Papers by Naima Carter-monroe
Medical Imaging 2009: Visualization, Image-Guided Procedures, and Modeling, 2009
Purpose: To compare the accuracy of detecting tumor location and size in the prostate using both ... more Purpose: To compare the accuracy of detecting tumor location and size in the prostate using both manual palpation and ultrasound elastography (UE). Methods: Tumors in the prostate were simulated using both synthetic and ex vivo tissue phantoms. 25 participants were asked to provide the presence, size and depth of these simulated lesions using manual palpation and UE. Ultrasound images were
Clinical Kidney Journal, 2015
Granulomatous interstitial nephritis (GIN) is a rare entity detected in ∼0.5-0.9% of all renal bi... more Granulomatous interstitial nephritis (GIN) is a rare entity detected in ∼0.5-0.9% of all renal biopsies. GIN has been linked to several antibiotics such as cephalosporins, vancomycin, nitrofurantoin and ciprofloxacin. It is also associated with NSAIDs and granulomatous disorders such as sarcoidosis, tuberculosis, fungal infections, and granulomatosis with polyangiitis. Renal biopsy is critical in establishing this diagnosis, and the extent of tubular atrophy and interstitial fibrosis may aid in determining prognosis. Retrospective data and clinical experience suggest that removal of the offending agent in conjunction with corticosteroid therapy often results in improvement in renal function. We describe a patient with a history of multiple spinal surgeries complicated by wound infection who presented with confusion and rash with subsequent development of acute kidney injury. Urinalysis demonstrated pyuria and eosinophiluria, and renal biopsy revealed acute interstitial nephritis with granulomas. These findings were attributed to doxycycline treatment of his wound infection. This review explores the clinical associations, presentation, diagnosis, and treatment of this uncommon cause of acute kidney injury.
Atherosclerosis Disease Management, 2010
... Atherosclerosis: Histologic Classification and Imaging Correlation Naima Carter-Monroe,Saami ... more ... Atherosclerosis: Histologic Classification and Imaging Correlation Naima Carter-Monroe,Saami K. Yazdani, Elena Ladich, Frank D. Kolodgie, and Renu Virmani Page 2. 4 N. Carter-Monroe, SK Yazdani, E. Ladich, FD Kolodgie, and R. Virmani ...
Revista española de cardiología, 2011
En este nú mero, Morentin et al 1 presentan un oportuno estudio de base poblacional en el que se ... more En este nú mero, Morentin et al 1 presentan un oportuno estudio de base poblacional en el que se exploran las causas de la muerte sú bita cardiaca (MSC) en adultos de una població n local. La MSC continú a siendo una de las principales causas de mortalidad de los adultos en los países desarrollados. Só lo en Estados Unidos, las proyecciones realizadas para la incidencia anual de la MSC oscilan entre cifras de tan só lo 100.000 a 250.000 casos por añ o en una serie 2 y de 400.000 a 450.000 muertes anuales al añ o segú n las estimaciones basadas en datos de estadísticas de vida 3 . Se ha estimado que la carga anual que supone la MSC alcanza en todo el mundo 4-5 millones de muertes (partiendo de una estimació n de la població n total mundial de 6.540 millones) 2 . Las repercusiones internacionales que tiene el impacto de la MSC en las poblaciones locales han sido subrayadas tambié n por el aumento de la demografía y los cambios de estilo de vida a los que se ha involucrado en el desarrollo de la enfermedad coronaria (EC) (es decir, diabetes mellitus, hipertensió n, hipercolesterolemia y tabaquismo), que en el pasado han sido una verdadera plaga en los países industrializados. Si las tendencias actuales continú an siendo vá lidas y la etiología subyacente predominante de la MSC es la EC grave, la proyecció n futura de esta tendencia indica que esto dará lugar a un aumento posterior de la MSC en todo el mundo, con la EC como primera causa de muerte en el mundo al llegar al añ o 2020 4 . A la vista de estas predicciones, no basta siquiera con afirmar que la obtenció n de un conocimiento detallado de las etiologías subyacentes que está n involucradas en la MSC será una de las misiones má s acuciantes en el á mbito de la salud pú blica tanto local como mundial. Uno de los obstá culos en el camino hacia una vigilancia efectiva de la MSC continú a siendo la forma en que los investigadores abordan el problema. Bá sicamente, ? estamos todos de acuerdo en lo que es una MSC?
Transplant International, 2013
Kidney transplantation (KTX) is the treatment of choice for patients with end-stage renal disease... more Kidney transplantation (KTX) is the treatment of choice for patients with end-stage renal disease (ESRD) due to ANCA-associated vasculitis (AAV). Recurrent ANCA-associated glomerulonephritis (GN) occurs after KTX and may adversely affect allograft survival. Cyclophosphamide (CYC) combined with glucocorticoids has been the cornerstone of treatment for recurrent GN. Rituximab (RTX), a B-cell-depleting monoclonal antibody, is approved for remission induction in AAV. We report the clinical presentation and outcomes of five KTX recipients treated with RTX for biopsy-confirmed recurrent GN. The median age at the time of KTX was 26 years (four Caucasian, three females). All patients were in remission with four being ANCA positive at time of KTX. Recurrent GN occurred at a median of 26 months post-KTX. All relapses were treated with RTX and glucocorticoids. Four patients achieved disease remission; the fifth patient was refractory to treatment with RTX and CYC. Follow-up biopsies (n = 3) showed resolution of active GN in two patients and persistent active GN in one patient. RTX is an alternative to CYC for remission induction in recurrent AAV-associated GN in KTX patients.
