced ejection fraction. Conclusions: Males are involved more than females. Most patients are in the middle age group between 25-49 years. Heterosexual mode was the most common mode of transmission. Most of the study population belonged to rural area 61.4%. Three patients (5.3%) were on anti tubercular drugs. The systolic LV dysfunction was found in 50% of PLHA patients with cardiac disorders. CD4 count was positively correlated with fractional shortening. Presence of cardiac dysfunction was significantly associated with the adherence to ART treatment. This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
International Journal of Pharmacy and Pharmaceutical Sciences, 2021
Abstract: Objective: India accounts for about one fourth of the global TB burden. WHO TB statisti... more Abstract: Objective: India accounts for about one fourth of the global TB burden. WHO TB statistics for India for 2018 gives an estimated incidence figure of 2.69 million cases (199 per one lakh population). Drug Induced Hepatotoxicity is responsible for significant morbidity and mortality of the TB patient if these drugs continued after symptoms of hepatotoxicity develop. Whether the hepatotoxicity is due to individual drug or due to additive effect is still unclear. The management therapy for TB patients with anti-TB DIH is imperative to ensure successful TB treatment and not recurrence DIH. Aim: Aim of the current study is to find out the pattern of Liver enzyme raised after antitubercular therapy in the tribal population of Koraput district where different phylogenetic populations reside where clinically it was observed by the physician little early onset of hepatotoxicity than national and international data. Methods: A prospective study was done after clearance from the Instit...
International Journal of Pharmacy and Pharmaceutical Sciences, 2020
Objective: Chronic Kidney Disease (CKD) is a silent epidemic of the 21st century. Cardiovascular ... more Objective: Chronic Kidney Disease (CKD) is a silent epidemic of the 21st century. Cardiovascular disease (CVD) is a major cause of morbidity and mortality among patients with CKD. This study aims to evaluate the type of dyslipidemia in CKD patients and correlates with the severity of renal dysfunction in CKD patients. Methods: The observational study was conducted in the Department of General Medicine, PRM MCH, Baripada between May 2018 and January 2019. 262 patients of CKD above 15 y of age, satisfying the inclusion and exclusion criteria were included in the study. Results: Out of 262 patients, 64.50% (169) were male and 35.50% (93) were females with M: F of 1.8:1. The age range was from 20 to 95. The average age of the patients in the study was 56.66+12.22 y. 45.04 % (118) of the patients were between 46 and 60 y of age. 68.70% of the patients had dyslipidemia. The comparison between lipid profiles of cases and controls showed a significant increase in total cholesterol, triglyce...
International Journal of Research in Medical Sciences
Background: Chronic kidney disease (CKD) is a worldwide public health problem. Globally, CKD is t... more Background: Chronic kidney disease (CKD) is a worldwide public health problem. Globally, CKD is the 12th cause of death and the 17th cause of disability, respectively. Yearly incidence of ESRD in India is approximately 150-200 pmp.Methods: The observational study was conducted in Department of General Medicine, Pandit Raghunath Murmu Medical College Hospital, Baripada between May 2018 and January 2019. 244 patients of Chronic Kidney Disease above 15 years of age satisfying the inclusion and exclusion criteria were included in the study.Results: Study group constitutes 64.34% (157) of male and 35.66% (87) of female patients with M:F of 1.8:1. The average age of the patients in the study was 55.91±12.49 yrs. 42.21% (103) of the patients were between 46 and 60 years of age. Maximum number of cases (190 cases) (77.87%) are in stage 4 and 5 with e-GFR <30 ml/ min. The average serum electrolytes in this study group for serum sodium, potassium, calcium are 137.31±10.05 mEq/L, 4.12±1.48 ...
Asian Journal of Pharmaceutical and Clinical Research
Objective: Efforts can be made to normalize the hematological parameters and slow the progress of... more Objective: Efforts can be made to normalize the hematological parameters and slow the progress of the disease so that the morbidity and mortality in these patients with chronic kidney disease could be effectively reduced. Methods: The observational study was carried out in the Department of General Medicine, Pandit Raghunath Murmu Medical College Hospital, Baripada, between May 2018 and January 2019. Two hundred seventy patients of chronic kidney disease (CKD) above 15 years of age, satisfying the inclusion and exclusion criteria, were included in the study. Results: In our study, 179 (66.30%) were male, and 91 (33.70%) were female with M:F of 1.97:1. The average age of the patients in the study was 55.72±12.77 years. About 42.59 % (115) of the patients were between 46 and 60 years of age. About 35.56% of CKD cases had determined etiology and, 64.44% of cases had unknown etiology. Hemoglobin, RBC, and packed cell volume were significantly lower in the patients with CKD compared to t...
