This work addresses cellular planning aspects for a WiMax (worldwide interoperability for microwa... more This work addresses cellular planning aspects for a WiMax (worldwide interoperability for microwave access) point-to-multipoint wireless network to be developed in the region of Beira Interior. It is concentrated in more detail in the district of Covilha, and, particularly, in the urban area of the city, in order to guarantee communications from the Health Science Faculty of University of Beira
Background: Clinical trials show that asthma can be controlled in the majority of patients, but p... more Background: Clinical trials show that asthma can be controlled in the majority of patients, but poorly controlled asthma still imposes a considerable burden. The level of asthma control achieved reflects the behaviour of both healthcare professionals and patients. A key challenge for healthcare professionals is to help patients to engage in self-management behaviours with optimal adherence to appropriate treatment. These issues are particularly relevant in primary care, where most asthma is managed. An international panel of experts invited by the International Primary Care Respiratory Group considered the evidence and discussed the implications for primary care practice.
Worldwide, most patients with asthma are treated in primary care. Optimal primary care management... more Worldwide, most patients with asthma are treated in primary care. Optimal primary care management of asthma is therefore of considerable importance. This IPCRG Guideline paper on the management of asthma in primary care is fully consistent with GINA guidelines. It is split into two sections, the first on the management of adults and schoolchildren, and the second on the management of pre-school children. It highlights the treatment goals for asthma and gives an overview of optimal management including the topics which should be covered by the primary care health professional when educating a patient about asthma. It covers the classification of the disease, the stepwise approach to pharmacologic therapy, disease monitoring, the management of exacerbations, and the identification of patients at risk of asthma death.
Prion (PrP) and amyloid-β (Aβ) peptides are involved in the neuronal loss that occurs in Prion di... more Prion (PrP) and amyloid-β (Aβ) peptides are involved in the neuronal loss that occurs in Prion disorders (PrD) and Alzheimer's disease (AD), respectively, partially due to Ca 2+ dysregulation. Besides, the endoplasmic reticulum (ER) stress has an active role in the neurotoxic mechanisms that lead to these pathologies. Here, we analyzed whether the ER-mediated apoptotic pathway is involved in the toxic effect of synthetic PrP and Aβ peptides. In PrP106-126-and Aβ1-40-treated cortical neurons, the release of Ca 2+ through ER ryanodine (RyR) and inositol 1,4,5-trisphosphate (IP 3 R) receptors induces ER stress and leads to increased cytosolic Ca 2+ and reactive oxygen species (ROS) levels and subsequently to apoptotic death involving mitochondrial cytochrome c release and caspases activation. These results demonstrate that the early PrP-and Aβ-induced perturbation of ER Ca 2+ homeostasis is a death message that leads to neuronal loss, suggesting that the regulation of ER Ca 2+ levels may be a potential therapeutical target for PrD and AD.
Prion (PrP) and amyloid-β (Aβ) peptides are involved in the neuronal loss that occurs in Prion di... more Prion (PrP) and amyloid-β (Aβ) peptides are involved in the neuronal loss that occurs in Prion disorders (PrD) and Alzheimer's disease (AD), respectively, partially due to Ca 2+ dysregulation. Besides, the endoplasmic reticulum (ER) stress has an active role in the neurotoxic mechanisms that lead to these pathologies. Here, we analyzed whether the ER-mediated apoptotic pathway is involved in the toxic effect of synthetic PrP and Aβ peptides. In PrP106-126-and Aβ1-40-treated cortical neurons, the release of Ca 2+ through ER ryanodine (RyR) and inositol 1,4,5-trisphosphate (IP 3 R) receptors induces ER stress and leads to increased cytosolic Ca 2+ and reactive oxygen species (ROS) levels and subsequently to apoptotic death involving mitochondrial cytochrome c release and caspases activation. These results demonstrate that the early PrP-and Aβ-induced perturbation of ER Ca 2+ homeostasis is a death message that leads to neuronal loss, suggesting that the regulation of ER Ca 2+ levels may be a potential therapeutical target for PrD and AD.
Uno de los grandes retos de vivir en nuestra sociedad es saber cuándo la gente está diciendo la v... more Uno de los grandes retos de vivir en nuestra sociedad es saber cuándo la gente está diciendo la verdad. Todos mentimos todo el tiempo y somos tremendamente malos para detectar que otras personas están deliberadamente tratando de engañarnos.
