Papers by Francesco Basso
Cytokine, 2002
Helicobacter pylori infection outcome might depend on genotypic polymorphisms of both the bacteri... more Helicobacter pylori infection outcome might depend on genotypic polymorphisms of both the bacterium and the host. We ascertained: (1) the functionality of H. pylori oipA gene; (2) the polymorphism of the host interleukin (IL-1 ) gene ( 31 C/T) and of the IL-1RN gene (intron 2 VNTR); (3) the association between the above genes and the histological and pathological outcome of H. pylori infection. One hundred and sixty-five H. pylori positive and 137 H. pylori negative subjects (23 gastric adenocarcinoma, 58 peptic ulcer, 221 gastritis) were studied. oipA was sequenced, IL-1 was RFLP analysed. Antral and body mucosal biopsies were histologically evaluated. Functional oipA genes were correlated with cagA gene; both genes were significantly associated with gastritis activity, peptic ulcer and gastric adenocarcinoma. In these patients heterozygous IL-1RN 1/2 and IL-1 C/T genotypes were more frequent than in gastritis patients. Intestinal metaplasia was associated with cagA, functional oipA and IL-1RN 2 allele. In conclusion, peptic ulcer and the preneoplastic intestinal metaplasia are associated with H. pylori virulence genes and with IL-1RN 2 host allele. An interplay between bacterial virulence factors and cytokines genotypes, is probably the main route causing H. pylori infection to lead to benign mild disease, benign severe disease or preneoplastic lesions.
Phytotherapy Research, 1998
Great interest in natural and aromatic plant cultivation arises from the need to guarantee a cons... more Great interest in natural and aromatic plant cultivation arises from the need to guarantee a constant supply to industry in terms of quality and quantity. Their cultivation seems to be the only possible way to obtain these plants in industrial nations, especially if one considers the high cost of finding wild plants. Too often the cultivation of natural drugs in Italy is associated with rigid rules that exclude indispensable agronomic techniques such as fertilization, protection against parasites (animal and fungus) as well as weed control that involves the use of chemical compounds. At the present time, it is known that the commercialization of plants cultivated with chemical compounds present acceptable risks for man and are an indispensable means for high yields. Correct cultivation techniques cannot exclude consideration of the use of these substances (herbicides, fungicides, insecticides, fertilizers) usually used for other crops. The lack of knowledge on cultivation techniques in order to correctly carry out the choice of products to be used for plant protection as well as tillage methods is rather high, but it would not be necessary to set them up ex-nova. In fact, much research has been carried out in many nations on how to use modern economic techniques that can be partly adapted to our environment. It is interesting to point out that many species are cultivated on fertile soils and easily accessible to machines, and not on marginal areas which are often infertile and difficult to reach. Plants cultivated on the latter soils would certainly not have competitive costs compared with those cultivated in other nations that have lower labour costs.
Therapy-related Acute Myelogenous Leukaemia (t-AML) carrying a 21q22 rearrangement accounts for a... more Therapy-related Acute Myelogenous Leukaemia (t-AML) carrying a 21q22 rearrangement accounts for about 15% among t-AML with balanced chromosome translocation. In this group t(16;21)(q24 ;q22) is very rare and even more so in children. In fact, review of the literature shows few ...
Journal of The Peripheral Nervous System, 2009
Dear Editor, Fulminant Guillain-Barré syndrome (GBS) is a rapidly progressive variant of acute in... more Dear Editor, Fulminant Guillain-Barré syndrome (GBS) is a rapidly progressive variant of acute inflammatory polyradiculoneuropathy in which the patient develops flaccid quadriplegia and loss of brainstem function. This entity is very rare and the diagnosis can be challenging. We report the case of a 61-year-old woman and review the literature on this topic.
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Papers by Francesco Basso