Papers by Anilkumar shinde
Research journal of pharmacy and technology, Dec 29, 2023
Journal of research in pharmacy, Jan 13, 2020
The objective of the present study was to prepare an amorphous system of BCS Class 2 drug meloxic... more The objective of the present study was to prepare an amorphous system of BCS Class 2 drug meloxicam (MLX) to improve its solubility and dissolution by using the melt solidification techniques. About 40% of new chemical entities do not reach to market due to its poor aqueous solubility. Melt solidification technique is an important process to control the transition from liquid in to solid phase to obtain product in an amorphous form. During the process of heating, some solid gets melted and if quench cooled, instead of crystallizing gets converted to amorphous solid form appearing as that of glass, which improve dissolution and bioavailability of drugs. Physical mixtures of MLX were prepared by melt solidification technique using polymer (soluplus). The solubility and dissolution studies for the meloxicam and batches were conducted in a phosphate buffer (pH 6.8). The fourier transform infrared(FTIR) spectrophotometry, X-ray diffraction microscopy(XDM) and Differential scanning calorimetry(DSC) studies were conducted to evaluated pure drug and optimized batch(MS7). Saturation solubility and % drug release showed the improve solubility and dissolution, results suggest that optimized batch (MS7) containing drug and polymer in proportion of 1:4 (MLX:soluplus) was a successful enhancing the solubility and dissolution of MLX. The % crystallinity of MLX in amorphous sample was 18.60%, which indicates significant decrease in crystallinity of MLX in an amorphous system. The best fit model of optimized batch (MS7) was zero order model, showing the %drug release 96.83% and R 2 0.9904. The present investigation, successfully enhancement solubility and dissolution of MLX by using melt solidification technique.
Research Journal of Pharmacy and Technology, 2020
Bangladesh Journal of Pharmacology, Jun 6, 2022
Asian Journal of Pharmaceutics, 2010
T ransdermal systems are ideally suited for diseases that demand chronic treatment. Hence, an ant... more T ransdermal systems are ideally suited for diseases that demand chronic treatment. Hence, an anti-diabetic agent of both therapeutic and prophylactic usage has been subjected to transdermal investigation. Gliclazide, a second-generation hypoglycemic agent, faces problems like its poor solubility, poor oral bioavailability with large individual variation and extensive metabolism. In the present work, transdermal matrix-type patches were prepared by film casting techniques on mercury using polymers like HPMC, Eudragit RL-100, and chitosan. Also an attempt was made to increase the permeation rate of drug by preparing an inclusion complex with hydroxypropyl β-cyclodextrin (HP β-CD). The possibility of a synergistic effect of chemical penetration enhancers (CPE) (propylene glycol and oleic acid) on the transdermal transport of the drug was also studied. Folding endurance was found to be high in patches containing higher amount of the Eudragit. There was increase in tensile strength with an increase in Eudragit in the polymer blend. In vitro drug release profile indicates that the drug release is sustained with increasing the amount of Eudragit in patches. The patches containing inclusion complex of drug showed higher permeation flux compared with patches containing plain drug. The result of the synergistic effect indicates that the HP β-CD in conjunction with other CPE showed a higher permeation flux.
Indian Journal of Pharmaceutical Education and Research, 2010
The objective of this study was to formulate an oral floating tablet of cephalexin (CEF) using th... more The objective of this study was to formulate an oral floating tablet of cephalexin (CEF) using the hydrophilic polymer 2 hydroxy propyl methyl cellulose (HPMC), gas generating agent sodium bicarbonate and citric acid. A 3 factorial design was applied systematically; the amount of citric acid (X1) and amount of HPMC K100M (X2) were selected as independent variables. The time required for 50% drug release (t), percentage drug release at 12hr (Q) and 50% 12 percentage drug release at 6 hr (Q) were selected as dependent variables. The results of factorial design indicated 6 that high level of HPMC K100M and citric acid favors preparation of floating sustained release tablet of cephalexin. The granules were prepared by wet granulation method and evaluated for their granules properties. Tablets were compressed by KBr press and evaluated with different parameters like diameter, thickness, average weight, hardness, friability, drug content, in vitro buoyancy study, swelling characteristics, scanning electron microscopy, kinetic 2 release data. Hardness was found to being the range of 13 ± 0.23 to 13 ± 0.40 kg/cm , the percent friability was in the range of 0.0010 ± 0.02 to 0.0027 ± 0.01, and tablets showed 99.63 ± 0.12 to 115.73 ± 0.13 of the labeled amount of cephalexin indicating uniformity content. The tablets containing CEF released 72.28 to 99.461 % of drug at the end of 12 hr by in vitro release study. The drug release followed the Korsmeyer and Peppas model controlled mechanism of cephalexin tablet.
