As previously announced, major changes are being made to enhance your GenBank submission experience. As of April 2026, you can submit to GenBank using our new simplified wizards in Submission Portal-GenBank.
Continue reading “BankIt Submitters: GenBank Submission Update”
RefSeq release 235 is now available online and from the FTP site! You can access RefSeq data through NCBI Datasets. The release is provided in several directories as a complete dataset and also as divided by logical groupings.
As of May 11, 2026, this full release incorporates genomic, transcript, and protein data containing:
Sequence data from the recent Andes hantavirus outbreak are now available through NLM’s NCBI resources, NCBI Virus web interface and NCBI Datasets command-line tool. These data were submitted by the University Hospitals of Geneva.
To find sequence records from 2026, search for “Orthohantavirus andesense” in NCBI Virus and apply the “Collection Date” filter. To get a quick overview of Andes hantavirus data available through GenBank, visit the NCBI Virus Outbreak Statistics page (select Andes hantavirus) which shows the collection location and host for recently collected samples. Continue reading “New Data Available! Access Hantavirus Sequences at NCBI”
The National Library of Medicine (NLM) has completed modernization of the Protocol Registration and Results System (PRS) and the public website, ClinicalTrials.gov. The Modernized PRS is now the primary system for protocol registration and results submission, and we will continue to add new features based on your feedback!
Highlights of updated and upcoming features: Continue reading “Protocol Registration and Results System (PRS) Modernization”
We are happy to announce the release of a new version of the stand-alone Prokaryotic Genome Annotation Pipeline (PGAP)!
As with previous releases, curators at NCBI continue to expand the library of Protein Family Models (PFMs) used by PGAP for structural and functional annotation. Continue reading “New: May 2026 Release of Stand-Alone PGAP”
As part of continued enhancements to offerings to support NIH-funded researchers and institutions with compliance with the 2024 NIH Public Access Policy, the National Center for Biotechnology Information (NCBI) at the National Library of Medicine (NLM) recently updated the NIH Manuscript Submission (NIHMS) system to facilitate review of submitted Author Accepted Manuscripts.
The NIHMS submission interface (see Figure 1) has been updated to assist Reviewers in applying the correct embargo as outlined in the 2024 NIH Public Access Policy. To learn more about the NIHMS process, see the Help documentation and NIHMS FAQs. Continue reading “Updates to the NIH Manuscript Submission (NIHMS) System”
As we previously announced, NCBI will discontinue support for the rsync protocol on June 1, 2026, as part of our ongoing effort to enhance security and efficiency. After June 1, attempts to connect to ftp.ncbi.nlm.gov using rsync will fail. To support this transition, we are announcing two temporary “brownout” periods. During these planned intervals, rsync access will be intentionally disabled to help our users identify and update affected workflows.
Rsync will be disabled during the following periods (all times are EDT):
Continue reading “Reminder! NCBI is Retiring rsync for FTP Downloads June 1, 2026”
GenBank release 271.0 (4/14/2026) is now available on the NCBI FTP site. This release has 53.90 trillion bases and 6.27 billion records.
The current release has:
ClinVar is a free, public resource you can use to research the clinical significance of genetic variants. Many people visit ClinVar multiple times a day! We previously announced an upcoming enhanced search experience and new ClinVar homepage, and these improvements are now live.
Search enhancements
The new search interface provides different search boxes for the types of terms typically used to search ClinVar. These search boxes provide additional help with syntax. One or more terms can be combined to create more complex searches. A “more search options” section can also be expanded to enter more atypical terms. Continue reading “ClinVar’s New Search Interface and Homepage are Here!”
In September 2025, PubMed Central (PMC) launched a new full text search. Some previously available features were not included in the initial release. Now, PMC is rolling out additional search features based on your feedback.
Page navigation
PMC recently updated the search results interface to make it easier to navigate your results and customize how they appear.
Page navigation now appears at both the top and bottom of the results page, with one-click options to jump to the first, previous, next, or last page. You can enter a number to jump to a specific page of results. If you prefer to scroll through a single, expanding list, you can still select “Show More Results.” Continue reading “PMC Continues to Improve New Search”