Papers by venkatesh sadhu
Zenodo (CERN European Organization for Nuclear Research), Jul 31, 2017
Zenodo (CERN European Organization for Nuclear Research), Oct 30, 2018
Cubosomes are nanoparticles in structure which is mainly made of certain amphiphilic lipids in de... more Cubosomes are nanoparticles in structure which is mainly made of certain amphiphilic lipids in definite proportion, known as bicontinuous cubic phase liquid crystals. Hydrating a surfactant or polar lipid that forms cubic phase and then dispersing a solid like phase into smaller particles usually forms a cubosomes. They perform solid like rheology with unique properties of practical interest. They are thermodynamically stable and they have carvenous (honeycomb) structures which are tightly packed twisted into three dimensional bilayers. This type of complex structure allows them to have greater drug loading ability. Cubosomes have ability to encapsulate the hydrophobic, hydrophilic, amphiphilic substances. Cubosomes can increase the solubility of poorly soluble drug. Cubosome dispersions are bioadhesive and biocompatible. Because of their properties, cubosome are versatile systems, administrable by different ways such as orally, percutaneously and parenterally. Cubosome structure by means of electron microscopy, light scattering, x-ray and NMR, nevertheless few researchers has been studying the potential of cubosome as delivery systems.
Zenodo (CERN European Organization for Nuclear Research), May 30, 2019
Linagliptin is an oral anti-diabetic drug belong to the class of dipeptidyl peptidase -4 (DPP-4 i... more Linagliptin is an oral anti-diabetic drug belong to the class of dipeptidyl peptidase -4 (DPP-4 inhibitors).It is widely used in the treatment of type –II diabetes mellitus which is characterized by insulin resistance in pheripheral tissue and insulin secretory defect of the β – cells.Linagliptin is been approved by the US food & Drug administration for the management of type –II diabetes. This work aims to compiling the published analytical methods referred so far in the literature in the determination of linagliptin in the biological samples and pharmaceutical formulations. Techniques like HPLC, UV & MASS spectroscopy, EI – Tandem Mass spectrometry, pharmacokinetic studies & spectrophotometric methods have been utilized so far in the analysis, from which we can seen HPLC methods have been operated most extensively in various analytical perspectives. Based on the findings of the present review, linagliptin is widely used as an treatment adjunctive to a regimen of an insulin secreta...
GSC Biological and Pharmaceutical Sciences, 2019
GSC Biological and Pharmaceutical Sciences, 2018
Cubosomes are nanoparticles in structure which is mainly made of certain amphiphilic lipids in de... more Cubosomes are nanoparticles in structure which is mainly made of certain amphiphilic lipids in definite proportion, known as bicontinuous cubic phase liquid crystals. Hydrating a surfactant or polar lipid that forms cubic phase and then dispersing a solid like phase into smaller particles usually forms a cubosomes. They perform solid like rheology with unique properties of practical interest. They are thermodynamically stable and they have carvenous (honeycomb) structures which are tightly packed twisted into three dimensional bilayers. This type of complex structure allows them to have greater drug loading ability. Cubosomes have ability to encapsulate the hydrophobic, hydrophilic, amphiphilic substances. Cubosomes can increase the solubility of poorly soluble drug. Cubosome dispersions are bioadhesive and biocompatible. Because of their properties, cubosome are versatile systems, administrable by different ways such as orally, percutaneously and parenterally. Cubosome structure by means of electron microscopy, light scattering, x-ray and NMR, nevertheless few researchers has been studying the potential of cubosome as delivery systems.
Drug Invention Today, 2018
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Papers by venkatesh sadhu