VALLE DEL CAUCA

The purposes of the present study have been to analyse the presenting features, response to therapy and survival of myeloma patients aged 70 years or more, in comparison to younger patients. From January 1985 to December 1989, 487 patients with multiple myeloma (MM) were randomized to receive melphalan and prednisone (MP) versus alternating cycles of vincristine, cyclophosphamide, melphalan, and prednisone (VCMP) and vincristine, BCNU, adriamycin, and prednisone (VBAP). The subset of 178 patients who were 70 or more years is the subject of this study, whereas the 309 patients younger than 70 years were used as a control group. The presenting features and response to chemotherapy of older patients were no different to those of the younger population. However, the survival of elderly patients was significantly shorter (median 23.4 vs. 33.5 months, p < 0.001). The overall response rate to MP in older patients was 50% (28% objective plus 22% partial response) compared with 61% (44% objective plus 17% partial response) to combination chemotherapy (p = not significant). Myelosuppression was moderate in both arms, although MP produced a higher degree of thrombocytopenia. There were no significant differences in survival between patients given MP versus VCMP/ VBAP (median, 20 vs. 27 months, p = 0.2). Response to treatment was associated with a significantly longer survival. Older patients with symptomatic myeloma tolerate chemotherapy and should be offered treatment.

Background and Objective. Intensive induction and post-remission therapies have improved the prognosis in adult acute lymphoblastic leukemia (ALL). However, different from children, the impact of late intensification therapy in the overall results of treatment has not been consistently evaluated. The objective of this study was to analyze the results of a multicenter prospective protocol, PETHEMA ALL-89, in which, after intensive induction and consolidation therapy, randomization to receive delayed intensification treatment was performed.

The objective of this research is to characterize the current situation of the practices and methods used to create new products from the harvest and post-harvest processes of the banana crop. Bananas' morphology is composed of a central stem, colines, flower, leaf in development, pseudostem, cluster, rachis and leaves. This article is aimed to identify the companies and / or people who are dedicated in the development of products from the banana fibers. It will also provide alternatives to take advantage of this waste, helping not only the environment but industrial development in the Department of Huila, hand in hand with environmental management.

Supine weight-bearing exercise within lower body negative pressure (LBNP) alleviates some of the skeletal deconditioning induced by simulated weightlessness in men. We examined the potential beneficial effect in women. Because dietary acid load affected the degree of bone resorption in men during bed rest, we also investigated this variable in women. Subjects were 7 pairs of female identical twins assigned at random to 2 groups, sedentary bed rest (control) or bed rest with supine treadmill exercise within LBNP. Dietary intake was controlled and monitored. Urinary calcium and markers of bone resorption were measured before bed rest (BR) and on BR days 5/6, 12/13, 19/20, and 26/27. Bone mineral content was assessed by dual-energy X-ray absorptiometry before and after bed rest. Data were analyzed by repeated measures two-way analysis of variance. Pearson correlation coefficients were used to define the relationships between diet and markers of bone metabolism, and to estimate heritability of markers. During bed rest, all markers of bone resorption and urinary calcium and phosphorus increased (P < 0.001); parathyroid hormone (P = 0.06), bone-specific alkaline phosphatase (P = 0.06), and 1,25-dihydroxyvitamin D (P = 0.09) tended to decrease. LBNP exercise tended to mitigate bone density loss. The ratio of dietary animal protein to potassium was positively correlated with urinary calcium excretion for all weeks of bed rest in the control group, but only during weeks 1 and 3 for the exercise group. Pre-bed rest data suggested that many markers of bone metabolism have strong genetic determinants. Treadmill exercise within LBNP had less of a protective effect on bone resorption during bed rest in women than previously-published results had shown for its effect in men, but the same trends were observed for both sexes. Dietary acid load of these female subjects was significantly correlated with calcium excretion but not with other bone resorption markers.

In this paper, we present a study of the linearity of the International Electrotechnical Commission (IEC) 61000-4-15 flickermeter when subject to rectangular fluctuations of different amplitude. We show, both analytically and through simulation, how the scaling in Block 1 causes the nonlinear response of the flickermeter. While the standard proposes scaling methods based on the rms value of the input voltage, we introduce an alternative method based on the mean value of the rectified input voltage. The measured P st using the new scaling method has a linear relationship to the amplitude of the voltage fluctuations.

Aim: To develop a new method to suppress the artefact generated by chest compressions during cardiopulmonary resuscitation (CPR) using only the frequency of the compressions as additional information. Materials and methods: The CPR artefact suppression method was developed and tested using a database of 381 ECG records (89 shockable and 292 non-shockable) from 299 patients. All records were extracted from real out-of-hospital cardiac arrest episodes. The suppression method consists of a Kalman filter that uses the frequency of the measured compressions to estimate the artefact and to remove it from the ECG. The performance of the filter was evaluated by comparing the sensitivity and specificity of an automated external defibrillator before and after the artefact suppression. Results: For the test database, the sensitivity improved from 57.8% (95% confidence interval, 43.3-71.0%) to 93.3% (81.5-98.4%) and the specificity decreased from 92.5% (87.0-95.9%) to 89.1% (83.0-93.3%). Conclusion: For a similar sensitivity, we obtained better specificity than that reported for other methods, although still short of the values recommended by the American Heart Association. The results suggest that the CPR artefact can be accurately modelled using only the frequency of the compressions. This information could be easily acquired through the defibrillator's CPR help pads, with minimal hardware modifications.

Providing cardiopulmonary resuscitation (CPR) to a patient in cardiac arrest introduces artefacts into the electrocardiogram (ECG), corrupting the diagnosis of the underlying heart rhythm. CPR must therefore be discontinued for reliable shock advice analysis by an automated external defibrillator (AED). Detection of ventricular fibrillation (VF) during CPR would enable CPR to continue during AED rhythm analysis, thereby increasing the likelihood of resuscitation success.

 Pero en vez de verse los descubrimientos de Mayo y su equipo como un llamado a un mayor respeto y una mayor preocupación por la persona del empleado y sus problemas, los administradores, ayudados por los continuadores de Mayo, sólo implementaron 'recetas' y manipulaciones.

El ex presidente Álvaro Uribe Vélez es un obstáculo para la paz en Colombia. Si bien, Uribe sostiene que la única vía para salir del conflicto armado en Colombia es la vía militar pero se sabe qué responder a la guerra con más guerra solo genera aún más guerra, lo cual es un impedimento para la paz.