This thesis by publication historicises and contextualises the evolution, production and developm... more This thesis by publication historicises and contextualises the evolution, production and development of key Mexican screen melodramas over seventy years to understand Mexico’s ambivalence around socioeconomic background, race and religion, gender and worth, family and duty. It establishes that this genre offers a unique opportunity to understand Mexico’s social dynamics. The relevance of this research has been highlighted across the Journal of Iberian and Latin American Research, Critical Arts and Critical Studies in Television, and will be published as a book chapter in Children, Youth, and International Television and within a special dossier for the Journal of Popular Television.
Isolated Extramedullary Relapse in Acute Lymphoblastic Leukemia: What Can We Do Before and After Transplant?
Oncology, 2020
• Isolated EMR is defined as the presence of clonal blasts in any tissue other than the medullary... more • Isolated EMR is defined as the presence of clonal blasts in any tissue other than the medullary compartment with a bone marrow evaluation with less than 5% clonal blasts and a full donor chimerism. • Patients with iEMR have shown better survival outcomes when compared to BMR and EMR and in most cases it heralds a systemic relapse. • Risk factors for iEMR include: younger age, history of EMD, poor risk cytogenetics, advanced disease at HSCT, development of GVHD, and non-TBI based conditioning regimens. • Combination therapy, local and systemic, can achieve better remission rates in this subgroup of patients.
Se ha seleccionado como objeto de estudio de la investigacion que se desarrolla a continuacion, l... more Se ha seleccionado como objeto de estudio de la investigacion que se desarrolla a continuacion, la Actividad Terapeutica (AT) en el marco de la formacion y docencia de Terapeutas Ocupacionales (TO). Asi, se considera su rol historico como medio de intervencion y su integracion en los planes de estudio.
De Cardoso a Houaiss: o léxico das cores: aspetos cognitivos, semânticos e lexicográficos
Dissertação de mestrado Europeu em LexicografiaO léxico, como parte da herança cultural de um pov... more Dissertação de mestrado Europeu em LexicografiaO léxico, como parte da herança cultural de um povo, pode ser classificado em vários subconjuntos, dentre os quais podemos destacar o das cores. Analisar o léxico cromático português é descrever, para além de um sistema que funciona sobre uma base limitada de termos diretos ou livres relacionados com as cores (e.g. vermelho), uma multitude de denominações de cores indiretas ou complexas (e.g. vermelho-cereja; vermelho-escuro, etc.), isto é, significados secundários adquiridos que resultam de analogias, metáforas, metonímias, entre outros. O que propomos neste trabalho, através da análise de dicionários (de Cardoso a Houaiss), é estudar a cor do ponto de vista linguístico, analisando alguns dos aspetos cognitivos, semânticos e lexicográficos dos termos cromáticos. Situando a área de estudo entre a Lexicografia, Lexicologia e a Semântica Cognitiva, procuramos demonstrar a sua importância na criação destes termos, apontando para aspetos universais, em relação à experiência humana, mas também para restrições culturais, em que as línguas estabelecem, e.g., diferentes classificações dentro dos campos cromáticos, como no caso do português, que apresenta uma divisão interna, no campo do *vermelho*, entre cor livre (não determinada no seu uso por uma ligação a um objeto - vermelho/encarnado) e cor contextual (termos cromáticos que ganham novos valores quando associados a um conceito - ruivo; corado). Partindo deste campo cromático, que serviu de exemplo de análise para os restantes inicialmente escolhidos, foram analisados, em primeiro lugar, os artigos dos termos cromáticos simples, as suas definições, exemplos e subentradas formadas por combinações livres ou combinações mais ou menos fixas, permitindo, por sua vez, a análise da evolução semântica: de termos genéricos a significados secundários, figurados ou simbólicos. Em segundo lugar, foram analisadas a formação e disposição das cores complexas nos dicionários e, ainda, obtidos dados quantitativos das cores livres e cores contextuais, bem como analisada a capacidade produtiva da língua na criação de derivados, contribuindo, assim, para a compreensão do tratamento dos termos cromáticos nas obras lexicográficas portuguesas, de forma a serem aperfeiçoadas no futuro, quer em papel, quer online, monolingues ou bilingues.The lexicon as part of the cultural heritage of a people can be classified into various subsets, among which we can highlight the