Prevalence and risk factors for allergic rhinitis and atopic eczema among schoolchildren in Israel: results from a national study
Annals of Allergy, Asthma & Immunology, 2004
There is growing evidence that the prevalence rates of asthma and allergic diseases are increasin... more There is growing evidence that the prevalence rates of asthma and allergic diseases are increasing, especially among children. Several risk factors are under investigation. To evaluate the prevalence and risk factors for allergic diseases, including allergic rhinitis (AR) and atopic eczema (AE), among 13- to 14-year-old schoolchildren in Israel. A modified version of the International Study of Asthma and Allergies in Childhood written questionnaire was administered to a national sample of schoolchildren 13 to 14 years old in Israel. The questionnaire was completed by the schoolchildren themselves. There were 10,057 complete questionnaires available for analysis. The prevalence of AR symptoms ever and current AR were 41.6% and 9.4%, respectively. Allergic rhinoconjunctivitis symptoms ever were reported by 15.8% of the children. The prevalence rates of 6 months of itchy rash ever and AE were 5.9% and 7.8%, respectively. After adjustment for demographic and environmental factors, current asthma, parental history of asthma, and population group were the most significant risk factors for current AR (odds ratio [OR], 4.47; 95% confidence interval [CI], 3.70-5.40; OR, 1.30; 95% CI, 1.02-1.66; and OR, 1.75; 95% CI 1.45-2.13; respectively) and AE (OR, 2.30; 95% CI, 1.80-2.90; OR, 1.80; 95% CI, 1.40-2.30; and OR, 1.70; 95% CI, 1.40-2.00; respectively). Israeli children have a low prevalence rate of current AR and a midrange rate of AE. Arabs have lower prevalence rates of allergic diseases than Jews, and the prominent risk factors for those diseases are current asthma and parental history of asthma.
Background— Chronic hypertension may cause left ventricular (LV) remodeling, alterations in cardi... more Background— Chronic hypertension may cause left ventricular (LV) remodeling, alterations in cardiac function, and the development of chronic heart failure (CHF). Changes in the composition of the extracellular matrix (ECM) known to occur in hypertension are believed to be causally related to these structural, functional, and clinical outcomes. However, whether the determinants of ECM composition, such as the balance between ECM proteases (matrix metalloproteinases [MMPs]) and their tissue inhibitors [TIMPs]), are altered in hypertensive heart disease is unknown. Methods and Results— Plasma MMP-2, -9, and -13 values, TIMP-1 and -2 values, and Doppler echocardiography images were obtained for 103 subjects divided into 4 groups: (1) reference subjects (CTL) with no evidence of cardiovascular disease, (2) hypertensive (HTN) subjects with controlled blood pressure and no LV hypertrophy, (3) hypertensive subjects with controlled blood pressure and with LV hypertrophy (HTN+LVH) but no CHF,...
The Role of NF-κB, PPAR-α, and PPAR-γ in Older Adults with Metabolic Syndrome
Hormone and Metabolic Research
The etiopathogenesis of metabolic syndrome (MetS) has not been fully understood yet, and chronic ... more The etiopathogenesis of metabolic syndrome (MetS) has not been fully understood yet, and chronic low-grade inflammation is thought to be associated with the development of complications related to MetS. We aimed to investigate the role of Nuclear factor Kappa B ( NF-κB ), Peroxisome Proliferator-Activated Receptor- α and γ (PPAR-α, and PPAR-γ) which are the main markers of inflammation in older adults with MetS. A total of 269 patients aged≥18, 188 patients with MetS who met the diagnostic criteria of the International Diabetes Federation, and 81 controls who applied to geriatrics and general internal medicine outpatient clinics for various reasons were included in the study. Patients were separated into four groups: young with MetS (< 60, n=76), elderly with MetS (≥60, n=96), young control (< 60, n=31), elderly controls (≥60, n=38). Carotid intima-media thickness (CIMT) and NF-κB , PPAR-α, and PPAR-γ plasma levels were measured in all of the participants. Age and sex distribu...
