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HDR vs NHEJ: Harnessing DNA Repair Mechanisms for Precision Gene Editing The CRISPR/Cas9 system has revolutionized genetic research, offering scientists unprecedented precision in genome editing. Never
Maintaining a clean and sterile environment is essential for zebrafish research facilities. Proper sterilization of zebrafish tanks not only prevents the spread of harmful pathogens
InVivo Biosystems, a leader in preclinical development and genome editing, announces the appointment of Brian Pollok, Ph.D., to its Board of Directors. EUGENE, OR, UNITED
At InVivo Biosystems (formerly NemaMetrix), our passion for innovation drives us to continually expand the horizons of genetic research. While Caenorhabditis elegans (C. elegans) has
Zebrafish embryos are one of the most powerful models for toxicity testing, offering a reliable and efficient method of determining toxicity levels for various substances.
The 2024 Nobel Prize in Physiology or Medicine has been awarded to groundbreaking microRNA research utilizing Caenorhabditis elegans (C. elegans), a nematode that has been at the heart of scientific discovery for
FDA Priority Review Voucher (PRV) Program Under Review: What’s Next for Rare Pediatric Disease Drug Development? As of September 27, 2024, the FDA’s Priority Review
Humanized in vivo Models: Shaping the Future of Drug Discovery and Development In the pursuit of novel therapies and deeper insights into human diseases, the
At InVivo Biosystems, we are driven by the belief that alternative animal models are a major pillar in the transformation of preclinical development, particularly in
At InVivo Biosystems, we optimized a groundbreaking multiplex CRISPR technology that is set to redefine how we approach target identification and validation in preclinical development.
At InVivo Biosystems, our expertise in zebrafish is deeply intertwined with the rich legacy of research that began right here in Eugene, Oregon. As a
Press Release Date: August 13, 2024 publicizing the MIC-Drop™ technology and partnership with IDEA Biomedical. See the original EIN Press Release HERE. “By performing an
In this blog post, we dive into how the InVivo Biosystems preclinical development platform is closing the gaps in finding successful treatments for Alzheimer’s disease
Eugene, OR – June 25, 2024 – InVivo Biosystems, a trailblazer at the forefront of a new era in preclinical development, today announced the appointment
Small animal models like C. elegans and Zebrafish will be essential tools if we are to find a cure for Huntington’s Disease. Huntington’s Disease Awareness
Parkinson’s disease (PD) moves slowly, taking decades to develop, and impacting patients over decades of their lives. Considering that this debilitating condition affects over 10
InVivo Biosystems Appoints Kat McCormick as Chief Executive Officer “I can’t thank the InVivo team and our customers enough for making these last few years
Imagine being able to track protein activity in real time, or model human disease with pinpoint accuracy in a living organism. The right CRISPR Knock-In
Dravet syndrome is a rare but severe form of epilepsy that begins in infancy, challenging families and neurodegenerative disease researchers alike to find effective treatments
As CRISPR injection mixes have become more readily available to make genome editing easier, it can be difficult to determine what the value is of
Summary InVivo Biosystems and BioReperia have partnered to deliver an expedited xenograft platform to accelerate cancer therapeutic discovery and development. The ZTX® tumor xenograft cuts
In this epilepsy news customer story on STXBP1 epilepsy, we have the pleasure of hearing from Lior Dor and Sagi Gidali from the Rare Smile
Summary: Computational modeling of STXBP1 protein docking with a compound repurposing library revealed a list of 15 drug candidates. Candidates were testing using a validated
2023, A Landmark Year for InVivo Biosystems The InVivo Biosystems team is excited to present another successful year’s accomplishments below. 2023 was a year full
Summary In this article, we compare and contrast Cas9 vs Cas12a. Cas12a is revolutionizing genome editing with its ability to access AT-rich genomes and difficult-to-edit
New Product Development Validation Services InVivo Biosystems is equipped with a technology platform and expert team ready to assist your organization with Biological Quality Control
Thigmotaxis Overview Thigmotaxis is a “wall hugging” behavior exhibited in both zebrafish and mice. Thigmotaxis has been used to model anxiety and stress response. Zebrafish
Eugene, Ore. – January 3, 2024 – InVivo Biosystems, experts in CRISPR-edited animals for biomedical discovery, today announced $3M in new investment in furtherance of
The Rise of Zebrafish Research In the realm of neuroscience, behavioral studies using animal models are essential for understanding brain functions and developing treatments for
RapidGen™ – Your fast lane to 2024 target validation breakthrough Knock-Out your drug development efforts in 2024 Our RapidGen™ technology executes proof-of-concept or viability testing
Summary Of the over 60 million people worldwide who suffer from epilepsy, approximately one third of them do not respond to available therapies. While genetic
A deep dive into the world of gene variants, their significance, and the potential to transform our understanding of epilepsy. Setting the Stage: Understanding Gene
Overview: A Massachusetts biopharma company developing therapeutics for neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease was able to accelerate their pre-clinical development by partnering