colours. To analyse the Portuguese chromatic lexicon is to describe, in addition to a system that works on a limited basis of direct or free colour terms (e.g. vermelho), a multitude of indirect or complex colour terms (e.g. vermelho-cereja; vermelho-escuro; etc.), i.e., acquired secondary meanings, resulting from analogies, metaphors, metonymies, etc. In this work, we propose to study colours from the linguistic point of view based on dictionary analysis (from Cardoso to Houaiss), by analysing some of the cognitive, semantic and lexicographic aspects of chromatic terms. Situating the study area between the fields of Lexicography, Lexicology and Cognitive Semantics, we try to demonstrate their importance in creating these terms, pointing to universal aspects in relation to human experience, but also to cultural constraints that lead languages to establish, e.g., different classifications within the colour fields, as in the case of the Portuguese that establishes an internal division in the field of *vermelho* between free colour (it is not determined in its use by a connection to an object- vermelho/encarnado) and contextual colour (chromatic terms that gain new values when associated with a concept – ruivo; corado). Taking the aforementioned chromatic field as an example for others fields initially chosen, firstly we analysed the dictionary entries of simple chromatic terms (definition, examples,subentries) formed by free or more or less fixed combinations, thus allowing, the analysis of their semantic evolution: from generic terms to secondary, figurative or symbolic meanings. Secondly, we analysed the formation and arrangement of complex colours in dictionaries and gathered quantitative data concerning the free and contextual colour terms. We also analysed the productive potential of the language to create derivative forms, thus contributing to the understanding of the treatment of chromatic terms in Portuguese lexicographical works and therefore enabling the improvement of paper or online, monolingual or bilingual dictionaries in the future.Le lexique, dans le cadre du patrimoine culturel d'un peuple, peut être classé en différents sous-ensembles, parmi lesquels on peut mettre en évidence les couleurs. Analyser le lexique chromatique portugais est décrire, au-delà d'un système qui fonctionne sur une base limitée de termes libres de couleurs (e.g. vermelho), une multitude de termes indirects (e.g. vermelho-cereja ; vermelho-escuro, etc.), c’est-à-dire de sens secondaires…
Pseudococcus calceolariae, the citrophilous mealybug, is a species of economic importance. Mating... more Pseudococcus calceolariae, the citrophilous mealybug, is a species of economic importance. Mating disruption (MD) is a potential control tool. During 2017–2020, trials were conducted to evaluate the potential of P. calceolariae MD in an apple and a tangerine orchard. Two pheromone doses, 6.32 g/ha (2017–2018) and 9.45 g/ha (2019–2020), were tested. The intermediate season (2018–2019) was evaluated without pheromone renewal to study the persistence of the pheromone effect. Male captures in pheromone traps, mealybug population/plant, percentage of infested fruit at harvest and mating disruption index (MDI) were recorded regularly. In both orchards, in the first season, male captures were significantly lower in MD plots compared to control plots, with an MDI > 94% in the first month after pheromone deployment. During the second season, significantly lower male captures in MD plots were still observed, with an average MDI of 80%. At the third season, male captures were again signific...
Cancer cell lines, which are cell cultures derived from tumor samples, represent one of the least... more Cancer cell lines, which are cell cultures derived from tumor samples, represent one of the least expensive and most studied preclinical models for drug development. Accurately predicting drug responses for a given cell line based on molecular features may help to optimize drug-development pipelines and explain mechanisms behind treatment responses. In this study, we focus on DNA methylation profiles as one type of molecular feature that is known to drive tumorigenesis and modulate treatment responses. Using genome-wide, DNA methylation profiles from 987 cell lines in the Genomics of Drug Sensitivity in Cancer database, we used machine-learning algorithms to evaluate the potential to predict cytotoxic responses for eight anti-cancer drugs. We compared the performance of five classification algorithms and four regression algorithms representing diverse methodologies, including tree-, probability-, kernel-, ensemble-, and distance-based approaches. We artificially subsampled the data ...
