SGLT1 - The Physics of Physiology

The SLC family: SGLT1 (SLC5A1)

This example is designed to show electrogenic cotransport through the SGLT1 (SLC5A1) transporter, transporting one glucose molecule into the small intestine, coupled with two sodium ions. The bond-graph model is illustrated in the figure below, with the CellML model added for simulation purposes.

The bond graph representation of transport of glucose amd sodium through the SGLT1 transporter, showing simplification of the full bond graph into the reduced form.

After clicking the CellML file, the Views Available menu to the right provides various options to explore this model here in the Physiome Model Repository. Of particular interest is the Launch with OpenCOR menu item, which will load the simulation experiment shown below directly into the OpenCOR desktop application.

Showing the result of launching the simulation experiment from this exposure in OpenCOR and executing the simulation.