sherif Ibrahim

Followers

Following

Public Views

Ruslaina Yusoff

Universiti Sains Malaysia

Rahmi YÜCEL

Abant Izzet Baysal University, Bolu, Turkey

Niamh M. Brennan

University College Dublin

norizan ahmad

Universiti Teknologi Mara

Gokhan Ozer

Kyrgyz-Turkish Manas University

Roberto Cippitani

Indepac

Iqbal Azhari

UiTM

Silvia Martinelli

Università degli Studi di Torino

Suhail Iqbal

Bahria University, Islamabad-Pakistan

diky kurnia

Sekolah Tinggi Akuntansi Negara STAN

Interests

Uploads

Papers by sherif Ibrahim

Bone Marrow Biopsy Needle Design Influences the Bone Content of Recovered Specimens

Blood, 2004

Introduction: The integrity and composition of bone marrow core biopsies may be influenced by man... more Introduction: The integrity and composition of bone marrow core biopsies may be influenced by many parameters including patient age, sex, bone density, operator experience, needle selection and biopsy technique. Biopsy needle design impacts on a needle’s performance and the quality of recovered specimens. We studied the effect of modifying the Snarecoil bone marrow biopsy needle tip on the recovery of trabecular bone in core specimens. Methods: 7 patients, ages 35–92, M/F = 4/3, (2 leukemias, 1 lymphoma, 1 cytopenia, 1 anemia, 2 other) underwent a bone marrow biopsy using a 8 gauge Snarecoil needle with a new needle tip (TPNSP). The tip has a twin peak point and more distal Snarecoil position. As a control group, 7 patients biopsied with a standard 8 gauge Snarecoil needle (NTP) were retrospectively identified and matched for age and sex and were ages 37–87, M/F = 5/2, (3 cytopenias, 2 leukemias, 1 lymphoma, 1 other). All biopsies were completed using a minimally manipulative techni...

Expression of c-MYC and MMP9 in Alternatively Activated Macrophages (M2) of Classical Hodgkin Lymphoma

Blood, 2014

Classical Hodgkin Lymphoma (CHL) is a monoclonal lymphoid neoplasm that accounts for approximatel... more Classical Hodgkin Lymphoma (CHL) is a monoclonal lymphoid neoplasm that accounts for approximately 30% of all lymphomas in the United States. Although multiagent chemotherapy and radiation therapy have made CHL a highly curable disease, approximately 15-20% of patients are refractory to the treatment or relapsed after remission. The rich inflammatory cellular microenvironment plays an important role in the pathogenesis of CHL. Gene-expression profiling has identified a gene signature of tumor-associated macrophages (TAMs) that was significantly associated with primary treatment failure. The potential of macrophage-specific markers, CD68 and CD163, as prognostic markers for resistance to therapy in CHL patients has been investigated; however, these studies generated inconsistent results. Roughly TAMs could be characterized into two distinct polarization states; the classically activated type 1 macrophages (M1) associated with acute inflammation and T-cell immunity and the alternative...

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

The Lancet, 2020

Background The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoper... more Background The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74•0%) had emergency surgery and 280 (24•8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26•1%) patients. 30-day mortality was 23•8% (268 of 1128). Pulmonary complications occurred in 577 (51•2%) of 1128 patients; 30-day mortality in these patients was 38•0% (219 of 577), accounting for 82•6% (219 of 265) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1•75 [95% CI 1•28-2•40], p<0•0001), age 70 years or older versus younger than 70 years (2•30 [1•65-3•22], p<0•0001), American Society of Anesthesiologists grades 3-5 versus grades 1-2 (2•35 [1•57-3•53], p<0•0001), malignant versus benign or obstetric diagnosis (1•55 [1•01-2•39], p=0•046), emergency versus elective surgery (1•67 [1•06-2•63], p=0•026), and major versus minor surgery (1•52 [1•01-2•31], p=0•047). Interpretation Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery.

sherif Ibrahim

Related Authors

Uploads

Papers by sherif Ibrahim

Log In