As a result of research it was succeeded to receive the model of non-alcoholic steatohepatitis wh... more As a result of research it was succeeded to receive the model of non-alcoholic steatohepatitis which is characterized by obesity, violation of the structural organization, a fabric necrosis, formation of fibrosis of a liver. The developed model of non-alcoholic steatohepatitis allows to study also staging of development of a fatty desease of the liver which is characterized by formation of a steatogepatitis and fibrosis. In quality the inducing factors the high-fat diet and antibiotics were used. The offered NASH model can be used in the field of chronic experiments for an assessment of extent of violation of a functional condition of hepatobiliary system and for search of the effective pharmacotheurapeutichepatoprotective agents.
Researches of age-dependent changes of liver functi
ons and their correction with the use of vari... more Researches of age-dependent changes of liver functi ons and their correction with the use of various biologically active substances are an important iss ue of modern biomedicine. Investigation of the infl uence of the enzymatic hydrolyzate of Chlorophytum comosum (L.) on the liver of rats at the age of two years at it s experimental toxic damage showed that the substrate has expressed a pr onounced hepatoprotective effect. Under its influen ce morphological changes in the rat liver induced by CCl 4 are much less pronounced than in the controls. The re are also less significant deviations from normal levels of Alanine transamila se (ALT), Alanine transaminase AST and Total Biliru bin in blood plasma. Information analysis of the state of the or gan indicates that the level of adaptation and rege neration opportunities of the liver of rats treated with an enzymatic hydroly zate of Chlorophytum comosum (L.) is significantly higher than at the liver of rats with experimental toxic liver damage without the use of studied substrate. Histopatholog ical analysis confirmed the alleviation of liver damage in connec tion with use of enzymatic hydrolyzate of Chlorophytum comosum (L.).
Conducted research shows that the resistance of organ to various influences depends on level of
... more Conducted research shows that the resistance of organ to various influences depends on level of
its organization. The tissue systems consisting of actively dividing cells on various stages of differentiation
are more subject for various influences, than the organs consisting of highly specialized cells with low degree
of proliferative activity. The conducted research shows that the studied organs can conditionally be divided
into two groups depending on the value of an existing structural variety. The liver, kidneys, pancreas, stomach,
mammary gland, skin, ovaries and endometriya entered the first group. These organs are characterized by H
value bigger than 2 bits. All types of muscles and the lungs, which have made the second group, are
characterized by the H value less than 2 bits. Level of the greatest possible information capacity and the
information morphological organization in tissues of dogs is defined by extent of differentiation of tissue and
level of its mitotic activity. Thus, quite essential level of information morphological organization and rather high
levels of relative morphological entropy, information morphological redundancy are noted in the tissues
consisting of highly specialized, low-active or inactive in proliferative aspect cells. Such biosystems are rather
steady against influences as in them sufficient level of reserves which can be involved in adaptation process
remains.
In the study the method of assessing adaptive and regenerative opportunities of the liver by
asse... more In the study the method of assessing adaptive and regenerative opportunities of the liver by assessing of its information state was applied. The research revealed achange in the nature of the information state of the tissue of the liver at hepatoadenoma, liver cancer and non-cancer pathologies. Discovered changes of the information parameters characterizing the liver, indicate various kinds of adaptive processes in the organ. It is shown that at the non-neoplastic diseases of the liver, tissue system uses the existing structural adaptation resources, but it tends tocollapse. Changes of the information parameters were more pronounced at malignant disease than at hepatoadenoma, it is revealed reduction of system reliability to negative value. When tumors of the liver, tissue system is simplified, ordered and directed the growth and increase the reliability, such system complicates the possibility of successful treatment of the organ in such pathologies.
We investigated the information state of the skin of dogs with benign and malignant tumors. It wa... more We investigated the information state of the skin of dogs with benign and malignant tumors. It was revealed that in all studied types of tumors information system of the skin becomes simpler, and as a result, increases its reliability and ordering, and the system is aimed at growth. It was found that the changes of information parameters are more pronounced in malignant pathologies than in benign tumors.
We investigated the developmental changes in the information parameters of the thymus to define t... more We investigated the developmental changes in the information parameters of the thymus to define the level of
adaptive resources of this organ. It was revealed that studied parameters undergo cyclic changes in ontogenesis.
