Na channel knowledge page

Landing page for the voltage-gated sodium potassium channel (Na). Other names for this protein: NaV1.1 to 1.9, fastNa

The Na channel is thought to be made of one type of pore-forming alpha subunit, modulated by one or more beta subunits.

The below image shows the bond graph diagram of the channel operating under normal physiological conditions.

Schematic of sodium channel (C) action, transferring sodium ions (a) from the extracellular fluid into the cell cytosol.

Variants within the human species
Name	Abbrev	Gene	Structure
Sodium channel protein type 1 subunit alpha	SCN1A	SCN1A (Uniprot)	SCN1A (PDB)
Sodium channel protein type 2 subunit alpha	SCN2A	SCN2A (Uniprot)	SCN2A (PDB)
Sodium channel protein type 3 subunit alpha	SCN3A	SCN3A (Uniprot)	SCN3A (PDB)
Sodium channel protein type 4 subunit alpha	SCN4A	SCN4A (Uniprot)	SCN4A (PDB)
Sodium channel protein type 5 subunit alpha	SCN5A	SCN5A (Uniprot)	SCN5A (PDB)
Sodium channel protein type 8 subunit alpha	SCN8A	SCN8A (Uniprot)	SCN8A (PDB)
Sodium channel protein type 9 subunit alpha	SCN9A	SCN9A (Uniprot)	SCN9A (AlphaFold)
Sodium channel protein type 10 subunit alpha	SCNAA	SCNAA (Uniprot)	SCNAA (PDB)
Sodium channel protein type 11 subunit alpha	SCNBA	SCNBA (Uniprot)	SCNBA (AlphaFold)
Sodium channel subunit beta-1	SCN1B	SCN1B (Uniprot)	SCN1B (AlphaFold)
Sodium channel subunit beta-2	SCN2B	SCN2B (Uniprot)	SCN2B (PDB)
Sodium channel subunit beta-3	SCN3B	SCN3B (Uniprot)	SCN3B (PDB)
Sodium channel subunit beta-4	SCN4B	SCN4B (Uniprot)	SCN4B (PDB)

For further reading
Title	Author
A computational model of induced pluripotent stem-cell derived cardiomyocytes incorporating experimental variability from multiple data sources	Kernik et al.
Bond graph modelling of the cardiac action potential: Implications for drift and non-unique steady states	Pan et al.

Link to other model workspaces or exposures
Title	Author
BG_fast_Na	S Fong
Bond graph modelling of the cardiac action potential: Implications for drift and non-unique steady states^	M Pan et al.
A Model of the Ventricular Cardiac Action Potential - Depolarisation, Repolarisation and Their Interaction*^	C Luo and Y Rudy

Models denoted by [*] are not in bond graph form. Models denoted by [^] are part of a whole cell model.

Item	Database
Family of Na channels, alpha subunit	Alpha (Interpro)
Family of Na channels, beta subunit	Beta (Interpro)
Cellular component	Gene Ontology
Gene activity	Gene Ontology (activity)