Papers by krishnakant T . waghmode
International journal of scientific research in science and technology, Apr 12, 2024
A simple, cost-effective, précised, accurate and robust Ultra Violet spectrophotometric method [1... more A simple, cost-effective, précised, accurate and robust Ultra Violet spectrophotometric method [1, 2 ] has been developed for the Identification and estimation of Quinoline Yellow in the Levodopa and Carbidopa tablet dosage forms. It is used as a colourant in the pharmaceutical tablet's dosage form. UV scan of Quinoline yellow was taken from the entire UV range of 200 to 800 nm. From the spectrum, maximum absorption was observed at 414nm (λmax) for the Quinoline Yellow. Method was found to be specific with no interference due to blank and placebo, The method was linear with a correlation coefficient of more than 0.999, and Accuracy was in the range of 98.3 to 101.3, In the robustness study employed for standard and sample preparation showed no impact on the results, by deliberate changes proves method is robust and can be utilized for regular analysis. Method validation was performed with reference to ICH guidelines Q2R1
Oriental Journal of Chemistry/Oriental journal of chemistry, Feb 25, 2024
A rapid, efficient, and precise RP-HPLC protocol has been developed to quantify dihydroquinine co... more A rapid, efficient, and precise RP-HPLC protocol has been developed to quantify dihydroquinine content in quinine sulfate pharmaceutical dosage form accurately. This reverse-phase high-performance liquid chromatography (RP-HPLC) method has been validated in compliance with the regulatory guidelines and has efficaciously met specified criteria. The RP-HPLC analysis utilized a Zorbax C18-column with an acetonitrile-buffer mobile phase. A constant 1.2 mL/min flow rate and a 20 μL injection volume were employed with a 316 nm detection wavelength. The linear range for standard solution concentrations was established at 48.7-193.87 μg/mL of quinine sulfate. Retention times were noted at 4.6 min for quinine and 6.9 min for dihydroquinine (impurity). The accuracy assessment of the dihydroquinine analysis revealed a recovery rate of 99.4%. In the present study, an analytical technique was devised and employed to quantify dihydroquinine in finished product tablets. The proposed technique is characterized by its precision, simplicity, and ease of adoption, demonstrating its robustness and applicability.
Chemical physics impact, Jun 1, 2024
Organic Preparations and Procedures International, Oct 10, 2023
International journal of pharma and bio sciences, Oct 10, 2017
Microwave promoted synthesis of pharmacologically active N-(1,3-benzothiazol-2-yl)-2-[(1,5-dimeth... more Microwave promoted synthesis of pharmacologically active N-(1,3-benzothiazol-2-yl)-2-[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)amino]acetamides is described. Microwave assisted synthesis not only reduced the reaction time drastically but also gave excellent yields. The synthesized compounds are characterized by Fourier Transform Infra-Red (FTIR), Proton Nuclear Magnetic Resonance (1H-NMR) and mass spectral data.
In the present study Indolo[2,3-b]quinoxalin-1-yl-N (4-oxo-2-phenyl-1,3-thiazolidin-3-yl)acetamid... more In the present study Indolo[2,3-b]quinoxalin-1-yl-N (4-oxo-2-phenyl-1,3-thiazolidin-3-yl)acetamide deri vat ves were synthesized from N’-benzylidene-2-(6H-indolo [2,3-b ] quinoxalin-6-yl ) acetohydrazide derivatives by c onventional method and under microwave irradiation. N’-benzylid ene-2-(6H-indolo [2,3-b] quinoxalin-6-yl ) acetohyd razide derivatives were synthesized from Indolo [2,3-b] qu inoxalin-6-yl ) acetohydrazide. The compounds obtai ned were purified by column chromatography using silica gel. The chemical structures of the compounds were conf irmed using IR, H-NMR and mass spectroscopy.
Microwave promoted synthesis of pharmacologically active Schiff bases of indolo [2, 3-b] quinoxal... more Microwave promoted synthesis of pharmacologically active Schiff bases of indolo [2, 3-b] quinoxaline is described. Microwave assisted synthesis not only reduced the reaction time drastically but also gave excellent yields of Schiff bases of indolo [2, 3-b] quinoxaline derivatives. The synthesized compounds are characterized by FTIR, 1H NMR and Mass spectral data.
