Centrally occurring salivary gland tumors are rare. Because of a considerable overlap between the... more Centrally occurring salivary gland tumors are rare. Because of a considerable overlap between the clinical and histopathological features, this group of tumors often produces a diagnostic difficulty to the clinicians and oral pathologists. Acinic cell carcinoma (ACC) is an unusual, low-grade, malignant salivary gland tumor that represents approximately 2% of the salivary gland tumors with almost 90% arising in the parotid gland. The rest involve the submandibular and the minor salivary gland. ACC of the jaw is extremely rare and, to our knowledge, only 8 cases have been reported in the English literature. Herein, a case of primary intraosseous ACC of the mandible in a 31-yearold woman is presented. The present case is unique, as the central ACC has never been reported in a patient in the third decade of life. The complete surgical removal of the tumor was carried out under general anesthesia along with the extraction of teeth #31, #32, #41, and #42. The follow-up period of 1-year was uneventful.
Angiolipomas, histopathological variant of lipoma are benign mesenchymal tumor characterized by p... more Angiolipomas, histopathological variant of lipoma are benign mesenchymal tumor characterized by proliferation of mature adipocytes and interspersed with angiomatous proliferation composed of several congested blood vessels. Although they are the most common tumor of trunk and extremities but they are exceedingly rare in oral cavity according to their capsulation they can be classified into infiltrating and non infiltrating. Intraorally tongue, buccal mucosa and floor of the mouth are commonest sites, but hard palate is a very rare site for angiolipoma. Here we report a case of angiolipoma of palate in a 39 year old male. The present case also emphasized the cytopathological features of angiolipoma.
Basal cell tumors (BCT) are tumors usually derived from pluripotential stem cell compartments of ... more Basal cell tumors (BCT) are tumors usually derived from pluripotential stem cell compartments of the basal layer of epidermis and/or oral epithelium. BCTs are infrequent entities in the oral cavity and are not discussed separately in general and oral pathology. A literature review did not reveal any classification of tumors with basaloid morphology. This paper is an attempt to categorize the oral neoplasms with basaloid morphology and discuss their differential diagnoses in detail. A review of the literature was carried out to rule out the frequency of different oral BCTs reported in the literature. Additionally, a simple working classification of oral BCTS has been proposed. We hope that this classification will be helpful for oral and general pathologists and students.
Spindle Cell Carcinoma (SpCC) is a biphasic tumor. They are proven to be monoclonal dedifferentia... more Spindle Cell Carcinoma (SpCC) is a biphasic tumor. They are proven to be monoclonal dedifferentiated forms of conventional squamous carcinomas. It is a rare tumor which is infrequently observed in head, neck and in the aerodigestive tract. The tumor is aggressive and shows high frequency of recurrence and metastasis. It is an aggressive variant of squamous cell carcinoma which resembles a true sarcoma. It is a proliferation of spindle cells and squamous cells. For confirmation of diagnosis, immunohistochemistry is used. A Rare case of spindle cell squamous cell carcinoma in a 61 years old male in the tongue.The patient reported of rapidly growing lesion from six months with pain severe pain, dysphagia and difficulty in swallowing patient had history of chewing tobacco from past 35 years. Keywords: Spindle Cell Variant, Biphasic tumor, Head and Neck, Pseudocarcinoma, Sqamous cell, Dysplastic.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2017