OBJECTIVES: Aging is characterized by appetite loss and cachexia, i.e., factors that contribute t... more OBJECTIVES: Aging is characterized by appetite loss and cachexia, i.e., factors that contribute to malnutrition. An infl ammation marker, neutrophil-to-lymphocyte ratio (NLR), is a signifi cant prognostic predictor of many geriatric syndromes. We aim to determine the association between NLR and malnutrition. METHODS: We designed a retrospective study on hospitalized patients in the geriatric unit of a university hospital between January 2019 and January 2021. Demographic data, chronic diseases, history of smoking, length of hospital stay, number of drugs, laboratory and further examinations, and comprehensive geriatric assessment scores were recorded from the hospital data system. The nutritional status of the patients was evaluated using the mini-nutritional assessment (MNA) questionnaire. RESULTS: Of the 220 patients, 121 (55 %) were female, and the mean age was 77.9 ± 7.3 years. According to the MNA, 60 % (n = 132) were malnourished or at risk of malnutrition. As many as 47.3 % (n = 104) of the patients had depressive symptoms, and 41.4 % (n = 91) were cognitively impaired. The mean age (79.3 ± 7.3), NLR, and GDS scores were signifi cantly higher, and MMSE scores were signifi cantly lower in malnourished patients or in those at risk of malnutrition as compared to patients with normal nutritional status.
Low Vitamin D Level in Patients with Alzheimer's Disease (Devit-Alz): A Cross-Sectional Multicenter Study
European Congress on Osteoporosis and Osteoarthritis (ESCEO-IOF) -- APR 17-20, 2013 -- Rome, ITAL... more European Congress on Osteoporosis and Osteoarthritis (ESCEO-IOF) -- APR 17-20, 2013 -- Rome, ITALYWOS: 000328346400192
Supplement_Table for Reliability and Validity of Rowland Universal Dementia Assessment Scale in T... more Supplement_Table for Reliability and Validity of Rowland Universal Dementia Assessment Scale in Turkish Population by Gizem Ayan, Ceyda Afacan, Burc Cagrı Poyraz, Onur Bilgic, Suna Avci, Hakan Yavuzer, Mehmet Yuruyen, Deniz Suna Erdincler, Burak Ayan, and Alper Doventas in American Journal of Alzheimer's Disease & Other Dementias
Prevalence and risk factors for allergic rhinitis and atopic eczema among schoolchildren in Israel: results from a national study
Annals of Allergy, Asthma & Immunology, 2004
There is growing evidence that the prevalence rates of asthma and allergic diseases are increasin... more There is growing evidence that the prevalence rates of asthma and allergic diseases are increasing, especially among children. Several risk factors are under investigation. To evaluate the prevalence and risk factors for allergic diseases, including allergic rhinitis (AR) and atopic eczema (AE), among 13- to 14-year-old schoolchildren in Israel. A modified version of the International Study of Asthma and Allergies in Childhood written questionnaire was administered to a national sample of schoolchildren 13 to 14 years old in Israel. The questionnaire was completed by the schoolchildren themselves. There were 10,057 complete questionnaires available for analysis. The prevalence of AR symptoms ever and current AR were 41.6% and 9.4%, respectively. Allergic rhinoconjunctivitis symptoms ever were reported by 15.8% of the children. The prevalence rates of 6 months of itchy rash ever and AE were 5.9% and 7.8%, respectively. After adjustment for demographic and environmental factors, current asthma, parental history of asthma, and population group were the most significant risk factors for current AR (odds ratio [OR], 4.47; 95% confidence interval [CI], 3.70-5.40; OR, 1.30; 95% CI, 1.02-1.66; and OR, 1.75; 95% CI 1.45-2.13; respectively) and AE (OR, 2.30; 95% CI, 1.80-2.90; OR, 1.80; 95% CI, 1.40-2.30; and OR, 1.70; 95% CI, 1.40-2.00; respectively). Israeli children have a low prevalence rate of current AR and a midrange rate of AE. Arabs have lower prevalence rates of allergic diseases than Jews, and the prominent risk factors for those diseases are current asthma and parental history of asthma.
