Papers by VUDDANTI SATHISH KUMAR
EJBPS, 2017
The present study was designed to investigate the antiulcer and analgesic potential of carum carv... more The present study was designed to investigate the antiulcer and analgesic potential of carum carvi seeds. caraway seeds use is common in diet, so there is no need for special administration of the drug and by little increase in intake quantity, the use of analgesics is abolished. Antiulcer activity was also evaluated by aspirin induced ulcer models. Effect of concurrent administration of ethanolic and aqueous extracts of seeds extract Carum carvi at a dose of 100 and 200 mg/kg b.w. respectively was given by oral route. Ethanolic and aqueous extracts of Carum carvi seeds significantly reduction in gastric content, total acidity, ulcer index, and increase in pH of gastric pylorus ligation ulcer model. In comparison with the standard drug, the results of hydro alcoholic extract at 100 mg dose showed good analgesic & at 200 mg dose showed antiulcer activity compared with a standard drug. Extracts of Carum carvi may be useful as a natural analgesic in the treatment of ulcer, inflammation, and pain.
IJPPR, 2019
Background: The main objective of drug utilization research is to assess the rationality of drug ... more Background: The main objective of drug utilization research is to assess the rationality of drug use. This study aims to manage the use of drugs in adults presenting with the severity of illness in a tertiary super specialty health center. Drug utilization research help in the identification of the exact use of drugs in population and its impact on the health care system. Symptomatic drug therapy is necessary for the safety of the patients and to decrease mortality and morbidity. Methodology: A Prospective observational study was conducted in a tertiary care hospital for a period of 6 months. Inpatient ward with or without co-morbidities was included in the study. The useful data were obtained from patient case profiles, 200 cases were collected from general medicine wards, according to study criteria. Results: Total 200 impairment patients were admitted. In this 51-60 age group, patients have shown more usage of antiplatelet drugs. Out of 200 cases, female patients were 123 (61.5%) and male patients were 77 (38.5%). in this study maximum number of disease was found to be coronary artery disease 78 (39%), The most commonly prescribed antiplatelet was aspirin. Majority of the patients recovered. Conclusion: The most frequently prescribed drug group is antiplatelet. Before prescribing to the patients, evaluation of the medications with their suitable criteria is required. By minimizing the number of drugs per prescription, the irrational prescribing pattern of the drugs can be avoided by strictly following to the treatment guidelines and Ideal prescription writing.
IJAPS, 2018
Aim & Objectives: Impact Of Patient Counselling And Drug Utilization Pattern On Asthma Patients A... more Aim & Objectives: Impact Of Patient Counselling And Drug Utilization Pattern On Asthma Patients At Tertiary Care Hospital To ascertain the knowledge of the patients regarding their disease and the therapy, To provide pharmaceutical care pertaining to disease and use of inhalational devices to the study group, which is to be compared with the control group. Methodology: A Prospective, observational study was conducted in the Department of General Medicine in Manipal super specialty Hospital, Vijayawada, India. for a period of 6 months. Patients were also distinguished between an intervention and control group. Results: the decreased order of patient preference of using anti-asthmatic drugs. The males in Intervention group and females in control group are high compared to females in intervention and males in control group. Bronchodilators and anti-inflammatory agents are highly prescribed for the patients. Discussion: seasonal changes, air pollution, brooms and dusters of these self-assessment triggers are the main causes of asthma. and interventional group shows fast recovery compared with control group. Conclusion: The drug utilization pattern shows a good functioning of lungs and relives from the various problems. clinical pharmacists can provide better health care to the patients. Better interventions improve quality of life of patients .
IJPSH, 2017
Homocysteine is an emerging new risk factor for cardiovascular disease. A common polymorphism in ... more Homocysteine is an emerging new risk factor for cardiovascular disease. A common polymorphism in the gene coding for the 5,10-methylenetetrahydrofolate reductase (MTHFR) is associated with a decreased activity of the enzyme due to thermolability. There is an accumulating evidence that adequate intake of folate may protect the risk of developing the athero-thrombotic disease and its complications. Hyperhomocysteinemia (HCA)either due to mutation of MTHFR gene or deficiency of vitamin B12 and folic acid, has been reported as a risk factor for coronary artery disease (CAD).the present study was aimed to determine plasma homocysteine (hcy) levels and to evaluate MTHFR C677T gene polymorphism as risk factors for CAD in younger Indians. the effect of vitamin B12 and folic acid supplements on the raised plasma hcy levels in patients with CAD was also assessed. In our results, 6 cases are effected with a mutation in MTHFR gene. among them 4 individuals may face the future threat of myocardial infarction remaining 2 individuals are mutated and risk factors are similar to that of myocardial infarction.