Oxazole derivatives of ferrocene have been synthesized. Acetyl ferrocene was reacted with substit... more Oxazole derivatives of ferrocene have been synthesized. Acetyl ferrocene was reacted with substituted benzaldehyde to get substituted chalcones of ferrocene. These were further reacted with hydroxylamine hydrochloride to get oxazole derivatives. Synthesized compounds were characterized by FT-IR, and H 1 -NMR spectroscopy, these were further evaluated for their Antibacterial activity. KeywordsAcetyl ferrocene, spectral data and anti-bacterial activity. -------------------------------------------------------------------------------------------------------------------------------------Date of Submission: 21-12-2018 Date of acceptance: 05-01-2019 --------------------------------------------------------------------------------------------------------------------------------------
Green synthesis of piperazine substituted Schiff bases is described. Microwave-assisted synthesis... more Green synthesis of piperazine substituted Schiff bases is described. Microwave-assisted synthesis not only reduced the reaction time drastically but also gave excellent yields. 2-naphthylpiperazine was converted to its ester followed by hydrazide. Hydrazide of 2-naphthyl piperazine was reacted with various substituted aromatic aldehydes under conventional heating and microwave irradiation method to get the final product. The synthesized compounds are characterized by FT-IR, H-NMR, and Mass spectral data.
Synthesized benzimidazole induced Schiff base analogues were characterized by mass, 13C NMR, 1H N... more Synthesized benzimidazole induced Schiff base analogues were characterized by mass, 13C NMR, 1H NMR and UV-visible spectroscopy. To get more information about binding mechanism, molecular docking studies were carried out and the obtained results concluded that the compounds could effectively bind with receptor. in vitro Antibacterial screening was carried out against four strains (S. aureus, B. subtilis, P. aeruginosa and E. coli) and exhibited good antibacterial activity. The gastrointestinal absorption (HIA) and brain penetration (BBB) was evaluated by The BOILED-Egg model, which showed that two compounds anticipated being effectively effluated by the P-glycoprotein from central nervous system after penetration and can accounts for brain access and passive gastrointestinal absorption. Computational screening showed 0.55 bioavailability score for all synthesized compounds.
IOSR Journal of Pharmacy (IOSRPHR), 2012
We have developed rapid and efficient method for the synthesis of pharmacologically active N-phen... more We have developed rapid and efficient method for the synthesis of pharmacologically active N-phenyl acetamide derivatives of indolo [2, 3-b] quinoxaline by using microwave irradiations. Condensation of Substituted phenyl iodoacetamide derivatives with indolo [2, 3-b] quinoxaline under the influence of microwave radiations gave the products. Microwave assisted synthesis not only reduced the reaction time drastically but also gave excellent yields of N-phenyl acetamide derivatives of indolo [2, 3-b] quinoxaline.
Letters in Organic Chemistry
: This report describes an efficient and mild approach for the synthesis of Piperastrol and Enast... more : This report describes an efficient and mild approach for the synthesis of Piperastrol and Enastron via a one-pot three-component cyclocondensation reaction employing ammonium sulfocyanate (NH4SCN) on gram scale in isopropyl alcohol–PEG 400 medium. In this reaction ammonium sulfocyanate is not only one of the reacting components, but also accelerates the rate of reaction to afford Biginelli compounds. High yields, short reaction time and easy workup procedure are the key advantages of the present protocol. Ammonium sulfocyanate is readily available, cheaper, safer and industrial acceptable inorganic salt.
Asian Journal of Organic & Medicinal Chemistry
Efferent, new and simple synthesis for antidepressant drug moclobemide has been developed via two... more Efferent, new and simple synthesis for antidepressant drug moclobemide has been developed via two liner steps. Initially, morpholine treated with 60% aqueous solution of 2-bromoethylamine hydrochloride under solvent and catalyst free condition leads to a key intermediate N-(2-aminoethyl)morpholine, which subsequently treated with p-chlorobenzoic acid in presence of commercially available solid catalysts, afforded moclobemide with good yield. Mild reaction conditions, short reaction time, easy workup, cost-effective, environment friendliness and high yields are attractive advantages of the present method, so our synthetic strategy was applicable to large scale manufacturing of moclobemide every conveniently.
Method of preparation of aldehydes and ketones 1. Oxidation of primary and secondary alcohols u... more Method of preparation of aldehydes and ketones 1. Oxidation of primary and secondary alcohols using pyridinium chlorochromate(PCC)-Corey Suggs Reagent.
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Papers by krishnakant T . waghmode