Asian Journal of Pharmaceutical and Clinical Research
Objective: Efforts can be made to normalize the hematological parameters so that the morbidity an... more Objective: Efforts can be made to normalize the hematological parameters so that the morbidity and mortality in these patients could be effectively reduced. Methods: This observational study was carried out among 69 cirrhosis patients that fulfills the inclusion and exclusion criteria, attended the medicine outpatient department, and admitted in medicine ward of PRM Medical College and Hospital, Baripada, Dist. Mayurbhanj, Odisha, India, from June 2018 to January 2019. Results: In our study, we had 59 male and 10 female patients with an average age of 49.8±13.19 years. About 92.75% of the patients were alcoholic. Abdominal distension (92.75%) and ascites (84.06%) were the most common presenting complaints. Pallor was present in 42 (60.87%) cases. Splenomegaly was present in 35 (50.72%) cirrhotic patients. Renal dysfunction was present in 23 (33.33%) cases. Sixty-six (95.65%) patients had anemia and 47 (68.12%) patients had thrombocytopenia. Conclusions: From this study, we can concl...
International Journal of Advances in Medicine
Background: Lipids are essential component of biological membranes: also a part of free molecules... more Background: Lipids are essential component of biological membranes: also a part of free molecules and metabolic regulators which control cellular function and homeostasis in the body. Liver plays a central role in lipid metabolism. Cardiovascular disease (CVD) risk stratification includes serum lipid profile. In the general population; global prevalence of cirrhosis from autopsy studies ranges from 4.5% to 9.5%. Deaths from cirrhosis have been estimated to increase and would make it as the 12th leading cause of death in 2020. Although several studies have been conducted on dyslipidemia in cirrhotics in developed countries, there is a paucity of data in this regard in India.Methods: This observational study was carried out amongst 60 cirrhosis patients that fulfils the inclusion and exclusion criteria and attended the medicine OPD and admitted in medicine ward of Pandit Raghunath Murmu Medical College and Hospital, Baripada, Dist. Mayurbhanj, Odisha, India from June 2018 to Jan 2019....
International Journal of Advances in Medicine
Background: Tuberculosis is one of the most common infection in India and is associated with high... more Background: Tuberculosis is one of the most common infection in India and is associated with high mortality. India ranks 14th out of top 22 countries who are burdened with TB infections.Methods: It is a prospective study after getting the ethical committee clearance from the institute. The patients admitted to Chest and TB, Medicine Department of SLN medical college and Hospital, Koraput, Odisha from Jan 2019 to December 2019 with pulmonary tuberculosis were included in the study.Results: A total of 65 adult patients with active PTB were included in this study with age ranging from 15 to 69 years. The mean age of patients was 38.80 + 15.03 years. The total mean serum sodium levels among the subjects was 135.5+7.23. Among 65 patients, 26 (40%) patients had low sodium levels which was less than 135mmol/l out of which 21 (42%) were males and 5 (33%) were females. In all the groups of hyponatremias, majority were found to be males when compared to the females in their respective groups....
International Journal of Research in Medical Sciences
Background: Tuberculosis is the ninth leading cause of death worldwide. India contributes to abou... more Background: Tuberculosis is the ninth leading cause of death worldwide. India contributes to about one fifth of global TB burden. It is very important to diagnose early and treat tuberculosis to cut down transmission of tuberculosis.Methods: Author conducted a retrospective study in Department of Pulmonary Medicine SLN Medical College, Koraput, Odisha to analyze the utility and yield of CBNAAT. Study period was from April 2018 to March 2019. Inclusion criteria was all patients whose samples were subjected to CBNAAT were included in our study. Sputum samples from pulmonary tuberculosis patients, and extra pulmonary samples (pleural fluid, ascitic fluid, CSF, synovial fluid and gastric lavage etc. were included in our study population. Exclusion criteria was patients who were under anti tubercular therapy for pulmonary, extra pulmonary and MDR TB were excluded from this study. Data were collected from Pulmonary Medicine Department, ART center, DOTS center and CBNAAT center. Total num...