Transplantation, 2014
Atypical hemolytic uremic syndrome (aHUS) is a rare disease with a high recurrence rate after kid... more Atypical hemolytic uremic syndrome (aHUS) is a rare disease with a high recurrence rate after kidney transplantation. In most cases, aHUS are caused by genetic mutations of components of the complement alternative pathway. In this single-center series, we present our data of 12 consecutive patients with aHUS and the outcome after kidney transplantation. In this 10-year retrospective study, we identified 12 patients with aHUS who were managed in our center since 2003. We reviewed clinical data, including genetic testing, posttransplant course and response to therapy including the prophylactic use of eculizumab. Overall, eight patients are women. Six of our patients have at least one genetic mutation causing aHUS, including 4 with complement factor H mutations. Nine patients had at least one previous kidney transplant that failed secondary to recurrent aHUS (75% of our patients). Three patients were treated with eculizumab and plasmapheresis for recurrent aHUS after kidney transplantation; two of them responded to the therapy. Four patients received prophylactic eculizumab; three of them received 6 months and one has been on life long therapy. No signs of recurrence have been observed in these 4 patients so far. Genetic mutations of the complement alternative pathway were confirmed in half of our patients, most of those mutations are in CHF. We demonstrate that treatment or prophylaxis with eculizumab was effective in reversing or preventing aHUS whether or not genetic complement mutations were identified.
AMIA ... Annual Symposium proceedings / AMIA Symposium. AMIA Symposium, 2008
Despite speculation that Telemicroscopy and Digital Microscopy will follow the same diffusion cur... more Despite speculation that Telemicroscopy and Digital Microscopy will follow the same diffusion curves as their counterparts in the world of Radiology - Teleradiology and Filmless Radiology, no study has offered definitive evidence in support of this hypothesis. To address this gap in the informatics knowledge base, dual survey instruments were created to measure current opinions on both technologies among Pathologists and Radiologists and disseminated to Pathologists and Radiologists at two major academic medical centers.
Methods in Molecular Biology, 2010
Cardiac regeneration in the form of cell-based therapy offers hope of becoming the breakthrough t... more Cardiac regeneration in the form of cell-based therapy offers hope of becoming the breakthrough technology that transforms the state of cardiac medicine. Before attempting to develop the techniques to assess the effectiveness of myocardial regeneration in humans, researchers must have at least a basic understanding of the human heart in its embryonic, normal, and diseased states. To this end, we provide an overview of the histology of the heart, including the current theories on normal embryogenesis and the histology of normal and ischemic myocardium as visualized by pathologists. Knowledge of the cellular constituents, including the controversial existence of resident cardiac stem and/or progenitor cells, and their actions and interactions in the normal state and under the conditions of myocardial ischemia is also crucial before embarking on the quest for cardiac regeneration. Despite widespread optimism in the success of cell-based therapy, inherent difficulties remain in the identification of effective cell populations proposed for cell-based therapy in the human heart.
Journal of the American College of Cardiology, 2010
The aim of this study was to assess differences in thrombus healing between ruptured and eroded p... more The aim of this study was to assess differences in thrombus healing between ruptured and eroded plaques, given the natural difference in lesion substrate and that thrombi might exist days to weeks before the presentation of sudden coronary death.
Journal of the American College of Cardiology, 2011
PLoS genetics, 2011
Sudden cardiac death (SCD) continues to be one of the leading causes of mortality worldwide, with... more Sudden cardiac death (SCD) continues to be one of the leading causes of mortality worldwide, with an annual incidence estimated at 250,000-300,000 in the United States and with the vast majority occurring in the setting of coronary disease. We performed a genome-wide association meta-analysis in 1,283 SCD cases and >20,000 control individuals of European ancestry from 5 studies, with follow-up genotyping in up to 3,119 SCD cases and 11,146 controls from 11 European ancestry studies, and identify the BAZ2B locus as associated with SCD (P = 1.8×10(-10)). The risk allele, while ancestral, has a frequency of ~1.4%, suggesting strong negative selection and increases risk for SCD by 1.92-fold per allele (95% CI 1.57-2.34). We also tested the role of 49 SNPs previously implicated in modulating electrocardiographic traits (QRS, QT, and RR intervals). Consistent with epidemiological studies showing increased risk of SCD with prolonged QRS/QT intervals, the interval-prolonging alleles are ...
Future Cardiology, 2011
With the aging of the general population in industrialized nations, calcific aortic stenosis (CAS... more With the aging of the general population in industrialized nations, calcific aortic stenosis (CAS) is becoming an increasingly important medical problem. The etiology is for the most part, dependent on the age at presentation; the two predominant causes in the western world are calcific aortic valve disease arising in a tricuspid aortic valve and bicuspid aortic valve (BAV). CAS is a progressive disease, exhibiting a spectrum of pathologic findings, ranging from valvular sclerosis to severe nodular calcification. Aortic valve replacement is the recommended treatment for severe disease but tissue valves may also calcify over time. Various atherosclerotic risk factors have been linked to aortic stenosis and there are mechanistic similarities between atherosclerosis and CAS. The precise pathologic mechanisms underlying aortic stenosis are poorly understood.
PLoS ONE, 2014
Background: Postinfectious glomerulonephritis (PIGN), a form of immune complex GN, is not well-de... more Background: Postinfectious glomerulonephritis (PIGN), a form of immune complex GN, is not well-defined in HIV-infected patients. This study characterizes PIGN in this patients' population and determine the impact of histopathological patterns on renal outcome and mortality.
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Papers by Naima Carter-monroe