Ivana Binic

University of Niš, Dermatovenerology, Faculty Member

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Armando Marques-Guedes

UNL - New University of Lisbon

Anna M . Czarnecka

Laura Bierema

The University of Georgia

Roshan Chitrakar

Nepal College of Information Technology

Lev Manovich

Graduate Center of the City University of New York

Aida Khairuddin

Universiti Teknologi Malaysia - UTM

Marie-France Waxin

American University of Sharjah

Radoslaw Spiewak

Jagiellonian University

Ferhat Bozkurt

Ataturk University

Ahmed El-Agwany

Alexandria University

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Papers by Ivana Binic

Keloids and Hypertrophic Scars

ABSTRACT

Vitiligo and Hyperpigmentation Disorders - What's Mutual?

Large growth on the face. Cutaneous horn

PubMed, Aug 1, 2012

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Gorlin-Goltz syndrome

PubMed, Dec 1, 2007

Gorlin-Goltz syndrome, also known as basal cell nevus syndrome, is an uncommon, autosomal dominan... more Gorlin-Goltz syndrome, also known as basal cell nevus syndrome, is an uncommon, autosomal dominant inherited disorder, which is characterized by numerous basal cell carcinomas, maxillary keratocysts, and musculoskeletal malformations. Occasionally, it is associated with aggressive basal cell carcinomas and internal malignancies. Early diagnosis and treatment are essential, as well as genetic counseling. A patient with characteristic symptoms of nevoid basal cell carcinomas and a review of the literature are presented.

Pityriasis Rubra Pilaris: A Report of Two Cases and Literature Review

Serbian Journal of Dermatology and Venereology, Dec 1, 2015

Pityriasis rubra pilaris (PRP) is an idiopathic inflammatory hyperproliferative chronic dermatosi... more Pityriasis rubra pilaris (PRP) is an idiopathic inflammatory hyperproliferative chronic dermatosis characterized by: perifollicular coalescing papules with central keratotic acuminate plugs gradually submerged in sheets of erythema; perifollicular erythema with islands of unaffected skin; palmoplantar keratoderma; diffuse desquamation which typically spreads from the head down to the feet. The cause of the condition is unknown, but possible etiological factors include: vitamin A deficiency, trauma, infections, autoimmune mechanisms, and malignancies. Taking into account different age of onset, clinical course, morphology and prognosis, there are six different types of the disease: two in adults (classical and atypical); three in children (classical, circumscribed and atypical); one in individuals infected with human immunodeficiency virus. This paper presents two male patients with clinical symptoms of classical PRP, 53 and 69 years of age at the onset of the disease, with rapid generalized involvement, typical erythematous perifollicular papules, islands of unaffected skin, palmoplantar hyperkeratosis with a waxy appearance and nail changes. The diagnosis was based on clinical findings and histopathologic analysis. Apart from topical therapy with emollients, corticosteroids and keratolytics, they received systemic retinoids and corticosteroids, which resulted in improvement of skin lesions. It is extremely important to consider the possible triggering factors, establish the diagnosis as soon as possible and begin proper treatment.

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Yellow Nail Syndrome - a Case Report

Serbian Journal of Dermatology and Venereology, Jun 1, 2015

Th e disorder is characterized by discoloration of nail plates which varies from light brown, dar... more Th e disorder is characterized by discoloration of nail plates which varies from light brown, dark yellow, yellow and green, with thickening, occasionally with transverse ridging and onycholysis, increased longitudinal and transversal over-curvature, partial or complete separation of the nail plate from the nail bed, without lunula and cuticle, with slow nail growth rate (13-16). Th e lymphedema is mostly peripheral (lower limbs or hands), or aff ects the face, larynx, with pleural eff usion and ascites, and occasionally it is universal (17). In some cases the edema has been shown to be due to abnormalities of the lymphatics, either atresia

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Acrokeratosis paraneoplastica (Bazex syndrome)n

Indian Journal of Dermatology, Venereology and Leprology, 2009

Acrokeratosis paraneoplastica of Bazex is rare condition, characterized with scaly hyperkeratotic... more Acrokeratosis paraneoplastica of Bazex is rare condition, characterized with scaly hyperkeratotic psoriasiform plaques on acral parts of body (helices, nose, and malar and acral surfaces), and in later stages propagation to the limbs and trunk.This syndrome is distinct marker for different neoplastic conditions, predominantly squamous cell carcinoma of the upper aerodigestive tract with possible cervical lymph node metastases.In this paper we present 56 years old male patient, with hyperkeratotic plaques on the skin of his palms, soles, ear lobes and apex of the nose. Detailed examination found tumorous swelling on the left side of his neck. Histopathologic examination revealed solid anaplastic metastatic tumor. Patient died before primary tumor could be found. Bazex syndrome can appear before the diagnosis of internal malignancies, and thus is important for dermatologists to recognize it in favor of early diagnosis of speciÞ c malignant process.