Summary: Thanks to the advances in CRISPR technology, the coming decades are poised to usher in the era of personalized medicine. While, on one hand,
In this blog post, we examine the IND application process and give insight on how to reach IND readiness faster with the InVivo Biosystems preclinical
Summary: Zebrafish are a commonly used model organism in the rare disease space, thanks to their significant advantages such as their affordability and ability to
Summary: As personalized medicine and the discovery of de novo variants that cause disease continue to grow, researchers are increasingly in need of alternative models
Summary: In a previous customer story we detailed our collaboration with Dr Dan Starr to generate transgenic C. elegans models for two potentially disease-causing variants
Summary: Gut microbiota impacts nearly every aspect of health, but researching it can be tricky due to differences between humans and commonly used model organisms,
Summary: Over the past decade there has been an explosion in people experiencing gastrointestinal issues, and, consequently, there has been increased interest in research looking
Summary: Organ and tissue regeneration is an area of research with a potential impact on millions of patients who have suffered traumas as diverse as
The FDA Modernization Act 3.0 was introduced in House as of February 6th 2024. The bill requires the FDA to establish a process supporting the
Summary: Summary: Antibody labeling has been revolutionary for research into immune function and inflammation responses, and, while zebrafish are one of the prominent models for
Summary: Previously existing solely as a pet, the zebrafish (danio rerio)was first brought into the lab in the 1960s by University of Oregon Professor, George
A Question One Might Ask: How do you make animal models more effective at drug discovery? One process, now made simple using CRISPR technologies, is
Our custom injection mix services utilize our patented CRISPR technology to enable specific protein point mutations. This customer story shows how our validated injection mixes
Summary: Humanization of druggable targets is an important tool for increasing drug translation to clinic. Current in vivo drug discovery platforms can be quite limited
Summary: On September 12, 2022, President Biden issued an Executive Order, titled ‘Advancing Biotechnology and Biomanufacturing Innovation for a Sustainable, Safe, and Secure American Bioeconomy.’
Rare diseases may be individually uncommon, but together they affect 3.5% to 5.9% of the global population, creating a significant healthcare challenge. In this article,
Summary: We are excited to announce that the USPTO has issued a patent titled, ‘Transgenic animal phenotyping platform and uses thereof’ to InVivo Biosystems. This
Ben joined InVivo Biosystems in June of 2018 as a Research & Development scientist after coming from the University of Utah. Recently, I interviewed
See the Amack & Pruyne Customer Story to learn more about Dr. Pruyne and Dr Amack’s research, why they chose to leverage the InVivo Biosystems’
Summary: Plant-based eating has exploded in popularity in the past few years, boasting advantages for individuals’ health as well as the environment. However, the
Summary: Drug discovery is the process of identifying and creating new therapies and treatment options. This being said, the traditional discovery process is expensive and
Summary: Drug repurposing takes previously known compounds and drugs, and applies them to current health problems. Drug repurposing is particularly beneficial for finding rare disease
Summary: Humans have been interested in extending our lifespans for centuries, from quests to find the fountain of youth, to Alchemists attempting to determine the
Summary: Parkinson’s disease [PD] is a progressive, debilitating condition which affects over 10 million people worldwide. Being such an impactful, and costly disease (~$52 billion
Summary: As we have discussed in previous blogs, Dietary Supplements are a booming industry, valued at $54 billion in the USA alone. Despite their growing popularity, however,
Summary: This past April, Senators Richard Durbin (D-IL) and Mike Braun (R-IN) introduced the Dietary Supplement Listing Act of 2022. The first piece of legislation to propose regulations
In 2019 Kalyn joined InVivo Biosystems, working in zebrafish husbandry. I recently sat down with Kalyn to discuss her day to day schedule, and to
– InVivo Biosystems, experts in preclinical in vivo testing and CRISPR genome editing, and Thaena Inc., a science-based wellness company developing novel microbiome-based therapies, today
Summary: We have previously discussed how the advancement of genomics technology has led to an increase in variants of unknown significance (VUS), and how important it
In 2018, Kolt joined InVivo Biosystems and works as a Senior Software Developer. Recently, I sat down with Kolt and discussed his role at InVivo,
Jordan Shavit is a professor of Pediatrics and Human Genetics, and the Henry and Mala Dorfman Family Professor at the University of Michigan. Dr. Shavit’s
Summary: The Western Medical Community has long viewed acupuncture with skepticism, but increasingly physicians are exploring the potential benefits of this traditional practice. In fact,
In Episode 67 of 17 Minutes of Science, we are joined by Dr. Gabriel Bossé. Gabriel Bossé is currently a postdoctoral fellow with Randall Peterson
Summary Inflammation’s role in diseases has become increasingly apparent, with inflammatory responses being linked to diseases as common as arthritis, and as debilitating as Parkinson’s.