International Journal of Advances in Medicine
Background: Worldwide, cerebrovascular accidents (stroke) are the second leading cause of death a... more Background: Worldwide, cerebrovascular accidents (stroke) are the second leading cause of death and the third leading cause of disability. According to WHO estimation, by 2050 nearly 80% of stroke cases may occur in low and middle-income countries like China and India. It is critical that we understand the etiology causing the stroke so that appropriate treatment can be initiated in a timely fashion. Furthermore, understanding the risk factors associated with stroke is important before primary and secondary preventive measures can be prescribed to the patient.Methods: This observational study was carried out amongst 481 acute ischemic stroke patients that fulfils the inclusion and exclusion criteria and admitted in medicine ward of Pandit Raghunath Murmu Medical College and Hospital, Baripada, Dist. Mayurbhanj, Odisha, India from June 2018 to January 2019. Results: In our study, 481(60.43%) patients had ischemic stroke and 315 (39.57%) patients had hemorrhagic stroke. The incidence ...
Journal of Medical Science And clinical Research
Background: Posterior circulation stroke is less common than stroke involving the anterior circul... more Background: Posterior circulation stroke is less common than stroke involving the anterior circulation. Posterior circulation stroke accounts for approximately 20% of all strokes with varied clinical presentation, which differ from strokes in anterior circulation, with reference to etiology, clinical features, and prognosis. Early diagnosis of stroke is essential so that appropriate preventive therapies may be instituted.
International Journal of Clinical Trials
Background: Globally, an estimated 10.0 million (range, 9.0 to 11.1 million) people infected with... more Background: Globally, an estimated 10.0 million (range, 9.0 to 11.1 million) people infected with tuberculosis (TB). Developing country like India accounts for one fourth of the global tuberculosis burden. TB is associated with diffuse functional impairment of most endocrine organs.Methods: We conducted a study to evaluate the thyroid profile status in new sputum positive pulmonary tuberculosis patients, aged 12 years and above; attended and admitted to chest and TB, Medicine Department of SLN MCH, Koraput, Odisha from January 2019 to December 2019. Patients with H/o old pulmonary tuberculosis, patient with known neurological, hypothalamic-pituitary or thyroid disorders, kidney disease, malignancies and patients receiving medications known to interfere with thyroid hormone metabolism were excluded from the study. Statistical analysis was done by using SPSS version 21.0 software. Results were expressed in average±SD, frequencies and percentages. Continuous data were compared using St...
Journal of Clinical and Diagnostic Research, 2021
Introduction: Acute Kidney Injury (AKI) occurs most commonly in Plasmodium falciparum infection. ... more Introduction: Acute Kidney Injury (AKI) occurs most commonly in Plasmodium falciparum infection. Next to cerebral malaria and anaemia, AKI is the third most common complication of falciparum malaria. N-Acetylcysteine (NAC) has been shown to decrease serum creatinine without affecting the Glomerular Filtration Rate (GFR) by activating creatinine kinase and possibly by increasing tubular secretion. Aim: To study the effect of NAC on improvement and deterioration of falciparum malarial AKI. Materials and Methods: This prospective observational study was undertaken on 100 patients of falciparum malaria with AKI who were admitted to the Department of General Medicine ward, VSSIMSAR, Burla, Odisha from November 2014 to October 2016. Patients who were treated with NAC were considered as NAC group (n=50) and those who were not given were considered as Non N-Acetylcysteine (NNAC) group (n=50). In both the groups serum creatinine level and urine output were compared on day 1, day 3 and on day...
The present study was undertaken to assess the prevalence of systolic and diastolic dysfunction, ... more The present study was undertaken to assess the prevalence of systolic and diastolic dysfunction, to determine the prevalence of left ventricular hypertrophy (LVH) from left ventricular mass index (LVMI), to correlate the degree of cardiac dysfunction with severity of chronic kidney disease (CKD) by echocardiography in patients of CKD on conservative management. Material & method: 75 CKD patients were taken in the study which were divided into three groups Group A Age and sex matched healthy controls (n=20). Group B Patients with mild to moderate CRF (n=45) (S. Creatinine =1.5-6.0 mg/dl). Group C Patients with severe CRF (n=30) (S. Creatinine > 6.0 mg/dl). Results: The prevalence of LVH along with systolic dysfunction was 10.0% (p<0.2653) in severe CRF (group C), higher than mild/moderate CRF (group B) which was 2.2% (p<1.0). The prevalence of LVH along with diastolic dysfunction was 76.7% (p<0.0001) in group C, which was significantly higher than group B which was ...
