For over 50 years, the Center for Strategic and International Studies (CSIS) has worked to develo... more For over 50 years, the Center for Strategic and International Studies (CSIS) has worked to develop solutions to the world's greatest policy challenges. Today, CSIS scholars are providing strategic insights and bipartisan policy solutions to help decisionmakers chart a course toward a better world. CSIS is a nonprofit organization headquartered in Washington, D.C. The Center's 220 fulltime staff and large network of affiliated scholars conduct research and analysis and develop policy initiatives that look into the future and anticipate change. Founded at the height of the Cold War by David M. Abshire and Admiral Arleigh Burke, CSIS was dedicated to finding ways to sustain American prominence and prosperity as a force for good in the world. Since 1962, CSIS has become one of the world's preeminent international institutions focused on defense and security; regional stability; and transnational challenges ranging from energy and climate to global health and economic integration. Thomas J. Pritzker was named chairman of the CSIS Board of Trustees in November 2015. Former U.S. deputy secretary of defense John J. Hamre has served as the Center's president and chief executive officer since 2000. CSIS does not take specific policy positions. Accordingly, all views, positions, and conclusions expressed in this publication should be understood to be solely those of the author(s).
Your reviewers echo Dr. Duff in lamenting teaching clinics' shortcomings.1 Perhaps the pediat... more Your reviewers echo Dr. Duff in lamenting teaching clinics' shortcomings.1 Perhaps the pediatric risorgimento is at hand! Crowding, noise, lack of interest, divided responsibility, and impecuniosity are everywhere and at their glaring worst in certain provincial clinics. Patients and physicians are bound to agree that "services and teaching are . . . confused and inadequate." The authors conclude, bleakly, that clinics cannot improve until society changes. Must we then wait for the millennium? I know no remedy for society's ills (except that money is not the solution) but can offer three modest proposals for hospital clinics:
Thalanga is a deformed and metamorphosed volcanic hosted massive sulphide deposit consisting of s... more Thalanga is a deformed and metamorphosed volcanic hosted massive sulphide deposit consisting of several thin, stratiform semi-connected lenses located at a sub-vertically dipping contact between rhyolite and dacite formations. Rocks composed of quartzmagnetite- barite and chlorite-tremolite-carbonate, which have previously been interpreted to be exhalites, exist in intimate stratabound association with sulphides, particularly in the western lenses. Rhyolites stratigraphically beneath the deposit are extensively hydrothermally altered with a stratabound stringer zone of intense silicification containing 4-20% pyrite in the immediate footwall of the sulphide lenses, grading outwards and downwards through progressively weaker zones of qu~rtzchlorite- sericite and quartz-sericite alteration. Titanium, aluminium and zirconium remained chemically immobile during alteration, and subsequent metamorphism. These immobile elements permit identification of the volcanic precursors of altered roc...
Thalanga is a deformed and metamorphosed volcanic hosted massive sulphide deposit consisting of s... more Thalanga is a deformed and metamorphosed volcanic hosted massive sulphide deposit consisting of several thin, stratiform semi-connected lenses located at a sub-vertically dipping contact between rhyolite and dacite formations. Rocks composed of quartzmagnetite-barite and chlorite-tremolite-carbonate, which have previously been interpreted to be exhalites, exist in intimate stratabound association with sulphides, particularly in the western lenses. Rhyolites stratigraphically beneath the deposit are extensively hydrothermally altered with a stratabound stringer zone of intense silicification containing 4-20% pyrite in the immediate footwall of the sulphide lenses, grading outwards and downwards through progressively weaker zones of qu~rtz chlorite-sericite and quartz-sericite alteration. Titanium, aluminium and zirconium remained chemically immobile during alteration, and subsequent metamorphism. These immobile elements permit identification of the volcanic precursors of altered roc...
ABSTRACT Gasterocoma ossicles, previously considered diagnostic of the Siegenian to Eifelian, are... more ABSTRACT Gasterocoma ossicles, previously considered diagnostic of the Siegenian to Eifelian, are recorded from the late Givetian (Dawson Bay Formation) of Saskatchewan and Manitoba.
Virchows Archiv A Pathological Anatomy and Histopathology, 1987
C cells of thyroid are known to express a variety of products beside calcitonin. These include th... more C cells of thyroid are known to express a variety of products beside calcitonin. These include the peptides PDN21 (katacalcin), calcitonin-gene related peptide (CGRP), bombesin and somatostatin. The expression of these products has been investigated by immunohistochemistry of thyroid tissue in six age ranges from fetal to late adult life. PDN 21 was found to have co-expression with calcitonin. CGRP and bombesin both demonstrated an age-related increase in numbers and intensity of cells stained. Somatostatin immunoreactivity was limited to small numbers of cells.