IJSR, 2017
Aim and Objective: Drug utilization research help in identification of the clinical use of drugs ... more Aim and Objective: Drug utilization research help in identification of the clinical use of drugs in population and its impact on health care system. To select the rational use of drugs as a predominant technique for the prevalence in the utilization of selective drugs in liver impairment. Methodology: A Prospective observational study was conducted in General Medicine department in tertiary care hospital for a period of 6 months. inpatient ward with or without co-morbidities was included in the study; antibiotics prescribed for liver impairment. Results: Total 150 impairment patients were admitted. In this study, almost all prescriptions were with polypharmacy. In this hepatic impairment, 41-50 age group patients have shown more prevalent. A total of-150 patients‖ who were prescribed antibiotic were included in the study Out of 150 cases, female patients were 98(65.%) and male patients were 52 (35%). in this study maximum number of disease was found to be pancreatitis 39(26%), Out of 1135 medications, the highly prescribed formulation was solid dosage forms 606 (53.39%). Conclusion: Alcohol consumption in liver impairment patient is prevalent. Before prescribing to the patients, evaluation of medications with the suitable criteria is required. In other words, rational use drug must be strictly followed.
IJPSR, 2018
Aim and Objective: Drug utilization research help in identification of the clinical use of drugs ... more Aim and Objective: Drug utilization research help in identification of the clinical use of drugs in population and its impact on health care system and to evaluate the rational drug usage. To study prescription pattern, to evaluate the adherence to treatment guidelines in diabetic patients attending the medical outpatient department in a tertiary care teaching hospital. Drug utilization research help in identification of the clinical use of drugs in population and its impact on health care system. To select the rational use of drugs as a predominant technique for the utilization of selective drugs in diabetes mellitus patients. Methodology: A cross-sectional retrospective study was carried out for 6 months in diabetic patients in the General Medicine Department. Data of 280 patients were collected and evaluated. Results: Total 280 diabetes mellitus patients were admitted. In this study, almost all prescriptions were with polypharmacy. The pattern of drug prescription in diabetes mellitus shows that insulin (22.14%) was most frequently prescribed followed by glimepiride (16.78%) and metformin (8.21%). In sulfonylureas monotherapy are 50.7%, a combination of two drugs are 21% and the combination of three drugs is 2.14%. Combination therapy was prescribed to 44.41% and monotherapy to 52.48% of patients; 54.28% of these patients were male and 45.71% were female. Conclusion: Glimepiride and insulin have been most frequently prescribed, before prescribing to the patients, evaluation of medications with the suitable criteria is required. In other words, rational use drug must be strictly followed. INTRODUCTION: Diabetes mellitus is an alarming rise from 40 million to 70 million people by 2025 in India 4, 12. It is a chronic disease that requires long-term medical attention both to limit the development of is devastating complications and to manage them they do occur. The WHO defines diabetes mellitus as "A metabolic disorder of multiple etiology characterized by chronic hyperglycemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in the insulin secretion, insulin action, or both" 3, 4, 18 .