A 54-year male presented to a private dental clinic with the chief complain of an asymptomatic no... more A 54-year male presented to a private dental clinic with the chief complain of an asymptomatic nodular swelling on his left buccal mucosa. Family history and past medical history were not relevant to the present swelling. Intra-oral examination revealed a dome shaped nodule on the left buccal mucosa measuring 2 x 1 cm in dimension. The color of the lesion was pink without ulceration (Figure 1). On palpation, the lesion was found to be firm and non-tender. A provisional diagnosis of fibroma with differential diagnosis of lipoma was given. The lesion was surgically excised under local anesthesia and the excised tissue was sent for histopathological evaluation (Figure 2) to the Department of Oral and Maxillofacial Pathology, NIMS Dental College, Jaipur. No recurrence was noted.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2016
Leiomyomas are benign soft tissue neoplasms that arise from smooth muscles. Three distinctive pat... more Leiomyomas are benign soft tissue neoplasms that arise from smooth muscles. Three distinctive patterns of leiomyoma have been described as piloleiomyomas, angioleiomyomas and genital leiomyomas. Here in, we report the case of 39-year male with chief complain of growth on his lower left front region of the jaw. On the basis of clinical examination, it was provisionally diagnosed as pyogenic granuloma; however, histopathological examination made to the final diagnosis of angioleiomyoma. Excision led to uneventful recovery.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2017
Odontogenic myxomas are rare odontogenic tumors of jaw characterised by accumulation of mucoid gr... more Odontogenic myxomas are rare odontogenic tumors of jaw characterised by accumulation of mucoid ground substance with little collagen. Peripheral odontogenic myxoma (POM) is extra-osseous variant of odontogenic myxomas, occurring solely in the soft tissue covering the tooth bearing portion of jaws. POM is exceedingly rare, less than 10 cases have been published till date. A case of POM is reported here in a 27-year female which was provisionally diagnosed as pyogenic granuloma.
Journal of Pakistan Association of Dermatology, 2018
Schwannomas are benign tumors of peripheral nerve sheath origin, composed of proliferation of Sch... more Schwannomas are benign tumors of peripheral nerve sheath origin, composed of proliferation of Schwann cells in a characteristic pattern. Ancient schwannomas are long-standing lesions exhibit degenerative changes and atypia due to which they could be mistaken for malignancy. The mean age of occurrence of AS in oral cavity is 43 years and no case of AS has been reported in a pediatric patient so far. Here we present a rare case of AS of oral cavity in a 10 year old male child.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2017
Angiomyxolipoma is a rare histological variant of lipoma, characterized by proliferation of adipo... more Angiomyxolipoma is a rare histological variant of lipoma, characterized by proliferation of adipose tissue associated with a variable amount of myxoid stroma with numerous thick- and thin-walled blood vessels. An exhaustive literature review could reveal only 12 cases of angiomyxolipoma affecting subcutaneous tissue, subungual area and spermatic cord. In oral cavity, only 2 cases of angiomyxolipoma have been reported to date, one case in the buccal mucosa and one case in the floor of the mouth. Hence, this is only the third case of angiomyxolipoma affecting oral cavity and the first case of angiomyxolipoma of the tongue. We report a case of a 51-year male presenting with a swelling on the right lateral border of the tongue. The lesion was excised and microscopical examination confirmed the diagnosis of angiomyxolipoma.
International Journal of Clinical Pediatric Dentistry, 2020
Dentinogenic ghost cell tumor (DGCT) is a very rare entity with controversies in its terminology ... more Dentinogenic ghost cell tumor (DGCT) is a very rare entity with controversies in its terminology and classification. It is the neoplastic solid counterpart of the calcifying odontogenic cyst (COC), which was first reported by Gorlin et al. in 1962. There are around 31 cases reported in the literature. The mean age of occurrence is 40.27 years, although very rarely is it associated with the pediatric age group. We are reporting a case of DGCT with dysplastic changes in an 11-year-old child which is very rare. The present case deals with the clinical, radiological, and histopathological aspects of the disease and the importance of an appropriate diagnosis.