The distribution and expression of parathyroid hormone (PTH) were investigated in normal and abno... more The distribution and expression of parathyroid hormone (PTH) were investigated in normal and abnormal parathyroid tissue. PTH was detected using a monoclonal antibody with specificity for the 44-68 region of the PTH molecule. Prominent reactivity for PTH was seen in normal parathyroid with a granular pattern of staining. Active parathyroid tissue (adenoma and hyperplasia) showed much less reactivity for PTH, although there was prominent reactivity in the normal tissue around adenomas. Comparison of expression of PTH with that of parathormone mRNA showed a reciprocal pattern in normal tissue and, to a less marked extent, in abnormal tissue. Parathyroid carcinoma in particular had coinciding areas of PTH and PTH mRNA expression. Oxyphil cells had little or no PTH expression, except in the associated 'colloid' in some cases. The findings indicate an inverse relationship between storage and cellular synthesis of PTH, this being more marked in physiological than in pathological conditions of the parathyroid.
Alkaline phosphatase immunochemical systems were evaluated for use in the demonstration of in sit... more Alkaline phosphatase immunochemical systems were evaluated for use in the demonstration of in situ hybridized biotin-labelled probes in frozen and fixed sections of tonsil. Three probes were used: total genomic DNA, pHY2.1, a human repetitive sequence which hybridizes to a 2.12 KB sequence on the Y chromosome (2000 repeats) and a 2.0 KB sequence on the autosomes (100-200 repeats), and human papilloma virus type II. Indirect, three-and five-stage detection methods were compared on cryostat sections. The indirect method involved the application of a streptavidin, biotinylated alkaline phosphatase sequence. The three-stage procedure comprised a mouse monoclonal anti-biotin, rabbit anti-(mouse immunoglobulin), mouse APAAP system. In the five-stage method the indirect and three-stage reagents were sequentially applied. Alkaline phosphatase was demonstrated using a Fast Red naphthol-capture method. The total genomic DNA probe was used initially to investigate hybridization conditions including the optimum temperature of denaturation, which was found to be higher than previously reported. The five-stage detection method gave the most sensitive results for the Y sequence probe, with intense demonstration of the Y body in male nuclei and autosomal sequences in female nuclei. This method was then applied to fixed tissue sections and gave Y body signals on Bouin's and Carnoy's fixed tissue. On the other hand tissue fixed using formalin-based solutions required proteolytic digestion as a pretreatment to hybridization for a Y body signal. The application of this methodology to viral diagnosis in routine fixed anogenital tissue and cytological preparations was also demonstrated.
The Australian and New Zealand Journal of Obstetrics and Gynaecology, 1982
Summary: An histological study of the behaviour of subcuticular green polyglycolic acid (GPGA) su... more Summary: An histological study of the behaviour of subcuticular green polyglycolic acid (GPGA) suture was undertaken to investigate if the green dye is retained by macrophages or histiocytes. Fifteen rats had subcuticular closure of a dorsal incision with GPGA suture. The closure site was excised at intervals and examined by light and electron microscopy. There was no evidence of dye retention, but a brisk inflammatory reaction was noted.
The distribution and expression of preproparathyroid hormone (PTH) mRNA were investigated in para... more The distribution and expression of preproparathyroid hormone (PTH) mRNA were investigated in parathyroid tissue from 57 parathyroidectomy specimens. PTH mRNA was detected by in situ hybridization using digoxigenin-labelled oligonucleotide probes. Cell morphology was seen to correlate with PTH mRNA expression. Strong expression of PTH mRNA was confined to cells which on haematoxylin and eosin staining had large vesicular nuclei. These included both vacuolated and non-vacuolated cells. Chief cells with small dark nuclei and scanty cytoplasm had little or no expression. In both adenoma and chief cell hyperplasia, the striking difference from normal was the greatly increased proportion of cells expressing PTH mRNA. In adenomas, the rim of uninvolved parathyroid tissue showed PTH mRNA expression similar to that of normal parathyroid. In hyperplasia, there was frequently concordance of staining within individual nodules. The findings establish morphological criteria for activity of parathyroid tissue and support current concepts of the different pathogenesis of hyperplasia and adenoma. The expression of PTH mRNA in oxyphil change and parathyroid carcinoma was also investigated.
he could, unchallenged, dispense his own brand of authori- tarian medicine to grateful Hottentots... more he could, unchallenged, dispense his own brand of authori- tarian medicine to grateful Hottentots. Today, however, health care is a political issue. The medical pie is full of fingers. Could a Schweitzer tolerate supervision, not to say interference, from self-important officials quite unqualified to evaluate his methods ? The point of all this is that " the special conflicts within medicine " exist wherever the art is practised, and the attitude of any individual doctor to these conflicts does not depend on geography. Horace was right: " Cslum non animum mutant aui trans mare currunt ... ".