Background— Chronic hypertension may cause left ventricular (LV) remodeling, alterations in cardi... more Background— Chronic hypertension may cause left ventricular (LV) remodeling, alterations in cardiac function, and the development of chronic heart failure (CHF). Changes in the composition of the extracellular matrix (ECM) known to occur in hypertension are believed to be causally related to these structural, functional, and clinical outcomes. However, whether the determinants of ECM composition, such as the balance between ECM proteases (matrix metalloproteinases [MMPs]) and their tissue inhibitors [TIMPs]), are altered in hypertensive heart disease is unknown. Methods and Results— Plasma MMP-2, -9, and -13 values, TIMP-1 and -2 values, and Doppler echocardiography images were obtained for 103 subjects divided into 4 groups: (1) reference subjects (CTL) with no evidence of cardiovascular disease, (2) hypertensive (HTN) subjects with controlled blood pressure and no LV hypertrophy, (3) hypertensive subjects with controlled blood pressure and with LV hypertrophy (HTN+LVH) but no CHF,...
The Role of NF-κB, PPAR-α, and PPAR-γ in Older Adults with Metabolic Syndrome
Hormone and Metabolic Research
The etiopathogenesis of metabolic syndrome (MetS) has not been fully understood yet, and chronic ... more The etiopathogenesis of metabolic syndrome (MetS) has not been fully understood yet, and chronic low-grade inflammation is thought to be associated with the development of complications related to MetS. We aimed to investigate the role of Nuclear factor Kappa B ( NF-κB ), Peroxisome Proliferator-Activated Receptor- α and γ (PPAR-α, and PPAR-γ) which are the main markers of inflammation in older adults with MetS. A total of 269 patients aged≥18, 188 patients with MetS who met the diagnostic criteria of the International Diabetes Federation, and 81 controls who applied to geriatrics and general internal medicine outpatient clinics for various reasons were included in the study. Patients were separated into four groups: young with MetS (< 60, n=76), elderly with MetS (≥60, n=96), young control (< 60, n=31), elderly controls (≥60, n=38). Carotid intima-media thickness (CIMT) and NF-κB , PPAR-α, and PPAR-γ plasma levels were measured in all of the participants. Age and sex distribu...
OBJECTIVES: Aging is characterized by appetite loss and cachexia, i.e., factors that contribute t... more OBJECTIVES: Aging is characterized by appetite loss and cachexia, i.e., factors that contribute to malnutrition. An infl ammation marker, neutrophil-to-lymphocyte ratio (NLR), is a signifi cant prognostic predictor of many geriatric syndromes. We aim to determine the association between NLR and malnutrition. METHODS: We designed a retrospective study on hospitalized patients in the geriatric unit of a university hospital between January 2019 and January 2021. Demographic data, chronic diseases, history of smoking, length of hospital stay, number of drugs, laboratory and further examinations, and comprehensive geriatric assessment scores were recorded from the hospital data system. The nutritional status of the patients was evaluated using the mini-nutritional assessment (MNA) questionnaire. RESULTS: Of the 220 patients, 121 (55 %) were female, and the mean age was 77.9 ± 7.3 years. According to the MNA, 60 % (n = 132) were malnourished or at risk of malnutrition. As many as 47.3 % (n = 104) of the patients had depressive symptoms, and 41.4 % (n = 91) were cognitively impaired. The mean age (79.3 ± 7.3), NLR, and GDS scores were signifi cantly higher, and MMSE scores were signifi cantly lower in malnourished patients or in those at risk of malnutrition as compared to patients with normal nutritional status.
Low Vitamin D Level in Patients with Alzheimer's Disease (Devit-Alz): A Cross-Sectional Multicenter Study
European Congress on Osteoporosis and Osteoarthritis (ESCEO-IOF) -- APR 17-20, 2013 -- Rome, ITAL... more European Congress on Osteoporosis and Osteoarthritis (ESCEO-IOF) -- APR 17-20, 2013 -- Rome, ITALYWOS: 000328346400192
Supplement_Table for Reliability and Validity of Rowland Universal Dementia Assessment Scale in T... more Supplement_Table for Reliability and Validity of Rowland Universal Dementia Assessment Scale in Turkish Population by Gizem Ayan, Ceyda Afacan, Burc Cagrı Poyraz, Onur Bilgic, Suna Avci, Hakan Yavuzer, Mehmet Yuruyen, Deniz Suna Erdincler, Burak Ayan, and Alper Doventas in American Journal of Alzheimer's Disease & Other Dementias
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