Bipolar disorder (BD) is a chronic psychiatric disorder characterized by recurrent mood episodes ... more Bipolar disorder (BD) is a chronic psychiatric disorder characterized by recurrent mood episodes interspersed with euthymic periods. A growing number of studies have indicated that zinc plays an important role in coordinating immune responses, as well as being involved in synaptic transmission. In the current study, we set out to measure serum levels of zinc in a meticulously phenotyped cohort of 121 euthymic BD subjects and 30 matched controls.
Nicotinic acid (NA), often called niacin, a form of vitamin B₃, is a water-soluble nutrient found... more Nicotinic acid (NA), often called niacin, a form of vitamin B₃, is a water-soluble nutrient found in animal and vegetarian foods. Vitamin B₃ for healthy people is considered to be needed in doses of less than 20 mg daily. In higher doses, NA has been described to be beneficial in some patients with psychiatric disorders. This report describes a male patient with bipolar type II disorder who for many years had been treated with lithium and other medications applied in affective disorders. These pharmacological drugs had beneficial effects but were at times insufficient. When the patient was prescribed NA, he experienced a comparatively strong effect. Slowly it was discovered that the patient could lower and cease all medications except NA. For over 11 years he has been stable and calm with NA and currently takes 1 g three times daily. When not taking NA, he consistently became anxious and depressed within 2-3 days. The resumption of NA resulted in a normal state usually within 1 day....
... Numera rekommenderas denna diet för diabetiker både i uSA och i Storbritan-nien, skriver uffe... more ... Numera rekommenderas denna diet för diabetiker både i uSA och i Storbritan-nien, skriver uffe ravnskov och Bo H jonsson. ... Med hänvisning till enmeta-analys av Sofi et al [6] menar Erlanson-Albertsson att en västerländsk kost rik på fett, kött och mjölkprodukter ...
... PER DALÉN med dr, docent, Viken [email protected] KARL-E. ARFORS professor, Stockholm karl.ar... more ... PER DALÉN med dr, docent, Viken [email protected] KARL-E. ARFORS professor, Stockholm [email protected] det sätt han/hon tror är bäst. ... Inge Axelsson överläkare, barnkliniken, Östersunds sjukhus [email protected] ...
The purpose was to compare the levels and patterns of plasma cortisol and prolactin in patients w... more The purpose was to compare the levels and patterns of plasma cortisol and prolactin in patients with functional dyspepsia (FD) during a controlled laboratory experiment. 25 patients (12 men, 13 women), aged 24-50, with recurrent FD, and 25 pair-wise gender- and age-matched community control subjects were studied at a gastroenterological laboratory in a Swedish university hospital. In an experiment, after a rest period, subjects were studied during a neutral interview and a stress interview. Before and during interventions, blood samples were drawn for later peptide analyses. The main outcome measures were the Gastrointestinal Symptom Rating Scale, heart rate, blood pressure, plasma cortisol and prolactin. Mean plasma cortisol concentration correlated negatively with diarrhoea symptoms (partial correlation; p < 0.01). The level of plasma proclatin ( microg/l) was significantly lower (paired t test; p < 0.01) in the patient group (mean = 3.34, CI: 2.75-3.93) compared to the control group (mean = 4.70, CI: 3.63-5.78). During the stress interview, prolactin increased significantly in both groups. When the whole sample was divided according to degree of reflux symptoms, those with high reflux symptomatology had lower prolactin (ANCOVA with covariates for group, gender, age, body mass index and smoking; p < 0.05). Plasma prolactin concentration was significantly lower in FD patients compared to a matched control group. A high degree of reflux symptoms was significantly associated with inhibition of the prolactin increase during a stress interview.