Research journal of pharmacy and technology, Oct 21, 2022
Objective: The objective of present work was to prepare colon-specific delivery systems for 5-ami... more Objective: The objective of present work was to prepare colon-specific delivery systems for 5-aminosalicylic acid (5-ASA) using fenugreek gum and chitosan as a carrier target to the colon. Methods: Core tablets containing 5-ASA were prepared by wet granulation with using polyvinyl pyrolidone (PVP) as a binder and sodium starch glycolate as a super disintegrant. The prepared granules were evaluated for the angle of repose, compressibility index and Hausner’s ratio. The prepared tablets were evaluated the hardness, friability, weight variation and disintegration studies. The core tablets were coated with the concentration of 2%, 5%, and 7% in the ratio of 50:50, 40:60, 60:40, 70:30 and 30:70 of fenugreek gum and chitosan. The enteric coated tablets were characterized for the in vitro disintegration, and dissolution. The drug polymer compatibility studies were determined by using FT-IR study and found out no interaction between the drug and polymers. Results: The formation of complexes between fenugreek gum and chitosan prevents the drug release in the stomach. The tablets coated with 7% concentration solutions in the ratio 70:30 (Fenugreek gum: Chitosan) shows better swelling property and 89.99% drug releases in the colon. FT-IR, DSC studies showed the absence of interaction between 5-ASA and the excipients on storage accelerated condition at 40°C±2°C, 75%±5% RH for 12 weeks. Conclusion: Thus, it can be concluded that developed fenugreek gum and chitosan coated 5-ASA tablets can be considered as a promising system for targeted delivery to colon for local action.
International Journal of Research in Pharmaceutical Sciences, Jul 1, 2021
Asian Journal of Pharmaceutical and Clinical Research, Oct 17, 2019
Objective: The objective of the present study was to the preparation of a coamorphous (COAM) syst... more Objective: The objective of the present study was to the preparation of a coamorphous (COAM) system of paracetamol (PA) (Biopharmaceutics Classification System [BCS] Class-III) and ibuprofen (IB) (BCS Class-II) for enhancement of solubility and dissolution of IB. Methods: The COAM system was prepared by chemical electric magnetic field microwave-assisted method. Several batches with different concentrations of COAM PA and IB were prepared at constant temperature, pressure, and holding time. Solubility studies were carried out in different pH condition and the batch, which show the highest increase in solubility 98.00%. COAM samples were characterized by solubility, dissolution, Fourier transform infrared (FTIR), X-ray diffraction (XRD), and differential scanning calorimetry (DSC) studies. Results: FTIR results showed evidence of molecular interactions between both the drugs. Maximum increase in aqueous solubility of IB was seen 500:200 mg dose ratio (COAM) batch E in phosphate buffer 7.4. The COAM system increased solubility of IB about 98.70%. The solubility and dissolution rate of IB were also enhanced. In vitro drug release study, 100% of the drug was released within 120 min. Thus, saturation solubility and dissolution rate of IB were found significant improved unlike PA. XRD and DSC results confirmed amorphization of IB. FTIR results evidenced hydrogen bonding interactions between both the drugs. In accelerated stability studies, powder XRD and DSC results demonstrated insignificant changes, thus confirming successful stabilization of IB by PA. Conclusion: Hence, it concluded that the study of COAM of PA and IB successfully prepared by microwave-assisted method to enhance solubility, dissolution, stability, and bioavailability.
Research Journal of Pharmacy and Technology, Mar 24, 2022
Psoriasis is an inflammatory skin condition characterised by scaling with inflammation (pain, ede... more Psoriasis is an inflammatory skin condition characterised by scaling with inflammation (pain, edema, warmth, and redness) that results in regions of thick, red skin covered in silvery scales. These spots can be itchy or painful. Systemic treatment, topical therapy, and phototherapy are all now used to treat psoriasis. These treatments have a variety of negative and perhaps fatal side effects. Patients with psoriasis are more likely to acquire other conditions such as psoriatic arthritis, anxiety and depression, cancer, metabolic syndrome, cardiovascular disease, and Crohn's disease. The majority of people use herbal medicine because it is readily available, inexpensive, and effective. Many plants have promising features, including significant results in the treatment of psoriasis. The present study plans to emphasize such plants, herbal formulations, and associated therapy, which could add value to the development of a better, safe, and efficacious formulation to treat psoriasis that may help new researchers in this field.