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Some therapeutic effects of herbal based ointment „Dermoplant G„on venous ulcers

Planta Medica, Aug 24, 2010

Ichthyosis follicularis with alopecia and photophobia (IFAP): late diagnosis in 18-year-old man

International Journal of Dermatology, Mar 18, 2011

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Cutaneous tuberculosis and squamous-cell carcinoma

Anais Brasileiros De Dermatologia, Jun 1, 2011

The incidence of all forms of cutaneous tuberculosis, including lupus vulgaris (the most common f... more The incidence of all forms of cutaneous tuberculosis, including lupus vulgaris (the most common form) decreased progressively in developed countries during the twentieth century, this change being attributed to improved living standards and specific therapy. Despite the decrease in cutaneous tuberculosis, some cases are still found and correct diagnosis and management are fundamental, both for the patients and for public health. Long lasting, misdiagnosed or untreated cutaneous tuberculosis may lead to different forms of cancer. This case report involves a 74-year old male farmer with lupus vulgaris on his face. During anti-tuberculosis treatment he developed a tumor on his forehead, which was histologically confirmed as a squamous cell carcinoma.

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Crusted (Norwegian) Scabies Following Systemic and Topical Corticosteroid Therapy

Journal of Korean Medical Science, 2010

It is a case study of a 62-yr-old female with crusted (Norwegian) scabies, which appeared during ... more It is a case study of a 62-yr-old female with crusted (Norwegian) scabies, which appeared during her treatment with systemic and topical corticosteroid therapy, under the diagnosis of erythroderma. In the same time, the patient had been suffered from hypothyoidism, and her skin changes were misdiagnosed, because it was thought that they are associated with her endocrine disorder. Suddenly, beside the erythema, her skin became hyperkeratotic, with widespread scaling over the trunk and limbs, and crusted lesions appeared on her scalp and ears. The microscopic examination of the skin scales with potassium hydroxide demonstrated numerous scabies mites and eggs. Repeated topical treatments with lindan, benzoyl benzoat and 10% precipitated sulphur ointment led to the complete resolution of her skin condition.

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Giant Congenital Nevus – Case Report

DOAJ (DOAJ: Directory of Open Access Journals), 2006

Kongenitalni nevomelanocitni nevusi (KN) benigne su nevusne proliferacije prisutne na rodjenju. I... more Kongenitalni nevomelanocitni nevusi (KN) benigne su nevusne proliferacije prisutne na rodjenju. Incidenca džinovskih KN je 0,002% novorodjene dece. Prikazujemo 20-godišnju osobu ženskog pola sa džinovskim KN koji zahvata gotovo celu površinu desne ruke. Dermoskopija je vrlo korisna u diferencijalnoj dijagnostici pigmentnih promena kože. KN se dermoskopski karakteriše prisustvom uniformnih globula, "oblutaka". Džinovski KN, koji zahvata više od 5% površine tela, ima povećan rizik za razvoj malignog melanoma. Terapijske mogućnosti KN su: ekscizija sa graftovima, dermabrazija kiretaža, laserski tretman. Neophodni su periodični pregledi kože.

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Interferon alpha-induced reduction in the values of myeloid-derived suppressor cells in melanoma patients

Vojnosanitetski Pregled, 2015

Background/Aim. Interaction between tumor cells and host's immunoregulatory cells in creation of ... more Background/Aim. Interaction between tumor cells and host's immunoregulatory cells in creation of microenvironment that supports tumor progression is the focus of numerous investigations in recent years. Myeloid-derived suppressor cells (MDSCs) are heterogeneous population of immature dendritic cells, macrophages and granulocytes. In cancer patients, these cells accumulate in tumor microenvironment, tumor-draining lymph nodes, peripheral blood and the liver and their numbers correlate with the stage of the disease and the metastatic disease. The aim of the study was to investigate the effect of interferon alpha on MDSCs percentage in peripheral blood of melanoma patients. Methods. The interferon treated melanoma patients were given subcutaneously interferon alpha, in optimal dose, for a period of at least 6 months before the analysis. Blood samples were collected from the melanoma patients (n = 91) and the age/sex matched healthy controls (n = 8). The following anti-human monoclonal antibodies were used for immunostaining:

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The effect of age and compression strength on venous leg ulcer healing

