International Journal of Otorhinolaryngology and Head and Neck Surgery, 2020
Background: Allergic rhinitis is the most prevalent of allergic diseases in the world. Pharmacoth... more Background: Allergic rhinitis is the most prevalent of allergic diseases in the world. Pharmacotherapy remains the mainstay of treatment. Nasal corticosteroids being the most applicable drugs for its treatment. The objective of this study was to compare the efficacy of fluticasone propionate (FP) and mometasone furoate (MF) nasal sprays in the treatment of allergic rhinitis based on total nasal symptom score (TNSS) questionnaire.Methods: A prospective, randomized, open-label, parallel-group, comparative study was conducted among 80 allergic rhinitis patients fulfilling the inclusion and exclusion criteria. They were randomly assigned to two groups: FP and MF groups. FP group received 200 µg dose of FP nasal spray (1 spray/nostril) daily and the MF group received 100 µg dose of MF nasal spray (1 spray/nostril) daily for 8 weeks. The effects of the two agents were compared based on TNSS questionnaire in 0, 4 and 8 weeks after the beginning of the treatment. Results: At the end of ei...
International Journal of Otorhinolaryngology and Head and Neck Surgery, 2020
Background: There is a range of negative consequences on the oral mucosa caused by the tobacco an... more Background: There is a range of negative consequences on the oral mucosa caused by the tobacco and alcohol from inceptive light mucosal changes to a full-blown malignancy. The purpose of this study was to assess the risk of oral lesions resulting from the habits of addiction and prevalence of oral soft tissues changes with alcohol consumption, smoking, chewing and both type habits in individual residing in slums.Methods: This cross-sectional study was carried out in the slums of Jammu city. A questionnaire was used to obtain the information on substance abuse habits followed by oral clinical examination in selected population of 1200 individuals >15 years of age. The data collected were statistically analysed using chi-square test. Results: Of the 1200 study population, 816 were males and 384 were females and 72% were addicted to one or the other form of tobacco and alcohol. 32.6% showed oral mucosal changes, out of these, smoker’s melanosis was found in 10.4%, leukoplakia in 9....
Objective: To find relationship between Bax SNPs and squamous cell carcinoma head and neck (SCCHN... more Objective: To find relationship between Bax SNPs and squamous cell carcinoma head and neck (SCCHN) in patients from Kashmir Study design: Case control study. Setting: Tertiary care hospital (SMHS associated Medical College, Srinagar, Kashmir, India) Participants: 50 cases and 50 controls of squamous cell carcinoma head and neck reported our hospital from 2013-2016. Results: In the present study no evidence of associations between BAX (-248 G>A) and squamous cell carcinoma head and neck , further analyses showed that among BAX heterozygotes after adjustment for age, sex, and smoking status, the BAX GC ( Arg-Pro) genotype was associated with an elevated risk of SCCHN [OR=1.354, 95% CI= 0.8629-2.124 )compared with the BAX GG genotype and OR=1.962, 95% CI=0.9129-2.465) compared with the combined genotypes (GG+CC)],. Our data suggest that the risk of SCCHN may be associated with these SNPs of BAX. Larger studies are needed to validate these findings.
Indian Journal of Otolaryngology and Head & Neck Surgery, 2015
Computerized tomography (CT) and magnetic resonance (MR) are complementary in the imaging of the ... more Computerized tomography (CT) and magnetic resonance (MR) are complementary in the imaging of the labyrinth, the internal auditory canal and the brain in children with sensorineural hearing loss who are being evaluated for cochlear implantation. An accurate anatomical description of the inner ear is essential in the preoperative work up. Computerized tomography visualizes the bony structures, whereas MR can discern soft-tissue components including intra labyrinthine fluid, cerebrospinal fluid (CSF), nerves, and vessels within the IAC. This prospective study was conducted in the Department of Otorhinolaryngology, Head & Neck Surgery, Government Medical College, Srinagar. 40 children in the age group of 1-16 years with unidentified causes of bilateral SNHL were analysed radiologically over the period of 2 years from Dec 2011 to Jan 2014. Each patient underwent MRI and high resolution CT scanning of temporal bone in axial and coronal planes. Out of the 40 patients 22 were males (55 %) and 18 were females (45 %). 30 patients (72.5 %)in our study had normal radiological scans. Five patients (12.5 %) had B/L large vestibular aqueduct and two patients (5 %) had internal auditory canal stenosis with cochlear nerve hypoplasia on CT and MR imaging. Cochlear dysplasia was present in two patients (5 %) and semicircular canal dysplasia was present in one patient (2.5 %) as an isolated finding on HRCT. In addition isolated cochlear nerve hypoplasia was present in one patient (2.5 %). Hyperintense basal ganglia lesion suggestive of kernicterus was present in one patient (2.5 %) and hyperintense posterior parietal and occipital white matter lesions suggestive of congenital CMV infection was present in one patient (2.5 %) on MR imaging. Arachnoid cysts of middle cranial fossa was an incidental finding present in one patient. Radiological abnormalities of the inner ear are not uncommon. Computerized tomography and MRI are important modalities to analyze the inner ear in children with unexplained SNHL. MRI with an extremely small field of view should be used to study possible abnormalities of the vestibulocochlear nerves.