Ontogenetic periods characterized by low values of information morphological organization are critical, because at this
time organs are characterized by a low level of regenerative-adaptability and less number of structural elements
constituting a potential reserve.
The study revealed the nature of the state change information system of the liver tissue with
he... more The study revealed the nature of the state change information system of the liver tissue with
hepatadenoma, liver cancer and non-cancer pathologies. Was shown that information parameters of non-cancer
diseases indicate that liver tissue system uses existing structural adaptation resources. Information system of
tumors of the liver is simplified and streamlined. Changes of information parameters characterizing a liver
indicate various kinds of adaptive processes in the tissue at various pathologies study the method of
assessing adaptive and regenerative opportunities of the liver by assessing of its information state was applied.
The research revealed a change in the nature of the information state of the tissue of the liver at
hepatoadenoma, liver cancer and non-cancer pathologies. Discovered changes of the information parameters
characterizing the liver, indicate various kinds of adaptive processes in the organ. It is shown that at the
non-neoplastic diseases of the liver, tissue system uses the existing structural adaptation resources, but it
tends to collapse. Changes of the information parameters were more pronounced at malignant disease than at
hepatoadenoma, it is revealed reduction of system reliability to negative value. When tumors of the liver, tissue
system is simplified, ordered and directed the growth and increase the reliability, such system complicates the
possibility of successful treatment of the organ in such pathologies.
Researches of age-dependent changes of liver functions are an important issue of modern biomedici... more Researches of age-dependent changes of liver functions are an important issue of modern biomedicine. In this regard the researches of correction of these changes with use of various biologically active agents are also very actual. Investigation of the influence of the enzymatic hydrolyzate of Chlorophytum comosum (L.) on the liver of rats at the age of 3 months at its experimental toxic damage by CCl 4 showed that the substrate has expressed hepatoprotective effect. At hydrolyzate application morphological changes in the rat liver with toxic damage are much less pronounced than in the controls. There are also less significant deviations from normal levels of Alanine transamilase (ALT), Alanine transaminase AST and Total Bilirubin in blood plasma in comparison with control group. Information analysis of the state of the organ indicates the substantial increase of adaptation and regeneration opportunities of the liver of rats treated with an enzymatic hydrolyzate of Chlorophytum comosum (L.) compared with the liver of rats with experimental toxic liver damage without the use of studied substrate. Histopathological analysis confirmed the simplification of liver damage at application of enzymatic hydrolyzate of Chlorophytum comosum (L.)
As a result of the conducted researches it is established that at using an identical dose of toxi... more As a result of the conducted researches it is established that at using an identical dose of toxin the severity of injury in organ and changes of information parameters of a liver of rats at the age of 1.5, 4.5, 11 and 30 months are more expressed, than in 1, 3, 8 and 18 months. Furthermore, application of a enzymatic hydrolyzate of the Chlorophytum comosum (L.) is effective at all listed age periods, but protective effect is much higher at the age of 1, 3, 8 and 18 months and at the age of 1.5, 4.5, 11 and 30 months the available hepatoprotective effect is lower and isn't so expressed. Based on the aforesaid, it is possible to claim that severity of toxic damage of a liver is depending on age of animals and, respectively, on information condition of organ. It testifies to existence of dependence of efficiency of application of a biostimulator on the period of ontogenesis. Thus, it is expedient to carry out biostimulation on the most sensitive to it development stages.
Investigation of the influence of the enzymatic hydrolyzate of Chlorophytum comosumthe first on t... more Investigation of the influence of the enzymatic hydrolyzate of Chlorophytum comosumthe first on the liver of rats at its toxic damage showed that the substrate has expressed a pronounced hepatoprotective effect. Under its influence in the rat liver morphological changes induced by CCl 4 are much less pronounced than in the controls. There are also less significant deviations from normal levels of ALT, AST and bilirubin. Information analysis of the state of the organ indicates that the level of adaptation and regeneration opportunities of the liver of rats treated with an enzymatic hydrolyzate of Chlorophytum comosum is significantly higher than that of the liver of rats with experimental toxic liver damage without the use of tested substrate.