To explore the pattern of gastrointestinal hormonal variations in plasma and to relate this to po... more To explore the pattern of gastrointestinal hormonal variations in plasma and to relate this to possible pathophysiological mechanisms in functional dyspepsia. There were 25 patients, 12 men and 13 women, aged 24 to 50 years, with recurrent functional dyspepsia, compared with community control subjects pair-wise, matched for age and sex. The subjects participated in a laboratory stress experiment with timed provocations. At fixed intervals, 22 samples of blood were drawn from each subject and frozen for later peptide analyses. Levels of gastrin, cholecystokinin (CCK), and somatostatin were measured by radioimmunoassay. Peptide levels were studied during a friendly greeting, a stress interview, and a food stimulation. Mean hormone values did not differ between the groups. Smokers had lower mean CCK than nonsmokers. Patients with a high degree of dyspeptic symptoms during the week preceding the experiment had a higher mean somatostatin level than patients with a low degree of dyspeptic symptoms. Heartburn correlated positively with the mean somatostatin level. Mean gastrin correlated with body mass index. During the 15-minute stress interview, significant changes in peptide variations were noted: Gastrin increased in both patient and control group subjects. CCK levels increased in patients from 7.2 pmol/l (6.0-8.5) to 9.8 pmol/l (8.2-11.4), but not in control subjects (p < 0.04, two-way interaction). Somatostatin increased significantly earlier in patients than in the control subjects during the stress interview. A positive relationship was found between the mean level of somatostatin and the degree of dyspeptic symptoms. Gastrin, CCK, and somatostatin were all sensitive to an anxiety-provoking interview. CCK and somatostatin may possibly link psychological reactions to the pathophysiology of functional dyspepsia.
Twenty-five patients, 12 men and 13 women, aged 24-50 yr, who had consulted physicians and had re... more Twenty-five patients, 12 men and 13 women, aged 24-50 yr, who had consulted physicians and had received the diagnosis functional dyspepsia after extensive examination 6-8 years prior to this study, and were still suffering from this condition, were compared with community control subjects pair-wise matched for age and sex. Control subjects who had ever consulted a physician for gastrointestinal symptoms were excluded. Questionnaires measuring symptoms, job strain, social support and personality traits were used. Relatively few differences were found between groups. Compared to the community controls, however, the patients reported more gastrointestinal and nervous symptoms, and higher somatization, measured by Symptom Check List-90. The extent of reported overall distress was greater in patients than in control subjects. The detachment score (Karolinska Scales of Personality) was significantly lower in patients than in control subjects; this difference was also significant in separate analysis for men. Female patients had lower socialization and higher suspicion scores than female control subjects. Male patients reported more decision latitude (job control) than male control subjects.
Integrative Physiological and Behavioral Science, 2000
Background The aim of the study was to compare plasma motilin-like immunoreactivity (MOT-LI) and... more Background The aim of the study was to compare plasma motilin-like immunoreactivity (MOT-LI) and neuropeptide Y (NPY)-like immunoreactivity (NPY-LI) in patients with functional dyspepsia (FD) during a controlled psychophysiological experiment. Method 25 patients (12 men, 13 women), age 24–50, with recurrent FD, and 25 pair-wise sex- and age-matched community control subjects were studied. In an experiment, after a rest period, subjects were
Polyphenols are widely distributed in the plant kingdom and represent an abundant antioxidant com... more Polyphenols are widely distributed in the plant kingdom and represent an abundant antioxidant component of the human diet. The review offers a brief description of the chemistry and occurrence in plant food of four important groups of polyphenols: phenolic acids, flavonoids, stilbenes, and lignans. Interest in the possible health benefits of polyphenols has increased due to corresponding antioxidant capacity. Considerable evidence is now available showing anticarcinogenic effects of polyphenolic compounds, as well as potential to prevent cardiovascular and cerebrovascular diseases. The use of botanicals has received a large amount of attention in recent years. Epidemiological studies have shown that a reduced risk of cancer is associated with diets rich in vegetables and fruits, and methods for the discovery and characterization of active compounds from plant sources are available. These results are promising, but additional research on the molecular mechanism of action of polyphenols and their application to human health is required.
International Journal of Psychosomatics Official Publication of the International Psychosomatics Institute, Feb 1, 1991
Three patients with documented peptic ulcer and four patients with depressive disorder were follo... more Three patients with documented peptic ulcer and four patients with depressive disorder were followed every month for 10 to 14 months. A life events inventory, clinical ratings of depressive mood and ulcer symptoms, and analysis of the urinary excretion of cortisol and melatonin were used on every occasion. Although the number of patients was small a few tentative findings were made. First of all, associations between life events and depressive mood seemed to be "delayed" more often in the ulcer patients than in the depression patients. Secondly, there were individual associations between cortisol excretion and life events or between cortisol excretion and ulcer symptoms, but these associations seemed to form individual patterns. Two of the ulcer patients who had correlations in the expected directions showed a personality profile close to the one expected from classical literature, whereas the third patient who showed no correlations showed alexithymic traits.
