Journal of the European Academy of Dermatology and Venereology, 2015
Onychomycosis is a common fungal infection of the nails that is increasing in prevalence in the o... more Onychomycosis is a common fungal infection of the nails that is increasing in prevalence in the old, diabetics and immunocompromised. Onychomycosis presents a therapeutic challenge that can lead to significant reductions in quality of life leading to both physical and psychological consequences. Current treatment modalities are difficult to implement due to the poor penetration of topical treatments to the nail bed, the slow growing nature of nails and the need for prolonged use of topical and/or oral medications. Standard of care medications have cure rates of 63-76% that leads to a high propensity of treatment failures and recurrences. Photodynamic therapy (PDT) offers an alternative treatment for onychomycosis. Methylene blue dye, methyl-aminolevulinate (MAL) and aminolevulinic acid (ALA) have been used as photosensitizers with approximately 630 nm light. These modalities are combined with pre-treatment of urea and/or microabrasion for better penetration. PDT treatments are well tolerated with only mild transient pain, burning and erythema. In addition, significant cure rates for patients who have contraindications to oral medications or failed standard medications can be obtained. With further enhancements in photosensitizer permeability, decreased pre-treatment and photosensitizer incubation times, PDT can be a more efficient and cost-effective in office based treatment for onychomycosis. However, more large-scale randomized control clinical trials are needed to access the efficacy of PDT treatments.
ABSTRACT The Journal of Investigative Dermatology publishes basic and clinical research in cutane... more ABSTRACT The Journal of Investigative Dermatology publishes basic and clinical research in cutaneous biology and skin disease.
ABSTRACT The Journal of Investigative Dermatology publishes basic and clinical research in cutane... more ABSTRACT The Journal of Investigative Dermatology publishes basic and clinical research in cutaneous biology and skin disease.
The use of silver for medicinal purposes dates back to the eighth century CE and is still in use ... more The use of silver for medicinal purposes dates back to the eighth century CE and is still in use today. 1-3 Generalized argyria is characterized by slate-gray to blue discoloration of the skin caused by cutaneous deposits of silver particles after long-term ingestion of solutions containing colloidal silver ingredients or silver salts. 1-3 The skin discoloration is more prominent in sunexposed areas and is usually permanent. There is no widely accepted effective treatment for the skin discoloration of argyria. 1 In 1999, the US Food and Drug Administration (FDA) responded to the widespread use of colloidal silver as a remedy for many ailments. 4 The FDA stated:
Mohs micrographic surgery is an excision technique that has been widely adapted as the recommende... more Mohs micrographic surgery is an excision technique that has been widely adapted as the recommended treatment for basal and squamous cell carcinomas and other skin cancers. It was developed by Frederic E. Mohs in the 1930s and has since advanced in its methods and applications. Mohs developed the practice in the process of determining a method to treat various neoplasms. Mohs micrographic surgery is a modality that involves serial excision of a tumor followed by microscopic evaluation of the tissue. It is a complicated surgical technique that involves scrupulous training and constant adaptation. It has greatly expanded since its inception to include new imaging techniques such as immunohistochemistry and confocal mosaicing microscopy. Further advancements include its application to other medical specialties, such as otolaryngology. This technique began as a revolutionary practice but has since become the standard treatment for a variety of skin cancers.
tients treated only with halobetasol had pruritus and one had worsening of psoriasis. Among subje... more tients treated only with halobetasol had pruritus and one had worsening of psoriasis. Among subjects treated only with calcipotriene, six had pruritus, two had eruptions, and one patient each had irritated skin, burning skin, or seborrheic dermatitis.
Journal of the European Academy of Dermatology and Venereology, 2015
Onychomycosis is a common fungal infection of the nails that is increasing in prevalence in the o... more Onychomycosis is a common fungal infection of the nails that is increasing in prevalence in the old, diabetics and immunocompromised. Onychomycosis presents a therapeutic challenge that can lead to significant reductions in quality of life leading to both physical and psychological consequences. Current treatment modalities are difficult to implement due to the poor penetration of topical treatments to the nail bed, the slow growing nature of nails and the need for prolonged use of topical and/or oral medications. Standard of care medications have cure rates of 63-76% that leads to a high propensity of treatment failures and recurrences. Photodynamic therapy (PDT) offers an alternative treatment for onychomycosis. Methylene blue dye, methyl-aminolevulinate (MAL) and aminolevulinic acid (ALA) have been used as photosensitizers with approximately 630 nm light. These modalities are combined with pre-treatment of urea and/or microabrasion for better penetration. PDT treatments are well tolerated with only mild transient pain, burning and erythema. In addition, significant cure rates for patients who have contraindications to oral medications or failed standard medications can be obtained. With further enhancements in photosensitizer permeability, decreased pre-treatment and photosensitizer incubation times, PDT can be a more efficient and cost-effective in office based treatment for onychomycosis. However, more large-scale randomized control clinical trials are needed to access the efficacy of PDT treatments.
ABSTRACT The Journal of Investigative Dermatology publishes basic and clinical research in cutane... more ABSTRACT The Journal of Investigative Dermatology publishes basic and clinical research in cutaneous biology and skin disease.
ABSTRACT The Journal of Investigative Dermatology publishes basic and clinical research in cutane... more ABSTRACT The Journal of Investigative Dermatology publishes basic and clinical research in cutaneous biology and skin disease.
The use of silver for medicinal purposes dates back to the eighth century CE and is still in use ... more The use of silver for medicinal purposes dates back to the eighth century CE and is still in use today. 1-3 Generalized argyria is characterized by slate-gray to blue discoloration of the skin caused by cutaneous deposits of silver particles after long-term ingestion of solutions containing colloidal silver ingredients or silver salts. 1-3 The skin discoloration is more prominent in sunexposed areas and is usually permanent. There is no widely accepted effective treatment for the skin discoloration of argyria. 1 In 1999, the US Food and Drug Administration (FDA) responded to the widespread use of colloidal silver as a remedy for many ailments. 4 The FDA stated:
Mohs micrographic surgery is an excision technique that has been widely adapted as the recommende... more Mohs micrographic surgery is an excision technique that has been widely adapted as the recommended treatment for basal and squamous cell carcinomas and other skin cancers. It was developed by Frederic E. Mohs in the 1930s and has since advanced in its methods and applications. Mohs developed the practice in the process of determining a method to treat various neoplasms. Mohs micrographic surgery is a modality that involves serial excision of a tumor followed by microscopic evaluation of the tissue. It is a complicated surgical technique that involves scrupulous training and constant adaptation. It has greatly expanded since its inception to include new imaging techniques such as immunohistochemistry and confocal mosaicing microscopy. Further advancements include its application to other medical specialties, such as otolaryngology. This technique began as a revolutionary practice but has since become the standard treatment for a variety of skin cancers.
tients treated only with halobetasol had pruritus and one had worsening of psoriasis. Among subje... more tients treated only with halobetasol had pruritus and one had worsening of psoriasis. Among subjects treated only with calcipotriene, six had pruritus, two had eruptions, and one patient each had irritated skin, burning skin, or seborrheic dermatitis.
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