Bangladesh Journal of Pharmacology, Jun 6, 2022
Asian Journal of Pharmacy and Technology, Nov 22, 2022
International Journal of Biology, 2021
Chyawanprash is an Ayurvedic dietary health supplement used for boosting immunity and help in mak... more Chyawanprash is an Ayurvedic dietary health supplement used for boosting immunity and help in making a person feel young. Chyawanprash is one of the anti-ageing supplements, which is purely herbal in nature. It has Amla as its main ingredient, which is a powerful antioxidant. Master Charaka is the first to mention this herbal medicine. Ayurveda recommends the use of herbal supplements to help the increase immunity, restore drained reserves of life force and to preserve strength, stamina, and vitality, while stalling the course of aging. There are many benefits of chyawanprash. It is useful in cough and cold. It helps in the rejuvenation of the aged and also in proper nourishment of young ones. It is effectively used in the treatments of throat infections. Chyawanprash is formulated by processing around 50 medicinal herbs, minerals sugar, honey, ghee, Indian gooseberry jam, sesame oil, berries and spices. Chyawanprash market has seen a sharp rise of 30 to 40 percent in the period of rising cases of coronavirus. This article focused on immunity boosting herbal medicine in COVID-19 pandemic.
Latin American Journal of Pharmacy, 2011
The objective of the present work was to formulate chitosan nanoparticles as carriers for the lov... more The objective of the present work was to formulate chitosan nanoparticles as carriers for the lovastatin, since this drug undergoes extensive first pass extraction in the liver, and bioavailibity is low (< 5 %). Nanoparticles were prepared by modified ionotropic gelation method using 3 2 full factorial design. From the preliminary trials, the constraints for independent variables X1 (concentration of chitosan) and X2 (concentration of sodium tripolyphosphate) have been fixed and examined to investigate effect on particle size, encapsulation efficiency, zeta potential, % release, SEM, FTIR, XRD and DSC analysis of lovastatin. The diameter of prepared nanoparticles was controlled in the range of 100-800 nm, spherical shape and narrow diameter distribution. The release profiles of all batches were very well fitted by both the zero order model and the anomalous transport. These results indicate that lovastatin nanoparticles could be effective in sustaining drug release for a prolonged period.
Journal of Drug Delivery and Therapeutics, Jun 25, 2014
The aim of the study was to compare the single dose oral bioavailability of lovastatin (LV) nanop... more The aim of the study was to compare the single dose oral bioavailability of lovastatin (LV) nanoparticles in albino rabbits. Plasma was analyzed for lovastatin using a sensitive, reproducible, accurate and validated RP-HPLC method. Pharmacokinetic parameters including AUC, Cmax, Tmax, t 1/2, MRT and Kel were determined from plasma concentration of the formulations. The randomly divided into three treatment groups with six animals in each group, as standard I, Standard II and Test. Lovastatin pure drug and lovastatin lovastatin marketed formulation were administered to standard group. Lovastatin loaded nanoparticles suspension was administered to test group. The Cmax of LV nanoparticles was found to be 72.28 ±0.158 ng/ml, whereas Cmax value for the drug suspension and marketed tablet formulation was found to be 33.10 ± 0.176ng/ml and 40.96 ± 0.244ng/ml respectively. (P < 0.001) indicating facilitated absorption of LV by nanoparticles. Tmax of lovastatin nanoparticles was 2 hrs, whereas for the drug suspension and marketed tablet formulation were 1 h respectively. (P < 0.001). The AUC (0-∞h) value for the lovastatin nanoparticles, drug suspension and marketed tablet formulation were found to be 301.43 ±0.165 (ng/ml × h), 73.88 ± 0.210 (ng/ml × h) and 120.51 ± 0.338 (ng/ml × h) respectively. (p < 0.001) The mean residence time (MRT) values for the lovastatin nanoparticles, drug suspension and marketed tablet formulation were found to be 1.41 h, 1.35 h and 1.63 h respectively. (P < 0.001) The relative bioavailability was found to be significant improvement in bioavailability (1.5 fold) as compared with the conventional tablets.