As a result of research it was succeeded to receive the model of non-alcoholic steatohepatitis wh... more As a result of research it was succeeded to receive the model of non-alcoholic steatohepatitis which is characterized by obesity, violation of the structural organization, a fabric necrosis, formation of fibrosis of a liver. The developed model of non-alcoholic steatohepatitis allows to study also staging of development of a fatty desease of the liver which is characterized by formation of a steatogepatitis and fibrosis. In quality the inducing factors the high-fat diet and antibiotics were used. The offered NASH model can be used in the field of chronic experiments for an assessment of extent of violation of a functional condition of hepatobiliary system and for search of the effective pharmacotheurapeutichepatoprotective agents.
Researches of age-dependent changes of liver functi
ons and their correction with the use of vari... more Researches of age-dependent changes of liver functi ons and their correction with the use of various biologically active substances are an important iss ue of modern biomedicine. Investigation of the infl uence of the enzymatic hydrolyzate of Chlorophytum comosum (L.) on the liver of rats at the age of two years at it s experimental toxic damage showed that the substrate has expressed a pr onounced hepatoprotective effect. Under its influen ce morphological changes in the rat liver induced by CCl 4 are much less pronounced than in the controls. The re are also less significant deviations from normal levels of Alanine transamila se (ALT), Alanine transaminase AST and Total Biliru bin in blood plasma. Information analysis of the state of the or gan indicates that the level of adaptation and rege neration opportunities of the liver of rats treated with an enzymatic hydroly zate of Chlorophytum comosum (L.) is significantly higher than at the liver of rats with experimental toxic liver damage without the use of studied substrate. Histopatholog ical analysis confirmed the alleviation of liver damage in connec tion with use of enzymatic hydrolyzate of Chlorophytum comosum (L.).
Conducted research shows that the resistance of organ to various influences depends on level of
... more Conducted research shows that the resistance of organ to various influences depends on level of
its organization. The tissue systems consisting of actively dividing cells on various stages of differentiation
are more subject for various influences, than the organs consisting of highly specialized cells with low degree
of proliferative activity. The conducted research shows that the studied organs can conditionally be divided
into two groups depending on the value of an existing structural variety. The liver, kidneys, pancreas, stomach,
mammary gland, skin, ovaries and endometriya entered the first group. These organs are characterized by H
value bigger than 2 bits. All types of muscles and the lungs, which have made the second group, are
characterized by the H value less than 2 bits. Level of the greatest possible information capacity and the
information morphological organization in tissues of dogs is defined by extent of differentiation of tissue and
level of its mitotic activity. Thus, quite essential level of information morphological organization and rather high
levels of relative morphological entropy, information morphological redundancy are noted in the tissues
consisting of highly specialized, low-active or inactive in proliferative aspect cells. Such biosystems are rather
steady against influences as in them sufficient level of reserves which can be involved in adaptation process
remains.
In the study the method of assessing adaptive and regenerative opportunities of the liver by
asse... more In the study the method of assessing adaptive and regenerative opportunities of the liver by assessing of its information state was applied. The research revealed achange in the nature of the information state of the tissue of the liver at hepatoadenoma, liver cancer and non-cancer pathologies. Discovered changes of the information parameters characterizing the liver, indicate various kinds of adaptive processes in the organ. It is shown that at the non-neoplastic diseases of the liver, tissue system uses the existing structural adaptation resources, but it tends tocollapse. Changes of the information parameters were more pronounced at malignant disease than at hepatoadenoma, it is revealed reduction of system reliability to negative value. When tumors of the liver, tissue system is simplified, ordered and directed the growth and increase the reliability, such system complicates the possibility of successful treatment of the organ in such pathologies.
We investigated the information state of the skin of dogs with benign and malignant tumors. It wa... more We investigated the information state of the skin of dogs with benign and malignant tumors. It was revealed that in all studied types of tumors information system of the skin becomes simpler, and as a result, increases its reliability and ordering, and the system is aimed at growth. It was found that the changes of information parameters are more pronounced in malignant pathologies than in benign tumors.
We investigated the developmental changes in the information parameters of the thymus to define t... more We investigated the developmental changes in the information parameters of the thymus to define the level of
adaptive resources of this organ. It was revealed that studied parameters undergo cyclic changes in ontogenesis.
