Research on the use of boron (B) in the field of oral health has gained momentum in recent years,... more Research on the use of boron (B) in the field of oral health has gained momentum in recent years, with various studies on the possibilities of using various B-containing compounds (BCCs). A multitude of applications have been discovered, from cariostatic activity to anti-inflammatory and antifungal activity, paving the way for other new research directions. B is a microelement that is commonly found in the human diet, and present throughout the body, with the highest concentration in the structure of bones, teeth, and gastrointestinal mucus gel layer. Multiple studies have demonstrated that B plays some important roles, especially in bone development and recently has been proposed to have an essential role in the healthy symbiosis. In addition, B has also attracted the interest of researchers, as various studies used BCCs in conventional or modern biomaterials. In this review, we have brought together the information we have found about B updates in the dental field and analyzing its future perspectives and potential for further studies.
Background: Boron was classified by the World Health Organization as ‘possible essential elements... more Background: Boron was classified by the World Health Organization as ‘possible essential elements for human health’. It can be found in different forms in the environment, has beneficial effects on bones and its deprivation can impair calcium and magnesium metabolism and bone development, their health and maintenance. Dietary boron supplementation can help prevent and manage degenerative and inflammatory bones and articular diseases, such as arthritis, osteoarthritis, rheumatoid arthritis and osteoporosis. Relevant articles were identified in PubMed, Google Scholar, ProQuest, and Scopus databases published until June 2021, describing the role of boron in the functioning of the osteoarticular system. Conclusions: From organic and inorganic boron forms that can enter the human body, organic plant based boron compounds are highly bioavailable. In the functioning of the osteoarticular system boron acts by regulation of calcium and magnesium metabolism, enhancing the vitamin D activation...
Breast Cancer-Current and Alternative Therapeutic Modalities 92 planar structures that are isoele... more Breast Cancer-Current and Alternative Therapeutic Modalities 92 planar structures that are isoelectronic neutral relative to carbocations. The additional bond with B allows the formation of anionic tetravalent compounds with tetrahedral structures, which behave as nucleophiles (Petasis, 2007). Various types of B-containing molecules already exist and have been investigated as therapeutic agents. These molecules include B-containing analogues of natural biomolecules (Morin, 1994), the antibacterial and antimalarial agent diazaborine (
Breast Cancer-Current and Alternative Therapeutic Modalities 92 planar structures that are isoele... more Breast Cancer-Current and Alternative Therapeutic Modalities 92 planar structures that are isoelectronic neutral relative to carbocations. The additional bond with B allows the formation of anionic tetravalent compounds with tetrahedral structures, which behave as nucleophiles (Petasis, 2007). Various types of B-containing molecules already exist and have been investigated as therapeutic agents. These molecules include B-containing analogues of natural biomolecules (Morin, 1994), the antibacterial and antimalarial agent diazaborine (
Journal of Trace Elements in Medicine and Biology, 2021
BACKGROUND The number of known boron-containing compounds (BCCs) is increasing due to their ident... more BACKGROUND The number of known boron-containing compounds (BCCs) is increasing due to their identification in nature and innovative synthesis procedures. Their effects on the fungal kingdom are interesting, and some of their mechanisms of action have recently been elucidated. METHODS In this review, scientific reports from relevant chemistry and biomedical databases were collected and analyzed. RESULTS It is notable that several BCC actions in fungi induce social and economic benefits for humans. In fact, boric acid was traditionally used for multiple purposes, but some novel synthetic BCCs are effective antifungal agents, particularly in their action against pathogen species, and some were recently approved for use in humans. Moreover, most reports testing BCCs in fungal species suggest a limiting effect of these compounds on some vital reactions. CONCLUSIONS New BCCs have been synthesized and tested for innovative technological and biomedical emerging applications, and new interest is developing for discovering new strategic compounds that can act as environmental or wood protectors, as well as antimycotic agents that let us improve food acquisition and control some human infections.
A collection of many articles on social, political and humanistic sciences with topics ranging fr... more A collection of many articles on social, political and humanistic sciences with topics ranging from the Bologna process to the common agricultural policy and the current food crisis.
