Papers by surya prakash gautam
Polymers
Silk is a wonderful biopolymer that has a long history of medical applications. Surgical cords an... more Silk is a wonderful biopolymer that has a long history of medical applications. Surgical cords and medically authorised human analogues made of silk have a long history of use in management. We describe the use of silk in the treatment of eye diseases in this review by looking at the usage of silk fibroin for eye-related drug delivery applications and medication transfer to the eyes. During this ancient art endeavour, a reduced engineering project that employed silk as a platform for medicine delivery or a cell-filled matrix helped reignite interest. With considerable attention, this study explores the present usage of silk in ocular-based drug delivery. This paper also examines emerging developments with the use of silk as a biopolymer for the treatment of eye ailments. As treatment options for glaucoma, diabetic retinopathy, retinitis pigmentosa, and other retinal diseases and degenerations are developed, the trans-scleral route of drug delivery holds great promise for the selecti...
Fifty years ago, the essential job of drug specialists has only been to apportion solutions. Givi... more Fifty years ago, the essential job of drug specialists has only been to apportion solutions. Giving clinical drug store administrations at the medical clinics’ wards spoke to the development of the calling. Be that as it may, the social insurance framework, around the world, is persistently creating. Today, the drug specialist’s unmistakable new jobs have emphatically added to human services and society around the world. Drug specialists are presently accepting more prominent accountability for patients’ well-being status and advancing the results of medication use. They give human services counsel and oversee interminable ailments. Different orders of social insurance where particular drug specialists are utilized to incorporate oncology offices, irresistible sickness control, general well-being, medicate data, toxicology and toxic substance control, atomic medication, and sustenance support. In any case, a fitting determination, instruction, preparing, and workforce arranging to s...
Research journal of pharmacy and technology, Dec 28, 2021
<jats:p>Cardiovascular diseases (CVDs) are primary reason of mortality and morbidity worldw... more <jats:p>Cardiovascular diseases (CVDs) are primary reason of mortality and morbidity worldwide. Angina pectoris (AP), myocardial infarction (MI), silent myocardial ischemia and sudden cardiac death occur due to blockage in the coronary artery by atherosclerotic clot. Atherosclerotic clot is a systemic inflammatory process characterised by the accumulation and subsequent thickening of the wall by blood borne materials like low-density lipoproteins and macrophages/lymphocytes within the intima of arteries. These initial fatty streak lesions may also evolve into vulnerable plaques susceptible to rupture or erosion. Plaque rupture initiates both platelet adhesion and aggregation as well as the activation of the clotting cascade leading to so-called athero-thrombotic process and leads to coronary artery blockade. Coronary artery blockage interrupts the coronary blood supply leading to damage of myocardium. Multiple factors such as intra cellular (Ca2+, pH) and inter cellular (adhesion molecules) factors, inflammation, environmental toxins as well as metals and oxygen free radicals are involved in the pathogenesis of coronary artery diseases. Furthermore, certain sigma receptor ligands have been reported to show protective action against coronary artery diseases. Sigma receptor, a transmembrane protein, is expressed in many tissues including cardiovascular, liver and central nervous system. Sigma ligands significantly prevented the deviated biochemical parameters such as cardiac marker enzymes, lipid profile and antioxidant parameters to near normal status. Therefore, sigma receptor stimulation represents a new therapeutic strategy to prevent heart from ischemic and hypertrophic dysfunction in case of cardiovascular disorders. This review summarises the sigma receptors and cardioprotective potential of sigma receptor ligands. The article also provides a comprehensive account of structure, types and medical efficacy of cardioprotective sigma agonists.</jats:p>
Polymers, 2022
Taro (Colocasia esculenta) is an important source of carbohydrates as an energy source and is use... more Taro (Colocasia esculenta) is an important source of carbohydrates as an energy source and is used as a staple food throughout the world. It is rich in mucilage and starch granules, making it a highly digestible ingredient. Mucilage can act as a matrix and a thickening, binding, emulsifying, or foaming agent in food, pharmaceutical, and several other fields of research. Moreover, mucilage can be extracted from several living organisms and has excellent functional properties, such as water-holding, oil-holding, and swelling capacities. Therefore, these remarkable functional properties make mucilage a promising ingredient with possible industrial applications. Furthermore, several extraction techniques, including enzyme-assisted, ultrasonication, microwave-assisted, aquatic, and solvent extraction methods, are used to obtain quantitative amounts of taro mucilage. Coldwater extraction with ethanol precipitation can be considered an effective and cost-effective technique to obtain high-...