This work addresses cellular planning aspects for a WiMax (worldwide interoperability for microwa... more This work addresses cellular planning aspects for a WiMax (worldwide interoperability for microwave access) point-to-multipoint wireless network to be developed in the region of Beira Interior. It is concentrated in more detail in the district of Covilha, and, particularly, in the urban area of the city, in order to guarantee communications from the Health Science Faculty of University of Beira
Background: Clinical trials show that asthma can be controlled in the majority of patients, but p... more Background: Clinical trials show that asthma can be controlled in the majority of patients, but poorly controlled asthma still imposes a considerable burden. The level of asthma control achieved reflects the behaviour of both healthcare professionals and patients. A key challenge for healthcare professionals is to help patients to engage in self-management behaviours with optimal adherence to appropriate treatment. These issues are particularly relevant in primary care, where most asthma is managed. An international panel of experts invited by the International Primary Care Respiratory Group considered the evidence and discussed the implications for primary care practice.
Worldwide, most patients with asthma are treated in primary care. Optimal primary care management... more Worldwide, most patients with asthma are treated in primary care. Optimal primary care management of asthma is therefore of considerable importance. This IPCRG Guideline paper on the management of asthma in primary care is fully consistent with GINA guidelines. It is split into two sections, the first on the management of adults and schoolchildren, and the second on the management of pre-school children. It highlights the treatment goals for asthma and gives an overview of optimal management including the topics which should be covered by the primary care health professional when educating a patient about asthma. It covers the classification of the disease, the stepwise approach to pharmacologic therapy, disease monitoring, the management of exacerbations, and the identification of patients at risk of asthma death.
Prion (PrP) and amyloid-β (Aβ) peptides are involved in the neuronal loss that occurs in Prion di... more Prion (PrP) and amyloid-β (Aβ) peptides are involved in the neuronal loss that occurs in Prion disorders (PrD) and Alzheimer's disease (AD), respectively, partially due to Ca 2+ dysregulation. Besides, the endoplasmic reticulum (ER) stress has an active role in the neurotoxic mechanisms that lead to these pathologies. Here, we analyzed whether the ER-mediated apoptotic pathway is involved in the toxic effect of synthetic PrP and Aβ peptides. In PrP106-126-and Aβ1-40-treated cortical neurons, the release of Ca 2+ through ER ryanodine (RyR) and inositol 1,4,5-trisphosphate (IP 3 R) receptors induces ER stress and leads to increased cytosolic Ca 2+ and reactive oxygen species (ROS) levels and subsequently to apoptotic death involving mitochondrial cytochrome c release and caspases activation. These results demonstrate that the early PrP-and Aβ-induced perturbation of ER Ca 2+ homeostasis is a death message that leads to neuronal loss, suggesting that the regulation of ER Ca 2+ levels may be a potential therapeutical target for PrD and AD.
Prion (PrP) and amyloid-β (Aβ) peptides are involved in the neuronal loss that occurs in Prion di... more Prion (PrP) and amyloid-β (Aβ) peptides are involved in the neuronal loss that occurs in Prion disorders (PrD) and Alzheimer's disease (AD), respectively, partially due to Ca 2+ dysregulation. Besides, the endoplasmic reticulum (ER) stress has an active role in the neurotoxic mechanisms that lead to these pathologies. Here, we analyzed whether the ER-mediated apoptotic pathway is involved in the toxic effect of synthetic PrP and Aβ peptides. In PrP106-126-and Aβ1-40-treated cortical neurons, the release of Ca 2+ through ER ryanodine (RyR) and inositol 1,4,5-trisphosphate (IP 3 R) receptors induces ER stress and leads to increased cytosolic Ca 2+ and reactive oxygen species (ROS) levels and subsequently to apoptotic death involving mitochondrial cytochrome c release and caspases activation. These results demonstrate that the early PrP-and Aβ-induced perturbation of ER Ca 2+ homeostasis is a death message that leads to neuronal loss, suggesting that the regulation of ER Ca 2+ levels may be a potential therapeutical target for PrD and AD.
Uno de los grandes retos de vivir en nuestra sociedad es saber cuándo la gente está diciendo la v... more Uno de los grandes retos de vivir en nuestra sociedad es saber cuándo la gente está diciendo la verdad. Todos mentimos todo el tiempo y somos tremendamente malos para detectar que otras personas están deliberadamente tratando de engañarnos.
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