IJPPR, 2017
The purpose of this study was to measure and compare the biodegradability of fabrics in laborator... more The purpose of this study was to measure and compare the biodegradability of fabrics in laboratory and large scale composting environments. Acid, alkali, thermal resistance and water absorption capacity of raw cotton and biodegraded cotton fibres were tested. Under controlled laboratory conditions, the carbon dioxide produced was monitored and integrated to determine the biodegradation rate by their enzymatic activity, and the weight losses were measured after biodegradation by microbial mass. The raw cotton showed a more alkali, thermal, acid resistance and less water absorption capacity comparatively with the biodegraded cotton under laboratory conditions. In the present study we have used different bacterial strains called Staphylococcus aureus and E.coli, B. Subtilis, Streptococcus. The optimum incubation for the maximum degradation is 72 hrs. Biodegradation is an easy, less expensive method to control the toxic effluents of various industries. CH.SUPRIYA*, PRATYUSHA GANDRAPU, ALEKYA MUNAGALA, V.SATHISH KUMAR, M.PRASHANTHI
JBCP, 2018
Aim and Background: The aim of this study is to evaluate anti‑hypertensive drug prescription patt... more Aim and Background: The aim of this study is to evaluate anti‑hypertensive drug prescription pattern and cost analysis in tertiary care hospital. Hypertension is one of the major chronic diseases resulting in high mortality and morbidity these days. Clinical pharmacists can play a role in pharmaceutical cost management by providing an outlook to the physicians for prescribing cost‑effective choices of drugs when it is clinically appropriate. Despite broad dissemination of the JNC guidelines, prescribing practices have long remained discrepant with recommendations. Methodology: An observational and cross‑sectional prospective. Was conducted in General Medicine department in tertiary care hospital for a period of 6 months. The study group consists of 200 patients, both males, and females diagnosed with hypertension and co‑morbid conditions. Results and Discussions: Out of 200 patients, 99 males and 101 females were identified to have prescribed with antihypertensive drugs during the study period. In combination drug therapy, total 59 medications were prescribed. Telmisartan+HCL Thiazide 18 (30.5%), Losartan+Hydrochlorothiazide 12 (20.33%) and Telmisartan+Amlodipine 7 (11.86%) were the most frequently prescribed combinations drugs. Combinational therapy contributes the highest annual cost of (3248.5 ± 401.5 INR) followed by monotherapy drugs from various classes (1956.4 ± 222.65 INR). 5204.9 INR was accounted for the total antihypertensive drugs prescribed. Conclusion: The economic studies state that 70.5% of patients had received monotherapy. The study reveals that majority of patients were treated with diuretics. They can also encourage prescribers to make cost‑effective choices of drugs when clinically appropriate.
RJPT, 2018
Background: General medications utilization also called drug utilization mainly focuses on the pa... more Background: General medications utilization also called drug utilization mainly focuses on the parameters related to the prescribing, dispensing, and administering of medications, its therapeutic efficacy or adverse effects. Aim: To analyze the general medications utilization, cost minimization analysis of antibiotics in hepatic impairment patients at a tertiary care hospital. Methodology: This prospective and observational based study was undertaken in the general medicine wards of the Manipal Super Specialty Hospital. Each patient age, sex, diagnosis (only hepatic impairment) and prescribed generic and brand names of the drugs were recorded. The collected data was analyzed in MS Excel and descriptive statistics were used for analyzing the result of the study. Results: The results are evident that maximum cases of Hepatic Impairment were found to be pancreatitis 61(30.5%). The majority of the patients out of 200 were in the age group 31-40 (n=46, 23%) followed by 51-60 (n=36, 18%). some drugs that are having cost percentage greater than 30 have to minimize the cost. Conclusion: The prevalence of pancreatitis in this current study was reported as 30.5% (n=61). By performing Cost minimization analysis it is evident that same drug molecule with the same strength varying in costs in different brands which will give similar clinical outcomes. Clinical pharmacologist or clinical pharmacist should be instituted for a better drug prescription, medications utilization control and cost minimization of drugs in a healthcare organization.
International Journal of Pharmaceutical Sciences Review and Research, 2019
The aim of this prospective descriptive study was to the evaluation of antibiotics and Apache-II ... more The aim of this prospective descriptive study was to the evaluation of antibiotics and Apache-II score correlation with mortality in an intensive care unit of hepatic impairment patients at tertiary care hospital. The estimated APACHE-II mortality rate percentage used for the impact of alcohol on the liver and calculate the severity stage of the liver. The APACHE-II is the predictive scoring method for distinguishing patients in I.C.U on the basis of physiological scores and chronic health status. A Hospital based prospective and observational study and it was conducted in the Department of I.C.U and general Medicine in Manipal Super Specialty Hospital, Vijayawada, India. During the period of the study (six months), two hundred (200) patients were studied, who were admitted into the Department of Medicine as hepatic impairment cases. The calculated APACHE II score reveals that 58 patients are in between 5-9 score having a mortality of 8%. The high risk of death rate was found in 4 patients. It is observed that the total numbers of DDDs consumed were maximum for Beta-lactam antibiotics. antibiotics like metronidazole, meropenem, amikacin, ciprofloxacin, piperacillin + tazobactam, amoxicillin, cefoperazone, imipenem, shows an average PDD lower than DDD. Antibiotics like ceftriaxone, cefuroxime shows an average PDD was similar to the DDD. Apache-II Score directly proportional to the mortality rate of patients. We cannot ask the hospital people to strictly follow the WHO DDD, because in some cases The DDD does not necessarily reflect the Prescribed Daily Dose.
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Papers by VUDDANTI SATHISH KUMAR