K ATP protein knowledge page
About
Landing page for the ATP-sensitive potassium channel (K-ATP).
This channel transports potassium ions across the plasma membrane according to the concentration gradient, and is inhibited by internal ATP. K-ATP is part of the inward rectifying (K-ir) family
All K-ATP channels are composed of four pore-forming channel subunits Kir6, and four regulatory sulfonylurea receptor SUR subunits.
Model
The below image shows the bond graph diagram of the channel operating under normal physiological conditions.
Subfamilies
The following list contains the known isoforms of K-ATP.
| Channel name | Alias | Gene | Structure | Interacts with |
|---|---|---|---|---|
| KCNJ8 | Kir6.1 | Uniprot 8 | SMR 8 | ABCC9 |
| KCNJ11 | Kir6.2 | Uniprot 11 | PDB 11 | ABCC8 |
| ABCC8 | SUR1 | Uniprot SUR1 | PDB SUR1 | KCNJ11 |
| ABCC9 | SUR2 | Uniprot SUR2 | SMR SUR2 | KCNJ8 |
The KCNJx protein forms the pore of the channel. Column 'Interacts with' contains the experimentally-proven interactions this protein makes with other proteins, which generally help in regulating the activity of KCNJx.
Literature
| Title | Author |
|---|---|
| KATP Channel Function: More than Meets the Eye | Shyng |
| 'KATP Channels and Cardiovascular Disease: Suddenly a Syndrome <https://doi.org/10.1161/CIRCRESAHA.112.300514> | Singh and Grange |
Existing models
| Title | Author |
|---|---|
| BG_K_ATP | S Fong |
| Action potential and contractility changes in [Na(+)](i) overloaded cardiac myocytes: a simulation study*^ | Faber and Rudy |
Models denoted by [*] are not in bond graph form. Models denoted by [^] are part of a whole cell model.