Phlebology, Dec 20, 2017

The aim of the study is to compare proportions of venous leg ulcers healed in patients treated wi... more The aim of the study is to compare proportions of venous leg ulcers healed in patients treated with two different sub-bandage pressure values in relation to age. Methods: The study included 102 outpatients with venous leg ulcers, one group with moderate compression pressure of 35-40 mmHg and the second with high pressure >45 mmHg. Each group was divided into two subgroups according to the age (!65 vs. <65 years). Computerized planimetry was used to measure the size of the ulcers at 6, 12, 18 and 24 weeks. Results: Kaplan-Maier analysis showed high pressure leads to higher proportion of healed venous leg ulcers, compared to moderate pressure, in patients aged !65 years (57.6% vs. 28%) and in patients <65 years (53.8% vs. 36%) (p < 0.05). Conclusion: The study showed that higher compression pressure leads to higher proportions of venous leg ulcers healed, independent of age and could be safely preferred in older patients.

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The Effects of Melatonin on Oxidative Stress Parameters and DNA Fragmentation in Testicular Tissue of Rats Exposed to Microwave Radiation

Advances in Clinical and Experimental Medicine, 2015

Background. Microwaves from mobile phones are one of the environmental toxicants that are capable... more Background. Microwaves from mobile phones are one of the environmental toxicants that are capable of compromising male fertility by inducing oxidative stress and apoptosis in the testes. Melatonin is a lipophilic tryptophan indole amine and a potent antioxidant. Objectives. The aim of the study was to evaluate the effect of melatonin treatment on oxidative stress parameters and DNA fragmentation in the testicular tissue of rats exposed to microwave radiation (4 h/day). Material and Methods. Adult Wistar rats were divided in 4 groups: I-treated with saline; II-treated with melatonin; III-exposed to microwaves; IV-exposed to microwaves and treated with melatonin. The melatonin (2 mg/kg ip) was administered daily. The animals were sacrificed after 20, 40 and 60 days. Results. Melatonin treatment prevented previously registered increases in malondialdehyde after only 20 days. Furthermore, it reversed the effects of microwave exposure on xanthine oxidase (after 40 days) and acid-DNase activity (after 20 days). However, neither protein carbonyl content nor catalase and alkaline Dnase activity were changed due to melatonin treatment. Conclusions. Melatonin exerts potent antioxidant effects in the testes of rats exposed to microwaves by decreasing the intensity of oxidative stress; it also reduces DNA fragmentation (Adv Clin Exp Med 2015, 24, 3, 429-436).

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A consensus-based practical and daily guide for the treatment of acne patients

Journal of The European Academy of Dermatology and Venereology, May 14, 2016

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Criotherapy in Dermatology

DOAJ (DOAJ: Directory of Open Access Journals), Mar 1, 2001

The criotherapy is a method of local curing by low temperature. It represents a relatively freque... more The criotherapy is a method of local curing by low temperature. It represents a relatively frequent therapeutic method and it is used in many medical disciplines. It makes use of evaporable fluid. Today the most often used is liquid nitrogen. In dermatology the criotherapy is used for curing numerous diseases and states, most often of smaller benign tumors, some inflammatory disease as well as smaller malign tumors such as basocellular carcinoma. It is a relatively simple method, almost painless and especially suitable for ambulance application.

Pharmacological therapy of vitiligo

Hypopigmentation, 2019

Fünfundzwanzig Mal Jahrestagung für Phytotherapie

Forschende Komplementärmedizin / Research in Complementary Medicine, 2010

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Interferon Alpha induced reduction in Myeloid Derived Suppressor Cell values in Melanoma Patients

Vojnosanitetski Pregled, 2015

INTRODUCTION Interaction between tumor cells and host’s immunoregulatory cells in creation of the... more INTRODUCTION Interaction between tumor cells and host’s immunoregulatory cells in creation of the micro-environment that supports tumor progression is focus of numerous investigations in recent years. Myeloid-derived suppressor cells are heterogeneous population of immature dendritic cells, macrophages and granulocytes. In cancer patients, these cells accumulate in the tumor microenvironment, tumor-draining lymph nodes, peripheral blood and liver and their numbers correlate with stage of the disease and metastatic disease. Our aim was to investigate the effect of interferon alpha on myeloid-derived suppressor cells percentage in the peripheral blood of melanoma patients. MATERIAL AND METHODS Interferon treated melanoma patients were given subcutaneously interferon alpha, in optimal dose, for a period of at least 6 months before the analysis. Blood samples were collected from melanoma patients (N=91) and age/sex matched healthy controls (N=8). The following anti-human monoclonal anti...

Keloids and Hypertrophic Scars

ABSTRACT

Vitiligo and Hyperpigmentation Disorders - What's Mutual?

Large growth on the face. Cutaneous horn

PubMed, Aug 1, 2012

Download

Gorlin-Goltz syndrome

PubMed, Dec 1, 2007