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2009
Gastric cancer is the second most common cause of cancer-related death in the world. Some studies... more Gastric cancer is the second most common cause of cancer-related death in the world. Some studies indicate that polyphenolic compounds and antioxidants exert a protective action against gastric cancer. Among the polyphenolic compounds tested and proven effective against gastric cancer is resveratrol, a natural polyphenol present in red wines and various human food items. Resveratrol has been shown to suppress proliferation of a wide variety of tumor cells. We tested the genotoxic activity of resveratrol in primary cell cultures from gastric adenocarcinoma, obtained by mucosal biopsy at upper digestive endoscopy. The adenocarcinoma cells were analyzed for the presence of micronuclei at different concentrations of resveratrol at 48 hours and at 72 hours. The results showed that resveratrol induced micronuclei dose-dependently. The frequency of micronuclei increased progressively with the dose of resveratrol used, the high frequency is in the primary culture initiated from gastric aden...
Breast Cancer - Current and Alternative Therapeutic Modalities, 2011
Breast Cancer-Current and Alternative Therapeutic Modalities 92 planar structures that are isoele... more Breast Cancer-Current and Alternative Therapeutic Modalities 92 planar structures that are isoelectronic neutral relative to carbocations. The additional bond with B allows the formation of anionic tetravalent compounds with tetrahedral structures, which behave as nucleophiles (Petasis, 2007). Various types of B-containing molecules already exist and have been investigated as therapeutic agents. These molecules include B-containing analogues of natural biomolecules (Morin, 1994), the antibacterial and antimalarial agent diazaborine (
Boron is probably a prebiotic element with special importance in the so-called &a... more Boron is probably a prebiotic element with special importance in the so-called "sugars world". Boron is not present on Earth in its elemental form. It is found only in compounds, e.g., borax, boric acid, kernite, ulexite, colemanite and other borates. Volcanic spring waters sometimes contain boron-based acids (e.g., boric, metaboric, tetraboric and pyroboric acid). Borates influence the formation of ribofuranose from formaldehyde that feeds the "prebiotic metabolic cycle". The importance of boron in the living world is strongly related to its implications in the prebiotic origins of genetic material; consequently, we believe that throughout the evolution of life, the primary role of boron has been to provide thermal and chemical stability in hostile environments. The complexation of boric acid and borates with organic cis-diols remains the most probable chemical mechanism for the role of this element in the evolution of the living world. Because borates can stabilize ribose and form borate ester nucleotides, boron may have provided an essential contribution to the "pre-RNA world".
The Autonomous Generator of Technical Oxygen (AGTO) has been achieved at ICMET Craiova, in cooper... more The Autonomous Generator of Technical Oxygen (AGTO) has been achieved at ICMET Craiova, in cooperation with ICSI Rm. Valcea. It represents a product finalizing a scientific research theme financed by the romanian Ministry of Education and Research.
An increasing number of studies conducted during recent years presumed that boron could be essent... more An increasing number of studies conducted during recent years presumed that boron could be essential in animals since its deprivation in both experimental animals and humans causes changes in biological function which are reversible by restoration of boron. The study of B essentiality in animal nutrition was limited until the report that supplemental B stimulated growth and partially corrected leg abnormalities in cholecalciferoldeficient chicks. As far as we know, the literature does not reports works on the correlations between the supplementary dietary boron given to livestock and on food quality. The purpose of this paper was to assess the effects of some boron-enriched products used as feed additives in poultry feeding (broilers and layers). The trials were conducted by the Institute of Biology and Animal Nutrition Balotesti in cooperation with SC Natural Research SA. The data obtained from the feeding experiments suggest that the supplemental dietary boron given to poultry has a beneficial effect particularly on egg quality due to its biochemical traits that make it an essential element.
Objective: To prove why Green Sugar® (as boron and stevia) is important for longevity and why bor... more Objective: To prove why Green Sugar® (as boron and stevia) is important for longevity and why boron (as natural fertilizer) is useful for stevia.Methodology: In-vivo and in-vitro studies proved that both stevia and boron are very strong anti-oxidant and anti-inflammatory agents1, 2. Boron and phenolic acid HPTLC fingerprints were used to check Green Sugar® quality.Results: Boron increases stevia’s temperature resistance, enhances its sweetness, and decreases its bitterness. In-vitro and in-vivo studies show that stevia and boron are anti-glycation agents. Subsequently by its antioxidant, anti-inflammatory and anti-glycation properties, Grenn Sugar® is an important food for longevity. As natural fertilizer, boron (as Folibor®) added to the soil or sprayed on the leaves, is increasing Stevia sweetness and steviosides level.Conclusions: Green Sugar® is the healthy sugar for future, important for longevity by daily intake. A healthy stevia culture is obtained by adding boron.References:...