International Journal of Psychosomatics Official Publication of the International Psychosomatics Institute, Feb 1, 1991
Three patients with documented peptic ulcer and four patients with depressive disorder were follo... more Three patients with documented peptic ulcer and four patients with depressive disorder were followed every month for 10 to 14 months. A life events inventory, clinical ratings of depressive mood and ulcer symptoms, and analysis of the urinary excretion of cortisol and melatonin were used on every occasion. Although the number of patients was small a few tentative findings were made. First of all, associations between life events and depressive mood seemed to be "delayed" more often in the ulcer patients than in the depression patients. Secondly, there were individual associations between cortisol excretion and life events or between cortisol excretion and ulcer symptoms, but these associations seemed to form individual patterns. Two of the ulcer patients who had correlations in the expected directions showed a personality profile close to the one expected from classical literature, whereas the third patient who showed no correlations showed alexithymic traits.
Nicotinic acid (NA), often called niacin, a form of vitamin B 3 , is a water-soluble nutrient fou... more Nicotinic acid (NA), often called niacin, a form of vitamin B 3 , is a water-soluble nutrient found in animal and vegetarian foods. Vitamin B 3 for healthy people is considered to be needed in doses of less than 20 mg daily. In higher doses, NA has been described to be beneficial in some patients with psychiatric disorders. This report describes a male patient with bipolar type II disorder who for many years had been treated with lithium and other medications applied in affective disorders. These pharmacological drugs had beneficial effects but were at times insufficient. When the patient was prescribed NA, he experienced a comparatively strong effect. Slowly it was discovered that the patient could lower and cease all medications except NA. For over 11 years he has been stable and calm with NA and currently takes 1 g three times daily. When not taking NA, he consistently became anxious and depressed within 2–3 days. The resumption of NA resulted in a normal state usually within 1 day. This finding has been described as a vitamin dependency. The paper discusses possible mechanisms for the effect of NA in this patient. Further studies are needed to investigate the prevalence of vitamin B 3 dependency and the biochemical explanations for this phenomenon.
Bipolar disorder (BD) is a chronic psychiatric disorder characterized by recurrent mood episodes ... more Bipolar disorder (BD) is a chronic psychiatric disorder characterized by recurrent mood episodes interspersed with euthymic periods. A growing number of studies have indicated that zinc plays an important role in coordinating immune responses, as well as being involved in synaptic transmission. In the current study, we set out to measure serum levels of zinc in a meticulously phenotyped cohort of 121 euthymic BD subjects and 30 matched controls.
Nicotinic acid (NA), often called niacin, a form of vitamin B₃, is a water-soluble nutrient found... more Nicotinic acid (NA), often called niacin, a form of vitamin B₃, is a water-soluble nutrient found in animal and vegetarian foods. Vitamin B₃ for healthy people is considered to be needed in doses of less than 20 mg daily. In higher doses, NA has been described to be beneficial in some patients with psychiatric disorders. This report describes a male patient with bipolar type II disorder who for many years had been treated with lithium and other medications applied in affective disorders. These pharmacological drugs had beneficial effects but were at times insufficient. When the patient was prescribed NA, he experienced a comparatively strong effect. Slowly it was discovered that the patient could lower and cease all medications except NA. For over 11 years he has been stable and calm with NA and currently takes 1 g three times daily. When not taking NA, he consistently became anxious and depressed within 2-3 days. The resumption of NA resulted in a normal state usually within 1 day....
... Numera rekommenderas denna diet för diabetiker både i uSA och i Storbritan-nien, skriver uffe... more ... Numera rekommenderas denna diet för diabetiker både i uSA och i Storbritan-nien, skriver uffe ravnskov och Bo H jonsson. ... Med hänvisning till enmeta-analys av Sofi et al [6] menar Erlanson-Albertsson att en västerländsk kost rik på fett, kött och mjölkprodukter ...
... PER DALÉN med dr, docent, Viken [email protected] KARL-E. ARFORS professor, Stockholm karl.ar... more ... PER DALÉN med dr, docent, Viken [email protected] KARL-E. ARFORS professor, Stockholm [email protected] det sätt han/hon tror är bäst. ... Inge Axelsson överläkare, barnkliniken, Östersunds sjukhus [email protected] ...
