TINF2

TINF2
사용 가능한 구조
PDB	동원체 검색: PDBe RCSB
PDB ID 코드 목록
	3BQO, 3BU8
식별자
다른 이름	TINF2, DKCA3, TIN2, TERF1 interacting nuclear factor 2
외부 ID	OMIM: 604319 MGI: 107246 HomoloGene: 8264 GeneCards: TINF2
유전자 위치 (인간)
염색체	14번 염색체
끝	24,242,674 bp
유전자 위치 (쥐)
염색체	14번 염색체 (쥐)
끝	55,919,277 bp
RNA 발현 패턴
	최상위 발현
	과립구; ; right adrenal gland; ; right adrenal cortex; ; left adrenal gland; ; 단핵구; ; left adrenal cortex; ; 골수세포; ; 혈액; ; 편도; ; 비장;
	최상위 발현
	primary oocyte; ; secondary oocyte; ; primitive streak; ; 수정란; ; 위판; ; 세정관; ; 정모세포; ; tail of embryo; ; 과립구; ; 몸 분절;
	추가 참조 발현 데이터
	n/a
유전자 온톨로지
분자 함수	DNA 결합; telomeric DNA binding; 단백질 결합;
세포 성분	nuclear telomere cap complex; nuclear matrix; perinucleolar chromocenter; 핵질; 염색체; shelterin complex; 텔로미어; 세포핵; nuclear body;
생물학적 과정	protein localization to chromosome, telomeric region; negative regulation of epithelial cell proliferation; telomere assembly; negative regulation of protein ADP-ribosylation; telomere capping; negative regulation of telomere maintenance via telomerase; regulation of telomere maintenance via telomere lengthening;
	출처: Amigo / QuickGO
동원체
	26277
	28113
	ENSG00000092330; ENSG00000284915
	ENSMUSG00000007589
	Q9BSI4
	Q9QXG9; Q8K1K3
	NM_001099274; NM_012461; NM_001363668
	NM_145705
	NP_001092744; NP_036593; NP_001350597
	NP_663751
	위키데이터
인간 보기/편집	쥐 보기/편집

TERF1 상호 작용 핵인자 2(TERF1-interacting nuclear factor 2)는 인간에서 TINF2 유전자에 의해 암호화되는 단백질이다.^[5]^[6] TIN2는 텔로미어 끝에 있는 셀테린(shelterin) 단백질 복합체의 성분이다.^[7]

상호 작용

TINF2는 ACD^[8]^[9], POT1^[10], TERF1와 상호 작용하는 것으로 나타났다.^[5]^[11]

각주

1 2 3 ENSG00000284915 GRCh38: Ensembl release 89: ENSG00000092330, ENSG00000284915 - 앙상블, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000007589 - 앙상블, May 2017
↑ “Human PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.
↑ “Mouse PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.
1 2 “TIN2, a new regulator of telomere length in human cells”. 《Nature Genetics》 23 (4): 405–12. Dec 1999. doi:10.1038/70508. PMC 4940194. PMID 10581025.
↑ “Entrez Gene: TINF2 TERF1 (TRF1)-interacting nuclear factor 2”.
↑ “TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita”. 《American Journal of Human Genetics》 82 (2): 501–9. Feb 2008. doi:10.1016/j.ajhg.2007.10.004. PMC 2427222. PMID 18252230.
↑ “POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex”. 《Genes & Development》 18 (14): 1649–54. Jul 2004. doi:10.1101/gad.1215404. PMC 478187. PMID 15231715.
↑ “PTOP interacts with POT1 and regulates its localization to telomeres”. 《Nature Cell Biology》 6 (7): 673–80. Jul 2004. doi:10.1038/ncb1142. PMID 15181449.
↑ “POT1 as a terminal transducer of TRF1 telomere length control”. 《Nature》 423 (6943): 1013–8. Jun 2003. doi:10.1038/nature01688. PMID 12768206.
↑ “A human protein-protein interaction network: a resource for annotating the proteome”. 《Cell》 122 (6): 957–68. Sep 2005. doi:10.1016/j.cell.2005.08.029. PMID 16169070.

[refGRCh38Ensembl-1] 1 2 3 ENSG00000284915 GRCh38: Ensembl release 89: ENSG00000092330, ENSG00000284915 - 앙상블, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000007589 - 앙상블, May 2017

[3] “Human PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.

[4] “Mouse PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.

[pmid10581025-5] 1 2 “TIN2, a new regulator of telomere length in human cells”. 《Nature Genetics》 23 (4): 405–12. Dec 1999. doi:10.1038/70508. PMC 4940194. PMID 10581025.

[entrez-6] “Entrez Gene: TINF2 TERF1 (TRF1)-interacting nuclear factor 2”.

[pmid18252230-7] “TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita”. 《American Journal of Human Genetics》 82 (2): 501–9. Feb 2008. doi:10.1016/j.ajhg.2007.10.004. PMC 2427222. PMID 18252230.

[pmid15231715-8] “POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex”. 《Genes & Development》 18 (14): 1649–54. Jul 2004. doi:10.1101/gad.1215404. PMC 478187. PMID 15231715.

[pmid15181449-9] “PTOP interacts with POT1 and regulates its localization to telomeres”. 《Nature Cell Biology》 6 (7): 673–80. Jul 2004. doi:10.1038/ncb1142. PMID 15181449.

[pmid12768206-10] “POT1 as a terminal transducer of TRF1 telomere length control”. 《Nature》 423 (6943): 1013–8. Jun 2003. doi:10.1038/nature01688. PMID 12768206.

[pmid16169070-11] “A human protein-protein interaction network: a resource for annotating the proteome”. 《Cell》 122 (6): 957–68. Sep 2005. doi:10.1016/j.cell.2005.08.029. PMID 16169070.

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