Urban and rural perimeters are boundaries that outline urban and rural areas. The delimitations o... more Urban and rural perimeters are boundaries that outline urban and rural areas. The delimitations of these areas are established according to a set of criteria supported in detailed baseline information such as resident population, the existing infrastructure, and the existence of public facilities. However, in situations where all the basic information needed to enable the current method of delimitation is not available or suitable, the planning process can be compromised. In these situations, it is necessary to create an alternative method that enables the delimitation of urban and rural perimeters in order to establish development conditions according to these perimeters and ensure the promotion of a correct and efficient transformation of the territory. This paper presents and discusses the method developed for the delimitation of urban and rural perimeters in the regional plan for Oé-Cusse Ambeno in Timor-Leste [Plano Director de Ordenamento Territorial da Região Administrativa Especial de Oé-Cusse Amben (PDOT)], supporting the elaboration of this plan by the Special Administrative Region of Oé-Cusse Ambeno. This method was developed specifically to enable the delimitation of urban perimeters in a context where the most basic baseline information is lacking, a characteristic situation in the majority of developing countries. In order to carry out the planning process, the method developed integrates a set of criteria from which it identifies the most determinant criteria to allow the establishment of a hierarchy of existing clusters (settlements) and the delimitation of the urban and rural perimeters. This activity has made use of a group of experts from the fields of architecture, territorial planning, geography, environmental sciences, landscape architecture, civil engineering, economics, and the law, all disciplines required to inform the applicability and weighting of each criteria. The result of the developed method has been applied in the conception of the PDOT in which the minimum baseline information to conduct future planning practices has been put in place. The conclusions show that the method applied provides an efficient delimitation of the urban and rural perimeters, which was validated on the PDOT framework and is able to be integrated into future plans.
This thesis by publication historicises and contextualises the evolution, production and developm... more This thesis by publication historicises and contextualises the evolution, production and development of key Mexican screen melodramas over seventy years to understand Mexico’s ambivalence around socioeconomic background, race and religion, gender and worth, family and duty. It establishes that this genre offers a unique opportunity to understand Mexico’s social dynamics. The relevance of this research has been highlighted across the Journal of Iberian and Latin American Research, Critical Arts and Critical Studies in Television, and will be published as a book chapter in Children, Youth, and International Television and within a special dossier for the Journal of Popular Television.
Isolated Extramedullary Relapse in Acute Lymphoblastic Leukemia: What Can We Do Before and After Transplant?
Oncology, 2020
• Isolated EMR is defined as the presence of clonal blasts in any tissue other than the medullary... more • Isolated EMR is defined as the presence of clonal blasts in any tissue other than the medullary compartment with a bone marrow evaluation with less than 5% clonal blasts and a full donor chimerism. • Patients with iEMR have shown better survival outcomes when compared to BMR and EMR and in most cases it heralds a systemic relapse. • Risk factors for iEMR include: younger age, history of EMD, poor risk cytogenetics, advanced disease at HSCT, development of GVHD, and non-TBI based conditioning regimens. • Combination therapy, local and systemic, can achieve better remission rates in this subgroup of patients.
Se ha seleccionado como objeto de estudio de la investigacion que se desarrolla a continuacion, l... more Se ha seleccionado como objeto de estudio de la investigacion que se desarrolla a continuacion, la Actividad Terapeutica (AT) en el marco de la formacion y docencia de Terapeutas Ocupacionales (TO). Asi, se considera su rol historico como medio de intervencion y su integracion en los planes de estudio.
