Many protein-protein interactions are mediated through independently folding modular domains. Pro... more Many protein-protein interactions are mediated through independently folding modular domains. Proteome-wide efforts to model protein-protein interaction or ''interactome'' networks have largely ignored this modular organization of proteins. We developed an experimental strategy to efficiently identify interaction domains and generated a domain-based interactome network for proteins involved in C. elegans earlyembryonic cell divisions. Minimal interacting regions were identified for over 200 proteins, providing important information on their domain organization. Furthermore, our approach increased the sensitivity of the two-hybrid system, resulting in a more complete interactome network. This interactome modeling strategy revealed insights into C. elegans centrosome function and is applicable to other biological processes in this and other organisms.
Don Ricardo Palma nació el 7 de febrero de 1833, para incorporarse a las filas de los románticos ... more Don Ricardo Palma nació el 7 de febrero de 1833, para incorporarse a las filas de los románticos peruanos que, desde la literatura, bregaron entre 1848 y 1860 por aquella otra liberación que debía producirse en el lenguaje y la mente.
Many protein-protein interactions are mediated through independently folding modular domains. Pro... more Many protein-protein interactions are mediated through independently folding modular domains. Proteome-wide efforts to model protein-protein interaction or ''interactome'' networks have largely ignored this modular organization of proteins. We developed an experimental strategy to efficiently identify interaction domains and generated a domain-based interactome network for proteins involved in C. elegans earlyembryonic cell divisions. Minimal interacting regions were identified for over 200 proteins, providing important information on their domain organization. Furthermore, our approach increased the sensitivity of the two-hybrid system, resulting in a more complete interactome network. This interactome modeling strategy revealed insights into C. elegans centrosome function and is applicable to other biological processes in this and other organisms.
Don Ricardo Palma nació el 7 de febrero de 1833, para incorporarse a las filas de los románticos ... more Don Ricardo Palma nació el 7 de febrero de 1833, para incorporarse a las filas de los románticos peruanos que, desde la literatura, bregaron entre 1848 y 1860 por aquella otra liberación que debía producirse en el lenguaje y la mente.
Uploads
Papers by Nas Galy