Background: Lipomas are benign mesenchymal tumors of soft tissue that can be found anywhere in th... more Background: Lipomas are benign mesenchymal tumors of soft tissue that can be found anywhere in the body: However their presence in oral cavity is very rare (4.4%). Histopathologically lipomas are classified as simple lipomas and different variants. The present study describes the prevalence of oral lipomas with relation to patient's age, their site of occurrence and histological pattern in Indian population. Methods: All cases of oral lipomas reported in the department of oral pathology and microbiology, N.I.M.S dental college Jaipur (India) from 2005 to 2017 for age, gender, site of occurrence, histopathological pattern and treatment mode were reviewed. The published case reports of oral lipomas reported in Indian patients from 1976 -2017 also reviewed through pubmed by using MeSH word; oral lipoma and combined the data with the data of present study to analyze the prevalence and histopathological characteristic of oral lipomas in Indian population. Results: Total of 23 (14 males and 9 females) cases included in the study. The mean age was 34.3 years (range 17 -71). The specific sites involved were buccal mucosa (n = 9) Tongue (n = 5) buccal vestibule (n = 2) Lip (n -= 3) Floor of mouth (n = 1), palate (n = 2) and retro molar pad (n = 1). Histopathological examination revealed 11 cases were diagnosed as simple lipoma, 6 cases were fibrolipoma, 2 cases were angiolipoma, 1 case each of osteolipoma, myxolioma, angiomyxolipoma and hibernoma. All cases treated with surgical excision only one case showed radiographical sign. This data was combined with the data of published cases (pubmed) of oral lipoma in Indian population. Conclusion: Oral lipomas are rare neoplasms of oral cavity; only 49 published cases have been found from 1976 -2017 in Indian population. Oral lipoma should be considered as a differential diagnosis of oral soft tissue swelling. Surgical excision is the treatment of choice for all such tumors.
Oral schwannomas (OSs) are rare benign tumors of oral cavity derived from peripheral nerve sheath... more Oral schwannomas (OSs) are rare benign tumors of oral cavity derived from peripheral nerve sheath, composed of proliferation of schwann cells in a characteristic pattern. AS are long-standing lesions which exhibit degenerative changes and atypia due to which they could be mistaken for malignancy. The mean age of occurrence of AS in oral cavity is 43 years, and no case of oral AS has been reported in a pediatric patient so far. Here, we present a rare case of AS of oral cavity in a 10-year-old male child.
Table 1. Histopathological differences between squamous cell carcinoma and verrucous carcinoma Ve... more Table 1. Histopathological differences between squamous cell carcinoma and verrucous carcinoma Verrucous carcinoma Squamous cell carcinoma Histopathological features Histopathological features Epithelium seldom shows dysplastic features. Elephant foot like rete ridges is seen. Parakeratin plugging is present. Keratin pearls are not seen. Breach in the basement membrane is absent. Islands of dysplastic epithelium are not seen in the connective tissue. Epithelium shows high dysplasia. Elephant foot like rete ridges is not seen. Parakeratin plugging is usually absent. Keratin pearls are seen. Breach in the basement membrane is present. Islands of dysplastic epithelium are seen in the connective tissue.
Journal of Ayub Medical College, Abbottabad : JAMC
Swelling on the lower left back region of the jaw CT Scan with 3D reconstruction Thin Spindle sha... more Swelling on the lower left back region of the jaw CT Scan with 3D reconstruction Thin Spindle shaped cells with variable amount of myxoid stroma (Hematoxylin and Eosin stain 40X)
The choice to use teeth for age determination is well accepted due to their longevity ability of ... more The choice to use teeth for age determination is well accepted due to their longevity ability of being resilient to change. The total of 228 extracted teeth collected from the patients visited to the Department of Oral and Maxillofacial Surgery, NIMS Dental College, Jaipur, the teeth were without dental fillings and without and/or cavity selected. The known age was from 21 to 70 years with the average age of 43.46 years. For age estimation the method according to Gustafson was used. Every tooth was subject to longitudinal section of the midpulpal area. The following dental parameters were studied in each case: attrition, periodontal bone loss, root translucency, secondary dentin deposition, cementum apposition and root resorption. Total scores of different parameters plotted against the chronological age and regression formula was obtained. Using this formula ages were estimated, Gustafson formula was also applied in the same scores and ages estimated. The results of the chronologic...