The purpose was to compare the levels and patterns of plasma cortisol and prolactin in patients w... more The purpose was to compare the levels and patterns of plasma cortisol and prolactin in patients with functional dyspepsia (FD) during a controlled laboratory experiment. 25 patients (12 men, 13 women), aged 24-50, with recurrent FD, and 25 pair-wise gender- and age-matched community control subjects were studied at a gastroenterological laboratory in a Swedish university hospital. In an experiment, after a rest period, subjects were studied during a neutral interview and a stress interview. Before and during interventions, blood samples were drawn for later peptide analyses. The main outcome measures were the Gastrointestinal Symptom Rating Scale, heart rate, blood pressure, plasma cortisol and prolactin. Mean plasma cortisol concentration correlated negatively with diarrhoea symptoms (partial correlation; p < 0.01). The level of plasma proclatin ( microg/l) was significantly lower (paired t test; p < 0.01) in the patient group (mean = 3.34, CI: 2.75-3.93) compared to the control group (mean = 4.70, CI: 3.63-5.78). During the stress interview, prolactin increased significantly in both groups. When the whole sample was divided according to degree of reflux symptoms, those with high reflux symptomatology had lower prolactin (ANCOVA with covariates for group, gender, age, body mass index and smoking; p < 0.05). Plasma prolactin concentration was significantly lower in FD patients compared to a matched control group. A high degree of reflux symptoms was significantly associated with inhibition of the prolactin increase during a stress interview.
To explore the pattern of gastrointestinal hormonal variations in plasma and to relate this to po... more To explore the pattern of gastrointestinal hormonal variations in plasma and to relate this to possible pathophysiological mechanisms in functional dyspepsia. There were 25 patients, 12 men and 13 women, aged 24 to 50 years, with recurrent functional dyspepsia, compared with community control subjects pair-wise, matched for age and sex. The subjects participated in a laboratory stress experiment with timed provocations. At fixed intervals, 22 samples of blood were drawn from each subject and frozen for later peptide analyses. Levels of gastrin, cholecystokinin (CCK), and somatostatin were measured by radioimmunoassay. Peptide levels were studied during a friendly greeting, a stress interview, and a food stimulation. Mean hormone values did not differ between the groups. Smokers had lower mean CCK than nonsmokers. Patients with a high degree of dyspeptic symptoms during the week preceding the experiment had a higher mean somatostatin level than patients with a low degree of dyspeptic symptoms. Heartburn correlated positively with the mean somatostatin level. Mean gastrin correlated with body mass index. During the 15-minute stress interview, significant changes in peptide variations were noted: Gastrin increased in both patient and control group subjects. CCK levels increased in patients from 7.2 pmol/l (6.0-8.5) to 9.8 pmol/l (8.2-11.4), but not in control subjects (p < 0.04, two-way interaction). Somatostatin increased significantly earlier in patients than in the control subjects during the stress interview. A positive relationship was found between the mean level of somatostatin and the degree of dyspeptic symptoms. Gastrin, CCK, and somatostatin were all sensitive to an anxiety-provoking interview. CCK and somatostatin may possibly link psychological reactions to the pathophysiology of functional dyspepsia.
Twenty-five patients, 12 men and 13 women, aged 24-50 yr, who had consulted physicians and had re... more Twenty-five patients, 12 men and 13 women, aged 24-50 yr, who had consulted physicians and had received the diagnosis functional dyspepsia after extensive examination 6-8 years prior to this study, and were still suffering from this condition, were compared with community control subjects pair-wise matched for age and sex. Control subjects who had ever consulted a physician for gastrointestinal symptoms were excluded. Questionnaires measuring symptoms, job strain, social support and personality traits were used. Relatively few differences were found between groups. Compared to the community controls, however, the patients reported more gastrointestinal and nervous symptoms, and higher somatization, measured by Symptom Check List-90. The extent of reported overall distress was greater in patients than in control subjects. The detachment score (Karolinska Scales of Personality) was significantly lower in patients than in control subjects; this difference was also significant in separate analysis for men. Female patients had lower socialization and higher suspicion scores than female control subjects. Male patients reported more decision latitude (job control) than male control subjects.