Objectives: To study various etiologies of tympanic membrane perforation, clinical presentations,... more Objectives: To study various etiologies of tympanic membrane perforation, clinical presentations, management and determine the group who are most likely to benefit from conservative management.
International Journal of Advanced Research, Apr 30, 2016
To find relationship between Bax SNPs and squamous cell carcinoma head and neck (SCCHN) in patien... more To find relationship between Bax SNPs and squamous cell carcinoma head and neck (SCCHN) in patients from Kashmir Study design: Case control study. Setting: Tertiary care hospital (SMHS associated Medical College,
Background: Ear, nose and throat (ENT) emergencies are very common throughout the world. Early di... more Background: Ear, nose and throat (ENT) emergencies are very common throughout the world. Early diagnosis and prompt treatment in the hands of expert will result in reduction of morbidity, mortality and referrals. Methods: This retrospective study was conducted on 352 patients reporting in out-patient department (OPD) and emergency of District Hospital Ramban from June 2016 to May 2017. Demographic data as well as diagnosis were studied. The type of anaesthesia and type of procedure and outcome of emergency case were recorded. Patients with terminal cancer care admitted were excluded from the study. Results: A total of 352 patients, 204 males and 148 females were included in present study. The commonest emergency was foreign body (69.03%), trauma (11.9%), epistaxis (9.6%), and abscess (6.8%). Procedures done were foreign body removal, fracture reductions, soft tissue injury repair, incision and drainage, packing and cauterisation. Conclusions: Foreign body is the most common cause of...
International Journal of Otorhinolaryngology and Head and Neck Surgery, 2020
Background: Allergic rhinitis is the most prevalent of allergic diseases in the world. Pharmacoth... more Background: Allergic rhinitis is the most prevalent of allergic diseases in the world. Pharmacotherapy remains the mainstay of treatment. Nasal corticosteroids being the most applicable drugs for its treatment. The objective of this study was to compare the efficacy of fluticasone propionate (FP) and mometasone furoate (MF) nasal sprays in the treatment of allergic rhinitis based on total nasal symptom score (TNSS) questionnaire.Methods: A prospective, randomized, open-label, parallel-group, comparative study was conducted among 80 allergic rhinitis patients fulfilling the inclusion and exclusion criteria. They were randomly assigned to two groups: FP and MF groups. FP group received 200 µg dose of FP nasal spray (1 spray/nostril) daily and the MF group received 100 µg dose of MF nasal spray (1 spray/nostril) daily for 8 weeks. The effects of the two agents were compared based on TNSS questionnaire in 0, 4 and 8 weeks after the beginning of the treatment. Results: At the end of ei...
International Journal of Otorhinolaryngology and Head and Neck Surgery, 2020
Background: There is a range of negative consequences on the oral mucosa caused by the tobacco an... more Background: There is a range of negative consequences on the oral mucosa caused by the tobacco and alcohol from inceptive light mucosal changes to a full-blown malignancy. The purpose of this study was to assess the risk of oral lesions resulting from the habits of addiction and prevalence of oral soft tissues changes with alcohol consumption, smoking, chewing and both type habits in individual residing in slums.Methods: This cross-sectional study was carried out in the slums of Jammu city. A questionnaire was used to obtain the information on substance abuse habits followed by oral clinical examination in selected population of 1200 individuals >15 years of age. The data collected were statistically analysed using chi-square test. Results: Of the 1200 study population, 816 were males and 384 were females and 72% were addicted to one or the other form of tobacco and alcohol. 32.6% showed oral mucosal changes, out of these, smoker’s melanosis was found in 10.4%, leukoplakia in 9....
