Topoisomerase II (topo II) catalyzes the decatenation of interlinked DNA molecules and is essenti... more Topoisomerase II (topo II) catalyzes the decatenation of interlinked DNA molecules and is essential for chromosome segregation. To test the hypothesis that the noncatalytic C-terminal domain of topo II is necessary for mediating interactions with other proteins required for ...
The Saccharomyces cerevisiae SGSl gene is homologous to Escherichia coli RecQ and the human BLM a... more The Saccharomyces cerevisiae SGSl gene is homologous to Escherichia coli RecQ and the human BLM and WRN proteins that are defective in the cancer-prone disorder Bloom's syndrome and the premature aging disorder Werner's syndrome, respectively. While recQmutants are deficient in conjugational recom- bination and DNA repair, Bloom's syndrome cell lines show hyperrecombination. Bloom's and Werner's syndrome cell lines both exhibit
Topoisomerase II (topo II) catalyzes the decatenation of interlinked DNA molecules and is essenti... more Topoisomerase II (topo II) catalyzes the decatenation of interlinked DNA molecules and is essential for chromosome segregation. To test the hypothesis that the noncatalytic C-terminal domain of topo II is necessary for mediating interactions with other proteins required for ...
The Saccharomyces cerevisiae SGSl gene is homologous to Escherichia coli RecQ and the human BLM a... more The Saccharomyces cerevisiae SGSl gene is homologous to Escherichia coli RecQ and the human BLM and WRN proteins that are defective in the cancer-prone disorder Bloom's syndrome and the premature aging disorder Werner's syndrome, respectively. While recQmutants are deficient in conjugational recom- bination and DNA repair, Bloom's syndrome cell lines show hyperrecombination. Bloom's and Werner's syndrome cell lines both exhibit
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