Abdel Omri

Laurentian University, Biochemistry, Faculty Member

Followers

Following

Co-authors

Public Views

Lipid-Based Drug & Vaccine Delivery Systems
Liposomes are one of the most versatile biochemical tools. They are microscopic, spherical closed vesicles composed of one or more lipid bilayer that form when phospholipids are hydrated. Hydrophilic molecules can be incorporated into the aqueous compartment and lipophilic molecules can be encapsulated in the lipid bilayers. Liposomes by themselves are considered nonimmunogenic, biodegradable and nontoxic. They have been utilized in numerous biomedical applications including gene therapy, for delivery of drugs and vaccines, cancer imaging agents and cosmetics. Liposomes have the capability to incorporate selected bioactive biologicals and adjuvant molecules and potentiate their efficacy and minimize their toxicity. They do this by beneficially altering the biodistribution and pharmacokinetics of the molecule in the body following its administration through various routes of delivery.

My research program is centered on the design, formulation, development and characterization of drug and vaccine delivery systems; particularly those based on liposomes. A special focus on the site-specific targeting controlled release, drug resistance, pharmacokinetic, pharmacodynamic, metabolism and toxicity of free and liposome-encapsulated biological active agents.

Liposomal Delivery of Antimicrobial Agents toward Resistant Bacteria.

Liposomal Delivery of Antioxidants and Oxidative Stress

Liposomal Delivery of Antisense Oligonucleotides

Liposomal Formulations of Drugs and Vaccines for Oral Administration

less

James Elkins

School of the Art Institute of Chicago

Asha Vijayan

Amrita Vishwa Vidyapeetham

Dr.Mahmoud Lotfy

Minufiya University

Nassim Tahouni

University of Tehran

Michael J. Gonzalez

Universidad de Puerto Rico Rio

Dr.Yousery Sherif

Mansoura University

Hanaa Ahmed

Animal Health Research Institute

Irina Kolesnik

Moscow State University

Prof. Tofazzal Islam

Bangabandhu Sheikh Mujibur Rahman Agricultural University

Kenneth Vecchio

University of California, San Diego

InterestsView All (9)

Uploads

Papers by Abdel Omri

Tuning: Identifying and Measuring Sector-Based Learning Outcomes in Postsecondary Education

As a key component of a comprehensive research program on learning outcomes, HEQCO initiated a Tu... more As a key component of a comprehensive research program on learning outcomes, HEQCO initiated a Tuning project to identify and measure learning outcomes in specific “sectors” of postsecondary education (i.e., life and health science, physical science and social science) in Ontario colleges and universities. The term “Tuning” refers to a process of bringing together individuals from across institutions to articulate common student learning outcomes. Quite simply, it is a bottom-up process by those who are “on the ground” to articulate learning outcomes that are relevant, appropriate and useable. Learning outcomes are measurable statements of student knowledge (what successful students should know) and skills (what successful students should be able to do) expected upon graduation. Clearly articulated learning outcomes are useful to ensure that students understand expectations and that instruction is constructively aligned with assessment (Biggs & Tang, 2011). When used in an effective...

Development of Antibiofilm Therapeutics Strategies to Overcome Antimicrobial Drug Resistance

Microorganisms

A biofilm is a community of stable microorganisms encapsulated in an extracellular matrix produce... more A biofilm is a community of stable microorganisms encapsulated in an extracellular matrix produced by themselves. Many types of microorganisms that are found on living hosts or in the environment can form biofilms. These include pathogenic bacteria that can serve as a reservoir for persistent infections, and are culpable for leading to a broad spectrum of chronic illnesses and emergence of antibiotic resistance making them difficult to be treated. The absence of biofilm-targeting antibiotics in the drug discovery pipeline indicates an unmet opportunity for designing new biofilm inhibitors as antimicrobial agents using various strategies and targeting distinct stages of biofilm formation. The strategies available to control biofilm formation include targeting the enzymes and proteins specific to the microorganism and those involved in the adhesion pathways leading to formation of resistant biofilms. This review primarily focuses on the recent strategies and advances responsible for i...

Abdel Omri

Uploads

Papers by Abdel Omri

Log In