Objective: To find relationship between Bax SNPs and squamous cell carcinoma head and neck (SCCHN... more Objective: To find relationship between Bax SNPs and squamous cell carcinoma head and neck (SCCHN) in patients from Kashmir Study design: Case control study. Setting: Tertiary care hospital (SMHS associated Medical College, Srinagar, Kashmir, India) Participants: 50 cases and 50 controls of squamous cell carcinoma head and neck reported our hospital from 2013-2016. Results: In the present study no evidence of associations between BAX (-248 G>A) and squamous cell carcinoma head and neck , further analyses showed that among BAX heterozygotes after adjustment for age, sex, and smoking status, the BAX GC ( Arg-Pro) genotype was associated with an elevated risk of SCCHN [OR=1.354, 95% CI= 0.8629-2.124 )compared with the BAX GG genotype and OR=1.962, 95% CI=0.9129-2.465) compared with the combined genotypes (GG+CC)],. Our data suggest that the risk of SCCHN may be associated with these SNPs of BAX. Larger studies are needed to validate these findings.
Indian Journal of Otolaryngology and Head & Neck Surgery, 2015
Computerized tomography (CT) and magnetic resonance (MR) are complementary in the imaging of the ... more Computerized tomography (CT) and magnetic resonance (MR) are complementary in the imaging of the labyrinth, the internal auditory canal and the brain in children with sensorineural hearing loss who are being evaluated for cochlear implantation. An accurate anatomical description of the inner ear is essential in the preoperative work up. Computerized tomography visualizes the bony structures, whereas MR can discern soft-tissue components including intra labyrinthine fluid, cerebrospinal fluid (CSF), nerves, and vessels within the IAC. This prospective study was conducted in the Department of Otorhinolaryngology, Head & Neck Surgery, Government Medical College, Srinagar. 40 children in the age group of 1-16 years with unidentified causes of bilateral SNHL were analysed radiologically over the period of 2 years from Dec 2011 to Jan 2014. Each patient underwent MRI and high resolution CT scanning of temporal bone in axial and coronal planes. Out of the 40 patients 22 were males (55 %) and 18 were females (45 %). 30 patients (72.5 %)in our study had normal radiological scans. Five patients (12.5 %) had B/L large vestibular aqueduct and two patients (5 %) had internal auditory canal stenosis with cochlear nerve hypoplasia on CT and MR imaging. Cochlear dysplasia was present in two patients (5 %) and semicircular canal dysplasia was present in one patient (2.5 %) as an isolated finding on HRCT. In addition isolated cochlear nerve hypoplasia was present in one patient (2.5 %). Hyperintense basal ganglia lesion suggestive of kernicterus was present in one patient (2.5 %) and hyperintense posterior parietal and occipital white matter lesions suggestive of congenital CMV infection was present in one patient (2.5 %) on MR imaging. Arachnoid cysts of middle cranial fossa was an incidental finding present in one patient. Radiological abnormalities of the inner ear are not uncommon. Computerized tomography and MRI are important modalities to analyze the inner ear in children with unexplained SNHL. MRI with an extremely small field of view should be used to study possible abnormalities of the vestibulocochlear nerves.
Objectives: To study various etiologies of tympanic membrane perforation, clinical presentations,... more Objectives: To study various etiologies of tympanic membrane perforation, clinical presentations, management and determine the group who are most likely to benefit from conservative management.
International Journal of Advanced Research, Apr 30, 2016
To find relationship between Bax SNPs and squamous cell carcinoma head and neck (SCCHN) in patien... more To find relationship between Bax SNPs and squamous cell carcinoma head and neck (SCCHN) in patients from Kashmir Study design: Case control study. Setting: Tertiary care hospital (SMHS associated Medical College,
Background: Ear, nose and throat (ENT) emergencies are very common throughout the world. Early di... more Background: Ear, nose and throat (ENT) emergencies are very common throughout the world. Early diagnosis and prompt treatment in the hands of expert will result in reduction of morbidity, mortality and referrals. Methods: This retrospective study was conducted on 352 patients reporting in out-patient department (OPD) and emergency of District Hospital Ramban from June 2016 to May 2017. Demographic data as well as diagnosis were studied. The type of anaesthesia and type of procedure and outcome of emergency case were recorded. Patients with terminal cancer care admitted were excluded from the study. Results: A total of 352 patients, 204 males and 148 females were included in present study. The commonest emergency was foreign body (69.03%), trauma (11.9%), epistaxis (9.6%), and abscess (6.8%). Procedures done were foreign body removal, fracture reductions, soft tissue injury repair, incision and drainage, packing and cauterisation. Conclusions: Foreign body is the most common cause of...
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