Integrative Physiological and Behavioral Science, 2000
Background The aim of the study was to compare plasma motilin-like immunoreactivity (MOT-LI) and... more Background The aim of the study was to compare plasma motilin-like immunoreactivity (MOT-LI) and neuropeptide Y (NPY)-like immunoreactivity (NPY-LI) in patients with functional dyspepsia (FD) during a controlled psychophysiological experiment. Method 25 patients (12 men, 13 women), age 24–50, with recurrent FD, and 25 pair-wise sex- and age-matched community control subjects were studied. In an experiment, after a rest period, subjects were
Polyphenols are widely distributed in the plant kingdom and represent an abundant antioxidant com... more Polyphenols are widely distributed in the plant kingdom and represent an abundant antioxidant component of the human diet. The review offers a brief description of the chemistry and occurrence in plant food of four important groups of polyphenols: phenolic acids, flavonoids, stilbenes, and lignans. Interest in the possible health benefits of polyphenols has increased due to corresponding antioxidant capacity. Considerable evidence is now available showing anticarcinogenic effects of polyphenolic compounds, as well as potential to prevent cardiovascular and cerebrovascular diseases. The use of botanicals has received a large amount of attention in recent years. Epidemiological studies have shown that a reduced risk of cancer is associated with diets rich in vegetables and fruits, and methods for the discovery and characterization of active compounds from plant sources are available. These results are promising, but additional research on the molecular mechanism of action of polyphenols and their application to human health is required.
International Journal of Psychosomatics Official Publication of the International Psychosomatics Institute, Feb 1, 1991
Three patients with documented peptic ulcer and four patients with depressive disorder were follo... more Three patients with documented peptic ulcer and four patients with depressive disorder were followed every month for 10 to 14 months. A life events inventory, clinical ratings of depressive mood and ulcer symptoms, and analysis of the urinary excretion of cortisol and melatonin were used on every occasion. Although the number of patients was small a few tentative findings were made. First of all, associations between life events and depressive mood seemed to be "delayed" more often in the ulcer patients than in the depression patients. Secondly, there were individual associations between cortisol excretion and life events or between cortisol excretion and ulcer symptoms, but these associations seemed to form individual patterns. Two of the ulcer patients who had correlations in the expected directions showed a personality profile close to the one expected from classical literature, whereas the third patient who showed no correlations showed alexithymic traits.
International Journal of Psychosomatics Official Publication of the International Psychosomatics Institute, Feb 1, 1991
Three patients with documented peptic ulcer and four patients with depressive disorder were follo... more Three patients with documented peptic ulcer and four patients with depressive disorder were followed every month for 10 to 14 months. A life events inventory, clinical ratings of depressive mood and ulcer symptoms, and analysis of the urinary excretion of cortisol and melatonin were used on every occasion. Although the number of patients was small a few tentative findings were made. First of all, associations between life events and depressive mood seemed to be "delayed" more often in the ulcer patients than in the depression patients. Secondly, there were individual associations between cortisol excretion and life events or between cortisol excretion and ulcer symptoms, but these associations seemed to form individual patterns. Two of the ulcer patients who had correlations in the expected directions showed a personality profile close to the one expected from classical literature, whereas the third patient who showed no correlations showed alexithymic traits.
Nicotinic acid (NA), often called niacin, a form of vitamin B 3 , is a water-soluble nutrient fou... more Nicotinic acid (NA), often called niacin, a form of vitamin B 3 , is a water-soluble nutrient found in animal and vegetarian foods. Vitamin B 3 for healthy people is considered to be needed in doses of less than 20 mg daily. In higher doses, NA has been described to be beneficial in some patients with psychiatric disorders. This report describes a male patient with bipolar type II disorder who for many years had been treated with lithium and other medications applied in affective disorders. These pharmacological drugs had beneficial effects but were at times insufficient. When the patient was prescribed NA, he experienced a comparatively strong effect. Slowly it was discovered that the patient could lower and cease all medications except NA. For over 11 years he has been stable and calm with NA and currently takes 1 g three times daily. When not taking NA, he consistently became anxious and depressed within 2–3 days. The resumption of NA resulted in a normal state usually within 1 day. This finding has been described as a vitamin dependency. The paper discusses possible mechanisms for the effect of NA in this patient. Further studies are needed to investigate the prevalence of vitamin B 3 dependency and the biochemical explanations for this phenomenon.
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