NAD+ is known classically as a metabolite that participates in catabolic and anabolic pathways th... more NAD+ is known classically as a metabolite that participates in catabolic and anabolic pathways throughout the metabolism that is taught to students in introductory biochemistry courses. However, non-classical studies starting over a decade ago found that NAD+ is also involved in higher order functions, in part because of its involvement in the activation of SIRTs and the support of the mitochondrial unfolded protein response. Many studies since have suggested that NAD+ is involved in an extensive spectrum of human pathologies, including neurodegenerative disorders, cardiomyopathy, obesity, and diabetes, Further, healthy aging and longevity appear to be closely related to NAD+ and its related metabolites, including NAR and NMN. Together, these studies show that this system has value as a dietary supplement to improve general health overall, as well as mitigating specific disease conditions. Accordingly, many are now recommending the consumption of materials in this system as dietary ...
Sugar-borates (SBs) are mono-or di-sugar-borate esters (SBEs) comprised of one or two monosacchar... more Sugar-borates (SBs) are mono-or di-sugar-borate esters (SBEs) comprised of one or two monosaccharide molecules linked to a boron (B) atom. SBEs occur naturally in commonly consumed herbs, vegetables, fruits, seeds, and nuts and, other than greatly varying levels of B found in local drinking water, are the primary natural dietary sources of B-containing molecules in humans. To date, the most studied SBE is calcium fructoborate (CaFB). CaFB represents an important example of how organic Bcontaining molecules are significantly distinct from their inorganic counterparts. During these past two decades, CaFB has been researched for its physical and biochemical characteristics, safety, and clinical outcomes. Results of these researches are presented and discussed herein. CaFB has been characterized using Fourier-transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA), high-performance thin-layer chromatography (HPTLC), nuclear magnetic resonance (NMR), liquid chromatography-multistage accurate mass spectrometry (LC-MSn), X-ray diffraction (XRD), Raman spectroscopy, and inductively coupled plasma (ICP) in non-biological and biological specimens. Potential health benefits of CaFB have been clinically investigated in pilot and efficacy studies demonstrating (i) significant reductions in knee discomfort and improved flexibility within 7, 14, and 90 days and (ii) significant effect on blood levels of inflammatory, cardiovascular, and other biomarkers. These studies support the use of CaFB as a dietary supplement for the management of joint discomfort. CaFB is presented here in order to illustrate how physiological benefits are imparted by distinct organic boron-containing molecules rather than solely by the element B itself. Considering recent National Health and Nutrition Examination Survey (NHANES) data reporting increases in age-related joint pain and an increasing elderly demographic, SBEs offer potential for safe, natural, and effective management of joint discomfort and improved mobility in human and animal health applications. Several of these studies may also open new opportunities for use of SBEs for health benefits beyond joint health.
Journal of Trace Elements in Medicine and Biology, 2018
Boron is considered to be a biological trace element but there is substantial and growing support... more Boron is considered to be a biological trace element but there is substantial and growing support for it to be classified as an essential nutrient for animals and humans, depending on its speciation. Boron-containing compounds have been reported to play an important role in biological systems. Although the exact biochemical functions of boron-containing compounds have not yet been fully elucidated, previous studies suggest an active involvement of these molecules in the mediation of inflammation and oxidative stress. Chronic inflammation and oxidative stress are known to amplify the effects of the main cardiovascular risk factors: smoking, diet, obesity, arterial hypertension, dyslipidemia, type 2 diabetes (as modifiable risk factors), and hyperhomocysteinemia and age (as independent risk factors). However, the role of boron-containing compounds in cardiovascular systems and disease prevention has yet to be established. This paper is a review of boron-containing compounds' existence in nature and their possible functions in living organisms, with a special focus on certain cardiovascular risk factors that may be diminished by intake of these compounds, leading to a reduction of cardiovascular morbidity and/or mortality.