Ontogenetic periods characterized by low values of information morphological organization are critical, because at this
time organs are characterized by a low level of regenerative-adaptability and less number of structural elements
constituting a potential reserve.
The study revealed the nature of the state change information system of the liver tissue with
he... more The study revealed the nature of the state change information system of the liver tissue with
hepatadenoma, liver cancer and non-cancer pathologies. Was shown that information parameters of non-cancer
diseases indicate that liver tissue system uses existing structural adaptation resources. Information system of
tumors of the liver is simplified and streamlined. Changes of information parameters characterizing a liver
indicate various kinds of adaptive processes in the tissue at various pathologies study the method of
assessing adaptive and regenerative opportunities of the liver by assessing of its information state was applied.
The research revealed a change in the nature of the information state of the tissue of the liver at
hepatoadenoma, liver cancer and non-cancer pathologies. Discovered changes of the information parameters
characterizing the liver, indicate various kinds of adaptive processes in the organ. It is shown that at the
non-neoplastic diseases of the liver, tissue system uses the existing structural adaptation resources, but it
tends to collapse. Changes of the information parameters were more pronounced at malignant disease than at
hepatoadenoma, it is revealed reduction of system reliability to negative value. When tumors of the liver, tissue
system is simplified, ordered and directed the growth and increase the reliability, such system complicates the
possibility of successful treatment of the organ in such pathologies.
Researches of age-dependent changes of liver functions are an important issue of modern biomedici... more Researches of age-dependent changes of liver functions are an important issue of modern biomedicine. In this regard the researches of correction of these changes with use of various biologically active agents are also very actual. Investigation of the influence of the enzymatic hydrolyzate of Chlorophytum comosum (L.) on the liver of rats at the age of 3 months at its experimental toxic damage by CCl 4 showed that the substrate has expressed hepatoprotective effect. At hydrolyzate application morphological changes in the rat liver with toxic damage are much less pronounced than in the controls. There are also less significant deviations from normal levels of Alanine transamilase (ALT), Alanine transaminase AST and Total Bilirubin in blood plasma in comparison with control group. Information analysis of the state of the organ indicates the substantial increase of adaptation and regeneration opportunities of the liver of rats treated with an enzymatic hydrolyzate of Chlorophytum comosum (L.) compared with the liver of rats with experimental toxic liver damage without the use of studied substrate. Histopathological analysis confirmed the simplification of liver damage at application of enzymatic hydrolyzate of Chlorophytum comosum (L.)
As a result of the conducted researches it is established that at using an identical dose of toxi... more As a result of the conducted researches it is established that at using an identical dose of toxin the severity of injury in organ and changes of information parameters of a liver of rats at the age of 1.5, 4.5, 11 and 30 months are more expressed, than in 1, 3, 8 and 18 months. Furthermore, application of a enzymatic hydrolyzate of the Chlorophytum comosum (L.) is effective at all listed age periods, but protective effect is much higher at the age of 1, 3, 8 and 18 months and at the age of 1.5, 4.5, 11 and 30 months the available hepatoprotective effect is lower and isn't so expressed. Based on the aforesaid, it is possible to claim that severity of toxic damage of a liver is depending on age of animals and, respectively, on information condition of organ. It testifies to existence of dependence of efficiency of application of a biostimulator on the period of ontogenesis. Thus, it is expedient to carry out biostimulation on the most sensitive to it development stages.
Investigation of the influence of the enzymatic hydrolyzate of Chlorophytum comosumthe first on t... more Investigation of the influence of the enzymatic hydrolyzate of Chlorophytum comosumthe first on the liver of rats at its toxic damage showed that the substrate has expressed a pronounced hepatoprotective effect. Under its influence in the rat liver morphological changes induced by CCl 4 are much less pronounced than in the controls. There are also less significant deviations from normal levels of ALT, AST and bilirubin. Information analysis of the state of the organ indicates that the level of adaptation and regeneration opportunities of the liver of rats treated with an enzymatic hydrolyzate of Chlorophytum comosum is significantly higher than that of the liver of rats with experimental toxic liver damage without the use of tested substrate.
