ABSTRACT Leukemic infiltration of the central nervous system (CNS) is a rare complication of chro... more ABSTRACT Leukemic infiltration of the central nervous system (CNS) is a rare complication of chronic lymphocytic leukemia (CLL), and it has never been described before in de novo prolymphocytic leukemia (PLL). Here, we present our 45-year-old patient with de novo PLL; he was given CHOP regimen and developed an acute flare of hepatitis B infection. Nine months after diagnosis, he came with headache, nausea and vomiting. Cranial MR showed infiltrative lesions. Cytologic examination of cerebrospinal fluid (CSF) revealed prolymphocytes; and flow cytometry of CSF revealed these cells to express CD19, CD20, CD22, CD79b, and FMC7 with lambda light chain restriction. He was treated with cranial irradiation and triple intrathecal chemotherapy with methotrexate, cytosine arabinoside, and dexamethasone. He had bone marrow relapse 3 months later and was started to be given FC regimen with which he had hematologic remission. However, he died later because of pneumonia.
[structure: see text] Novel "cone conformation" calix[4]arene d... more [structure: see text] Novel "cone conformation" calix[4]arene derivatives, carrying either one or two cyclen (1,4,7,10-tetra-azacyclododecane) moieties at the upper rim, have been synthesized. The hydrolytic activities of the Zn(II) complexes of these calixarenes were studied. A surprising behavior was observed with p-nitrophenylstearate; whereas the bis-cyclenyl-2Zn(II) complex showed negligible hydrolytic activity over the background, the mononuclear complex showed a significant 400-fold rate increase at pH 8.5.
ABSTRACT Leukemic infiltration of the central nervous system (CNS) is a rare complication of chro... more ABSTRACT Leukemic infiltration of the central nervous system (CNS) is a rare complication of chronic lymphocytic leukemia (CLL), and it has never been described before in de novo prolymphocytic leukemia (PLL). Here, we present our 45-year-old patient with de novo PLL; he was given CHOP regimen and developed an acute flare of hepatitis B infection. Nine months after diagnosis, he came with headache, nausea and vomiting. Cranial MR showed infiltrative lesions. Cytologic examination of cerebrospinal fluid (CSF) revealed prolymphocytes; and flow cytometry of CSF revealed these cells to express CD19, CD20, CD22, CD79b, and FMC7 with lambda light chain restriction. He was treated with cranial irradiation and triple intrathecal chemotherapy with methotrexate, cytosine arabinoside, and dexamethasone. He had bone marrow relapse 3 months later and was started to be given FC regimen with which he had hematologic remission. However, he died later because of pneumonia.
[structure: see text] Novel "cone conformation" calix[4]arene d... more [structure: see text] Novel "cone conformation" calix[4]arene derivatives, carrying either one or two cyclen (1,4,7,10-tetra-azacyclododecane) moieties at the upper rim, have been synthesized. The hydrolytic activities of the Zn(II) complexes of these calixarenes were studied. A surprising behavior was observed with p-nitrophenylstearate; whereas the bis-cyclenyl-2Zn(II) complex showed negligible hydrolytic activity over the background, the mononuclear complex showed a significant 400-fold rate increase at pH 8.5.
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