De Cardoso a Houaiss: o léxico das cores: aspetos cognitivos, semânticos e lexicográficos
Dissertação de mestrado Europeu em LexicografiaO léxico, como parte da herança cultural de um pov... more Dissertação de mestrado Europeu em LexicografiaO léxico, como parte da herança cultural de um povo, pode ser classificado em vários subconjuntos, dentre os quais podemos destacar o das cores. Analisar o léxico cromático português é descrever, para além de um sistema que funciona sobre uma base limitada de termos diretos ou livres relacionados com as cores (e.g. vermelho), uma multitude de denominações de cores indiretas ou complexas (e.g. vermelho-cereja; vermelho-escuro, etc.), isto é, significados secundários adquiridos que resultam de analogias, metáforas, metonímias, entre outros. O que propomos neste trabalho, através da análise de dicionários (de Cardoso a Houaiss), é estudar a cor do ponto de vista linguístico, analisando alguns dos aspetos cognitivos, semânticos e lexicográficos dos termos cromáticos. Situando a área de estudo entre a Lexicografia, Lexicologia e a Semântica Cognitiva, procuramos demonstrar a sua importância na criação destes termos, apontando para aspetos universais, em relação à experiência humana, mas também para restrições culturais, em que as línguas estabelecem, e.g., diferentes classificações dentro dos campos cromáticos, como no caso do português, que apresenta uma divisão interna, no campo do *vermelho*, entre cor livre (não determinada no seu uso por uma ligação a um objeto - vermelho/encarnado) e cor contextual (termos cromáticos que ganham novos valores quando associados a um conceito - ruivo; corado). Partindo deste campo cromático, que serviu de exemplo de análise para os restantes inicialmente escolhidos, foram analisados, em primeiro lugar, os artigos dos termos cromáticos simples, as suas definições, exemplos e subentradas formadas por combinações livres ou combinações mais ou menos fixas, permitindo, por sua vez, a análise da evolução semântica: de termos genéricos a significados secundários, figurados ou simbólicos. Em segundo lugar, foram analisadas a formação e disposição das cores complexas nos dicionários e, ainda, obtidos dados quantitativos das cores livres e cores contextuais, bem como analisada a capacidade produtiva da língua na criação de derivados, contribuindo, assim, para a compreensão do tratamento dos termos cromáticos nas obras lexicográficas portuguesas, de forma a serem aperfeiçoadas no futuro, quer em papel, quer online, monolingues ou bilingues.The lexicon as part of the cultural heritage of a people can be classified into various subsets, among which we can highlight the colours. To analyse the Portuguese chromatic lexicon is to describe, in addition to a system that works on a limited basis of direct or free colour terms (e.g. vermelho), a multitude of indirect or complex colour terms (e.g. vermelho-cereja; vermelho-escuro; etc.), i.e., acquired secondary meanings, resulting from analogies, metaphors, metonymies, etc. In this work, we propose to study colours from the linguistic point of view based on dictionary analysis (from Cardoso to Houaiss), by analysing some of the cognitive, semantic and lexicographic aspects of chromatic terms. Situating the study area between the fields of Lexicography, Lexicology and Cognitive Semantics, we try to demonstrate their importance in creating these terms, pointing to universal aspects in relation to human experience, but also to cultural constraints that lead languages to establish, e.g., different classifications within the colour fields, as in the case of the Portuguese that establishes an internal division in the field of *vermelho* between free colour (it is not determined in its use by a connection to an object- vermelho/encarnado) and contextual colour (chromatic terms that gain new values when associated with a concept – ruivo; corado). Taking the aforementioned chromatic field as an example for others fields initially chosen, firstly we analysed the dictionary entries of simple chromatic terms (definition, examples,subentries) formed by free or more or less fixed combinations, thus allowing, the analysis of their semantic evolution: from generic terms to secondary, figurative or symbolic meanings. Secondly, we analysed the formation and arrangement of complex colours in dictionaries and gathered quantitative data concerning the free and contextual colour terms. We also analysed the productive potential of the language to create derivative forms, thus contributing to the understanding of the treatment of chromatic terms in Portuguese lexicographical works and therefore enabling the improvement of paper or online, monolingual or bilingual dictionaries in the future.Le lexique, dans le cadre du patrimoine culturel d'un peuple, peut être classé en différents sous-ensembles, parmi lesquels on peut mettre en évidence les couleurs. Analyser le lexique chromatique portugais est décrire, au-delà d'un système qui fonctionne sur une base limitée de termes libres de couleurs (e.g. vermelho), une multitude de termes indirects (e.g. vermelho-cereja ; vermelho-escuro, etc.), c’est-à-dire de sens secondaires…