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Papers by Maria Kozlova
ons and their correction with the use of various
biologically active substances are an important iss
ue of modern biomedicine. Investigation of the infl
uence of the
enzymatic hydrolyzate of
Chlorophytum comosum (L.)
on the liver of rats at the age of two years at it
s experimental toxic
damage showed that the substrate has expressed a pr
onounced hepatoprotective effect. Under its influen
ce morphological
changes in the rat liver induced by CCl
4
are much less pronounced than in the controls. The
re are also less significant
deviations from normal levels of Alanine transamila
se (ALT), Alanine transaminase AST and Total Biliru
bin in blood
plasma. Information analysis of the state of the or
gan indicates that the level of adaptation and rege
neration opportunities of
the liver of rats treated with an enzymatic hydroly
zate of
Chlorophytum comosum
(L.) is significantly higher than at the
liver of rats with experimental toxic liver damage
without the use of studied substrate. Histopatholog
ical analysis
confirmed the alleviation of liver damage in connec
tion with use of enzymatic hydrolyzate of
Chlorophytum comosum (L.).
its organization. The tissue systems consisting of actively dividing cells on various stages of differentiation
are more subject for various influences, than the organs consisting of highly specialized cells with low degree
of proliferative activity. The conducted research shows that the studied organs can conditionally be divided
into two groups depending on the value of an existing structural variety. The liver, kidneys, pancreas, stomach,
mammary gland, skin, ovaries and endometriya entered the first group. These organs are characterized by H
value bigger than 2 bits. All types of muscles and the lungs, which have made the second group, are
characterized by the H value less than 2 bits. Level of the greatest possible information capacity and the
information morphological organization in tissues of dogs is defined by extent of differentiation of tissue and
level of its mitotic activity. Thus, quite essential level of information morphological organization and rather high
levels of relative morphological entropy, information morphological redundancy are noted in the tissues
consisting of highly specialized, low-active or inactive in proliferative aspect cells. Such biosystems are rather
steady against influences as in them sufficient level of reserves which can be involved in adaptation process
remains.
assessing of its information state was applied. The research revealed achange in the nature of the information
state of the tissue of the liver at hepatoadenoma, liver cancer and non-cancer pathologies. Discovered changes
of the information parameters characterizing the liver, indicate various kinds of adaptive processes in the
organ. It is shown that at the non-neoplastic diseases of the liver, tissue system uses the existing structural
adaptation resources, but it tends tocollapse. Changes of the information parameters were more pronounced
at malignant disease than at hepatoadenoma, it is revealed reduction of system reliability to negative value.
When tumors of the liver, tissue system is simplified, ordered and directed the growth and increase the
reliability, such system complicates the possibility of successful treatment of the organ in such pathologies.
that in all studied types of tumors information system of the skin becomes simpler, and as a result, increases its reliability
and ordering, and the system is aimed at growth. It was found that the changes of information parameters are more
pronounced in malignant pathologies than in benign tumors.
adaptive resources of this organ. It was revealed that studied parameters undergo cyclic changes in ontogenesis.
Ontogenetic periods characterized by low values of information morphological organization are critical, because at this
time organs are characterized by a low level of regenerative-adaptability and less number of structural elements
constituting a potential reserve.
hepatadenoma, liver cancer and non-cancer pathologies. Was shown that information parameters of non-cancer
diseases indicate that liver tissue system uses existing structural adaptation resources. Information system of
tumors of the liver is simplified and streamlined. Changes of information parameters characterizing a liver
indicate various kinds of adaptive processes in the tissue at various pathologies study the method of
assessing adaptive and regenerative opportunities of the liver by assessing of its information state was applied.
The research revealed a change in the nature of the information state of the tissue of the liver at
hepatoadenoma, liver cancer and non-cancer pathologies. Discovered changes of the information parameters
characterizing the liver, indicate various kinds of adaptive processes in the organ. It is shown that at the
non-neoplastic diseases of the liver, tissue system uses the existing structural adaptation resources, but it
tends to collapse. Changes of the information parameters were more pronounced at malignant disease than at
hepatoadenoma, it is revealed reduction of system reliability to negative value. When tumors of the liver, tissue
system is simplified, ordered and directed the growth and increase the reliability, such system complicates the
possibility of successful treatment of the organ in such pathologies.