Research on the use of boron (B) in the field of oral health has gained momentum in recent years,... more Research on the use of boron (B) in the field of oral health has gained momentum in recent years, with various studies on the possibilities of using various B-containing compounds (BCCs). A multitude of applications have been discovered, from cariostatic activity to anti-inflammatory and antifungal activity, paving the way for other new research directions. B is a microelement that is commonly found in the human diet, and present throughout the body, with the highest concentration in the structure of bones, teeth, and gastrointestinal mucus gel layer. Multiple studies have demonstrated that B plays some important roles, especially in bone development and recently has been proposed to have an essential role in the healthy symbiosis. In addition, B has also attracted the interest of researchers, as various studies used BCCs in conventional or modern biomaterials. In this review, we have brought together the information we have found about B updates in the dental field and analyzing its future perspectives and potential for further studies.
Background: Boron was classified by the World Health Organization as ‘possible essential elements... more Background: Boron was classified by the World Health Organization as ‘possible essential elements for human health’. It can be found in different forms in the environment, has beneficial effects on bones and its deprivation can impair calcium and magnesium metabolism and bone development, their health and maintenance. Dietary boron supplementation can help prevent and manage degenerative and inflammatory bones and articular diseases, such as arthritis, osteoarthritis, rheumatoid arthritis and osteoporosis. Relevant articles were identified in PubMed, Google Scholar, ProQuest, and Scopus databases published until June 2021, describing the role of boron in the functioning of the osteoarticular system. Conclusions: From organic and inorganic boron forms that can enter the human body, organic plant based boron compounds are highly bioavailable. In the functioning of the osteoarticular system boron acts by regulation of calcium and magnesium metabolism, enhancing the vitamin D activation...
Breast Cancer-Current and Alternative Therapeutic Modalities 92 planar structures that are isoele... more Breast Cancer-Current and Alternative Therapeutic Modalities 92 planar structures that are isoelectronic neutral relative to carbocations. The additional bond with B allows the formation of anionic tetravalent compounds with tetrahedral structures, which behave as nucleophiles (Petasis, 2007). Various types of B-containing molecules already exist and have been investigated as therapeutic agents. These molecules include B-containing analogues of natural biomolecules (Morin, 1994), the antibacterial and antimalarial agent diazaborine (
Breast Cancer-Current and Alternative Therapeutic Modalities 92 planar structures that are isoele... more Breast Cancer-Current and Alternative Therapeutic Modalities 92 planar structures that are isoelectronic neutral relative to carbocations. The additional bond with B allows the formation of anionic tetravalent compounds with tetrahedral structures, which behave as nucleophiles (Petasis, 2007). Various types of B-containing molecules already exist and have been investigated as therapeutic agents. These molecules include B-containing analogues of natural biomolecules (Morin, 1994), the antibacterial and antimalarial agent diazaborine (
Journal of Trace Elements in Medicine and Biology, 2021
BACKGROUND The number of known boron-containing compounds (BCCs) is increasing due to their ident... more BACKGROUND The number of known boron-containing compounds (BCCs) is increasing due to their identification in nature and innovative synthesis procedures. Their effects on the fungal kingdom are interesting, and some of their mechanisms of action have recently been elucidated. METHODS In this review, scientific reports from relevant chemistry and biomedical databases were collected and analyzed. RESULTS It is notable that several BCC actions in fungi induce social and economic benefits for humans. In fact, boric acid was traditionally used for multiple purposes, but some novel synthetic BCCs are effective antifungal agents, particularly in their action against pathogen species, and some were recently approved for use in humans. Moreover, most reports testing BCCs in fungal species suggest a limiting effect of these compounds on some vital reactions. CONCLUSIONS New BCCs have been synthesized and tested for innovative technological and biomedical emerging applications, and new interest is developing for discovering new strategic compounds that can act as environmental or wood protectors, as well as antimycotic agents that let us improve food acquisition and control some human infections.
A collection of many articles on social, political and humanistic sciences with topics ranging fr... more A collection of many articles on social, political and humanistic sciences with topics ranging from the Bologna process to the common agricultural policy and the current food crisis.
