NCE - The Physics of Physiology
The SLC family: NCE (SLC8A1)
Sodium calcium exchanger
This transporter allows entry of 3 sodium ions, in exchange for the extrusion of one calcium ion. The bond-graph model is illustrated in the figure below, with the CellML model added for simulation purposes.
The bond graph representation of the NCE, showing simplification of the full bond graph into the reduced form.
Because this has not been parameterised yet, there are no simulation results to show. The associated CellML file contains all equations needed to execute this model.
Protein knowledge
NCE 2 structure predicted by Alphafold software:
Jumper, J et al. Highly accurate protein structure prediction with AlphaFold. Nature (2021).
Varadi, M et al. AlphaFold Protein Structure Database in 2024: providing structure coverage for over 214 million protein sequences. Nucleic Acids Research (2024).
Subfamilies
The following list contains all known member of the SLC8 family.
| Name | Alias | Gene | Structure |
|---|---|---|---|
| SLC8A1 | NCE1/NAC1 | Uniprot 1 | PDB 1 |
| SLC8A2 | NCE2/NAC2 | Uniprot 2 | Alphafold 2 |
| SLC8A3 | NCE3/NAC3 | Uniprot 3 | Alphafold 3 |
Literature
| Title | Author |
|---|---|
| A computational model of induced pluripotent stem-cell derived cardiomyocytes incorporating experimental variability from multiple data sources | Kernik et al. |
| A thermodynamic framework for modelling membrane transporters | Pan et al. |
Existing models
| Title | Author |
|---|---|
| BG_NCE | S Fong |
| Bond graph modelling of the cardiac action potential: Implications for drift and non-unique steady states^ | M Pan et al. |
| IPSC-model | Kernik et al. |
Models denoted by [*] are not in bond graph form. Models denoted by [^] are part of a whole cell model.
Other annotations
| Item | Database |
|---|---|
| calcium:sodium antiporter activity | Gene Ontology |