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Mike Lippincott
Computational Cell Biologist - PhD Candidate
University of Colorado Anschutz Medical Campus - CV

About

My scientific vision is to bridge cell biology and computational science to advance fundamental biological knowledge to improve human health outcomes.


I am keen on understanding complex, dynamic cell death mechanisms via innovative, high throughput, high content microscopy and machine learning techniques. I am paving the way to model complex cell processes through temporal and 3D image data. It is with this approach that new interventions can be discovered to improve human health outcomes.

Live-cell timelapse
image-based profiling

3D image-based profiling of
NF1 patient derived organoids

3D Cell Painting representations of a NF1 patient derived organoid

3D Segmentation masks of NF1 patient derived organoids

Publications

Google Scholar: profile

  • High-content live-cell time-lapse imaging predicts cells about to die via apoptosis

    Michael J. Lippincott, Jenna Tomkinson, Ibrahim Bilem, Mahomi Suzuki, Akiko Nakde, Toshiaki Endou, Simon Mathien, Felix Lavoie-Perusse, Carla Basualto-Alarcón, Gregory P Way (2025)

    In Review at Cell Reports Methods: bioRxiv

  • Scalable data harmonization for single-cell image-based profiling with CytoTable

    Dave Bunten, Jenna Tomkinson, Erik Serrano, Michael J. Lippincott, Kenneth I. Brewer, Vince Rubinetti, Faisal Alquaddoomi, Gregory P. Way (2025)

    In Review at Patterns: bioRxiv

  • Progress and new challenges in image-based profiling

    Erik Serrano, John Peters, Jesko Wagner, Rebecca E. Graham, Zhenghao Chen, Brian Feng, Gisele Miranda, Alexandr A. Kalinin, Loan Vulliard, Jenna Tomkinson, Cameron Mattson, Michael J. Lippincott, Ziqi Kang, Divya Sitani, Dave Bunten, Srijit Seal, Neil O. Carragher, Anne E. Carpenter, Shantanu Singh, Paula A. Marin Zapata, Juan C. Caicedo, Gregory P. Way (2025)

    Available at: Molecular Systems Biology

  • A quadratic paradigm describes the relationship between phenotype severity and variation

    Abigail Mumme-Monheit, Grace E. Gustafson, Colette A. Hopkins, Raisa Bailon-Zambrano, Juliana Sucharov, Michael J. Lippincott, Gregory P. Way, Kathryn L. Colborn, James T. Nichols (2025)

    Available at: Nature Communications

  • A morphology and secretome map of pyroptosis

    Michael J. Lippincott, Jenna Tomkinson, Dave Bunten, Milad Mohammadi, Johanna Kastl, Johannes Knop, Ralf Schwandner, Jiamin Huang, Grant Ongo, Nathaniel Robichaud, Milad Dagher, Masafumi Tsuboi, Carla Basualto-Alarcón, Gregory P. Way (2025)

    Available at: MBoC

  • Protein prediction models support widespread post-transcriptional regulation of protein abundance by interacting partners

    Srivastava H, Michael J. Lippincott, Currie J, Canfield R, Lam MPY, Lau E (2022)

    Available at: PLOS Computational Biology

  • Genetic and Epigenetic Inheritance at Telomeres

    Lister-Shimauchi EH, McCarthy B, Michael J. Lippincott, Ahmed S (2022)

    Available at: Epigenomes

Scientific Appointments

  • 2024 – Present

    Wellbeing and engagement committee, Department of Biomedical Informatics

    University of Colorado Anschutz Medical Campus, Aurora, CO

  • Aug. 2022 – Present

    PhD student

    University of Colorado Anschutz Medical Campus, Aurora, CO

  • 2023 – 2025

    Journal Club Committee, Cell Biology, Stem Cells, and Development

    University of Colorado Anschutz Medical Campus, Aurora, CO

  • 2023 – Present

    Volunteer

    Clear Directions Mentoring, Aurora, CO

  • 2023 – Present

    Cell Biology Graduate Teaching Assistant

    University of Colorado Anschutz Medical Campus, Aurora, CO

  • May. 2021 – May. 2022

    Research Assistant

    University of North Carolina at Chapel Hill, Chapel Hill, NC

  • 2019 – 2021

    Teaching Aid – Chemistry/Cell Biology

    Maryville University of Saint Louis, Saint Louis, MO

  • 2019 – 2021

    Lab technician training manager

    Maryville University of Saint Louis, Saint Louis, MO

  • 2017 – 2019

    Biology and Maths Tutor

    Maryville University of Saint Louis, Saint Louis, MO

Presentations

  • Invited speaker, Jan. 28, 2026
    Michael Johnson Seminar Series, Maryville University, Saint Louis, MO

  • Oral presentation, Dec. 4, 2025
    Neurofibramatosis Young Investigator's Forum, Baltimore, MD

  • Oral presentation, Oct. 27, 2025
    Society of Biomolecular Imaging and Informatics, Boston, MA

  • Poster presentation, Oct. 26, 2025
    Society of Biomolecular Imaging and Informatics, Boston, MA

  • Oral presentation, Oct. 24, 2025
    Cell Biology, Stem Cells, and Development Retreat, Estes Park, CO

  • Poster presentation, Feb. 10, 2025
    Systems applications for cancer biology, Aurora, CO

  • Oral presentation, Dec. 3, 2024
    American Society for Cell Biology Cell Bio conference, San Diego, CA

  • Poster presentation, Oct. 18, 2024
    Cell Biology, Stem Cells, and Development Retreat, Breckinridge, CO

  • Poster presentation, Aug. 27, 2024
    Center for Health Artificial Intelligence Retreat, Denver, CO

  • Oral presentation, Jul. 18, 2024
    Computational Systems for Integrative Genomics, New York, NY

  • Poster presentation, Dec. 3, 2023
    American Society for Cell Biology Cell Bio conference, Boston, MA

  • Oral presentation, Aug. 19, 2023
    Center for Health Artificial Intelligence Retreat, Aurora, CO

  • Poster presentation, Oct. 13, 2023
    Cell Biology, Stem Cells, and Development Retreat, Breckinridge, CO

Languages