For over 50 years, the Center for Strategic and International Studies (CSIS) has worked to develo... more For over 50 years, the Center for Strategic and International Studies (CSIS) has worked to develop solutions to the world's greatest policy challenges. Today, CSIS scholars are providing strategic insights and bipartisan policy solutions to help decisionmakers chart a course toward a better world. CSIS is a nonprofit organization headquartered in Washington, D.C. The Center's 220 fulltime staff and large network of affiliated scholars conduct research and analysis and develop policy initiatives that look into the future and anticipate change. Founded at the height of the Cold War by David M. Abshire and Admiral Arleigh Burke, CSIS was dedicated to finding ways to sustain American prominence and prosperity as a force for good in the world. Since 1962, CSIS has become one of the world's preeminent international institutions focused on defense and security; regional stability; and transnational challenges ranging from energy and climate to global health and economic integration. Thomas J. Pritzker was named chairman of the CSIS Board of Trustees in November 2015. Former U.S. deputy secretary of defense John J. Hamre has served as the Center's president and chief executive officer since 2000. CSIS does not take specific policy positions. Accordingly, all views, positions, and conclusions expressed in this publication should be understood to be solely those of the author(s).
Your reviewers echo Dr. Duff in lamenting teaching clinics' shortcomings.1 Perhaps the pediat... more Your reviewers echo Dr. Duff in lamenting teaching clinics' shortcomings.1 Perhaps the pediatric risorgimento is at hand! Crowding, noise, lack of interest, divided responsibility, and impecuniosity are everywhere and at their glaring worst in certain provincial clinics. Patients and physicians are bound to agree that "services and teaching are . . . confused and inadequate." The authors conclude, bleakly, that clinics cannot improve until society changes. Must we then wait for the millennium? I know no remedy for society's ills (except that money is not the solution) but can offer three modest proposals for hospital clinics:
Thalanga is a deformed and metamorphosed volcanic hosted massive sulphide deposit consisting of s... more Thalanga is a deformed and metamorphosed volcanic hosted massive sulphide deposit consisting of several thin, stratiform semi-connected lenses located at a sub-vertically dipping contact between rhyolite and dacite formations. Rocks composed of quartzmagnetite- barite and chlorite-tremolite-carbonate, which have previously been interpreted to be exhalites, exist in intimate stratabound association with sulphides, particularly in the western lenses. Rhyolites stratigraphically beneath the deposit are extensively hydrothermally altered with a stratabound stringer zone of intense silicification containing 4-20% pyrite in the immediate footwall of the sulphide lenses, grading outwards and downwards through progressively weaker zones of qu~rtzchlorite- sericite and quartz-sericite alteration. Titanium, aluminium and zirconium remained chemically immobile during alteration, and subsequent metamorphism. These immobile elements permit identification of the volcanic precursors of altered roc...
Thalanga is a deformed and metamorphosed volcanic hosted massive sulphide deposit consisting of s... more Thalanga is a deformed and metamorphosed volcanic hosted massive sulphide deposit consisting of several thin, stratiform semi-connected lenses located at a sub-vertically dipping contact between rhyolite and dacite formations. Rocks composed of quartzmagnetite-barite and chlorite-tremolite-carbonate, which have previously been interpreted to be exhalites, exist in intimate stratabound association with sulphides, particularly in the western lenses. Rhyolites stratigraphically beneath the deposit are extensively hydrothermally altered with a stratabound stringer zone of intense silicification containing 4-20% pyrite in the immediate footwall of the sulphide lenses, grading outwards and downwards through progressively weaker zones of qu~rtz chlorite-sericite and quartz-sericite alteration. Titanium, aluminium and zirconium remained chemically immobile during alteration, and subsequent metamorphism. These immobile elements permit identification of the volcanic precursors of altered roc...
ABSTRACT Gasterocoma ossicles, previously considered diagnostic of the Siegenian to Eifelian, are... more ABSTRACT Gasterocoma ossicles, previously considered diagnostic of the Siegenian to Eifelian, are recorded from the late Givetian (Dawson Bay Formation) of Saskatchewan and Manitoba.
Virchows Archiv A Pathological Anatomy and Histopathology, 1987
C cells of thyroid are known to express a variety of products beside calcitonin. These include th... more C cells of thyroid are known to express a variety of products beside calcitonin. These include the peptides PDN21 (katacalcin), calcitonin-gene related peptide (CGRP), bombesin and somatostatin. The expression of these products has been investigated by immunohistochemistry of thyroid tissue in six age ranges from fetal to late adult life. PDN 21 was found to have co-expression with calcitonin. CGRP and bombesin both demonstrated an age-related increase in numbers and intensity of cells stained. Somatostatin immunoreactivity was limited to small numbers of cells.