Frontiers in Optics + Laser Science 2021, 2021
Object autocorrelation obtained from the far field intensity pattern of the asymmetric object con... more Object autocorrelation obtained from the far field intensity pattern of the asymmetric object contains the object features. This fact is utilized here in the phase retrieval algorithm to remove the twin image problem.
Extracting information of an object which is hidden behind a translucent obstacle is a difficult ... more Extracting information of an object which is hidden behind a translucent obstacle is a difficult task. When the obstacle is a diffusing or scattering medium, it becomes much more complicated. The scattering medium makes the phase random, which cannot be retrieved or undone by simple techniques. Many approaches based on interference have been proposed to realise this goal. These approaches have produced good results meanwhile are also very expensive and complex in nature due to the requirement of a separate reference beam to form the interference pattern. We hereby, propose a novel method in which we are illuminating a hidden object with shifted dual beams simultaneously and these two beams are then reflected from the object to produce an interference pattern. This method does not require any separate reference beam to form the interference pattern. The purpose of using dual beam illumination is to eliminate the need of any shearing device to give shear between the object’s fields th...
Nanotechnology covers a different phenomenon that prepares novel operation in various fields. Nan... more Nanotechnology covers a different phenomenon that prepares novel operation in various fields. Nanotechnology assured a renewable future by its growth in green chemistry to develop green nanotechnology .Green nanotechnology intend not only to give Nano-products, but also to produce nanomaterial without degrading the environment or human health. It is established that current fossil fuel use is unsustainable and related with ozone harming substance production. The significant advances such as hydrogen fuel, solar cell, biotechnology depends upon nanotechnology and the applicable evident for manipulate the future energy for the well-disposed conditions are reviewed. This review reproduces how nanotechnology can be advantages as a green preference in various parts of nanoparticle synthesis. Keywords: Green nanotechnology, future energy, fuel cell, solar cell, biotechnology, biofuel Cite this Article Baldeep Kaur, Surya Prakash Gautam, Gaganpreet Kaur, Nitesh Gupta. Current and Future St...
The aim of the present research work was to investigate the potential of emulgel in enhancing the... more The aim of the present research work was to investigate the potential of emulgel in enhancing the topical delivery of ketoconazole. Emulgel formulations of Ketoconazole were prepared using 2 types of gelling agents: Carbopol 934 and Carbopol 940. The influence of the type of the gelling agent and the concentration of both the oil phase and emulsifying agent on the drug release from the prepared emulgel was investigated using a 23 factorial design. The prepared emulgel were evaluated for their physical appearance, viscosity, drug release, globule size, skin irritation test, antifungal activity, transmission electron microscopy and stability. Commercially available ketoconazole cream was used for comparison. All the prepared emulgel showed acceptable physical properties concerning color, homogeneity, consistency, spreadability, and pH value. The antifungal activity and drug release were found to be higher for optimized formulation as compared to the marketed ketoconazole cream. The hi...
Journal of Natural Science, Biology and Medicine, 2011
The antinociceptive activity of ethanolic extract of the plant bark of Dalbergia sissoo (Roxb.) w... more The antinociceptive activity of ethanolic extract of the plant bark of Dalbergia sissoo (Roxb.) was investigated using tail fl ick method on Wistar rats. Three different dose levels (300, 500, and 1000 mg/kg) in 0.5% carboxyl methyl cellulose (CMC) were administered by p.o. route. The antinociceptive activities of the all doses were compared with that of the standard drug asprin (300 mg/kg) administered by p.o. route and the results were found to be signifi cant (P < 0.01). At the above doses, the extract exhibited signifi cant and dose-dependent antinociceptive activity. Phytochemical investigation of the ethanolic extract indicated the presence of carbohydrates, proteins, amino acids, phenolic compounds, and fl avanoids. The antinociceptive activity of the bark extract of D. sissoo may be due to the presence of phytochemical constituents such as fl avanoids. The acute toxicity study revealed that ethanolic extract was not toxic up to 3000 mg/kg body weight.
Bioorganic & Medicinal Chemistry Letters, 2010
Healthcare, 2022
Artificial intelligence (AI) has been described as one of the extremely effective and promising s... more Artificial intelligence (AI) has been described as one of the extremely effective and promising scientific tools available to mankind. AI and its associated innovations are becoming more popular in industry and culture, and they are starting to show up in healthcare. Numerous facets of healthcare, as well as regulatory procedures within providers, payers, and pharmaceutical companies, may be transformed by these innovations. As a result, the purpose of this review is to identify the potential machine learning applications in the field of infectious diseases and the general healthcare system. The literature on this topic was extracted from various databases, such as Google, Google Scholar, Pubmed, Scopus, and Web of Science. The articles having important information were selected for this review. The most challenging task for AI in such healthcare sectors is to sustain its adoption in daily clinical practice, regardless of whether the programs are scalable enough to be useful. Based ...