IJAM, 2019
INTRODUCTION Worldwide, cerebrovascular accidents (stroke) are the second leading cause of death ... more INTRODUCTION Worldwide, cerebrovascular accidents (stroke) are the second leading cause of death and the third leading cause of disability. 1 Stroke, the sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is lost by blockage or rupture of an artery to the brain, is also a leading cause of dementia and depression. 2 Globally, 70% of strokes and 87% of both stroke-related deaths and disability-adjusted life years occur in low-and middle-income countries. 3-5 Over the last four decades, the stroke incidence in low-and middle-income countries has more than doubled. During these decades stroke incidence has declined by 42% in high-income countries.3 On average, stroke occurs 15 years earlier in-and causes more deaths of-people living in low-and middle-income countries, when compared to those in high-income countries. 2 Strokes mainly affect individuals ABSTRACT Background: Worldwide, cerebrovascular accidents (stroke) are the second leading cause of death and the third leading cause of disability. According to WHO estimation, by 2050 nearly 80% of stroke cases may occur in low and middle-income countries like China and India. It is critical that we understand the etiology causing the stroke so that appropriate treatment can be initiated in a timely fashion. Furthermore, understanding the risk factors associated with stroke is important before primary and secondary preventive measures can be prescribed to the patient. Methods: This observational study was carried out amongst 481 acute ischemic stroke patients that fulfils the inclusion and exclusion criteria and admitted in medicine ward Results: In our study, 481(60.43%) patients had ischemic stroke and 315 (39.57%) patients had hemorrhagic stroke. The incidence of stroke is maximum in 51-70 years of age group which comprises of 59.46% of total patients. The average age + SD were 61.4±13.1 in our study. The most common risk factor was hypertension with 69.85% followed by dyslipidemia 51.77%. Most common clinical presentation was hemiplegia (72.35%) followed by speech involvement (59.46%). Most common site of infarct was parietal (22.25%), followed by periventricular (12.68%). Conclusions: Most of the patients had ischemic stroke as compared to hemorrhagic stroke. It was more common in males. The study contributes to understanding of demographic characteristics, risk factors, and stroke subtypes in acute ischemic stroke. The importance of various risk factors among ischemic stroke subtypes should be stressed for prompt preventive strategies and treatment.
IJPPS, 2020
Objective: Chronic Kidney Disease (CKD) is a silent epidemic of the 21 st century. Cardiovascular... more Objective: Chronic Kidney Disease (CKD) is a silent epidemic of the 21 st century. Cardiovascular disease (CVD) is a major cause of morbidity and mortality among patients with CKD. This study aims to evaluate the type of dyslipidemia in CKD patients and correlates with the severity of renal dysfunction in CKD patients. Methods: The observational study was conducted in the Department of General Medicine, PRM MCH, Baripada between May 2018 and January 2019. 262 patients of CKD above 15 y of age, satisfying the inclusion and exclusion criteria were included in the study. Results: Out of 262 patients, 64.50% (169) were male and 35.50% (93) were females with M: F of 1.8:1. The age range was from 20 to 95. The average age of the patients in the study was 56.66+12.22 y. 45.04 % (118) of the patients were between 46 and 60 y of age. 68.70% of the patients had dyslipidemia. The comparison between lipid profiles of cases and controls showed a significant increase in total cholesterol, triglyceride, LDL and decrease in HDL. Conclusion: The prevalence of dyslipidemia in non-diabetic CKD is high. A high degree of abnormality is found in HDL with disease progression, which is statistically significant. Therefore, maintenance of desired lipid levels either through diet or early initiation of lipid-lowering drugs can be helpful in decreasing the risk of cardiovascular complications in CKD patients.
AJPCR, 2020
Objective: Efforts can be made to normalize the hematological parameters and slow the progress of... more Objective: Efforts can be made to normalize the hematological parameters and slow the progress of the disease so that the morbidity and mortality in these patients with chronic kidney disease could be effectively reduced. Methods: The observational study was carried out in the seventy patients of chronic kidney disease (CKD) above 15 years of age, satisfying the inclusion and exclusion criteria, were included in the study. Results: In our study, 179 (66.30%) were male, and 91 (33.70%) were female with M:F of 1.97:1. The average age of the patients in the study was 55.72±12.77 years. About 42.59 % (115) of the patients were between 46 and 60 years of age. About 35.56% of CKD cases had determined etiology and, 64.44% of cases had unknown etiology. Hemoglobin, RBC, and packed cell volume were significantly lower in the patients with CKD compared to the controls (p=0.0001), and RDW was considerably higher in the patients with CKD compared to the controls (p=0.0001). Microcytic anemia was the most prevalent type of anemia. There was a hugely significant association between the prevalence of thrombocytopenia and the severity of CKD (p=0.006). Conclusion: This study concluded that patients with CKD show abnormal hematological parameters. Evaluation of hematological parameters in these patients helps in classifying the type of anemia, aids in choosing the correct treatment modalities, and decreases mortality.
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Papers by Dr Bibhu Prasad Behera