Department of Microbiology

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Programmatic introduction of the BPaL regimen: A practical implementation guide. November 2021. ABBREVIATIONS i aDSM Active TB drug safety monitoring and management AE Adverse event AFB Acid-fast bacilli AIDS Acquired immunodeficiency syndrome aIPD Adult individual patient data aOR Adjusted odds ratio aRD Adjusted risk difference ART Antiretroviral therapy AST Aspartate aminotransferase ATS American Thoracic Society BDQ Bedaquiline BPaL regimen Bedaquiline + Pretomanid + Linezolid CDC Centers for Disease Control and Prevention CL (95%) confidence limits CNS Central nervous system DALY Disability-adjusted life year DCGI Drug Controller General of India DOI WHO Declaration of Interest DOT Directly observed therapy DR-TB Drug-resistant tuberculosis DS-TB Drug susceptibility tuberculosis DST Drug susceptibility testing EC European Commission EML Essential Medicines List ERG External Review Group FDC Fixed-dose combination (medicines) GDF Global Drug Facility GDG Guideline Development Group GRADE Grading of Recommendations Assessment, Development and Evaluation GRADEPro Online tool to create guideline materials (see https://gradepro.org/)

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