PMCA knowledge page
About
Landing page for the plasma membrane calcium-transporting ATPase (PMCA).
Other name for these proteins: Ca2 + pump
Its major function is to catalyze the hydrolysis of ATP coupled with the extrusion of calcium from the cytoplasm to the extracellular space.
Model
The below image shows the bond graph diagram of the channel operating under normal physiological conditions.
Prottein knowledge
Rendered image of the PMCA
Subfamilies
The following list contains the known isoforms of PMCA.
| Channel name | Alias | Gene | Structure |
|---|---|---|---|
| PMCA1 | ATP2B1 | Uniprot 1 | PDB 1 |
| PMCA2 | ATP2B2 | Uniprot 2 | SMR 2 |
| PMCA3 | ATP2B3 | Uniprot 3 | SMR 3 |
| PMCA4 | ATP2B4 | Uniprot 4 | PDB 4 |
Literature
| Title | Author |
|---|---|
| A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes | Luo and Rudy |
Existing models
| Title | Author |
|---|---|
| BG_pCa | S Fong |
| A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes*^ | Luo and Rudy |
Models denoted by [*] are not in bond graph form. Models denoted by [^] are part of a whole cell model.