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2009
Gastric cancer is the second most common cause of cancer-related death in the world. Some studies... more Gastric cancer is the second most common cause of cancer-related death in the world. Some studies indicate that polyphenolic compounds and antioxidants exert a protective action against gastric cancer. Among the polyphenolic compounds tested and proven effective against gastric cancer is resveratrol, a natural polyphenol present in red wines and various human food items. Resveratrol has been shown to suppress proliferation of a wide variety of tumor cells. We tested the genotoxic activity of resveratrol in primary cell cultures from gastric adenocarcinoma, obtained by mucosal biopsy at upper digestive endoscopy. The adenocarcinoma cells were analyzed for the presence of micronuclei at different concentrations of resveratrol at 48 hours and at 72 hours. The results showed that resveratrol induced micronuclei dose-dependently. The frequency of micronuclei increased progressively with the dose of resveratrol used, the high frequency is in the primary culture initiated from gastric aden...
Breast Cancer - Current and Alternative Therapeutic Modalities, 2011
Breast Cancer-Current and Alternative Therapeutic Modalities 92 planar structures that are isoele... more Breast Cancer-Current and Alternative Therapeutic Modalities 92 planar structures that are isoelectronic neutral relative to carbocations. The additional bond with B allows the formation of anionic tetravalent compounds with tetrahedral structures, which behave as nucleophiles (Petasis, 2007). Various types of B-containing molecules already exist and have been investigated as therapeutic agents. These molecules include B-containing analogues of natural biomolecules (Morin, 1994), the antibacterial and antimalarial agent diazaborine (
Boron is probably a prebiotic element with special importance in the so-called &a... more Boron is probably a prebiotic element with special importance in the so-called "sugars world". Boron is not present on Earth in its elemental form. It is found only in compounds, e.g., borax, boric acid, kernite, ulexite, colemanite and other borates. Volcanic spring waters sometimes contain boron-based acids (e.g., boric, metaboric, tetraboric and pyroboric acid). Borates influence the formation of ribofuranose from formaldehyde that feeds the "prebiotic metabolic cycle". The importance of boron in the living world is strongly related to its implications in the prebiotic origins of genetic material; consequently, we believe that throughout the evolution of life, the primary role of boron has been to provide thermal and chemical stability in hostile environments. The complexation of boric acid and borates with organic cis-diols remains the most probable chemical mechanism for the role of this element in the evolution of the living world. Because borates can stabilize ribose and form borate ester nucleotides, boron may have provided an essential contribution to the "pre-RNA world".
The Autonomous Generator of Technical Oxygen (AGTO) has been achieved at ICMET Craiova, in cooper... more The Autonomous Generator of Technical Oxygen (AGTO) has been achieved at ICMET Craiova, in cooperation with ICSI Rm. Valcea. It represents a product finalizing a scientific research theme financed by the romanian Ministry of Education and Research.
An increasing number of studies conducted during recent years presumed that boron could be essent... more An increasing number of studies conducted during recent years presumed that boron could be essential in animals since its deprivation in both experimental animals and humans causes changes in biological function which are reversible by restoration of boron. The study of B essentiality in animal nutrition was limited until the report that supplemental B stimulated growth and partially corrected leg abnormalities in cholecalciferoldeficient chicks. As far as we know, the literature does not reports works on the correlations between the supplementary dietary boron given to livestock and on food quality. The purpose of this paper was to assess the effects of some boron-enriched products used as feed additives in poultry feeding (broilers and layers). The trials were conducted by the Institute of Biology and Animal Nutrition Balotesti in cooperation with SC Natural Research SA. The data obtained from the feeding experiments suggest that the supplemental dietary boron given to poultry has a beneficial effect particularly on egg quality due to its biochemical traits that make it an essential element.
Objective: To prove why Green Sugar® (as boron and stevia) is important for longevity and why bor... more Objective: To prove why Green Sugar® (as boron and stevia) is important for longevity and why boron (as natural fertilizer) is useful for stevia.Methodology: In-vivo and in-vitro studies proved that both stevia and boron are very strong anti-oxidant and anti-inflammatory agents1, 2. Boron and phenolic acid HPTLC fingerprints were used to check Green Sugar® quality.Results: Boron increases stevia’s temperature resistance, enhances its sweetness, and decreases its bitterness. In-vitro and in-vivo studies show that stevia and boron are anti-glycation agents. Subsequently by its antioxidant, anti-inflammatory and anti-glycation properties, Grenn Sugar® is an important food for longevity. As natural fertilizer, boron (as Folibor®) added to the soil or sprayed on the leaves, is increasing Stevia sweetness and steviosides level.Conclusions: Green Sugar® is the healthy sugar for future, important for longevity by daily intake. A healthy stevia culture is obtained by adding boron.References:...