The distribution and expression of parathyroid hormone (PTH) were investigated in normal and abno... more The distribution and expression of parathyroid hormone (PTH) were investigated in normal and abnormal parathyroid tissue. PTH was detected using a monoclonal antibody with specificity for the 44-68 region of the PTH molecule. Prominent reactivity for PTH was seen in normal parathyroid with a granular pattern of staining. Active parathyroid tissue (adenoma and hyperplasia) showed much less reactivity for PTH, although there was prominent reactivity in the normal tissue around adenomas. Comparison of expression of PTH with that of parathormone mRNA showed a reciprocal pattern in normal tissue and, to a less marked extent, in abnormal tissue. Parathyroid carcinoma in particular had coinciding areas of PTH and PTH mRNA expression. Oxyphil cells had little or no PTH expression, except in the associated 'colloid' in some cases. The findings indicate an inverse relationship between storage and cellular synthesis of PTH, this being more marked in physiological than in pathological conditions of the parathyroid.
Alkaline phosphatase immunochemical systems were evaluated for use in the demonstration of in sit... more Alkaline phosphatase immunochemical systems were evaluated for use in the demonstration of in situ hybridized biotin-labelled probes in frozen and fixed sections of tonsil. Three probes were used: total genomic DNA, pHY2.1, a human repetitive sequence which hybridizes to a 2.12 KB sequence on the Y chromosome (2000 repeats) and a 2.0 KB sequence on the autosomes (100-200 repeats), and human papilloma virus type II. Indirect, three-and five-stage detection methods were compared on cryostat sections. The indirect method involved the application of a streptavidin, biotinylated alkaline phosphatase sequence. The three-stage procedure comprised a mouse monoclonal anti-biotin, rabbit anti-(mouse immunoglobulin), mouse APAAP system. In the five-stage method the indirect and three-stage reagents were sequentially applied. Alkaline phosphatase was demonstrated using a Fast Red naphthol-capture method. The total genomic DNA probe was used initially to investigate hybridization conditions including the optimum temperature of denaturation, which was found to be higher than previously reported. The five-stage detection method gave the most sensitive results for the Y sequence probe, with intense demonstration of the Y body in male nuclei and autosomal sequences in female nuclei. This method was then applied to fixed tissue sections and gave Y body signals on Bouin's and Carnoy's fixed tissue. On the other hand tissue fixed using formalin-based solutions required proteolytic digestion as a pretreatment to hybridization for a Y body signal. The application of this methodology to viral diagnosis in routine fixed anogenital tissue and cytological preparations was also demonstrated.
The Australian and New Zealand Journal of Obstetrics and Gynaecology, 1982
Summary: An histological study of the behaviour of subcuticular green polyglycolic acid (GPGA) su... more Summary: An histological study of the behaviour of subcuticular green polyglycolic acid (GPGA) suture was undertaken to investigate if the green dye is retained by macrophages or histiocytes. Fifteen rats had subcuticular closure of a dorsal incision with GPGA suture. The closure site was excised at intervals and examined by light and electron microscopy. There was no evidence of dye retention, but a brisk inflammatory reaction was noted.
The distribution and expression of preproparathyroid hormone (PTH) mRNA were investigated in para... more The distribution and expression of preproparathyroid hormone (PTH) mRNA were investigated in parathyroid tissue from 57 parathyroidectomy specimens. PTH mRNA was detected by in situ hybridization using digoxigenin-labelled oligonucleotide probes. Cell morphology was seen to correlate with PTH mRNA expression. Strong expression of PTH mRNA was confined to cells which on haematoxylin and eosin staining had large vesicular nuclei. These included both vacuolated and non-vacuolated cells. Chief cells with small dark nuclei and scanty cytoplasm had little or no expression. In both adenoma and chief cell hyperplasia, the striking difference from normal was the greatly increased proportion of cells expressing PTH mRNA. In adenomas, the rim of uninvolved parathyroid tissue showed PTH mRNA expression similar to that of normal parathyroid. In hyperplasia, there was frequently concordance of staining within individual nodules. The findings establish morphological criteria for activity of parathyroid tissue and support current concepts of the different pathogenesis of hyperplasia and adenoma. The expression of PTH mRNA in oxyphil change and parathyroid carcinoma was also investigated.
he could, unchallenged, dispense his own brand of authori- tarian medicine to grateful Hottentots... more he could, unchallenged, dispense his own brand of authori- tarian medicine to grateful Hottentots. Today, however, health care is a political issue. The medical pie is full of fingers. Could a Schweitzer tolerate supervision, not to say interference, from self-important officials quite unqualified to evaluate his methods ? The point of all this is that " the special conflicts within medicine " exist wherever the art is practised, and the attitude of any individual doctor to these conflicts does not depend on geography. Horace was right: " Cslum non animum mutant aui trans mare currunt ... ".
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