Manual worm counting to measure lifespan is still very common, but it brings with it a lot of potential for human errors and inconsistencies in
Summary: Natural products (bioactive compounds derived from natural resources, most predominantly plants) have been used in medicines, notably ayurvedic and chinese medicine, for
Between the early 2000s and mid-2010s, artificial enzymes engineered to manipulate genomes – Zinc-finger nucleases (ZFNs) and transcription-activator–like effector nucleases (TALENs) – had garnered considerable
Over the past several years, we have seen a huge increase in clients who are turning to us to help test the efficacy of their
Summary Pets have been shown to improve human health by lowering blood pressure and cortisol levels (a stress-related hormone) (NIH, 2018). But could they also
Summary Knockout and knock-in technologies enable researchers to modify genes in a chosen model system, and thus, can reveal a lot about how a gene
Disease Modeling, View from the Bench / By Christine Kim and Thomas Adams Summary: We recently published a piece on the importance of temperature in C.elegans which got the
Discover the future of medicine through our comprehensive drug discovery and development services. Reach out to us today and take the first step towards revolutionizing
HDR vs NHEJ: Harnessing DNA Repair Mechanisms for Precision Gene Editing The CRISPR/Cas9 system has revolutionized genetic research, offering scientists unprecedented precision in genome editing. Never
We recently were asked to procure a special zebrafish diet, which got us thinking about zebrafish diets overall. Once we started researching this custom diet,
Knock-ins have become invaluable in allowing researchers to better model mutations associated with disease, right down to a single nucleotide change. However, there remain many
Here at InVivo Biosystems we spend a lot of time thinking, and talking, about genome editing. We thought it would be fun to compile a
Summary From pet to model organism, zebrafish have made impressive strides since the 1960s, when George Stresinger pitched its use in research. In this white
Summary The nematode C. elegans has been used as a model organism for nearly sixty years and has made significant contributions to science in that
Summary: The standard growth temperatures for C. elegans in the lab range between 15°C and 25°C [Figure 1]. While this only spans 10 degrees, the
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Summary A recent publication by Crouzier et al. emphasized the utility of zebrafish as a model for investigating rare diseases – enabling better understanding of
Summary Turmeric has become a buzzword in the health community, its market size growing immensely in the past few years: approximately doubling from $50.3 million
Summary Zebrafish models largely began as a way to research developmental biology, however, their potential to be a preclinical model of human disease quickly became
Over the years InVivo Biosystems has worked closely with the University of Oregon Aquatic Animal Care Services (AqACS) to deliver the highest quality animal care
Summary: Neuroscience has a long history of working with sea animals as they often have large, easily accessible neurons with more simplistic neural networks than mammals.
When working with C. elegans it is vital that you can deftly handle them. Worm picking, however, is a skill where practice makes perfect. At
Summary Recently, researchers at Cleveland Clinic’s Genomic Medicine Institute published an article in Nature Aging which has caused quite a stir in the medical community
Summary As we head into 2022, we are reflecting on the exciting projects we’ve been involved with over the past few years, and the engrossing
Summary Experiments fall into three categories – in vivo, in vitro, and in silico studies, and all of them have a different, but important role
For the purpose of this article the terms ‘women’ and ‘female’ refers to people who were assigned female sex at birth and similarly for ‘men’
Summary In a previous article we discussed the differences between the FDA and FTC agencies, and how, while pharmaceuticals are overseen by the FDA, nutraceuticals
Summary When asked how someone died, ‘they died of old age’ is an acceptable answer – it is given as the cause, like a heart