NAD+ is known classically as a metabolite that participates in catabolic and anabolic pathways th... more NAD+ is known classically as a metabolite that participates in catabolic and anabolic pathways throughout the metabolism that is taught to students in introductory biochemistry courses. However, non-classical studies starting over a decade ago found that NAD+ is also involved in higher order functions, in part because of its involvement in the activation of SIRTs and the support of the mitochondrial unfolded protein response. Many studies since have suggested that NAD+ is involved in an extensive spectrum of human pathologies, including neurodegenerative disorders, cardiomyopathy, obesity, and diabetes, Further, healthy aging and longevity appear to be closely related to NAD+ and its related metabolites, including NAR and NMN. Together, these studies show that this system has value as a dietary supplement to improve general health overall, as well as mitigating specific disease conditions. Accordingly, many are now recommending the consumption of materials in this system as dietary ...
Sugar-borates (SBs) are mono-or di-sugar-borate esters (SBEs) comprised of one or two monosacchar... more Sugar-borates (SBs) are mono-or di-sugar-borate esters (SBEs) comprised of one or two monosaccharide molecules linked to a boron (B) atom. SBEs occur naturally in commonly consumed herbs, vegetables, fruits, seeds, and nuts and, other than greatly varying levels of B found in local drinking water, are the primary natural dietary sources of B-containing molecules in humans. To date, the most studied SBE is calcium fructoborate (CaFB). CaFB represents an important example of how organic Bcontaining molecules are significantly distinct from their inorganic counterparts. During these past two decades, CaFB has been researched for its physical and biochemical characteristics, safety, and clinical outcomes. Results of these researches are presented and discussed herein. CaFB has been characterized using Fourier-transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA), high-performance thin-layer chromatography (HPTLC), nuclear magnetic resonance (NMR), liquid chromatography-multistage accurate mass spectrometry (LC-MSn), X-ray diffraction (XRD), Raman spectroscopy, and inductively coupled plasma (ICP) in non-biological and biological specimens. Potential health benefits of CaFB have been clinically investigated in pilot and efficacy studies demonstrating (i) significant reductions in knee discomfort and improved flexibility within 7, 14, and 90 days and (ii) significant effect on blood levels of inflammatory, cardiovascular, and other biomarkers. These studies support the use of CaFB as a dietary supplement for the management of joint discomfort. CaFB is presented here in order to illustrate how physiological benefits are imparted by distinct organic boron-containing molecules rather than solely by the element B itself. Considering recent National Health and Nutrition Examination Survey (NHANES) data reporting increases in age-related joint pain and an increasing elderly demographic, SBEs offer potential for safe, natural, and effective management of joint discomfort and improved mobility in human and animal health applications. Several of these studies may also open new opportunities for use of SBEs for health benefits beyond joint health.
Journal of Trace Elements in Medicine and Biology, 2018
Boron is considered to be a biological trace element but there is substantial and growing support... more Boron is considered to be a biological trace element but there is substantial and growing support for it to be classified as an essential nutrient for animals and humans, depending on its speciation. Boron-containing compounds have been reported to play an important role in biological systems. Although the exact biochemical functions of boron-containing compounds have not yet been fully elucidated, previous studies suggest an active involvement of these molecules in the mediation of inflammation and oxidative stress. Chronic inflammation and oxidative stress are known to amplify the effects of the main cardiovascular risk factors: smoking, diet, obesity, arterial hypertension, dyslipidemia, type 2 diabetes (as modifiable risk factors), and hyperhomocysteinemia and age (as independent risk factors). However, the role of boron-containing compounds in cardiovascular systems and disease prevention has yet to be established. This paper is a review of boron-containing compounds' existence in nature and their possible functions in living organisms, with a special focus on certain cardiovascular risk factors that may be diminished by intake of these compounds, leading to a reduction of cardiovascular morbidity and/or mortality.
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