ons and their correction with the use of various
biologically active substances are an important iss
ue of modern biomedicine. Investigation of the infl
uence of the
enzymatic hydrolyzate of
Chlorophytum comosum (L.)
on the liver of rats at the age of two years at it
s experimental toxic
damage showed that the substrate has expressed a pr
onounced hepatoprotective effect. Under its influen
ce morphological
changes in the rat liver induced by CCl
4
are much less pronounced than in the controls. The
re are also less significant
deviations from normal levels of Alanine transamila
se (ALT), Alanine transaminase AST and Total Biliru
bin in blood
plasma. Information analysis of the state of the or
gan indicates that the level of adaptation and rege
neration opportunities of
the liver of rats treated with an enzymatic hydroly
zate of
Chlorophytum comosum
(L.) is significantly higher than at the
liver of rats with experimental toxic liver damage
without the use of studied substrate. Histopatholog
ical analysis
confirmed the alleviation of liver damage in connec
tion with use of enzymatic hydrolyzate of
Chlorophytum comosum (L.).
its organization. The tissue systems consisting of actively dividing cells on various stages of differentiation
are more subject for various influences, than the organs consisting of highly specialized cells with low degree
of proliferative activity. The conducted research shows that the studied organs can conditionally be divided
into two groups depending on the value of an existing structural variety. The liver, kidneys, pancreas, stomach,
mammary gland, skin, ovaries and endometriya entered the first group. These organs are characterized by H
value bigger than 2 bits. All types of muscles and the lungs, which have made the second group, are
characterized by the H value less than 2 bits. Level of the greatest possible information capacity and the
information morphological organization in tissues of dogs is defined by extent of differentiation of tissue and
level of its mitotic activity. Thus, quite essential level of information morphological organization and rather high
levels of relative morphological entropy, information morphological redundancy are noted in the tissues
consisting of highly specialized, low-active or inactive in proliferative aspect cells. Such biosystems are rather
steady against influences as in them sufficient level of reserves which can be involved in adaptation process
remains.
assessing of its information state was applied. The research revealed achange in the nature of the information
state of the tissue of the liver at hepatoadenoma, liver cancer and non-cancer pathologies. Discovered changes
of the information parameters characterizing the liver, indicate various kinds of adaptive processes in the
organ. It is shown that at the non-neoplastic diseases of the liver, tissue system uses the existing structural
adaptation resources, but it tends tocollapse. Changes of the information parameters were more pronounced
at malignant disease than at hepatoadenoma, it is revealed reduction of system reliability to negative value.
When tumors of the liver, tissue system is simplified, ordered and directed the growth and increase the
reliability, such system complicates the possibility of successful treatment of the organ in such pathologies.
that in all studied types of tumors information system of the skin becomes simpler, and as a result, increases its reliability
and ordering, and the system is aimed at growth. It was found that the changes of information parameters are more
pronounced in malignant pathologies than in benign tumors.
adaptive resources of this organ. It was revealed that studied parameters undergo cyclic changes in ontogenesis.
Ontogenetic periods characterized by low values of information morphological organization are critical, because at this
time organs are characterized by a low level of regenerative-adaptability and less number of structural elements
constituting a potential reserve.
hepatadenoma, liver cancer and non-cancer pathologies. Was shown that information parameters of non-cancer
diseases indicate that liver tissue system uses existing structural adaptation resources. Information system of
tumors of the liver is simplified and streamlined. Changes of information parameters characterizing a liver
indicate various kinds of adaptive processes in the tissue at various pathologies study the method of
assessing adaptive and regenerative opportunities of the liver by assessing of its information state was applied.
The research revealed a change in the nature of the information state of the tissue of the liver at
hepatoadenoma, liver cancer and non-cancer pathologies. Discovered changes of the information parameters
characterizing the liver, indicate various kinds of adaptive processes in the organ. It is shown that at the
non-neoplastic diseases of the liver, tissue system uses the existing structural adaptation resources, but it
tends to collapse. Changes of the information parameters were more pronounced at malignant disease than at
hepatoadenoma, it is revealed reduction of system reliability to negative value. When tumors of the liver, tissue
system is simplified, ordered and directed the growth and increase the reliability, such system complicates the
possibility of successful treatment of the organ in such pathologies.