Centrally occurring salivary gland tumors are rare. Because of a considerable overlap between the... more Centrally occurring salivary gland tumors are rare. Because of a considerable overlap between the clinical and histopathological features, this group of tumors often produces a diagnostic difficulty to the clinicians and oral pathologists. Acinic cell carcinoma (ACC) is an unusual, low-grade, malignant salivary gland tumor that represents approximately 2% of the salivary gland tumors with almost 90% arising in the parotid gland. The rest involve the submandibular and the minor salivary gland. ACC of the jaw is extremely rare and, to our knowledge, only 8 cases have been reported in the English literature. Herein, a case of primary intraosseous ACC of the mandible in a 31-yearold woman is presented. The present case is unique, as the central ACC has never been reported in a patient in the third decade of life. The complete surgical removal of the tumor was carried out under general anesthesia along with the extraction of teeth #31, #32, #41, and #42. The follow-up period of 1-year was uneventful.
Angiolipomas, histopathological variant of lipoma are benign mesenchymal tumor characterized by p... more Angiolipomas, histopathological variant of lipoma are benign mesenchymal tumor characterized by proliferation of mature adipocytes and interspersed with angiomatous proliferation composed of several congested blood vessels. Although they are the most common tumor of trunk and extremities but they are exceedingly rare in oral cavity according to their capsulation they can be classified into infiltrating and non infiltrating. Intraorally tongue, buccal mucosa and floor of the mouth are commonest sites, but hard palate is a very rare site for angiolipoma. Here we report a case of angiolipoma of palate in a 39 year old male. The present case also emphasized the cytopathological features of angiolipoma.
Basal cell tumors (BCT) are tumors usually derived from pluripotential stem cell compartments of ... more Basal cell tumors (BCT) are tumors usually derived from pluripotential stem cell compartments of the basal layer of epidermis and/or oral epithelium. BCTs are infrequent entities in the oral cavity and are not discussed separately in general and oral pathology. A literature review did not reveal any classification of tumors with basaloid morphology. This paper is an attempt to categorize the oral neoplasms with basaloid morphology and discuss their differential diagnoses in detail. A review of the literature was carried out to rule out the frequency of different oral BCTs reported in the literature. Additionally, a simple working classification of oral BCTS has been proposed. We hope that this classification will be helpful for oral and general pathologists and students.
Spindle Cell Carcinoma (SpCC) is a biphasic tumor. They are proven to be monoclonal dedifferentia... more Spindle Cell Carcinoma (SpCC) is a biphasic tumor. They are proven to be monoclonal dedifferentiated forms of conventional squamous carcinomas. It is a rare tumor which is infrequently observed in head, neck and in the aerodigestive tract. The tumor is aggressive and shows high frequency of recurrence and metastasis. It is an aggressive variant of squamous cell carcinoma which resembles a true sarcoma. It is a proliferation of spindle cells and squamous cells. For confirmation of diagnosis, immunohistochemistry is used. A Rare case of spindle cell squamous cell carcinoma in a 61 years old male in the tongue.The patient reported of rapidly growing lesion from six months with pain severe pain, dysphagia and difficulty in swallowing patient had history of chewing tobacco from past 35 years. Keywords: Spindle Cell Variant, Biphasic tumor, Head and Neck, Pseudocarcinoma, Sqamous cell, Dysplastic.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2017
