Run Zhang

Macquarie University, CBMS, Faculty Member

Followers

Following

Co-authors

Public Views

After received his B.Sc degree in Applied Chemistry in July 2006, Dr. Run Zhang entered a PhD program (Master + PhD) in Chemistry at Dalian University of Technology (DUT) under supervision of Professor Jingli Yuan. His PhD research works focused on the design, synthesis and photochemical and electrochemical investigation of the metal complexes (including transition metal complexes and lanthanide chelates) based luminescence materials. After the completion of PhD program (awarded in July 2012), he moved to Macquarie University (MQ) immediately as a full-time postdoctoral research fellow. Here, Dr. Run Zhang won the prestigious Macquarie University Research Fellow (MQRF), and took up the appointment in January 2013. The main aim of this program is to establish the new methodology to monitor the bioactive target molecules by using the technology of in situ optical imaging.

His research interests:

(i) design, engineering novel organic/organometallic materials for photochemical and electrochemical application;
(ii) development of new-generation responsive biosensors for biological systems;
(iii) design and preparation of functional bionanomaterials.

Editorial Review Board: Since 2015, Dr. Zhang has been appointed as an international Editorial Board of Journal of Biomedical Engineering and Informatics (JBEI).

Publication: (Google Scholar)
https://scholar.google.com.au/citations?user=Rs_l3nkAAAAJ&hl=en

H-index: 13, citation: 450 in five years
Phone: +61298506267
Address: E8C 257, Macquarie University

less

Béatrice L'Azou

Céline Ohayon-courtes

Université de Bordeaux

أحمد شاكر سعد الطحان

Suez Canal University

G.Ali Mansoori

University of Illinois at Chicago

Jonathan Zuckerman

University of California, Los Angeles

Universidad de Cadiz

Interests

Uploads

Papers by Run Zhang

Short-and Long-Term Tracking of Anionic Ultrasmall Nanoparticles in Kidney

by Xiaowen Liang, Run Zhang, and Haolu Wang

While biodistribution of nanoparticles (NPs) has been widely studied at the organ level, relative... more While biodistribution of nanoparticles (NPs) has been widely studied at the organ level, relatively little is known about their disposition in organs at the cellular level, especially after long-term exposure. The kidney is regarded as the key organ for the clearance of ultrasmall NPs (<5.5 nm). However, recent studies indicate that NPs in this size range could accumulate in the kidney for extended times without urinary excretion. Using negatively charged quantum dots (QDs) (∼3.7 nm) as a model system, we examined the suborgan disposition of anionic ultrasmall NPs in the kidney at the cellular level after intravenous injection by multiphoton microscopy coupled with fluorescence lifetime imaging. Most of the NPs were initially distributed in the peritubular capillaries or glomerular arterioles after injection, whereas they passed through the fenestrated glomerular endothelium and were gradually taken up by mesangial cells up to 30 days after injection. Only trace amounts of anionic QDs could be detected in the urine, which could be attributed to the barrier of the anionic glomerular basement membrane preventing filtration of anionic QDs. In contrast, cationic QDs of similar size (∼5.67 nm) were found to be readily excreted into urine. This study thus highlights the importance of surface charge in determining renal clearance of ultrasmall NPs. It provides a framework for characterizing and predicting the subcellular disposition in organs and long-term targeting of other NPs, with a physiologically based kinetic model being subsequently developed to describe the suborgan kinetics of anionic ultrasmall NPs.

Run Zhang

Uploads

Papers by Run Zhang

Log In