Der Pharmacia Lettre, 2014
The present study was to formulate nanoparticles (NPs) containing simvastatin (SV) prepared with ... more The present study was to formulate nanoparticles (NPs) containing simvastatin (SV) prepared with Poly (D, L Lactide-co-Glycolide) by nano-precipitation-solvent displacement method to achieve a better release profile suitable for per oral administration with enhanced efficacy. The formulations were fabricated according to a 3² full factorial design, allowing the simultaneous evaluation of two formulation independent variables and their interaction. The dependent variables that were selected for study were particle size and % drug entrapment. The influence of various formulation factors (drug: polymer ratio and concentration of surfactants) on particle size, size distribution, zeta potential, drug loading and encapsulation efficiency were investigated. Encapsulation efficiency and drug loading capacity were found to be increased as drug concentration increases with respect to polymer. Addition of surfactants showed a promising result in decreasing particle size of NPs. Dissolution study revealed increased release of SV from NPs. Transmission electron microscopy (TEM) study revealed spherical morphology of the developed NPs. Differential scanning calorimetry (DSC) studies confirmed phase transition behavior of NPs. They also showed very significant change in saturation solubility in comparison with pure drug. The in vitro release data follows matrix and first order release kinetics mechanism, good correlation coefficients (R 2 ≥ 0.9915) could be obtained.
The whole world facing COVID-19 pandemic, so there has been a lot of interest in ways to boosting... more The whole world facing COVID-19 pandemic, so there has been a lot of interest in ways to boosting our immune system, and thus build a first line of defence against the deadly virus. Since ancient times, medicinal plants, herbs and spices were well known for their medicinal properties. Therefore, the medicinal plants and herbs playing a critical role to boosting our immunity during the COVID-19 pandemic. it is also very important to consume supplements in the form of immune nutrients such as vitamin A, C, E, D, Bcomplex, Zinc and copper that will support your body to fight against the pathogens. This paper presents an analysis of popular immune-boosting medicinal plants and herbs.
International Journal of Pharmacy and Pharmaceutical Sciences, Jul 29, 2014
Objective: The objective of present study was to formulate an oral mcoadhesive tablet of diltiaze... more Objective: The objective of present study was to formulate an oral mcoadhesive tablet of diltiazem hydrochloride. Methods: Investigate the effect of amount of HPMC K4M and sodium alginate on the sustained release and gastric residence time of dosage form. The mucoadhesive tablet prepared by direct compression method was used varying concentrations of HPMC K4M and Sodium alginate and (1:1, 1:1.5, 1:2) Drug and Polymer ratio. Results: The formulations were evaluated and results revealed that FTIR studies showed no evidence of interactions between drug and excipients used. The mucoadhesive strength, residence time and drug content of formulation F3 was found to be 26.35 ± 1.15 mg, >7.5hrs, and 98.75 ± 0.05 % respectively. The formulation F3 exhibited sustained drug release i.e. 75.71% in 12 h. The In Vitro release kinetics studies reveal that formulations fit well with zero order kinetics and mechanism of drug release is Super case II transport. Conclusion: The study was concluded that formulation of mucoadhesive tablets from the cumulative % drug release study reveals that increase in the concentration of adhesive polymers cause slow the drug release. Sustained release tablet of DTZ can be beneficial in treatment of hypertension.
Der Pharmacia sinica, 2011
The objective of the present work was to formulate nanoparticles for simvastatin drug. Simvastati... more The objective of the present work was to formulate nanoparticles for simvastatin drug. Simvastatin is a lipid lowering agent, undergoes extensive first pass extraction in the liver, the availability of the drug to the general circulation is low (< 5%). Nanoparticles were prepared by precipitation-solvent deposition method using 3² full factorial design, Pluronic F-68 as polymeric stabilizer. From the preliminary trials, the constraints for independent variables X1 (amount of PLGA) and X2 (amount of Pleuronic F-68) have been fixed. The prepared formulations were further evaluated for % encapsulation efficiency, particle size, Polydispersity index, in vitro drug release pattern and drug excipient interactions. Drug: polymer ratio and concentration of stabilizer were found to influence the particle size and entrapment efficiency of simvastatin loaded PLGA nanoparticles. In vitro drug release study of selected factorial formulations (PS1, PS4, PS7) showed, 84.56%, 89.65% and 73.46 % release respectively in 24 hrs. The formulation batch PS3 having lowest particle size 122 nm. The release was found to follow first order release kinetics with fickian diffusion mechanism for all batches. These results indicate that simvastatin loaded PLGA nanoparticles could be effective in sustaining drug release for a prolonged period.
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Papers by Anilkumar shinde