A 54-year male presented to a private dental clinic with the chief complain of an asymptomatic no... more A 54-year male presented to a private dental clinic with the chief complain of an asymptomatic nodular swelling on his left buccal mucosa. Family history and past medical history were not relevant to the present swelling. Intra-oral examination revealed a dome shaped nodule on the left buccal mucosa measuring 2 x 1 cm in dimension. The color of the lesion was pink without ulceration (Figure 1). On palpation, the lesion was found to be firm and non-tender. A provisional diagnosis of fibroma with differential diagnosis of lipoma was given. The lesion was surgically excised under local anesthesia and the excised tissue was sent for histopathological evaluation (Figure 2) to the Department of Oral and Maxillofacial Pathology, NIMS Dental College, Jaipur. No recurrence was noted.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2016
Leiomyomas are benign soft tissue neoplasms that arise from smooth muscles. Three distinctive pat... more Leiomyomas are benign soft tissue neoplasms that arise from smooth muscles. Three distinctive patterns of leiomyoma have been described as piloleiomyomas, angioleiomyomas and genital leiomyomas. Here in, we report the case of 39-year male with chief complain of growth on his lower left front region of the jaw. On the basis of clinical examination, it was provisionally diagnosed as pyogenic granuloma; however, histopathological examination made to the final diagnosis of angioleiomyoma. Excision led to uneventful recovery.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2017
Odontogenic myxomas are rare odontogenic tumors of jaw characterised by accumulation of mucoid gr... more Odontogenic myxomas are rare odontogenic tumors of jaw characterised by accumulation of mucoid ground substance with little collagen. Peripheral odontogenic myxoma (POM) is extra-osseous variant of odontogenic myxomas, occurring solely in the soft tissue covering the tooth bearing portion of jaws. POM is exceedingly rare, less than 10 cases have been published till date. A case of POM is reported here in a 27-year female which was provisionally diagnosed as pyogenic granuloma.
Journal of Pakistan Association of Dermatology, 2018
Schwannomas are benign tumors of peripheral nerve sheath origin, composed of proliferation of Sch... more Schwannomas are benign tumors of peripheral nerve sheath origin, composed of proliferation of Schwann cells in a characteristic pattern. Ancient schwannomas are long-standing lesions exhibit degenerative changes and atypia due to which they could be mistaken for malignancy. The mean age of occurrence of AS in oral cavity is 43 years and no case of AS has been reported in a pediatric patient so far. Here we present a rare case of AS of oral cavity in a 10 year old male child.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2017
Angiomyxolipoma is a rare histological variant of lipoma, characterized by proliferation of adipo... more Angiomyxolipoma is a rare histological variant of lipoma, characterized by proliferation of adipose tissue associated with a variable amount of myxoid stroma with numerous thick- and thin-walled blood vessels. An exhaustive literature review could reveal only 12 cases of angiomyxolipoma affecting subcutaneous tissue, subungual area and spermatic cord. In oral cavity, only 2 cases of angiomyxolipoma have been reported to date, one case in the buccal mucosa and one case in the floor of the mouth. Hence, this is only the third case of angiomyxolipoma affecting oral cavity and the first case of angiomyxolipoma of the tongue. We report a case of a 51-year male presenting with a swelling on the right lateral border of the tongue. The lesion was excised and microscopical examination confirmed the diagnosis of angiomyxolipoma.
International Journal of Clinical Pediatric Dentistry, 2020
Dentinogenic ghost cell tumor (DGCT) is a very rare entity with controversies in its terminology ... more Dentinogenic ghost cell tumor (DGCT) is a very rare entity with controversies in its terminology and classification. It is the neoplastic solid counterpart of the calcifying odontogenic cyst (COC), which was first reported by Gorlin et al. in 1962. There are around 31 cases reported in the literature. The mean age of occurrence is 40.27 years, although very rarely is it associated with the pediatric age group. We are reporting a case of DGCT with dysplastic changes in an 11-year-old child which is very rare. The present case deals with the clinical, radiological, and histopathological aspects of the disease and the importance of an appropriate diagnosis.