Pseudococcus calceolariae, the citrophilous mealybug, is a species of economic importance. Mating... more Pseudococcus calceolariae, the citrophilous mealybug, is a species of economic importance. Mating disruption (MD) is a potential control tool. During 2017–2020, trials were conducted to evaluate the potential of P. calceolariae MD in an apple and a tangerine orchard. Two pheromone doses, 6.32 g/ha (2017–2018) and 9.45 g/ha (2019–2020), were tested. The intermediate season (2018–2019) was evaluated without pheromone renewal to study the persistence of the pheromone effect. Male captures in pheromone traps, mealybug population/plant, percentage of infested fruit at harvest and mating disruption index (MDI) were recorded regularly. In both orchards, in the first season, male captures were significantly lower in MD plots compared to control plots, with an MDI > 94% in the first month after pheromone deployment. During the second season, significantly lower male captures in MD plots were still observed, with an average MDI of 80%. At the third season, male captures were again signific...
Cancer cell lines, which are cell cultures derived from tumor samples, represent one of the least... more Cancer cell lines, which are cell cultures derived from tumor samples, represent one of the least expensive and most studied preclinical models for drug development. Accurately predicting drug responses for a given cell line based on molecular features may help to optimize drug-development pipelines and explain mechanisms behind treatment responses. In this study, we focus on DNA methylation profiles as one type of molecular feature that is known to drive tumorigenesis and modulate treatment responses. Using genome-wide, DNA methylation profiles from 987 cell lines in the Genomics of Drug Sensitivity in Cancer database, we used machine-learning algorithms to evaluate the potential to predict cytotoxic responses for eight anti-cancer drugs. We compared the performance of five classification algorithms and four regression algorithms representing diverse methodologies, including tree-, probability-, kernel-, ensemble-, and distance-based approaches. We artificially subsampled the data ...
Urban and rural perimeters are boundaries that outline urban and rural areas. The delimitations o... more Urban and rural perimeters are boundaries that outline urban and rural areas. The delimitations of these areas are established according to a set of criteria supported in detailed baseline information such as resident population, the existing infrastructure, and the existence of public facilities. However, in situations where all the basic information needed to enable the current method of delimitation is not available or suitable, the planning process can be compromised. In these situations, it is necessary to create an alternative method that enables the delimitation of urban and rural perimeters in order to establish development conditions according to these perimeters and ensure the promotion of a correct and efficient transformation of the territory. This paper presents and discusses the method developed for the delimitation of urban and rural perimeters in the regional plan for Oé-Cusse Ambeno in Timor-Leste [Plano Director de Ordenamento Territorial da Região Administrativa Especial de Oé-Cusse Amben (PDOT)], supporting the elaboration of this plan by the Special Administrative Region of Oé-Cusse Ambeno. This method was developed specifically to enable the delimitation of urban perimeters in a context where the most basic baseline information is lacking, a characteristic situation in the majority of developing countries. In order to carry out the planning process, the method developed integrates a set of criteria from which it identifies the most determinant criteria to allow the establishment of a hierarchy of existing clusters (settlements) and the delimitation of the urban and rural perimeters. This activity has made use of a group of experts from the fields of architecture, territorial planning, geography, environmental sciences, landscape architecture, civil engineering, economics, and the law, all disciplines required to inform the applicability and weighting of each criteria. The result of the developed method has been applied in the conception of the PDOT in which the minimum baseline information to conduct future planning practices has been put in place. The conclusions show that the method applied provides an efficient delimitation of the urban and rural perimeters, which was validated on the PDOT framework and is able to be integrated into future plans.
Uploads
Papers by sofia miranda