In this era of innovation and advancement in drug delivery for better clinical effects convention... more In this era of innovation and advancement in drug delivery for better clinical effects conventional dosages form have still a strong grip and most popular in all kinds of medicinal preparation intended for oral use. To satisfy the need of growing market tablets dosages form have incorporated automation in manufacturing and some advanced tablet types. Modified release tablet formulations including, layered tablets such as In-lay tablet,
Indian Journal of Forensic and Community Medicine
Swine flu, also called Hog or Pig Flu, is a contamination because of someone of the several forms... more Swine flu, also called Hog or Pig Flu, is a contamination because of someone of the several forms of Swine Influenza Virus (SIV). It is common place through pig populace worldwide. Until now only folks were inside the direct contact with pigs were found to get swine flu. But, H1N1 virus is a brand new swine flu virus and it includes the genetic material of swine, hen and human influenza virus. H1N1 influenza or swine flu is a contagious disease this is as a result of the influenza virus. Infection with the H1N1 influenza virus can bring about intense illness and lifestyles threatening complications. Symptoms of H1N1 flu are similar to the ones of the common place flu and scientists are actively reading the scenario to better recognize its variety of signs and how it is spread. The intensity of this disorder may be lowered with the aid of diagnosing and taking proper treatments.
The Open COVID Journal
The outbreak of coronavirus disease 2019 (COVID-19) has stunned the world owing to the surreal, u... more The outbreak of coronavirus disease 2019 (COVID-19) has stunned the world owing to the surreal, unprecedented, and completely unbelievable manner in which it has spread globally within a short span of time. This spread has led to the common combination of variety and has promoted the passage of species blockade and genetic combination of these types of viruses. Despite the short history of the COVID-19 outbreak, with its global spread and frequent mutations, it has impacted the whole world and has become a worrying threat to the society. Scientific reports have disclosed that members of the coronavirus family, such as SARS-CoV, Middle East respiratory syndrome coronavirus (MERS-CoV), HCoV-NL63, HCoV-229E, HCoV-OC43, and HKU1 have infected the humans earlier too and that mutations in these viruses have resulted in the more complex severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In the present review, we have discussed how scientists keep track of the genetic tweaks to S...
Research in Medical & Engineering Sciences, 2019
In early 1980 Donald A. Tomalia started and published the birth of new member of Nano family. Vog... more In early 1980 Donald A. Tomalia started and published the birth of new member of Nano family. Vogtle, Jean Fréchet, Newcome have initiated and dedicated their work for dendrimers and have contributed scientifically [1,2]. The journey has started from providing proof of concepts and the number of research publications, patents filed every year is justifications of its global presence. The science of miniature has gained attraction of both beginners and advanced scientists (Figure 1).
Virosomes are reconstituted viral envelopes that can fill in as vaccines and as vehicles for cell... more Virosomes are reconstituted viral envelopes that can fill in as vaccines and as vehicles for cell conveyance of different macromolecules. The prospect of drug delivery and targeting systems utilizing virosomes is an intriguing innovative work field. Since virosomes are biocompatible, biodegradable, non-poisonous and non-autoimmunogenuic; endeavors have been made to use them as antibodies or adjuvants and also conveyance frameworks for drugs and organic for remedial purposes. The achievement of virosomal medicate conveyance relies on upon strategy used to set up the typified bioactive materials and fuse them into the virosomes. Virosome innovation could conceivably be utilized to convey peptides, nucleic acids or, then again qualities and medications like anti-toxins, anticancer agents, and steroids.
International Journal of Current Pharmaceutical Research, 2021
Delivery systems with a pulsatile-release method are particularly involved in designing medicines... more Delivery systems with a pulsatile-release method are particularly involved in designing medicines for which traditional managed drug-release systems with the continuous release are not suitable. This medication also has a high first-pass impact or special conditions for chrono-pharmacology. These medications also have a high first-pass or unique chronopharmacological effect. The pulsatile release profile is characterised by a duration of no release (lag time) followed by a fast and full release of the drug. Pulsatile drug delivery systems may be classified into site-specific systems in which the drug is released inside the gastrointestinal system (e. g. colon) or time-controlled devices wherein the drug is released after a well-defined time period. Site-regulated release is typically controlled by environmental factors, such as pH or enzymes found in the intestinal tract, whereas drug release from time-controlled processes is controlled mainly by the delivery system and, preferably,...
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Papers by surya prakash gautam