M ASTER OF PHARMACY

Doxorubicin has become one of the most effective chemotherapeutic agents, but its use was complicated by the development of heart failure. Proposed mechanisms for its antitumor effects included intercalation into DNA that caused the prevention of micro molecule synthesis, DNA cross-linkage and binding, DNA damage due to topoisomerase 2b suppression, reactive oxygen species production, and induction of apoptosis. Several drugs such as ACE inhibitors or the angiotensin receptor blockers, beta-blockers and the CHF therapy are used for the treatment processes. The present brief review of the literature, focuses on literature based on the mechanism of anthracycline-induced cardiotoxicity.

Nanobiocomposite recycling is straightforward because nanofillers' physical properties do not modify throughout processing because of their considerable thermal stability. Additionally, the low nanofiller loading has no notable effect on the density of nanobiocomposite during an elevated appearance ratio, designate that nanobiocomposite has a very elevated prospective for use. Under mild situation, we present an easy technique for fabricating silver nanoparticles spontaneously in the presence of gum tragacanth polymer (a natural polymer) without the use of a conventional reducing agent. Silver nanoparticles were formulated by mixing equal quantities of tragacanth and silver nitrate aqueous solutions at 0.5 weight percent. UV–visible, Fourier transform infrared, X-ray diffraction and X-ray photoelectron spectroscopy were utilized to substantiate the production of silver nanoparticles. Gum tragacanth polymeric chains aid in the reduction process and serve as superior stabilisers t...

In the present study, the Ashwagandha plant as a natural source has been extensively utilized for antimicrobial activity. Withania somnifera (L.) is a nontoxic popular medicinal plant in Ayurvedic medicine also used for antifungal activity, antibacterial activity and antiviral activity. The Principle active compounds include several withanolide-type compounds. Various plant parts, like roots and fewer, often leaves and fruits of Ashwagandha, are used as plant-derived medicines. The potent antimicrobial activity against the phytopathogenic fungi and bacteria tested. The protein designated WSG (Withania somnifera glycoprotein) which has seen possesses the antimicrobial activity. The inhibition of virus at a maximum of 99.9 was shown by the hydroalcoholic extract of Withania somnifera roots, studied of its highest nontoxic concentration, 25μg/ml in Cytopathic Effect Reduction Assay. By compiling the results indicated the antiviral property Withania somnifera root extract against Infectious Bursal Disease virus.

There are several purported biological effects of babchi oil (BO), including its ability to reduce inflammation, modulate the immune system, fight free radical damage, eliminate fungi and germs, and more. This study aims to develop microsponges containing BO encapsulated in ethyl cellulose (EC) and the natural gum Sterculia foetida (SF), hoping to improve their stability, immunomodulatory function, and cutaneous toxicity. Polyvinyl alcohol (PVA) was utilized as a stabilizer, and dichloro methane (DCM) was used as a solvent in a process known as quasi-emulsion solvent evaporation. The produced micro formulations were studied for their in-vitro drug release rate, particle size, encapsulation efficiency, and overall manufacturing yield. Stability testing showed that applying the natural gum SFG (S. foetida gum) increased the stability of BEO-loaded microsponges, making them suitable for human consumption.

Introduction: Incorporation of pH modifier has been the usual strategy employed to enhance the dissolution of weakly basic drug from floating microspheres. Microspheres prepared using a combination of both ethyl cellulose (EC) and hydroxypropyl methylcellulose (HPMC) which shows highest release were utilize to investigate the effect of fumaric acid (FA), citric acid (CA), ascorbic acid (AA) and tartaric acid (TA) (all 5-20% w/w) incorporation on metoprolol succinate (MS) release. Materials and Methods: EC, HPMC alone or in combination were used to prepare microspheres that floated in simulated gastric fluid and evaluated for a percent yield, drug entrapment, percent buoyancy and drug release. The higher drug release in combination (MS:HPMC:EC, 1:1:2) was selected for the evaluation of influence of pH modifiers on MS release. CA (5-20% w/w), AA (5-20% w/w), FA (5-20% w/w) and TA (5-20% w/w) were added and evaluated for drug release. Present investigation is directed to develop floating drug delivery system of MS by solvent evaporation technique. Results: The microspheres of MS:HPMC:EC (1:1:2) exhibited the highest entrapment (74.36 ± 2.18). The best percentage yield was obtained at MS:HPMC (1:1) (83.96 ± 1.50) and combination of MS:HPMC:EC (1:1:2) (79.23 ± 1.63). Conclusion: MS release from the prepared microspheres was influenced by changing MS-polymer, MS-polymer-polymer ratio and pH modifier. Although significant increment in MS release was observed with CA (20% w/w), TA (20% w/w) and AA (20% w/w), addition of 20% w/w FA demonstrated more pronounced and significant increase in drug entrapment as well as release from MS:HPMC:EC (1:1:2) buoyant microspheres.