Background: Lipomas are benign mesenchymal tumors of soft tissue that can be found anywhere in th... more Background: Lipomas are benign mesenchymal tumors of soft tissue that can be found anywhere in the body: However their presence in oral cavity is very rare (4.4%). Histopathologically lipomas are classified as simple lipomas and different variants. The present study describes the prevalence of oral lipomas with relation to patient's age, their site of occurrence and histological pattern in Indian population. Methods: All cases of oral lipomas reported in the department of oral pathology and microbiology, N.I.M.S dental college Jaipur (India) from 2005 to 2017 for age, gender, site of occurrence, histopathological pattern and treatment mode were reviewed. The published case reports of oral lipomas reported in Indian patients from 1976 -2017 also reviewed through pubmed by using MeSH word; oral lipoma and combined the data with the data of present study to analyze the prevalence and histopathological characteristic of oral lipomas in Indian population. Results: Total of 23 (14 males and 9 females) cases included in the study. The mean age was 34.3 years (range 17 -71). The specific sites involved were buccal mucosa (n = 9) Tongue (n = 5) buccal vestibule (n = 2) Lip (n -= 3) Floor of mouth (n = 1), palate (n = 2) and retro molar pad (n = 1). Histopathological examination revealed 11 cases were diagnosed as simple lipoma, 6 cases were fibrolipoma, 2 cases were angiolipoma, 1 case each of osteolipoma, myxolioma, angiomyxolipoma and hibernoma. All cases treated with surgical excision only one case showed radiographical sign. This data was combined with the data of published cases (pubmed) of oral lipoma in Indian population. Conclusion: Oral lipomas are rare neoplasms of oral cavity; only 49 published cases have been found from 1976 -2017 in Indian population. Oral lipoma should be considered as a differential diagnosis of oral soft tissue swelling. Surgical excision is the treatment of choice for all such tumors.
Oral schwannomas (OSs) are rare benign tumors of oral cavity derived from peripheral nerve sheath... more Oral schwannomas (OSs) are rare benign tumors of oral cavity derived from peripheral nerve sheath, composed of proliferation of schwann cells in a characteristic pattern. AS are long-standing lesions which exhibit degenerative changes and atypia due to which they could be mistaken for malignancy. The mean age of occurrence of AS in oral cavity is 43 years, and no case of oral AS has been reported in a pediatric patient so far. Here, we present a rare case of AS of oral cavity in a 10-year-old male child.
Table 1. Histopathological differences between squamous cell carcinoma and verrucous carcinoma Ve... more Table 1. Histopathological differences between squamous cell carcinoma and verrucous carcinoma Verrucous carcinoma Squamous cell carcinoma Histopathological features Histopathological features Epithelium seldom shows dysplastic features. Elephant foot like rete ridges is seen. Parakeratin plugging is present. Keratin pearls are not seen. Breach in the basement membrane is absent. Islands of dysplastic epithelium are not seen in the connective tissue. Epithelium shows high dysplasia. Elephant foot like rete ridges is not seen. Parakeratin plugging is usually absent. Keratin pearls are seen. Breach in the basement membrane is present. Islands of dysplastic epithelium are seen in the connective tissue.
Journal of Ayub Medical College, Abbottabad : JAMC
Swelling on the lower left back region of the jaw CT Scan with 3D reconstruction Thin Spindle sha... more Swelling on the lower left back region of the jaw CT Scan with 3D reconstruction Thin Spindle shaped cells with variable amount of myxoid stroma (Hematoxylin and Eosin stain 40X)
The choice to use teeth for age determination is well accepted due to their longevity ability of ... more The choice to use teeth for age determination is well accepted due to their longevity ability of being resilient to change. The total of 228 extracted teeth collected from the patients visited to the Department of Oral and Maxillofacial Surgery, NIMS Dental College, Jaipur, the teeth were without dental fillings and without and/or cavity selected. The known age was from 21 to 70 years with the average age of 43.46 years. For age estimation the method according to Gustafson was used. Every tooth was subject to longitudinal section of the midpulpal area. The following dental parameters were studied in each case: attrition, periodontal bone loss, root translucency, secondary dentin deposition, cementum apposition and root resorption. Total scores of different parameters plotted against the chronological age and regression formula was obtained. Using this formula ages were estimated, Gustafson formula was also applied in the same scores and ages estimated. The results of the chronologic...
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Papers by Manas Bajpai