Kuan-Hon Lim
Natural Product Chemistry and Biological Evaluation
My major research interests focus on discovery of novel natural products from plants, particularly on alkaloids that possess interesting biological activities. The common activities involved in my projects include large scale extraction of plant material, chromatographic isolation of pure compounds, structure elucidation using spectroscopic techniques, chemical modification of natural products, and of biological evaluation of pure compounds and their derivatives. Amongst the various analytical tools involved in my projects are high-field FT-NMR, high resolution mass spectrometry, FT-IR, UV-vis, single crystal X-ray crystallography, circular dichroism, and various chromatographic techniques. I am also particularly interested in evaluating the medicinal importance of the natural products isolated in our laboratory, including anticancer, vasorelaxant, anticholinesterase, and antimuscarinic properties. For example, our recent work has yielded a promising novel class of alkaloids that induce relaxation on aorta, tracheal and ileum smooth muscles. In some instances the activity is comparable or better than commercially available drugs.
Phone: +60 (0)3 8924 8208
Address: School of Pharmacy
The University of Nottingham Malaysia Campus
Jalan Broga
43500 Semenyih
Selangor
Malaysia
My major research interests focus on discovery of novel natural products from plants, particularly on alkaloids that possess interesting biological activities. The common activities involved in my projects include large scale extraction of plant material, chromatographic isolation of pure compounds, structure elucidation using spectroscopic techniques, chemical modification of natural products, and of biological evaluation of pure compounds and their derivatives. Amongst the various analytical tools involved in my projects are high-field FT-NMR, high resolution mass spectrometry, FT-IR, UV-vis, single crystal X-ray crystallography, circular dichroism, and various chromatographic techniques. I am also particularly interested in evaluating the medicinal importance of the natural products isolated in our laboratory, including anticancer, vasorelaxant, anticholinesterase, and antimuscarinic properties. For example, our recent work has yielded a promising novel class of alkaloids that induce relaxation on aorta, tracheal and ileum smooth muscles. In some instances the activity is comparable or better than commercially available drugs.
Phone: +60 (0)3 8924 8208
Address: School of Pharmacy
The University of Nottingham Malaysia Campus
Jalan Broga
43500 Semenyih
Selangor
Malaysia
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